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The map label for this gene is gcdH [H]

Identifier: 110833845

GI number: 110833845

Start: 1108976

End: 1110142

Strand: Direct

Name: gcdH [H]

Synonym: ABO_0984

Alternate gene names: 110833845

Gene position: 1108976-1110142 (Clockwise)

Preceding gene: 110833844

Following gene: 110833853

Centisome position: 35.54

GC content: 54.07

Gene sequence:

>1167_bases
ATGAGTGTTTTTGTATGGAATGATGCGCTATTGCTGGAAACTCAGCTCAGCGACGATGAGCGGATGATCCGTGATGCAGC
GCAGGATTACTGCCAAAGTAAACTGATGACCAGGGTGCTTGAGGCGAACCGGCACGAGATTTTTCATCGCGAGATCATGA
CAGAAATGGGGGCACAGGGGTTTCTTGGATCCACCATTCCTGAGCAATATGGTGGCGCGGGAGTGAACCACGTTAGCTAC
GGCTTGGTGGCTCGGGAAGTAGAGCGGGTGGATTCCGGGTATCGCTCCGCCATGAGTGTGCAGTCGTCCCTGGTGATGTT
TCCCATTTATACCTTTGGCAGTGAAGCGGTGCGCAACAAGTACCTGCCAAAGTTGGCCAGTGGCGAATGGGTGGGGTGTT
TTGGTCTTACCGAGCCAGACCACGGCTCTGACCCGGGTTCCATGAGCACTCGCGCTAAAAAAGTGGATGGTGGTTACCTG
TTAAATGGTTCCAAAACGTGGATTACTAATTCGCCAATAGCCGATGTGGCGGTGGTGTGGGCGAACCTAGACGGTAAGAT
CAACGGCTTTGTGGTAGAGCGGGGCTTTGACGGGTTTAGCGCGCCTAAGATTGAAGGCAAGTTCTCTCTACGGGCATCGA
TCACTGGTCAGATCATGCTGGATGACTGCTTTGTACCGGAACAAAACCGATTGGACGTGGAGGGCTTAAAGGGGCCCTTC
AGTTGCCTGAACAAAGCGCGCTACGGGATCAGCTGGGGAGCCATGGGTGCGGCTGAATTCTGTTGGCAGGCGGCTCGTCA
GTACACTTTGGACCGCAAACAATTTGGCCGCCCGCTGGCGGCTACCCAGCTGATTCAGAAAAAGCTGGCGGACATGCAGA
CTGAGATTACCTTAGGTTTGCAAGGGGCGCTGCAATTAGGGCGCTTGATAGATGCGGGAAACTGGGCGCCGGAAATGGTC
TCGTTGATGAAGCGCAATAACTGTGGCAAGGCCATTGATATTGCTCGTCAGGCTCGAGATATGCATGGCGGCAATGGCAT
TAGTGACGAGTATCATGTGATTCGCCACGTAATGAATCTGGAAGCGGTGAATACCTATGAAGGTACCCACGATGTCCATG
CCCTGATCTTGGGCCGGGCCCAGACCGGGCTGCAAGCATTCGGCTGA

Upstream 100 bases:

>100_bases
CCATGCGTCAGTTGGAGCGAACCCGCGGTCGTTATGCACTTCTTAGTTTGTGCATTGGCGTAGGTCAGGGCGTTGCCATG
GTGCTGGAGAGGGTAGATTC

Downstream 100 bases:

>100_bases
TGAGTACCTAGTGTTTAGCCCTGGTTATTCTGGTGTTTTGTCAGAATAGCCGGGGGTTTCCCCTCCTTGCGTTTTCTTCC
CCGTTTCACCTCCTTGGTGT

Product: glutaryl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MSVFVWNDALLLETQLSDDERMIRDAAQDYCQSKLMTRVLEANRHEIFHREIMTEMGAQGFLGSTIPEQYGGAGVNHVSY
GLVAREVERVDSGYRSAMSVQSSLVMFPIYTFGSEAVRNKYLPKLASGEWVGCFGLTEPDHGSDPGSMSTRAKKVDGGYL
LNGSKTWITNSPIADVAVVWANLDGKINGFVVERGFDGFSAPKIEGKFSLRASITGQIMLDDCFVPEQNRLDVEGLKGPF
SCLNKARYGISWGAMGAAEFCWQAARQYTLDRKQFGRPLAATQLIQKKLADMQTEITLGLQGALQLGRLIDAGNWAPEMV
SLMKRNNCGKAIDIARQARDMHGGNGISDEYHVIRHVMNLEAVNTYEGTHDVHALILGRAQTGLQAFG

Sequences:

