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The map label for this gene is dsbD-2

Identifier: 110833935

GI number: 110833935

Start: 1216125

End: 1216751

Strand: Direct

Name: dsbD-2

Synonym: ABO_1074

Alternate gene names: 110833935

Gene position: 1216125-1216751 (Clockwise)

Preceding gene: 110833934

Following gene: 110833936

Centisome position: 38.98

GC content: 58.69

Gene sequence:

>627_bases
ATGAGCGGTCGCTTTATTACCCTAGAAGGCGGAGAGGGTGCAGGTAAGAGTAGCAACCTCGTTTGGTTGGCAGAGGCGCT
TCGGGCCGAGGGTAAGACGGTGATGGTAAGCCGAGAGCCCGGAGGCACAGCCCTGGCTGAATCGATTCGCGAAGTGCTGC
TGGCACCCAGTAACGAAGTCATGGCTGACGATACCGAATTACTGCTGGTCTTTGCTGCACGGGCGCAGCATTTGGAGCAG
AAGATTCGTCCGGCACTAGCGCGCGGCGAATGGGTCTTGTGTGATCGATTTTTGGATGCCACCTGGGCTTACCAGGGAGC
AGGGCGGGGACTAGATAGCGCCGCCATTGCTGCACTGGAGGCCCTCGTTATTCGAGATACCCGTCCAGACATGACTATAC
TGTTCGATGTGCCGGTGGAGGTGGGCATGGCGCGCGCGGGCAAGCGTGCCGCACTGGACCGCATTGAACAGGAGGATCGA
GCTTTTTTTGATCGCATCCGCCAGTGTTACCTGGCTCGGGCAGCCCAGGAGCCCAATCGGTTTCGCACGGTAGACGCTAG
CCAGCCGCTGGAATCAGTACAGCAACAACTAGCCCGGATTGTTGAGGAGATGCAGGCATGGCCGTAA

Upstream 100 bases:

>100_bases
GCCACTATTTTTCCAAGACCCTGGCGGAACATCGAAGAGCGGTGCGCGAATACCAATTACGACGCCGGGAAGGATACCGG
TCTTCGCCGGGAGGAGGGCA

Downstream 100 bases:

>100_bases
CCGGTGCAAAAGTTCAGGTCCCTTGCCCTTGGCACAGCGATGCTATGGCGCAGCTGCTTGATCAACACGCCCGGGGGCGG
CTGCCCCATGCCCTGTTGCT

Product: dTMP kinase; thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSGRFITLEGGEGAGKSSNLVWLAEALRAEGKTVMVSREPGGTALAESIREVLLAPSNEVMADDTELLLVFAARAQHLEQ
KIRPALARGEWVLCDRFLDATWAYQGAGRGLDSAAIAALEALVIRDTRPDMTILFDVPVEVGMARAGKRAALDRIEQEDR
AFFDRIRQCYLARAAQEPNRFRTVDASQPLESVQQQLARIVEEMQAWP

Sequences:

>Translated_208_residues
MSGRFITLEGGEGAGKSSNLVWLAEALRAEGKTVMVSREPGGTALAESIREVLLAPSNEVMADDTELLLVFAARAQHLEQ
KIRPALARGEWVLCDRFLDATWAYQGAGRGLDSAAIAALEALVIRDTRPDMTILFDVPVEVGMARAGKRAALDRIEQEDR
AFFDRIRQCYLARAAQEPNRFRTVDASQPLESVQQQLARIVEEMQAWP
>Mature_207_residues
SGRFITLEGGEGAGKSSNLVWLAEALRAEGKTVMVSREPGGTALAESIREVLLAPSNEVMADDTELLLVFAARAQHLEQK
IRPALARGEWVLCDRFLDATWAYQGAGRGLDSAAIAALEALVIRDTRPDMTILFDVPVEVGMARAGKRAALDRIEQEDRA
FFDRIRQCYLARAAQEPNRFRTVDASQPLESVQQQLARIVEEMQAWP

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=197, Percent_Identity=47.7157360406091, Blast_Score=167, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_ALCBS (Q0VQM6)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692794.1
- ProteinModelPortal:   Q0VQM6
- SMR:   Q0VQM6
- STRING:   Q0VQM6
- GeneID:   4211410
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1074
- NMPDR:   fig|393595.12.peg.1083
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   Q0VQM6
- BioCyc:   ABOR393595:ABO_1074-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 22967; Mature: 22836

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRFITLEGGEGAGKSSNLVWLAEALRAEGKTVMVSREPGGTALAESIREVLLAPSNEV
CCCCEEEEECCCCCCCCCCEEHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCC
MADDTELLLVFAARAQHLEQKIRPALARGEWVLCDRFLDATWAYQGAGRGLDSAAIAALE
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCHHHHHHHHH
ALVIRDTRPDMTILFDVPVEVGMARAGKRAALDRIEQEDRAFFDRIRQCYLARAAQEPNR
HHHHCCCCCCEEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FRTVDASQPLESVQQQLARIVEEMQAWP
EEECCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGRFITLEGGEGAGKSSNLVWLAEALRAEGKTVMVSREPGGTALAESIREVLLAPSNEV
CCCEEEEECCCCCCCCCCEEHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCC
MADDTELLLVFAARAQHLEQKIRPALARGEWVLCDRFLDATWAYQGAGRGLDSAAIAALE
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCHHHHHHHHH
ALVIRDTRPDMTILFDVPVEVGMARAGKRAALDRIEQEDRAFFDRIRQCYLARAAQEPNR
HHHHCCCCCCEEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FRTVDASQPLESVQQQLARIVEEMQAWP
EEECCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA