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The map label for this gene is metC [H]

Identifier: 110635955

GI number: 110635955

Start: 3918336

End: 3919502

Strand: Reverse

Name: metC [H]

Synonym: Meso_3629

Alternate gene names: 110635955

Gene position: 3919502-3918336 (Counterclockwise)

Preceding gene: 110635956

Following gene: 110635954

Centisome position: 88.83

GC content: 64.1

Gene sequence:

>1167_bases
ATGGCTGAGAACAACGAGGACATGCGCACGACGCTGGTCCATGCGGGGCGAGGTCCGCAATACCGGGGAAACACGGTCAG
CCCGCCCGTGCACCGCGCGTCGACCTTCCTGTTCGACACTCTCGCTGAGATGGACCAGGCATCGAAGACGCCCTTCCGCG
GCGTCTTCTACGGCCGCAACGGCACGCCAACATCGGTGGCGTTCGAGGATGCCATGGCCAAAATCTCCAACGCCCACGGC
GCGATTGCGACGGCCTCGGGCGTATCCGCCATCATGGGGGTCATGCTCGGCCTGCTGAACAGCGGCGACCATGTGCTGAT
ACCTGACAGCGTCTATGACATCGTTCGGCGTTCGGCCGACGGCATGCTGGCCCGCATGGGTATTGAATACGAGTATTACG
ACCCAGTGGTAGGCGCGGGCATCGAGAGCCTGCTGCGGCCGAACACCCGGCTCATCTATCTGGAATCGCCCGGCTCCGGC
ACCTTCGAGGTGCAGGACGTTCCTGCTATCGTCGCGGTTGCGAAGGCGCGCAACATCCGTACCGCCATCGACAACACCTG
GGCGACACCCGTCTTCTTCCGCCCGCTCGAGCTCGGCGTCGACGCCGTCATCGAAGCAGGCACGAAATACATCGTCGGAC
ATTCCGATGCGATGCTGGGCGTCGTCGCTGCCAACGAACTGACCTATGGCCCGATCCGTCAGGCGATTCGCGATTTCGGC
GCGGTCGTCGGTACCGAGGAAGCCAATCTGGGCCTGCGCGGGTTGCGCACCATGGAAGTGCGGCTGCAGCGCCATTTCGC
CGCCGCGCTGGAGATAGCCACATGGCTGGAAGGTCAGCCCGGCGTTGCGCGGGTGATGCACCCGGCGCTACCCTCCTTCC
CCGGCCACACATTGTGGAAGCGCGACTTCAGCGGCGCCTCCGGCCTCTTTTCGATCGAGCTTGCGAACCGCGACCCGGCG
GCGATGACACGATTCGTTGACAGCCTTAAGCTTTTCAAGATCGGCTTCAGCTGGGGCGGCTTCGAAAGCCTCGTGCTTCC
CGCCCATCCCGAAAGGCGGAAGGTAGCGGTGTGGACGGGCGGTCCAGTCGTGCGCTTTCATATCGGGCTGGAAGCAATTG
ACGACCTCAAGGCCGACCTCGCCGCAGCGCTGCCGCTGATCGCCTGA

Upstream 100 bases:

>100_bases
GCGTTCCACCTCGAACGCATCGGCAGGCATGGCTGGCACATCTATGACGGCTCCTGGCACGAGTGGGGCCAGCGGGACGA
TCTACCCAAGGAGACGTCGA

Downstream 100 bases:

>100_bases
TTTCGCGTGTTTTCAACGCGCTGCTAATCAGCCGGTAGAGGGCGGCCGTTGCGAGGAAAAAGGCGCGCTACGCAATCTTC
GGGATCCCCTTATTAGAGCG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MAENNEDMRTTLVHAGRGPQYRGNTVSPPVHRASTFLFDTLAEMDQASKTPFRGVFYGRNGTPTSVAFEDAMAKISNAHG
AIATASGVSAIMGVMLGLLNSGDHVLIPDSVYDIVRRSADGMLARMGIEYEYYDPVVGAGIESLLRPNTRLIYLESPGSG
TFEVQDVPAIVAVAKARNIRTAIDNTWATPVFFRPLELGVDAVIEAGTKYIVGHSDAMLGVVAANELTYGPIRQAIRDFG
AVVGTEEANLGLRGLRTMEVRLQRHFAAALEIATWLEGQPGVARVMHPALPSFPGHTLWKRDFSGASGLFSIELANRDPA
AMTRFVDSLKLFKIGFSWGGFESLVLPAHPERRKVAVWTGGPVVRFHIGLEAIDDLKADLAAALPLIA

Sequences:

>Translated_388_residues
MAENNEDMRTTLVHAGRGPQYRGNTVSPPVHRASTFLFDTLAEMDQASKTPFRGVFYGRNGTPTSVAFEDAMAKISNAHG
AIATASGVSAIMGVMLGLLNSGDHVLIPDSVYDIVRRSADGMLARMGIEYEYYDPVVGAGIESLLRPNTRLIYLESPGSG
TFEVQDVPAIVAVAKARNIRTAIDNTWATPVFFRPLELGVDAVIEAGTKYIVGHSDAMLGVVAANELTYGPIRQAIRDFG
AVVGTEEANLGLRGLRTMEVRLQRHFAAALEIATWLEGQPGVARVMHPALPSFPGHTLWKRDFSGASGLFSIELANRDPA
AMTRFVDSLKLFKIGFSWGGFESLVLPAHPERRKVAVWTGGPVVRFHIGLEAIDDLKADLAAALPLIA
>Mature_387_residues
AENNEDMRTTLVHAGRGPQYRGNTVSPPVHRASTFLFDTLAEMDQASKTPFRGVFYGRNGTPTSVAFEDAMAKISNAHGA
IATASGVSAIMGVMLGLLNSGDHVLIPDSVYDIVRRSADGMLARMGIEYEYYDPVVGAGIESLLRPNTRLIYLESPGSGT
FEVQDVPAIVAVAKARNIRTAIDNTWATPVFFRPLELGVDAVIEAGTKYIVGHSDAMLGVVAANELTYGPIRQAIRDFGA
VVGTEEANLGLRGLRTMEVRLQRHFAAALEIATWLEGQPGVARVMHPALPSFPGHTLWKRDFSGASGLFSIELANRDPAA
MTRFVDSLKLFKIGFSWGGFESLVLPAHPERRKVAVWTGGPVVRFHIGLEAIDDLKADLAAALPLIA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=347, Percent_Identity=33.4293948126801, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI299473759, Length=347, Percent_Identity=29.971181556196, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI25453487, Length=346, Percent_Identity=30.0578034682081, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1789383, Length=392, Percent_Identity=39.7959183673469, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1790375, Length=380, Percent_Identity=31.0526315789474, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17560056, Length=375, Percent_Identity=33.8666666666667, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17538055, Length=377, Percent_Identity=31.8302387267904, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71980708, Length=392, Percent_Identity=30.8673469387755, Blast_Score=181, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6321170, Length=334, Percent_Identity=43.4131736526946, Blast_Score=300, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6319307, Length=398, Percent_Identity=28.643216080402, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323333, Length=411, Percent_Identity=25.0608272506083, Blast_Score=109, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6321904, Length=393, Percent_Identity=26.7175572519084, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321254, Length=417, Percent_Identity=27.3381294964029, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI19922554, Length=389, Percent_Identity=34.9614395886889, Blast_Score=208, Evalue=5e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41855; Mature: 41724

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAENNEDMRTTLVHAGRGPQYRGNTVSPPVHRASTFLFDTLAEMDQASKTPFRGVFYGRN
CCCCCCCCEEHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
GTPTSVAFEDAMAKISNAHGAIATASGVSAIMGVMLGLLNSGDHVLIPDSVYDIVRRSAD
CCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCC
GMLARMGIEYEYYDPVVGAGIESLLRPNTRLIYLESPGSGTFEVQDVPAIVAVAKARNIR
CHHHHHCCCEEECCCHHHHCHHHHHCCCCEEEEEECCCCCEEEECCCCHHHHHHHHCCHH
TAIDNTWATPVFFRPLELGVDAVIEAGTKYIVGHSDAMLGVVAANELTYGPIRQAIRDFG
HHHCCCCCCCEEECHHHHCHHHHHHCCCEEEEECCCCEEEEEEECCCCHHHHHHHHHHHH
AVVGTEEANLGLRGLRTMEVRLQRHFAAALEIATWLEGQPGVARVMHPALPSFPGHTLWK
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHH
RDFSGASGLFSIELANRDPAAMTRFVDSLKLFKIGFSWGGFESLVLPAHPERRKVAVWTG
CCCCCCCCEEEEEECCCCHHHHHHHHHHHEEEEEECCCCCCCCEEECCCCCCCEEEEEEC
GPVVRFHIGLEAIDDLKADLAAALPLIA
CCEEEEEECHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AENNEDMRTTLVHAGRGPQYRGNTVSPPVHRASTFLFDTLAEMDQASKTPFRGVFYGRN
CCCCCCCEEHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
GTPTSVAFEDAMAKISNAHGAIATASGVSAIMGVMLGLLNSGDHVLIPDSVYDIVRRSAD
CCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCC
GMLARMGIEYEYYDPVVGAGIESLLRPNTRLIYLESPGSGTFEVQDVPAIVAVAKARNIR
CHHHHHCCCEEECCCHHHHCHHHHHCCCCEEEEEECCCCCEEEECCCCHHHHHHHHCCHH
TAIDNTWATPVFFRPLELGVDAVIEAGTKYIVGHSDAMLGVVAANELTYGPIRQAIRDFG
HHHCCCCCCCEEECHHHHCHHHHHHCCCEEEEECCCCEEEEEEECCCCHHHHHHHHHHHH
AVVGTEEANLGLRGLRTMEVRLQRHFAAALEIATWLEGQPGVARVMHPALPSFPGHTLWK
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHH
RDFSGASGLFSIELANRDPAAMTRFVDSLKLFKIGFSWGGFESLVLPAHPERRKVAVWTG
CCCCCCCCEEEEEECCCCHHHHHHHHHHHEEEEEECCCCCCCCEEECCCCCCCEEEEEEC
GPVVRFHIGLEAIDDLKADLAAALPLIA
CCEEEEEECHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]