>Translated_388_residues
MSVFVWNDALLLETQLSDDERMIRDAAQDYCQSKLMTRVLEANRHEIFHREIMTEMGAQGFLGSTIPEQYGGAGVNHVSY
GLVAREVERVDSGYRSAMSVQSSLVMFPIYTFGSEAVRNKYLPKLASGEWVGCFGLTEPDHGSDPGSMSTRAKKVDGGYL
LNGSKTWITNSPIADVAVVWANLDGKINGFVVERGFDGFSAPKIEGKFSLRASITGQIMLDDCFVPEQNRLDVEGLKGPF
SCLNKARYGISWGAMGAAEFCWQAARQYTLDRKQFGRPLAATQLIQKKLADMQTEITLGLQGALQLGRLIDAGNWAPEMV
SLMKRNNCGKAIDIARQARDMHGGNGISDEYHVIRHVMNLEAVNTYEGTHDVHALILGRAQTGLQAFG
>Mature_387_residues
SVFVWNDALLLETQLSDDERMIRDAAQDYCQSKLMTRVLEANRHEIFHREIMTEMGAQGFLGSTIPEQYGGAGVNHVSYG
LVAREVERVDSGYRSAMSVQSSLVMFPIYTFGSEAVRNKYLPKLASGEWVGCFGLTEPDHGSDPGSMSTRAKKVDGGYLL
NGSKTWITNSPIADVAVVWANLDGKINGFVVERGFDGFSAPKIEGKFSLRASITGQIMLDDCFVPEQNRLDVEGLKGPFS
CLNKARYGISWGAMGAAEFCWQAARQYTLDRKQFGRPLAATQLIQKKLADMQTEITLGLQGALQLGRLIDAGNWAPEMVS
LMKRNNCGKAIDIARQARDMHGGNGISDEYHVIRHVMNLEAVNTYEGTHDVHALILGRAQTGLQAFG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=388, Percent_Identity=69.0721649484536, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI7669494, Length=368, Percent_Identity=68.2065217391304, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=31.9148936170213, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4557233, Length=383, Percent_Identity=30.5483028720627, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI226958414, Length=340, Percent_Identity=32.3529411764706, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4501859, Length=365, Percent_Identity=29.3150684931507, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI7656849, Length=381, Percent_Identity=29.6587926509186, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI4557235, Length=340, Percent_Identity=32.0588235294118, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI21361497, Length=354, Percent_Identity=30.225988700565, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI76496475, Length=340, Percent_Identity=32.0588235294118, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4501857, Length=384, Percent_Identity=27.6041666666667, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=26.6666666666667, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=26.6666666666667, Blast_Score=136, Evalue=4e-32,
Organism=Escherichia coli, GI1786223, Length=349, Percent_Identity=24.6418338108883, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87081958, Length=347, Percent_Identity=25.3602305475504, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17534353, Length=394, Percent_Identity=61.4213197969543, Blast_Score=493, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17538396, Length=376, Percent_Identity=32.4468085106383, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17508101, Length=366, Percent_Identity=29.7814207650273, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=28.8359788359788, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI71985184, Length=356, Percent_Identity=32.0224719101124, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17569725, Length=374, Percent_Identity=28.6096256684492, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=27.9452054794521, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17534899, Length=375, Percent_Identity=28.5333333333333, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI71985192, Length=260, Percent_Identity=34.6153846153846, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71990804, Length=244, Percent_Identity=34.8360655737705, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=30.8823529411765, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=34.1991341991342, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=25.8666666666667, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17505929, Length=348, Percent_Identity=25.5747126436782, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17551932, Length=296, Percent_Identity=25.6756756756757, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19920834, Length=391, Percent_Identity=64.7058823529412, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI21356377, Length=376, Percent_Identity=30.8510638297872, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=30.9895833333333, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24666513, Length=367, Percent_Identity=31.6076294277929, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=29.0322580645161, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=30.1587301587302, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI281363737, Length=344, Percent_Identity=31.3953488372093, Blast_Score=149, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42714; Mature: 42583

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVFVWNDALLLETQLSDDERMIRDAAQDYCQSKLMTRVLEANRHEIFHREIMTEMGAQG
CEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FLGSTIPEQYGGAGVNHVSYGLVAREVERVDSGYRSAMSVQSSLVMFPIYTFGSEAVRNK
CCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHCCHHHHHHH
YLPKLASGEWVGCFGLTEPDHGSDPGSMSTRAKKVDGGYLLNGSKTWITNSPIADVAVVW
CCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHEECCCCEEECCCEEEECCCCCCCEEEEE
ANLDGKINGFVVERGFDGFSAPKIEGKFSLRASITGQIMLDDCFVPEQNRLDVEGLKGPF
ECCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCCCCCHH
SCLNKARYGISWGAMGAAEFCWQAARQYTLDRKQFGRPLAATQLIQKKLADMQTEITLGL
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
QGALQLGRLIDAGNWAPEMVSLMKRNNCGKAIDIARQARDMHGGNGISDEYHVIRHVMNL
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EAVNTYEGTHDVHALILGRAQTGLQAFG
HHEECCCCCCCEEHHEEHHHHCCHHHCC
>Mature Secondary Structure 
SVFVWNDALLLETQLSDDERMIRDAAQDYCQSKLMTRVLEANRHEIFHREIMTEMGAQG
EEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FLGSTIPEQYGGAGVNHVSYGLVAREVERVDSGYRSAMSVQSSLVMFPIYTFGSEAVRNK
CCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHCCHHHHHHH
YLPKLASGEWVGCFGLTEPDHGSDPGSMSTRAKKVDGGYLLNGSKTWITNSPIADVAVVW
CCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHEECCCCEEECCCEEEECCCCCCCEEEEE
ANLDGKINGFVVERGFDGFSAPKIEGKFSLRASITGQIMLDDCFVPEQNRLDVEGLKGPF
ECCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCCCCCHH
SCLNKARYGISWGAMGAAEFCWQAARQYTLDRKQFGRPLAATQLIQKKLADMQTEITLGL
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
QGALQLGRLIDAGNWAPEMVSLMKRNNCGKAIDIARQARDMHGGNGISDEYHVIRHVMNL
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EAVNTYEGTHDVHALILGRAQTGLQAFG
HHEECCCCCCCEEHHEEHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]