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The map label for this gene is gph [H]

Identifier: 110833923

GI number: 110833923

Start: 1206158

End: 1206847

Strand: Direct

Name: gph [H]

Synonym: ABO_1062

Alternate gene names: 110833923

Gene position: 1206158-1206847 (Clockwise)

Preceding gene: 110833922

Following gene: 110833924

Centisome position: 38.66

GC content: 56.09

Gene sequence:

>690_bases
ATGAGTGTTGTTCGCCCCTACGACCTGGTGATTTTTGATTGGGACGGCACAGTGATGGATTCCACGGGGCGCATTGTGAG
CTGCATGCAGCTGGCAGCGGTGGACATGGCGTTGCCGTCATTGGCTGATTCGGTAGTTTGCAGCATTATTGGGCTAGGGT
TGCCGGAAGCAATCGCTACACTCTATCCGCAGCTGGATGATGCTGGCATTGTTGCCATGCGTGATCGTTATGCGTTTCAT
TTTATTGCCGCCGAGCAGACACCCAGTGCCCTTTATCCGGCTGCTGAGCAGGTTTTGATTCACCTGCGTGAGCAGGGTCT
TAAGCTGGCAGTGGCAACCGGAAAGAGTCGCAAGGGGTTGCAGAGGGTGTGGGGCAATACCGGCCTAGAACGTTATTTTG
ATGCTTCCAGATGCGCCGACGAAAGCCATTCTAAGCCGCACCCAGCCATGGTGCTGGAACTGCTGGAGGCGATGGCAGTG
CCTGCTGAGCGGGCCGTGGTGGTGGGTGACACCACCTATGATCTGGAGATGGCCCGTGCTGCTAGGGTAGACCGCATAGG
GGTGAGTTATGGTGCGCATCCAGTTGAGCAGTTGCTCCCATGCGAGCCCTTGGCGGTGATCGATCGTTTGGACCATTTGT
TGCCGCTAGTGGGGTTGGCAGCGTCTGAATTTGTAATGGAGAGCGTATGA

Upstream 100 bases:

>100_bases
CTCTGGTTTTTGTGCACCCGAATACGGGTAAAAGGCTGACGGTTACCGCGCCGCTGGATGATGACTACGAGGCCATTTTG
ACTGCCCTGAGGAGCAAACC

Downstream 100 bases:

>100_bases
CTATGAATAATCAGCCATCTTCTCAGCCCCCTCAGAATGAGCGGGAATGGAAGCTGATAGAGAAATTACTGGGCCAGGCC
CAAGATGAGCAGCGTAAATC

Product: HAD superfamily hydrolase

Products: NA

Alternate protein names: PGP; PGPase [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MSVVRPYDLVIFDWDGTVMDSTGRIVSCMQLAAVDMALPSLADSVVCSIIGLGLPEAIATLYPQLDDAGIVAMRDRYAFH
FIAAEQTPSALYPAAEQVLIHLREQGLKLAVATGKSRKGLQRVWGNTGLERYFDASRCADESHSKPHPAMVLELLEAMAV
PAERAVVVGDTTYDLEMARAARVDRIGVSYGAHPVEQLLPCEPLAVIDRLDHLLPLVGLAASEFVMESV

Sequences:

>Translated_229_residues
MSVVRPYDLVIFDWDGTVMDSTGRIVSCMQLAAVDMALPSLADSVVCSIIGLGLPEAIATLYPQLDDAGIVAMRDRYAFH
FIAAEQTPSALYPAAEQVLIHLREQGLKLAVATGKSRKGLQRVWGNTGLERYFDASRCADESHSKPHPAMVLELLEAMAV
PAERAVVVGDTTYDLEMARAARVDRIGVSYGAHPVEQLLPCEPLAVIDRLDHLLPLVGLAASEFVMESV
>Mature_228_residues
SVVRPYDLVIFDWDGTVMDSTGRIVSCMQLAAVDMALPSLADSVVCSIIGLGLPEAIATLYPQLDDAGIVAMRDRYAFHF
IAAEQTPSALYPAAEQVLIHLREQGLKLAVATGKSRKGLQRVWGNTGLERYFDASRCADESHSKPHPAMVLELLEAMAVP
AERAVVVGDTTYDLEMARAARVDRIGVSYGAHPVEQLLPCEPLAVIDRLDHLLPLVGLAASEFVMESV

Specific function: Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stres

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family [H]

Homologues:

Organism=Escherichia coli, GI1789787, Length=236, Percent_Identity=25.4237288135593, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR006346
- InterPro:   IPR023198 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.18 [H]

Molecular weight: Translated: 24832; Mature: 24701

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVRPYDLVIFDWDGTVMDSTGRIVSCMQLAAVDMALPSLADSVVCSIIGLGLPEAIAT
CCCCCCEEEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LYPQLDDAGIVAMRDRYAFHFIAAEQTPSALYPAAEQVLIHLREQGLKLAVATGKSRKGL
HCCCCCCCCEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHH
QRVWGNTGLERYFDASRCADESHSKPHPAMVLELLEAMAVPAERAVVVGDTTYDLEMARA
HHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHH
ARVDRIGVSYGAHPVEQLLPCEPLAVIDRLDHLLPLVGLAASEFVMESV
HHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVVRPYDLVIFDWDGTVMDSTGRIVSCMQLAAVDMALPSLADSVVCSIIGLGLPEAIAT
CCCCCEEEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LYPQLDDAGIVAMRDRYAFHFIAAEQTPSALYPAAEQVLIHLREQGLKLAVATGKSRKGL
HCCCCCCCCEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHH
QRVWGNTGLERYFDASRCADESHSKPHPAMVLELLEAMAVPAERAVVVGDTTYDLEMARA
HHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHH
ARVDRIGVSYGAHPVEQLLPCEPLAVIDRLDHLLPLVGLAASEFVMESV
HHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]