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The map label for this gene is nhaA [H]

Identifier: 110833924

GI number: 110833924

Start: 1206844

End: 1207824

Strand: Direct

Name: nhaA [H]

Synonym: ABO_1063

Alternate gene names: 110833924

Gene position: 1206844-1207824 (Clockwise)

Preceding gene: 110833923

Following gene: 110833926

Centisome position: 38.68

GC content: 53.72

Gene sequence:

>981_bases
ATGACTATGAATAATCAGCCATCTTCTCAGCCCCCTCAGAATGAGCGGGAATGGAAGCTGATAGAGAAATTACTGGGCCA
GGCCCAAGATGAGCAGCGTAAATCCCGTCGTTGGGGTATTTTCTTCAAGGCCCTGACCTTTGTGTATCTGTTTACCTTGT
TGGTGATAGTGATTCCGGGCAAAACCGGTTCTGCTGTGACCATGGCGGAAGCCCATGTGGGGATCGTAGATGTGAACGGC
GTGATTGCGCCGGATCAGGAGGCGAGTGCGGACTTGATCGTCACCGGCTTAACGAGAGCCTTTGAAGCGGAAAACACCAC
CGCCGTTCTATTGAAAATCAACAGCCCAGGTGGCTCACCAGTACAATCTAATCAGGTGTACAACGCCATCAAGCGGCTGC
GGGCTGAATACCCGGAAAAGAAACTGTATGCGGCGATTACCGATGTGGGTGCCTCTGGGGCGTACTTTATTGCCTCCGCT
GCAGATGAAATCTATGCGGACCCGGCCAGCATTGTAGGTTCCATTGGCGTGATCATGGCTGGCTTTGGGCTGGAGCAGGC
GGCCGACAAACTGGGTGTGGAGCGCCGTGTGTTTACCGCTGGCGAAAACAAGGATTTGATGGATCCGTTTTCACCGGTGA
AGCCGGCCCATCGCAAACACGTACAAACCATGCTGGATGATATTCATCAGCAGTTTATTGCGGCGGTGAAGAAGGGGCGC
GGCAATAGGTTGAAAGTTGATGGGCATCCAGAATTGTTTTCCGGCTTGTTCTGGACTGGCGAGCGGGCTATGGATTTGGG
TCTGATTGATGGACTAATGAGCCCGGGGCAGGTGGTTCGCGAAGTGGTAGGCGAGGAGGAGATGCTCAACTACAGTGCCA
GCCGCTCTCCTATGGAAGAGTTTATTCGCCGTTTTGGGGTTTCCATTGGCGAAGGCGTGGCTACGCAGCTGGGGTTGAGT
GCATCGCCGGTGATTCGTTAA

Upstream 100 bases:

>100_bases
AGCAGTTGCTCCCATGCGAGCCCTTGGCGGTGATCGATCGTTTGGACCATTTGTTGCCGCTAGTGGGGTTGGCAGCGTCT
GAATTTGTAATGGAGAGCGT

Downstream 100 bases:

>100_bases
TCATAATGGCGAGAAACGAGAAGAGACGCGTTCCGAAACCCCAAGGGCGTTCGGTTCCCGCCTCTTCCCTTTATAGAATA
GAGGCAGCTGGTTATAGGGG

Product: peptidase

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTMNNQPSSQPPQNEREWKLIEKLLGQAQDEQRKSRRWGIFFKALTFVYLFTLLVIVIPGKTGSAVTMAEAHVGIVDVNG
VIAPDQEASADLIVTGLTRAFEAENTTAVLLKINSPGGSPVQSNQVYNAIKRLRAEYPEKKLYAAITDVGASGAYFIASA
ADEIYADPASIVGSIGVIMAGFGLEQAADKLGVERRVFTAGENKDLMDPFSPVKPAHRKHVQTMLDDIHQQFIAAVKKGR
GNRLKVDGHPELFSGLFWTGERAMDLGLIDGLMSPGQVVREVVGEEEMLNYSASRSPMEEFIRRFGVSIGEGVATQLGLS
ASPVIR

Sequences:

>Translated_326_residues
MTMNNQPSSQPPQNEREWKLIEKLLGQAQDEQRKSRRWGIFFKALTFVYLFTLLVIVIPGKTGSAVTMAEAHVGIVDVNG
VIAPDQEASADLIVTGLTRAFEAENTTAVLLKINSPGGSPVQSNQVYNAIKRLRAEYPEKKLYAAITDVGASGAYFIASA
ADEIYADPASIVGSIGVIMAGFGLEQAADKLGVERRVFTAGENKDLMDPFSPVKPAHRKHVQTMLDDIHQQFIAAVKKGR
GNRLKVDGHPELFSGLFWTGERAMDLGLIDGLMSPGQVVREVVGEEEMLNYSASRSPMEEFIRRFGVSIGEGVATQLGLS
ASPVIR
>Mature_325_residues
TMNNQPSSQPPQNEREWKLIEKLLGQAQDEQRKSRRWGIFFKALTFVYLFTLLVIVIPGKTGSAVTMAEAHVGIVDVNGV
IAPDQEASADLIVTGLTRAFEAENTTAVLLKINSPGGSPVQSNQVYNAIKRLRAEYPEKKLYAAITDVGASGAYFIASAA
DEIYADPASIVGSIGVIMAGFGLEQAADKLGVERRVFTAGENKDLMDPFSPVKPAHRKHVQTMLDDIHQQFIAAVKKGRG
NRLKVDGHPELFSGLFWTGERAMDLGLIDGLMSPGQVVREVVGEEEMLNYSASRSPMEEFIRRFGVSIGEGVATQLGLSA
SPVIR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=252, Percent_Identity=26.984126984127, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788064, Length=268, Percent_Identity=25.7462686567164, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 35462; Mature: 35331

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMNNQPSSQPPQNEREWKLIEKLLGQAQDEQRKSRRWGIFFKALTFVYLFTLLVIVIPG
CCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
KTGSAVTMAEAHVGIVDVNGVIAPDQEASADLIVTGLTRAFEAENTTAVLLKINSPGGSP
CCCCEEEEECCCEEEEECCCEECCCCCCCCCEEEHHHHHHHCCCCCEEEEEEEECCCCCC
VQSNQVYNAIKRLRAEYPEKKLYAAITDVGASGAYFIASAADEIYADPASIVGSIGVIMA
CCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEHHHHHHHCCHHHHHHHHHHHHH
GFGLEQAADKLGVERRVFTAGENKDLMDPFSPVKPAHRKHVQTMLDDIHQQFIAAVKKGR
CCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GNRLKVDGHPELFSGLFWTGERAMDLGLIDGLMSPGQVVREVVGEEEMLNYSASRSPMEE
CCEEEECCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCHHHHHHCCCCCCHHHH
FIRRFGVSIGEGVATQLGLSASPVIR
HHHHHCCCCCCCHHHHCCCCCCCCCC
>Mature Secondary Structure 
TMNNQPSSQPPQNEREWKLIEKLLGQAQDEQRKSRRWGIFFKALTFVYLFTLLVIVIPG
CCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
KTGSAVTMAEAHVGIVDVNGVIAPDQEASADLIVTGLTRAFEAENTTAVLLKINSPGGSP
CCCCEEEEECCCEEEEECCCEECCCCCCCCCEEEHHHHHHHCCCCCEEEEEEEECCCCCC
VQSNQVYNAIKRLRAEYPEKKLYAAITDVGASGAYFIASAADEIYADPASIVGSIGVIMA
CCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEHHHHHHHCCHHHHHHHHHHHHH
GFGLEQAADKLGVERRVFTAGENKDLMDPFSPVKPAHRKHVQTMLDDIHQQFIAAVKKGR
CCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GNRLKVDGHPELFSGLFWTGERAMDLGLIDGLMSPGQVVREVVGEEEMLNYSASRSPMEE
CCEEEECCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCHHHHHHCCCCCCHHHH
FIRRFGVSIGEGVATQLGLSASPVIR
HHHHHCCCCCCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA