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The map label for this gene is thrC [H]

Identifier: 229259627

GI number: 229259627

Start: 834808

End: 836205

Strand: Reverse

Name: thrC [H]

Synonym: Meso_0760

Alternate gene names: 229259627

Gene position: 836205-834808 (Counterclockwise)

Preceding gene: 110633119

Following gene: 110633116

Centisome position: 18.95

GC content: 63.3

Gene sequence:

>1398_bases
ATGGAATATGTGAGTACCCGCGGCGAGGCGCCGGTGCTGGGCTTTTCGGACGTGCTTCTCGCGGGGCTTGCGCGCGACGG
CGGTCTTTATGTTCCCCGCGAATGGCCGCGCTTCTCGCCGGAGGAAATCCGCGCCCTGCGGGGCCGCCCCTATGAAGAAG
CCGCCCTCACCCTGATCCGGCCGTTCATCGGCGGGGAAGTTCCAGATCAGGAACTGAAGCGCATCATCGACGAGAGTTAC
GCCACCTTCCGCCACAAGGCGGTCTGCCCAATCGTCCAGACCGCGCCCGGCGAGTTCGTCCTGGAGCTCTTTCACGGCCC
TACCCTTGCCTTCAAGGATGTGGCGATGCAGTTCCTCGCCCGCATTATGGACCACGTGCTCGCCGAGCGGGGGCAGCGCG
TGACCATCGTCGGCGCGACCTCCGGGGACACCGGCGGTGCGGCCATCCATGCATTTGCCGGATCGAAACGGGCGGATGTC
TTCATCCTCTTCCCGCACGGGCGCGTGTCGCCGGTGCAGCAGCGGCAGATGACCACCTCCGGCGCGGCGAATGTGCAGGC
GCTTGCGATCGAAGGGACGTTCGACGATTGCCAGGGGATGGTGAAGAGCCTCTTCAACGACCATGCCTTCCGCGACCGAA
TGTCGCTCTCCGGCGTCAATTCTATCAACTGGGCGCGCATCCTGGCCCAAATCGTCTACTACTTCACCTCGGCGATTTCG
CTCGGCGCGCCCGACCGCTCCGTCTCCTTCACGGTGCCCACCGGAAATTTCGGAGACATTTTCGCCGGGTATGCGGCCAA
GCGCATGGGCCTTCCGATCGACCGGCTGATCATCGCCACAAACGAGAACGACATTCTCGCGCGCACGCTCGACGGCGGGG
AATATGCGACACGCCCCGTTATCGCCACAACTTCGCCATCGATGGACATTCAGATTTCCTCGAACTTCGAACGGCTGCTC
TTCGAGGCATCCGGAAGGAAGGCGGAAGAAATCCGTGCCTATATGGATGGTCTGAAACAGTCCGGAAGCTTCACCCTGGG
AAATGACACGCTCGCCAGGATCAGGGACGAGTTTGCCGCCGGCCGTGTGAGCATGGAGGAAACCGCCGCCACAATCGCCG
GCACGCTTCGCGAGAGCGGATATCTCGCCGATCCGCATACGGCGACCGCGCTCAAGGTCGCGCGCGAGCACGCGCGGCCT
CACGAAAACATGATCGTGCTTTCGACGGCGCATCCGGCGAAGTTTCCGCAAGCCGTCGCAGAGGCCTGCGGGATTTCGCC
CGCCCTGCCCCAGTGGCTGGGCGGCTTGATGGAGAGCACGGAGACTTACACGGTCCTTCCCTCGGACCTGAAAATGGTGG
AAGATCACATCAGCCGCCACGCAAGGGCGGAAGGATAG

Upstream 100 bases:

>100_bases
CAAGACAAGGTAGCTGTTCTATACCAACCGCTCGGTGAAATTTCGACTGCCTGTTAATAACTTCTCATGGGCGGCTCTCG
CGCGGAGTAAATGAATGGCA

Downstream 100 bases:

>100_bases
AAAGCGAGTAACATATGGGCGTAGAAGTGAGCCGTCTTTCGAACGGCTTGACGGTGGCAACCGAAACTCTTCCGCATCTT
GAATCGGTTGCTTTGGGCGT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MEYVSTRGEAPVLGFSDVLLAGLARDGGLYVPREWPRFSPEEIRALRGRPYEEAALTLIRPFIGGEVPDQELKRIIDESY
ATFRHKAVCPIVQTAPGEFVLELFHGPTLAFKDVAMQFLARIMDHVLAERGQRVTIVGATSGDTGGAAIHAFAGSKRADV
FILFPHGRVSPVQQRQMTTSGAANVQALAIEGTFDDCQGMVKSLFNDHAFRDRMSLSGVNSINWARILAQIVYYFTSAIS
LGAPDRSVSFTVPTGNFGDIFAGYAAKRMGLPIDRLIIATNENDILARTLDGGEYATRPVIATTSPSMDIQISSNFERLL
FEASGRKAEEIRAYMDGLKQSGSFTLGNDTLARIRDEFAAGRVSMEETAATIAGTLRESGYLADPHTATALKVAREHARP
HENMIVLSTAHPAKFPQAVAEACGISPALPQWLGGLMESTETYTVLPSDLKMVEDHISRHARAEG

Sequences:

>Translated_465_residues
MEYVSTRGEAPVLGFSDVLLAGLARDGGLYVPREWPRFSPEEIRALRGRPYEEAALTLIRPFIGGEVPDQELKRIIDESY
ATFRHKAVCPIVQTAPGEFVLELFHGPTLAFKDVAMQFLARIMDHVLAERGQRVTIVGATSGDTGGAAIHAFAGSKRADV
FILFPHGRVSPVQQRQMTTSGAANVQALAIEGTFDDCQGMVKSLFNDHAFRDRMSLSGVNSINWARILAQIVYYFTSAIS
LGAPDRSVSFTVPTGNFGDIFAGYAAKRMGLPIDRLIIATNENDILARTLDGGEYATRPVIATTSPSMDIQISSNFERLL
FEASGRKAEEIRAYMDGLKQSGSFTLGNDTLARIRDEFAAGRVSMEETAATIAGTLRESGYLADPHTATALKVAREHARP
HENMIVLSTAHPAKFPQAVAEACGISPALPQWLGGLMESTETYTVLPSDLKMVEDHISRHARAEG
>Mature_465_residues
MEYVSTRGEAPVLGFSDVLLAGLARDGGLYVPREWPRFSPEEIRALRGRPYEEAALTLIRPFIGGEVPDQELKRIIDESY
ATFRHKAVCPIVQTAPGEFVLELFHGPTLAFKDVAMQFLARIMDHVLAERGQRVTIVGATSGDTGGAAIHAFAGSKRADV
FILFPHGRVSPVQQRQMTTSGAANVQALAIEGTFDDCQGMVKSLFNDHAFRDRMSLSGVNSINWARILAQIVYYFTSAIS
LGAPDRSVSFTVPTGNFGDIFAGYAAKRMGLPIDRLIIATNENDILARTLDGGEYATRPVIATTSPSMDIQISSNFERLL
FEASGRKAEEIRAYMDGLKQSGSFTLGNDTLARIRDEFAAGRVSMEETAATIAGTLRESGYLADPHTATALKVAREHARP
HENMIVLSTAHPAKFPQAVAEACGISPALPQWLGGLMESTETYTVLPSDLKMVEDHISRHARAEG

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=456, Percent_Identity=36.1842105263158, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI153792148, Length=490, Percent_Identity=33.6734693877551, Blast_Score=256, Evalue=5e-68,
Organism=Escherichia coli, GI1786185, Length=461, Percent_Identity=33.8394793926247, Blast_Score=254, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6319901, Length=457, Percent_Identity=44.2013129102845, Blast_Score=359, Evalue=1e-100,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50604; Mature: 50604

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYVSTRGEAPVLGFSDVLLAGLARDGGLYVPREWPRFSPEEIRALRGRPYEEAALTLIR
CCCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
PFIGGEVPDQELKRIIDESYATFRHKAVCPIVQTAPGEFVLELFHGPTLAFKDVAMQFLA
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHCCCCHHHHHHHHHHHH
RIMDHVLAERGQRVTIVGATSGDTGGAAIHAFAGSKRADVFILFPHGRVSPVQQRQMTTS
HHHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHCC
GAANVQALAIEGTFDDCQGMVKSLFNDHAFRDRMSLSGVNSINWARILAQIVYYFTSAIS
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGAPDRSVSFTVPTGNFGDIFAGYAAKRMGLPIDRLIIATNENDILARTLDGGEYATRPV
CCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEEECCCCEEEEEECCCCCCCCCE
IATTSPSMDIQISSNFERLLFEASGRKAEEIRAYMDGLKQSGSFTLGNDTLARIRDEFAA
EEECCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHH
GRVSMEETAATIAGTLRESGYLADPHTATALKVAREHARPHENMIVLSTAHPAKFPQAVA
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHH
EACGISPALPQWLGGLMESTETYTVLPSDLKMVEDHISRHARAEG
HHHCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEYVSTRGEAPVLGFSDVLLAGLARDGGLYVPREWPRFSPEEIRALRGRPYEEAALTLIR
CCCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
PFIGGEVPDQELKRIIDESYATFRHKAVCPIVQTAPGEFVLELFHGPTLAFKDVAMQFLA
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHCCCCHHHHHHHHHHHH
RIMDHVLAERGQRVTIVGATSGDTGGAAIHAFAGSKRADVFILFPHGRVSPVQQRQMTTS
HHHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHCC
GAANVQALAIEGTFDDCQGMVKSLFNDHAFRDRMSLSGVNSINWARILAQIVYYFTSAIS
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGAPDRSVSFTVPTGNFGDIFAGYAAKRMGLPIDRLIIATNENDILARTLDGGEYATRPV
CCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEEECCCCEEEEEECCCCCCCCCE
IATTSPSMDIQISSNFERLLFEASGRKAEEIRAYMDGLKQSGSFTLGNDTLARIRDEFAA
EEECCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHH
GRVSMEETAATIAGTLRESGYLADPHTATALKVAREHARPHENMIVLSTAHPAKFPQAVA
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHH
EACGISPALPQWLGGLMESTETYTVLPSDLKMVEDHISRHARAEG
HHHCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]