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The map label for this gene is fadE [H]

Identifier: 110635365

GI number: 110635365

Start: 3307390

End: 3309663

Strand: Reverse

Name: fadE [H]

Synonym: Meso_3036

Alternate gene names: 110635365

Gene position: 3309663-3307390 (Counterclockwise)

Preceding gene: 110635366

Following gene: 110635357

Centisome position: 75.01

GC content: 61.96

Gene sequence:

>2274_bases
ATGGGTTTTCGCCGCGATCGTCTCACCGCGCCCATTTTCAAGTGGGCTTCCGGCATCATGCCTCCCATCTCCCAGACGGA
GCGGGAGGCGATCGATGCCGGCACTGTCTGGTGGGACGGGGCTCTCTTTACCGGAAATCCGGATTGGAACGAGCTTCTCT
CCATGCCGGAGGCCGAGCTTTCGGCAGAGGAGCAGGCCTTCATGGACGGGCCGGTGCGCCAGCTTTGCGCCATGGTCGAC
GATTGGACGCTCAACTGGCGCGACCGCGACCTCGCGAACTCGGTTTGGGATTTCATGCGCCGCGAGAAGTTCTTCGGCAT
GATCATTCCGAAGGCGTATGGCGGGCTTGGCTTCTCCAATTTCGCCCATTCGGAGGTCGTTCGCACCGTCTCCTCCGCAA
GCGTGGTCGCGGGTGTGACCGTGATGGTGCCGAACTCTCTCGGACCCGGCGAACTCCTCATGCATTTCGGTACCGACGAG
CAGCGGGATTATTGGCTGCCGCGGCTGGCGGACGGCCGGGAAATCCCCTGCTTCGGGCTTACATCGCCGCATGCGGGTTC
GGATGCCGCGTCCATGACGGATACGGGCGTGGTGGAATACGGCACGTGGAAGGGGAGGAAGGTCCTTGGCATCAGGCTCA
ATTTCCACAAGCGCTATATCACGCTAGGACCGATCGCGACCGTCATGGGCCTCGCCTTCAAGATGCGCGATCCGCAAAAA
CTCCTCGGCCGCGGGGAAGAGCTTGGCATCACGGTGGCGTTGCTCCCCACCGACACGCCCGGCGTTTCCCATGGCGAGCG
GCACATTCCGCTCTTCACCTTTTTCCAGAACGGCCCCCTCTACGGCAAGGATGTTTTCGTGCCGCTCGACCACATTCTCG
GCGGAGAAAAACAGATCGGCCAGGGATGGACCATGCTGATGACCGCGCTTGCCGCCGGGCGCAGCATTTCGCTGCCCTCC
CAATCGGCGGCATCCGCGGCGATGGCCGCGCGAACGAGCGGGGCTTATGCGCGGATTCGCACCCAGTTCAATGTCCCCAT
TGGTTTTTTCGAGGGCGTGCAAGTGCCGCTGGCCGAAATGGCGGCCAATGCCTATCTGATCGATGCCGGAAGGAGGCTGA
CCCTCGCCGCCCTGGACAAGGGCCATCGGCCGTCAGTGCTTTCGGCCATCATGAAATATCATGCCACAGAACGCATGCGC
CGTTCCATGACGCACGCGATGGATGTCCACGGCGGCAAAGCCATCATCGAGGGGCCGCGTAACTATCTGGCCTCAGGCTA
TCGCTCGGTCCCCATCGGCATTACGGTGGAGGGCGCCAATATCCTCACGCGCAATCTGATGATTTTCGGCCAGGGCGCGA
TCCGTTCGCATCCATTCATGCTGAAGGAGCTGTTGGCGCTTTCAAATGAGGACAAAGGCCGCGGGCTGACCGCATTTGAT
GATGTTTTTTGGAAGCATCTCGCGCATGCCGCAAAGAATGCAGGCCGCGCCTTTTTCCGCGGCTGGTCGGGATCAATGAT
TGGTCCCGCTCCGCGCAGTGCCGCGAACCCGCGCTACTGGAAGAAGCTTTCCCGCCATACGGCGGCATTTGCGCTTACCG
CCGATCTTGCGCTCCTGACGCTGGGCGGGTCTTTGAAACGCAAGGAGATGCTTTCGGCCCGGCTGGGCGATATCCTTGCG
GAACTTTATCTCCTGGGCGCGGTGCTGAAGCGCTTCGAAGACGAAGGCCGCCAAGCCGAAGATCTGCCGATCGTGGAGTA
TTTGATGCGGCAGGGAGAAAGCCGCATCGCCGCCGCCTTTCGCGGCGTGCTCGACAATCTGCCCGCGCGTTGGGCGGCGT
GGCTGGTGCGGCTGCTCGCCTTTCCATTCGGCGTGCCCGATCCCACTCCCTCCGACCGGCTGACGGCGCGCATCGCGGAA
ATTCTTTTGAAACCCTCATCTCAAAGGGACCGTCTGACACCCGGCCTCTATCTTGGCGACGGCCATGCCGAGCATCCCCT
CAAGGATTTGGAGGAAGCTTTCCGGCTTGTGATTGAAGCCGCGCCTATCGAGAAGAAGATGCGGGAAGCACGCATTCACG
ACACTCAAGCGGCGCTGGATGAGAAGGTCATTACGCCAGCGGAACGGGAGTTGCTTGGCCGCGCTGCGGCGGCGGTGGAA
AAGGTTGTTGCGGTCGATGCGTTCCCGATGGAGGCGCTTTCTCCCACGGCCGGCCAGCACAAGCGGCAGAAGCCCACACC
GCGGCGCCCACGTCAGAAGCAAACAGCGGAATAG

Upstream 100 bases:

>100_bases
ATCCGCCATAGCGGATGCCATTCCTTCCTGGAACCTGCCCAAGGGTGAGCCTATTCTCAAGGCAGCTGATGCCAGCCGAG
AGGCCAAGGAGAGCTGCGCC

Downstream 100 bases:

>100_bases
GCTTTGCGGAAATCCATTCCAAGCTAGCGTGTCGGAACCGGCGGATCTTCGCGGTAATCGTAGAAGCCGCGGCCCGTCTT
GCGGCCGAGCCAGCCTGCCT

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 757; Mature: 756

Protein sequence:

>757_residues
MGFRRDRLTAPIFKWASGIMPPISQTEREAIDAGTVWWDGALFTGNPDWNELLSMPEAELSAEEQAFMDGPVRQLCAMVD
DWTLNWRDRDLANSVWDFMRREKFFGMIIPKAYGGLGFSNFAHSEVVRTVSSASVVAGVTVMVPNSLGPGELLMHFGTDE
QRDYWLPRLADGREIPCFGLTSPHAGSDAASMTDTGVVEYGTWKGRKVLGIRLNFHKRYITLGPIATVMGLAFKMRDPQK
LLGRGEELGITVALLPTDTPGVSHGERHIPLFTFFQNGPLYGKDVFVPLDHILGGEKQIGQGWTMLMTALAAGRSISLPS
QSAASAAMAARTSGAYARIRTQFNVPIGFFEGVQVPLAEMAANAYLIDAGRRLTLAALDKGHRPSVLSAIMKYHATERMR
RSMTHAMDVHGGKAIIEGPRNYLASGYRSVPIGITVEGANILTRNLMIFGQGAIRSHPFMLKELLALSNEDKGRGLTAFD
DVFWKHLAHAAKNAGRAFFRGWSGSMIGPAPRSAANPRYWKKLSRHTAAFALTADLALLTLGGSLKRKEMLSARLGDILA
ELYLLGAVLKRFEDEGRQAEDLPIVEYLMRQGESRIAAAFRGVLDNLPARWAAWLVRLLAFPFGVPDPTPSDRLTARIAE
ILLKPSSQRDRLTPGLYLGDGHAEHPLKDLEEAFRLVIEAAPIEKKMREARIHDTQAALDEKVITPAERELLGRAAAAVE
KVVAVDAFPMEALSPTAGQHKRQKPTPRRPRQKQTAE

Sequences:

>Translated_757_residues
MGFRRDRLTAPIFKWASGIMPPISQTEREAIDAGTVWWDGALFTGNPDWNELLSMPEAELSAEEQAFMDGPVRQLCAMVD
DWTLNWRDRDLANSVWDFMRREKFFGMIIPKAYGGLGFSNFAHSEVVRTVSSASVVAGVTVMVPNSLGPGELLMHFGTDE
QRDYWLPRLADGREIPCFGLTSPHAGSDAASMTDTGVVEYGTWKGRKVLGIRLNFHKRYITLGPIATVMGLAFKMRDPQK
LLGRGEELGITVALLPTDTPGVSHGERHIPLFTFFQNGPLYGKDVFVPLDHILGGEKQIGQGWTMLMTALAAGRSISLPS
QSAASAAMAARTSGAYARIRTQFNVPIGFFEGVQVPLAEMAANAYLIDAGRRLTLAALDKGHRPSVLSAIMKYHATERMR
RSMTHAMDVHGGKAIIEGPRNYLASGYRSVPIGITVEGANILTRNLMIFGQGAIRSHPFMLKELLALSNEDKGRGLTAFD
DVFWKHLAHAAKNAGRAFFRGWSGSMIGPAPRSAANPRYWKKLSRHTAAFALTADLALLTLGGSLKRKEMLSARLGDILA
ELYLLGAVLKRFEDEGRQAEDLPIVEYLMRQGESRIAAAFRGVLDNLPARWAAWLVRLLAFPFGVPDPTPSDRLTARIAE
ILLKPSSQRDRLTPGLYLGDGHAEHPLKDLEEAFRLVIEAAPIEKKMREARIHDTQAALDEKVITPAERELLGRAAAAVE
KVVAVDAFPMEALSPTAGQHKRQKPTPRRPRQKQTAE
>Mature_756_residues
GFRRDRLTAPIFKWASGIMPPISQTEREAIDAGTVWWDGALFTGNPDWNELLSMPEAELSAEEQAFMDGPVRQLCAMVDD
WTLNWRDRDLANSVWDFMRREKFFGMIIPKAYGGLGFSNFAHSEVVRTVSSASVVAGVTVMVPNSLGPGELLMHFGTDEQ
RDYWLPRLADGREIPCFGLTSPHAGSDAASMTDTGVVEYGTWKGRKVLGIRLNFHKRYITLGPIATVMGLAFKMRDPQKL
LGRGEELGITVALLPTDTPGVSHGERHIPLFTFFQNGPLYGKDVFVPLDHILGGEKQIGQGWTMLMTALAAGRSISLPSQ
SAASAAMAARTSGAYARIRTQFNVPIGFFEGVQVPLAEMAANAYLIDAGRRLTLAALDKGHRPSVLSAIMKYHATERMRR
SMTHAMDVHGGKAIIEGPRNYLASGYRSVPIGITVEGANILTRNLMIFGQGAIRSHPFMLKELLALSNEDKGRGLTAFDD
VFWKHLAHAAKNAGRAFFRGWSGSMIGPAPRSAANPRYWKKLSRHTAAFALTADLALLTLGGSLKRKEMLSARLGDILAE
LYLLGAVLKRFEDEGRQAEDLPIVEYLMRQGESRIAAAFRGVLDNLPARWAAWLVRLLAFPFGVPDPTPSDRLTARIAEI
LLKPSSQRDRLTPGLYLGDGHAEHPLKDLEEAFRLVIEAAPIEKKMREARIHDTQAALDEKVITPAERELLGRAAAAVEK
VVAVDAFPMEALSPTAGQHKRQKPTPRRPRQKQTAE

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=542, Percent_Identity=27.1217712177122, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI4557233, Length=353, Percent_Identity=28.8951841359773, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI4557235, Length=568, Percent_Identity=23.943661971831, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI76496475, Length=547, Percent_Identity=24.3144424131627, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI4501859, Length=366, Percent_Identity=26.5027322404372, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI226958414, Length=345, Percent_Identity=25.5072463768116, Blast_Score=78, Evalue=4e-14,
Organism=Homo sapiens, GI226958412, Length=328, Percent_Identity=25.609756097561, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI87081702, Length=742, Percent_Identity=48.6522911051213, Blast_Score=712, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985184, Length=376, Percent_Identity=25.2659574468085, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17538396, Length=396, Percent_Identity=25.7575757575758, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71985192, Length=320, Percent_Identity=24.375, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17534899, Length=325, Percent_Identity=27.3846153846154, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17570075, Length=326, Percent_Identity=26.6871165644172, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17569725, Length=329, Percent_Identity=26.4437689969605, Blast_Score=76, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17533517, Length=357, Percent_Identity=26.3305322128852, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI281363737, Length=576, Percent_Identity=22.9166666666667, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21356377, Length=308, Percent_Identity=27.9220779220779, Blast_Score=83, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24660351, Length=335, Percent_Identity=25.0746268656716, Blast_Score=77, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 83358; Mature: 83227

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFRRDRLTAPIFKWASGIMPPISQTEREAIDAGTVWWDGALFTGNPDWNELLSMPEAEL
CCCCCHHCCHHHHHHHHCCCCCCCHHHHHHHCCCCEEECCEEECCCCCHHHHHCCCCHHH
SAEEQAFMDGPVRQLCAMVDDWTLNWRDRDLANSVWDFMRREKFFGMIIPKAYGGLGFSN
CHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCEECCHHHCCCCCCH
FAHSEVVRTVSSASVVAGVTVMVPNSLGPGELLMHFGTDEQRDYWLPRLADGREIPCFGL
HHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHEEECCCCCCCCCCCCCCCCCCCCCEECC
TSPHAGSDAASMTDTGVVEYGTWKGRKVLGIRLNFHKRYITLGPIATVMGLAFKMRDPQK
CCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEEEECCEEEEEHHHHHHHHHHHHCCCHHH
LLGRGEELGITVALLPTDTPGVSHGERHIPLFTFFQNGPLYGKDVFVPLDHILGGEKQIG
HHCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHHCCCCHHHC
QGWTMLMTALAAGRSISLPSQSAASAAMAARTSGAYARIRTQFNVPIGFFEGVQVPLAEM
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCHHCCCCCCHHHH
AANAYLIDAGRRLTLAALDKGHRPSVLSAIMKYHATERMRRSMTHAMDVHGGKAIIEGPR
CCCEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCH
NYLASGYRSVPIGITVEGANILTRNLMIFGQGAIRSHPFMLKELLALSNEDKGRGLTAFD
HHHHCCCCCCCEEEEECCCHHHEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHH
DVFWKHLAHAAKNAGRAFFRGWSGSMIGPAPRSAANPRYWKKLSRHTAAFALTADLALLT
HHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LGGSLKRKEMLSARLGDILAELYLLGAVLKRFEDEGRQAEDLPIVEYLMRQGESRIAAAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHH
RGVLDNLPARWAAWLVRLLAFPFGVPDPTPSDRLTARIAEILLKPSSQRDRLTPGLYLGD
HHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECC
GHAEHPLKDLEEAFRLVIEAAPIEKKMREARIHDTQAALDEKVITPAERELLGRAAAAVE
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
KVVAVDAFPMEALSPTAGQHKRQKPTPRRPRQKQTAE
HHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GFRRDRLTAPIFKWASGIMPPISQTEREAIDAGTVWWDGALFTGNPDWNELLSMPEAEL
CCCCHHCCHHHHHHHHCCCCCCCHHHHHHHCCCCEEECCEEECCCCCHHHHHCCCCHHH
SAEEQAFMDGPVRQLCAMVDDWTLNWRDRDLANSVWDFMRREKFFGMIIPKAYGGLGFSN
CHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCEECCHHHCCCCCCH
FAHSEVVRTVSSASVVAGVTVMVPNSLGPGELLMHFGTDEQRDYWLPRLADGREIPCFGL
HHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHEEECCCCCCCCCCCCCCCCCCCCCEECC
TSPHAGSDAASMTDTGVVEYGTWKGRKVLGIRLNFHKRYITLGPIATVMGLAFKMRDPQK
CCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEEEECCEEEEEHHHHHHHHHHHHCCCHHH
LLGRGEELGITVALLPTDTPGVSHGERHIPLFTFFQNGPLYGKDVFVPLDHILGGEKQIG
HHCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHHCCCCHHHC
QGWTMLMTALAAGRSISLPSQSAASAAMAARTSGAYARIRTQFNVPIGFFEGVQVPLAEM
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCHHCCCCCCHHHH
AANAYLIDAGRRLTLAALDKGHRPSVLSAIMKYHATERMRRSMTHAMDVHGGKAIIEGPR
CCCEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCH
NYLASGYRSVPIGITVEGANILTRNLMIFGQGAIRSHPFMLKELLALSNEDKGRGLTAFD
HHHHCCCCCCCEEEEECCCHHHEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHH
DVFWKHLAHAAKNAGRAFFRGWSGSMIGPAPRSAANPRYWKKLSRHTAAFALTADLALLT
HHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LGGSLKRKEMLSARLGDILAELYLLGAVLKRFEDEGRQAEDLPIVEYLMRQGESRIAAAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHH
RGVLDNLPARWAAWLVRLLAFPFGVPDPTPSDRLTARIAEILLKPSSQRDRLTPGLYLGD
HHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECC
GHAEHPLKDLEEAFRLVIEAAPIEKKMREARIHDTQAALDEKVITPAERELLGRAAAAVE
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
KVVAVDAFPMEALSPTAGQHKRQKPTPRRPRQKQTAE
HHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]