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The map label for this gene is hetI [H]

Identifier: 110634924

GI number: 110634924

Start: 2782947

End: 2783759

Strand: Reverse

Name: hetI [H]

Synonym: Meso_2583

Alternate gene names: 110634924

Gene position: 2783759-2782947 (Counterclockwise)

Preceding gene: 110634925

Following gene: 110634918

Centisome position: 63.09

GC content: 62.24

Gene sequence:

>813_bases
ATGCGGTATAGCCCCGTCACGATCGGACCGGACGTCATCGATCTCTGGAGATGGCCTCTCGATGTCATTGCCGGTGAACT
GCCGCGATATGTGGAGGCGCTGAGCGATACGGAATTCGCCCGTGCCGGCCGATTTCTGCAGGAACGTGATCGACTGCGTT
TTCTGGTAGGGCGCGGACGGCTTCGGGAGATCCTGGCGCGTTATCTCGGTCTTCCCGCCAAGCGGCTCGTCTTCACCTAT
AATGCTTTCGGCAAGCCGCGTCTTGCGGGTGCAAAACCGCCGCTTCACTTCAATCTCAGCCATTCCGGCGGTATGGCAGT
GCTTGCGGTGTCGGACCGGTATCAGGTGGGCGTGGATATCGAGCAGGCGCTTCCTCTGAAGGAAGACGTAGCGCAGCATT
TCTTTTCTCCCGCCGAGCAGCAGGCGCTCGGGACCCTGCCGCCGAGCGAATACCTAGAGGCGTTCTATCGTTGCTGGACA
CGCAAGGAAGCCTTTGTGAAGGCCCATGGCGCCGGCCTTTCGCTTCCGCTCGACGCGTTCGACGTATCCATAGATGACGC
CAGCGAGCCCAAGCTCCTGAGGCTGGAAGGCGACCCTCGGGCGCCGCTTCGGTGGCGGCTGGCCGAGATTGCAATGCCCT
ACGGGTATATCGGGGCGGTGGCGGCATCGACGGGCGGCAACAGGATTTGGTTGCGCTATCGCTCTGTCACCGAGGATCAA
AACGGAAGCGAGTGGCCCGAGCCTCTGCGCCCGCTGCGCCGGGCACCGCCGTTGGCCGACGATCACCTGTTTAACCGCGC
ATCCAGGATGTAG

Upstream 100 bases:

>100_bases
AGCTGCCGCATCAGCCTCGGCGAAAACTATCCTCTGCCGCTTGTGGCTTATGTCGCCCGGCGGCTCGCCAGCGGTGGCGA
GGCAGCAAGGCAGGTGTCCT

Downstream 100 bases:

>100_bases
CGCCCGCCGCTGGCATCGAAGTGGTGGCAGCCTATGAGGCCCGGTTTGAAGTCGGGCAGTATGGTCCTGATGCAGCGCTC
CCGATAGGTCTCCCGCGTAA

Product: 4'-phosphopantetheinyl transferase

Products: adenosine 3',5'-bisphosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MRYSPVTIGPDVIDLWRWPLDVIAGELPRYVEALSDTEFARAGRFLQERDRLRFLVGRGRLREILARYLGLPAKRLVFTY
NAFGKPRLAGAKPPLHFNLSHSGGMAVLAVSDRYQVGVDIEQALPLKEDVAQHFFSPAEQQALGTLPPSEYLEAFYRCWT
RKEAFVKAHGAGLSLPLDAFDVSIDDASEPKLLRLEGDPRAPLRWRLAEIAMPYGYIGAVAASTGGNRIWLRYRSVTEDQ
NGSEWPEPLRPLRRAPPLADDHLFNRASRM

Sequences:

>Translated_270_residues
MRYSPVTIGPDVIDLWRWPLDVIAGELPRYVEALSDTEFARAGRFLQERDRLRFLVGRGRLREILARYLGLPAKRLVFTY
NAFGKPRLAGAKPPLHFNLSHSGGMAVLAVSDRYQVGVDIEQALPLKEDVAQHFFSPAEQQALGTLPPSEYLEAFYRCWT
RKEAFVKAHGAGLSLPLDAFDVSIDDASEPKLLRLEGDPRAPLRWRLAEIAMPYGYIGAVAASTGGNRIWLRYRSVTEDQ
NGSEWPEPLRPLRRAPPLADDHLFNRASRM
>Mature_270_residues
MRYSPVTIGPDVIDLWRWPLDVIAGELPRYVEALSDTEFARAGRFLQERDRLRFLVGRGRLREILARYLGLPAKRLVFTY
NAFGKPRLAGAKPPLHFNLSHSGGMAVLAVSDRYQVGVDIEQALPLKEDVAQHFFSPAEQQALGTLPPSEYLEAFYRCWT
RKEAFVKAHGAGLSLPLDAFDVSIDDASEPKLLRLEGDPRAPLRWRLAEIAMPYGYIGAVAASTGGNRIWLRYRSVTEDQ
NGSEWPEPLRPLRRAPPLADDHLFNRASRM

Specific function: Probably activates the acyl carrier protein (ACP) domain of hetM, by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. May be required for maintaining vegetative growth and probably acts via hetN to inhibit differenti

COG id: COG2091

COG function: function code H; Phosphopantetheinyl transferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the P-Pant transferase superfamily. Gsp/sfp/hetI/acpT family [H]

Homologues:

Organism=Homo sapiens, GI20357568, Length=167, Percent_Identity=32.9341317365269, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1789886, Length=124, Percent_Identity=39.5161290322581, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24663173, Length=238, Percent_Identity=27.7310924369748, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008278 [H]

Pfam domain/function: PF01648 ACPS [H]

EC number: NA

Molecular weight: Translated: 30467; Mature: 30467

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYSPVTIGPDVIDLWRWPLDVIAGELPRYVEALSDTEFARAGRFLQERDRLRFLVGRGR
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCH
LREILARYLGLPAKRLVFTYNAFGKPRLAGAKPPLHFNLSHSGGMAVLAVSDRYQVGVDI
HHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCEEECCCH
EQALPLKEDVAQHFFSPAEQQALGTLPPSEYLEAFYRCWTRKEAFVKAHGAGLSLPLDAF
HHHCCCHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHE
DVSIDDASEPKLLRLEGDPRAPLRWRLAEIAMPYGYIGAVAASTGGNRIWLRYRSVTEDQ
EEECCCCCCCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHEECCCCCEEEEEEECCCCCC
NGSEWPEPLRPLRRAPPLADDHLFNRASRM
CCCCCCHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MRYSPVTIGPDVIDLWRWPLDVIAGELPRYVEALSDTEFARAGRFLQERDRLRFLVGRGR
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCH
LREILARYLGLPAKRLVFTYNAFGKPRLAGAKPPLHFNLSHSGGMAVLAVSDRYQVGVDI
HHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCEEECCCH
EQALPLKEDVAQHFFSPAEQQALGTLPPSEYLEAFYRCWTRKEAFVKAHGAGLSLPLDAF
HHHCCCHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHE
DVSIDDASEPKLLRLEGDPRAPLRWRLAEIAMPYGYIGAVAASTGGNRIWLRYRSVTEDQ
EEECCCCCCCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHEECCCCCEEEEEEECCCCCC
NGSEWPEPLRPLRRAPPLADDHLFNRASRM
CCCCCCHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; apo-[acyl carrier protein] [C]

Specific reaction: Coenzyme A + apo-[acyl carrier protein] = adenosine 3',5'-bisphosphate + [acyl carrier protein] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8157596; 11759840; 8939709 [H]