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The map label for this gene is hom [H]

Identifier: 110833667

GI number: 110833667

Start: 898329

End: 899630

Strand: Direct

Name: hom [H]

Synonym: ABO_0806

Alternate gene names: 110833667

Gene position: 898329-899630 (Clockwise)

Preceding gene: 110833666

Following gene: 110833668

Centisome position: 28.79

GC content: 54.99

Gene sequence:

>1302_bases
GTGAAATCGGTGAAAGTGGGTATTGCTGGTCTGGGTACGGTTGGTTCAGGCACCGTGAATGTGTTGAAGCGTAACGCGCG
GGATATTGCTCGACGCGTCGGATGTCCGATTGAAATTACCCATATCGGTGCGCGCCGCGACAATGCGGCCTGTGATACCA
GTGATATTCGCCTTTCTCGCGATATTTTTGCTGTGGCGACAGATCCAGATATCGACATTTTGGTAGAACTTATTGGCGGC
ATTGATACTGCCCGTGAGTTGGTACTTACCGCCATTAGAAATGGCAAGCACGTTGTCACTGCCAACAAGGCGCTGATTGC
CGAACACGGTAACGAAATTTTCCAGGCGGCTCAGGATAATGGCGTGGATGTGGCGTTCGAAGCCTCTGTGGCTGGCGGGA
TTCCCATTCTCAAATCCCTGGGCGAAGGTCTGGCCGCGAACCACGTGAACTGGCTGGCGGGGATCATTAATGGCACCGGC
AACTTTATCCTTACCGAGATGGAAGAGGGCGGCCGCGCTTTTGATGACGTGCTAGCCGAAGCGCAGCAATTGGGCTATGC
GGAAGCGGACCCTACCTTCGATGTGGAAGGCATTGACGCGGCCCACAAGCTAACCATTCTGGCTTCTATTGCCTTTGGTA
TCCCGCTGCAATACTCCAAGGTCTACACCGAAGGCATCAGCCGGATCACCATTGAAGATGTGGCCAGCGCCGCGCACTTT
GGCTACCGCATTAAGCACTTGGGGATTGCCAAGGACACCGGTAACGGGATTGAGCTGCGTGTGCACCCAACCCTAATTCC
CAAGGAAACCATGCTGTCTGCAGTGAATGGCGTAATGAACGCGATCATGATCGACGGTGACGCCGTCGGGCCGACACTGT
TCTACGGTGCTGGTGCGGGTGCCGAGCCCACCGCGTCTGCGGTGGTGGCGGACATCATCGAACTGGGCCGTGCGCTGACC
GTAGACTATGACGAGCGGGTACCTTACCTAGGCTTCCATACAGACCAGATGTCTGATGAGCCGATTCTCACCATCGACGA
TGTGTCCTGTAGCTTCTATCTACGTTTGCACGTGCAAGATAAGACCGGTGTATTGGCTGACGTAACGCGCATTCTCAGCG
ACAATAATGTCAGCATTGATGCCCTGGTGCAGCGTGACGTGGATCAGGGTTTGGTGCCCATTGTCATGATGACCCACGTG
GTCCGCGAAGGAGACATGAGTGCCGCCCTCGCCAAGATCGGTGCCCTTGAGTCGGTGAATAGCGATATAATGCGGATTCG
AGTAGAAATGCTGGACGCTTGA

Upstream 100 bases:

>100_bases
CCGGCAGGCCATGCGCGGCATCAAAAAGATGTTCCGTCAGGATGGGTTGCTGGACTAACAGGATGCGCCTCGGCGCCCCT
GAATAAAGAGAGGAAATGTC

Downstream 100 bases:

>100_bases
TTTCCGATGTTGGACGCTGCGGTTTAAGCGTTCGGCCTCACGCATCTAGCGTATGTCGTGTCGCTCAATATGACCACATT
CAAGAACCGTAGAGCCTAGA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKSVKVGIAGLGTVGSGTVNVLKRNARDIARRVGCPIEITHIGARRDNAACDTSDIRLSRDIFAVATDPDIDILVELIGG
IDTARELVLTAIRNGKHVVTANKALIAEHGNEIFQAAQDNGVDVAFEASVAGGIPILKSLGEGLAANHVNWLAGIINGTG
NFILTEMEEGGRAFDDVLAEAQQLGYAEADPTFDVEGIDAAHKLTILASIAFGIPLQYSKVYTEGISRITIEDVASAAHF
GYRIKHLGIAKDTGNGIELRVHPTLIPKETMLSAVNGVMNAIMIDGDAVGPTLFYGAGAGAEPTASAVVADIIELGRALT
VDYDERVPYLGFHTDQMSDEPILTIDDVSCSFYLRLHVQDKTGVLADVTRILSDNNVSIDALVQRDVDQGLVPIVMMTHV
VREGDMSAALAKIGALESVNSDIMRIRVEMLDA

Sequences:

>Translated_433_residues
MKSVKVGIAGLGTVGSGTVNVLKRNARDIARRVGCPIEITHIGARRDNAACDTSDIRLSRDIFAVATDPDIDILVELIGG
IDTARELVLTAIRNGKHVVTANKALIAEHGNEIFQAAQDNGVDVAFEASVAGGIPILKSLGEGLAANHVNWLAGIINGTG
NFILTEMEEGGRAFDDVLAEAQQLGYAEADPTFDVEGIDAAHKLTILASIAFGIPLQYSKVYTEGISRITIEDVASAAHF
GYRIKHLGIAKDTGNGIELRVHPTLIPKETMLSAVNGVMNAIMIDGDAVGPTLFYGAGAGAEPTASAVVADIIELGRALT
VDYDERVPYLGFHTDQMSDEPILTIDDVSCSFYLRLHVQDKTGVLADVTRILSDNNVSIDALVQRDVDQGLVPIVMMTHV
VREGDMSAALAKIGALESVNSDIMRIRVEMLDA
>Mature_433_residues
MKSVKVGIAGLGTVGSGTVNVLKRNARDIARRVGCPIEITHIGARRDNAACDTSDIRLSRDIFAVATDPDIDILVELIGG
IDTARELVLTAIRNGKHVVTANKALIAEHGNEIFQAAQDNGVDVAFEASVAGGIPILKSLGEGLAANHVNWLAGIINGTG
NFILTEMEEGGRAFDDVLAEAQQLGYAEADPTFDVEGIDAAHKLTILASIAFGIPLQYSKVYTEGISRITIEDVASAAHF
GYRIKHLGIAKDTGNGIELRVHPTLIPKETMLSAVNGVMNAIMIDGDAVGPTLFYGAGAGAEPTASAVVADIIELGRALT
VDYDERVPYLGFHTDQMSDEPILTIDDVSCSFYLRLHVQDKTGVLADVTRILSDNNVSIDALVQRDVDQGLVPIVMMTHV
VREGDMSAALAKIGALESVNSDIMRIRVEMLDA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=121, Percent_Identity=31.404958677686, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=266, Percent_Identity=27.0676691729323, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46018; Mature: 46018

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVKVGIAGLGTVGSGTVNVLKRNARDIARRVGCPIEITHIGARRDNAACDTSDIRLSR
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEC
DIFAVATDPDIDILVELIGGIDTARELVLTAIRNGKHVVTANKALIAEHGNEIFQAAQDN
CEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCHHHHCCHHHHHHHCCC
GVDVAFEASVAGGIPILKSLGEGLAANHVNWLAGIINGTGNFILTEMEEGGRAFDDVLAE
CCEEEEECCCCCCCHHHHHHCCCHHHCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHH
AQQLGYAEADPTFDVEGIDAAHKLTILASIAFGIPLQYSKVYTEGISRITIEDVASAAHF
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEHHHHHHHHHH
GYRIKHLGIAKDTGNGIELRVHPTLIPKETMLSAVNGVMNAIMIDGDAVGPTLFYGAGAG
CEEEEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHEEEECCCCCCCEEEECCCCC
AEPTASAVVADIIELGRALTVDYDERVPYLGFHTDQMSDEPILTIDDVSCSFYLRLHVQD
CCCHHHHHHHHHHHCCCEEEEEHHCCCCEEEEECCCCCCCCEEEEECCCEEEEEEEEEEC
KTGVLADVTRILSDNNVSIDALVQRDVDQGLVPIVMMTHVVREGDMSAALAKIGALESVN
CCCHHHHHHHHHCCCCCEEHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
SDIMRIRVEMLDA
HHHHEEEEEECCC
>Mature Secondary Structure
MKSVKVGIAGLGTVGSGTVNVLKRNARDIARRVGCPIEITHIGARRDNAACDTSDIRLSR
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEC
DIFAVATDPDIDILVELIGGIDTARELVLTAIRNGKHVVTANKALIAEHGNEIFQAAQDN
CEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCHHHHCCHHHHHHHCCC
GVDVAFEASVAGGIPILKSLGEGLAANHVNWLAGIINGTGNFILTEMEEGGRAFDDVLAE
CCEEEEECCCCCCCHHHHHHCCCHHHCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHH
AQQLGYAEADPTFDVEGIDAAHKLTILASIAFGIPLQYSKVYTEGISRITIEDVASAAHF
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEHHHHHHHHHH
GYRIKHLGIAKDTGNGIELRVHPTLIPKETMLSAVNGVMNAIMIDGDAVGPTLFYGAGAG
CEEEEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHEEEECCCCCCCEEEECCCCC
AEPTASAVVADIIELGRALTVDYDERVPYLGFHTDQMSDEPILTIDDVSCSFYLRLHVQD
CCCHHHHHHHHHHHCCCEEEEEHHCCCCEEEEECCCCCCCCEEEEECCCEEEEEEEEEEC
KTGVLADVTRILSDNNVSIDALVQRDVDQGLVPIVMMTHVVREGDMSAALAKIGALESVN
CCCHHHHHHHHHCCCCCEEHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
SDIMRIRVEMLDA
HHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]