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The map label for this gene is fumC [H]

Identifier: 110635947

GI number: 110635947

Start: 3907027

End: 3908439

Strand: Reverse

Name: fumC [H]

Synonym: Meso_3621

Alternate gene names: 110635947

Gene position: 3908439-3907027 (Counterclockwise)

Preceding gene: 110635948

Following gene: 110635946

Centisome position: 88.58

GC content: 62.92

Gene sequence:

>1413_bases
ATGACTATTCGCTCGGAATCGGACGCAAACGGTCCCATTGAAATTCCAGCGGATCGCTACTGGGGAGCGCAGACCGCCCG
CGCGCTGAGGCTGTTCCCGCAGGAAGGACCGCGATTGCCTGTGAGTTTCCTGCGTGCCTTCGGCCTCCAGAAGGCCGCCG
CTGCCCGAGCGAACATGGCGCTTGGCGTACTTGATCGAGAACGCGGCGAACGTATCCTCGCCGCTGCCGTGGAATTGCGC
GACGGCCGTTTTGACGACCACTTCCCGCTCTCCATTTGGCAGACGGGAAGCGGCACGCAGACGAATATGAACGCCAACGA
GGTGCTGGCCAACCGAGCCAACGAACTGTCCGGCCAGCCGCTAGGCACGCGCGACCCGATCCATCCCAACGACCACGTCA
ATCTCGGCCAGTCGTCCAACGACACCTTTCCCACGGTGATGCATGTCGCCGCCGTACTGGAGCTTCAAGATGGCGTTCTG
CCGGCGCTGGATCAATTGGAAACGGCGTTCGCGCGGCTCGAAACCGATCACGGCGCCTATGTCCGCATGGGGCGTACGCA
TCTCAACGATGCCGTTCCGGTAACGCTTGGCCAGACCTTGGCATCGTATCGCAGGCAGGTGAGCCAGGCTCAAAAACGGA
TTGCGGCAACGCTGGCCGATCTCAAAGTGCTTTCGCAGGGTGGAACAGCCGCGGGCAGCGGGTTGAATGCCGCCGAAGGG
TTCGATCAGGCGTTTTGCGCAGCGCTCAGCGACGCGACCGGGATCGATTTCGCACCAAATCCCGTCAAGGTGGAGGGCAT
GGCCGCGCATGACGCGCTCGTGGCGGCATCGGCCGCTCTCGAAGGGCTCGCCACGGCATTGATTCATATCCTCAACGATA
TCCGGCTTCTTGCGGCCGGTCCGCGCGCCGGACTGGCCGAACTGACACTTCCCGACGACGGGCTGTCGTCCTCAATCATG
CCGGGCAAGCGGAACGCGACGCTGGCGGAAGCCCTGTTGCAGGTCTGCTTCCGCGTGATTGGCAATCACACCACGGTCGT
GTGGGCTGCCGGTTCCGGCCTGTTCGAGCTCAATGTCGCAAAGCCGGTGCTGATCCACGCGTTCCTCGAAAGCGCGACCG
CCCTGAAGGTCGCCATCGCATCCTTTGTCGCGGGAACGTTGAACGGATTAGAGGTCAATGGCGAGCGGATGGCGCACTAC
GTCAATTCCTCGCTGATGCTGGCGACCGCCCTGACACCGCGCCTCGGCTACGACCGTGTGGCGGAAGTTATACGCCTGGC
CGACCTCGAAAACCTCACCCTGCGGGAGGCCTGCGCCCGTTTCGGCGTGATCTCCATGCAGGATTACGACGCTCTGATCG
ATCCGGCGCGCATGGCAAATGGCGGCCGCATGAAGGAAGGGGAGAGGGAATGA

Upstream 100 bases:

>100_bases
TGGCCAAGCCGCTCGGCGAAGAGGCGCTCAGGGATCTGACTGATCCCCGCAACTATCTCGGCAGCGCCGGCGCTATGGTC
GACAATGTGCTCGGCGGCCG

Downstream 100 bases:

>100_bases
AGATCGTTCGCATCCTGGAGAAAGACCTGCCGATAACGTCTCCAGGCGCCAATGCGGTGGTCGACTTCGCCGGGCTAACG
ACGTCGGCGGTCGCGATCGT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MTIRSESDANGPIEIPADRYWGAQTARALRLFPQEGPRLPVSFLRAFGLQKAAAARANMALGVLDRERGERILAAAVELR
DGRFDDHFPLSIWQTGSGTQTNMNANEVLANRANELSGQPLGTRDPIHPNDHVNLGQSSNDTFPTVMHVAAVLELQDGVL
PALDQLETAFARLETDHGAYVRMGRTHLNDAVPVTLGQTLASYRRQVSQAQKRIAATLADLKVLSQGGTAAGSGLNAAEG
FDQAFCAALSDATGIDFAPNPVKVEGMAAHDALVAASAALEGLATALIHILNDIRLLAAGPRAGLAELTLPDDGLSSSIM
PGKRNATLAEALLQVCFRVIGNHTTVVWAAGSGLFELNVAKPVLIHAFLESATALKVAIASFVAGTLNGLEVNGERMAHY
VNSSLMLATALTPRLGYDRVAEVIRLADLENLTLREACARFGVISMQDYDALIDPARMANGGRMKEGERE

Sequences:

>Translated_470_residues
MTIRSESDANGPIEIPADRYWGAQTARALRLFPQEGPRLPVSFLRAFGLQKAAAARANMALGVLDRERGERILAAAVELR
DGRFDDHFPLSIWQTGSGTQTNMNANEVLANRANELSGQPLGTRDPIHPNDHVNLGQSSNDTFPTVMHVAAVLELQDGVL
PALDQLETAFARLETDHGAYVRMGRTHLNDAVPVTLGQTLASYRRQVSQAQKRIAATLADLKVLSQGGTAAGSGLNAAEG
FDQAFCAALSDATGIDFAPNPVKVEGMAAHDALVAASAALEGLATALIHILNDIRLLAAGPRAGLAELTLPDDGLSSSIM
PGKRNATLAEALLQVCFRVIGNHTTVVWAAGSGLFELNVAKPVLIHAFLESATALKVAIASFVAGTLNGLEVNGERMAHY
VNSSLMLATALTPRLGYDRVAEVIRLADLENLTLREACARFGVISMQDYDALIDPARMANGGRMKEGERE
>Mature_469_residues
TIRSESDANGPIEIPADRYWGAQTARALRLFPQEGPRLPVSFLRAFGLQKAAAARANMALGVLDRERGERILAAAVELRD
GRFDDHFPLSIWQTGSGTQTNMNANEVLANRANELSGQPLGTRDPIHPNDHVNLGQSSNDTFPTVMHVAAVLELQDGVLP
ALDQLETAFARLETDHGAYVRMGRTHLNDAVPVTLGQTLASYRRQVSQAQKRIAATLADLKVLSQGGTAAGSGLNAAEGF
DQAFCAALSDATGIDFAPNPVKVEGMAAHDALVAASAALEGLATALIHILNDIRLLAAGPRAGLAELTLPDDGLSSSIMP
GKRNATLAEALLQVCFRVIGNHTTVVWAAGSGLFELNVAKPVLIHAFLESATALKVAIASFVAGTLNGLEVNGERMAHYV
NSSLMLATALTPRLGYDRVAEVIRLADLENLTLREACARFGVISMQDYDALIDPARMANGGRMKEGERE

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=459, Percent_Identity=45.0980392156863, Blast_Score=400, Evalue=1e-111,
Organism=Escherichia coli, GI1787896, Length=466, Percent_Identity=44.8497854077253, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI87082375, Length=454, Percent_Identity=36.784140969163, Blast_Score=271, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI17553882, Length=458, Percent_Identity=44.5414847161572, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=40.7407407407407, Blast_Score=254, Evalue=7e-68,
Organism=Saccharomyces cerevisiae, GI6324993, Length=459, Percent_Identity=45.7516339869281, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24640179, Length=459, Percent_Identity=44.0087145969499, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24640177, Length=459, Percent_Identity=44.0087145969499, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24662684, Length=459, Percent_Identity=43.3551198257081, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI78710009, Length=460, Percent_Identity=41.0869565217391, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24583245, Length=459, Percent_Identity=37.037037037037, Blast_Score=321, Evalue=7e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50006; Mature: 49875

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRSESDANGPIEIPADRYWGAQTARALRLFPQEGPRLPVSFLRAFGLQKAAAARANMA
CCCCCCCCCCCCEECCCHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHH
LGVLDRERGERILAAAVELRDGRFDDHFPLSIWQTGSGTQTNMNANEVLANRANELSGQP
EEEHHHHHCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCC
LGTRDPIHPNDHVNLGQSSNDTFPTVMHVAAVLELQDGVLPALDQLETAFARLETDHGAY
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCE
VRMGRTHLNDAVPVTLGQTLASYRRQVSQAQKRIAATLADLKVLSQGGTAAGSGLNAAEG
EEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
FDQAFCAALSDATGIDFAPNPVKVEGMAAHDALVAASAALEGLATALIHILNDIRLLAAG
HHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
PRAGLAELTLPDDGLSSSIMPGKRNATLAEALLQVCFRVIGNHTTVVWAAGSGLFELNVA
CCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECC
KPVLIHAFLESATALKVAIASFVAGTLNGLEVNGERMAHYVNSSLMLATALTPRLGYDRV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHCCCCEEEHHHCCCCCHHHH
AEVIRLADLENLTLREACARFGVISMQDYDALIDPARMANGGRMKEGERE
HHHHHHHCCCCHHHHHHHHHCCCCEECCHHHHHCHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TIRSESDANGPIEIPADRYWGAQTARALRLFPQEGPRLPVSFLRAFGLQKAAAARANMA
CCCCCCCCCCCEECCCHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHH
LGVLDRERGERILAAAVELRDGRFDDHFPLSIWQTGSGTQTNMNANEVLANRANELSGQP
EEEHHHHHCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCC
LGTRDPIHPNDHVNLGQSSNDTFPTVMHVAAVLELQDGVLPALDQLETAFARLETDHGAY
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCE
VRMGRTHLNDAVPVTLGQTLASYRRQVSQAQKRIAATLADLKVLSQGGTAAGSGLNAAEG
EEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
FDQAFCAALSDATGIDFAPNPVKVEGMAAHDALVAASAALEGLATALIHILNDIRLLAAG
HHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
PRAGLAELTLPDDGLSSSIMPGKRNATLAEALLQVCFRVIGNHTTVVWAAGSGLFELNVA
CCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECC
KPVLIHAFLESATALKVAIASFVAGTLNGLEVNGERMAHYVNSSLMLATALTPRLGYDRV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHCCCCEEEHHHCCCCCHHHH
AEVIRLADLENLTLREACARFGVISMQDYDALIDPARMANGGRMKEGERE
HHHHHHHCCCCHHHHHHHHHCCCCEECCHHHHHCHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]