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The map label for this gene is nadC [H]

Identifier: 110634896

GI number: 110634896

Start: 2743775

End: 2744626

Strand: Reverse

Name: nadC [H]

Synonym: Meso_2555

Alternate gene names: 110634896

Gene position: 2744626-2743775 (Counterclockwise)

Preceding gene: 110634897

Following gene: 110634893

Centisome position: 62.2

GC content: 64.67

Gene sequence:

>852_bases
ATGAATATTCCTCCGCTTCCCACCGTCATGTTCGAGCCGTTGGTTCGCTCAACGTTGCTGGAGGATCTTGGCCGCGCGGG
CGATCTCACCACGGATGCAGTCGTTCCCGCCGGCCTTCATGCCGAACTGACGCTGACCGCCCGCCAGCCGGGCGTTGTCG
CGGGACTCGATGTGGCTGCGCTTGCGTTCCGCCTTATCGATCCGGCGATCTCGGTGAAGATCGAGCGGCCCGATGGCAGC
GCGATTGCTCCGGGAGATGTGATTGCCAGTGTCAGCGGGCCCGCGCGCGGCCTGCTGATTGCCGAGCGCACGGCGCTTAA
CTTCCTCTGTCATCTCTGCGGCATCGCCACGGCCACTGCTGGGATCGTCGAGGTCGTCAGGGGCCACAAGGCGCAGATCG
TCTGCACGCGCAAAACGACTCCTGGCCTGCGGGCGCTCGAAAAATACGCTGTGCGGGCCGGTGGCGGCTCAAACCACCGC
TTCGGGCTGGACGACGCCATCCTCATCAAGGACAACCATATTGCGATCGCCGGTGGTATCCGCCCTGCCATTGAGCGGGC
GCGGGCGCATGCGGGCCATATGGTCAAGATCGAGGTGGAAGTCGATACGCTGGCCCAGCTCGAAGAGGTGCTCGCCCGGA
AAGTCGATGCGGTTCTGCTCGACAATATGTCGCCCGAGCAGCTCGCGCGCGCTGTAGAGCTGACGGCCGGCCGCGCGATC
ACCGAAGCCTCAGGCCGGGTAACACGGGAAACCGCGCCCGCAATTGCCGCTTCGGGCGTTGATCTCATCTCGGTCGGCTG
GATCACCCACAGCGCGCCGGTGCTGGATATCGGGTTGGATTATCGCGCCTGA

Upstream 100 bases:

>100_bases
GTGAGTATGCGGTGCATTCGCGCCTTACGCTGGCCAACGCATTCGAGACGGCGCGGAGTCTCGTGCCCGAGCCTGCAATC
CCGATGGCCAGGAGCGCATG

Downstream 100 bases:

>100_bases
GGCGACGAGTTCACTCTTCCTCTCCCGGCAATTCGGTGTCCTCGTCCAGCGTGTCGCGAACCCACAGCTTCTTTACCGAA
ACGAAGACGACAACCAGGAG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MNIPPLPTVMFEPLVRSTLLEDLGRAGDLTTDAVVPAGLHAELTLTARQPGVVAGLDVAALAFRLIDPAISVKIERPDGS
AIAPGDVIASVSGPARGLLIAERTALNFLCHLCGIATATAGIVEVVRGHKAQIVCTRKTTPGLRALEKYAVRAGGGSNHR
FGLDDAILIKDNHIAIAGGIRPAIERARAHAGHMVKIEVEVDTLAQLEEVLARKVDAVLLDNMSPEQLARAVELTAGRAI
TEASGRVTRETAPAIAASGVDLISVGWITHSAPVLDIGLDYRA

Sequences:

>Translated_283_residues
MNIPPLPTVMFEPLVRSTLLEDLGRAGDLTTDAVVPAGLHAELTLTARQPGVVAGLDVAALAFRLIDPAISVKIERPDGS
AIAPGDVIASVSGPARGLLIAERTALNFLCHLCGIATATAGIVEVVRGHKAQIVCTRKTTPGLRALEKYAVRAGGGSNHR
FGLDDAILIKDNHIAIAGGIRPAIERARAHAGHMVKIEVEVDTLAQLEEVLARKVDAVLLDNMSPEQLARAVELTAGRAI
TEASGRVTRETAPAIAASGVDLISVGWITHSAPVLDIGLDYRA
>Mature_283_residues
MNIPPLPTVMFEPLVRSTLLEDLGRAGDLTTDAVVPAGLHAELTLTARQPGVVAGLDVAALAFRLIDPAISVKIERPDGS
AIAPGDVIASVSGPARGLLIAERTALNFLCHLCGIATATAGIVEVVRGHKAQIVCTRKTTPGLRALEKYAVRAGGGSNHR
FGLDDAILIKDNHIAIAGGIRPAIERARAHAGHMVKIEVEVDTLAQLEEVLARKVDAVLLDNMSPEQLARAVELTAGRAI
TEASGRVTRETAPAIAASGVDLISVGWITHSAPVLDIGLDYRA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=283, Percent_Identity=37.4558303886926, Blast_Score=152, Evalue=3e-37,
Organism=Escherichia coli, GI1786299, Length=272, Percent_Identity=39.7058823529412, Blast_Score=166, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6321162, Length=252, Percent_Identity=34.5238095238095, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29582; Mature: 29582

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIPPLPTVMFEPLVRSTLLEDLGRAGDLTTDAVVPAGLHAELTLTARQPGVVAGLDVAA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEECHHHHH
LAFRLIDPAISVKIERPDGSAIAPGDVIASVSGPARGLLIAERTALNFLCHLCGIATATA
HHHHHHCCEEEEEEECCCCCCCCCCCEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
GIVEVVRGHKAQIVCTRKTTPGLRALEKYAVRAGGGSNHRFGLDDAILIKDNHIAIAGGI
HHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEECCC
RPAIERARAHAGHMVKIEVEVDTLAQLEEVLARKVDAVLLDNMSPEQLARAVELTAGRAI
HHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEE
TEASGRVTRETAPAIAASGVDLISVGWITHSAPVLDIGLDYRA
ECCCCCEEHHHCCHHHHCCCCEEEEEEEECCCCEEEECCCCCC
>Mature Secondary Structure
MNIPPLPTVMFEPLVRSTLLEDLGRAGDLTTDAVVPAGLHAELTLTARQPGVVAGLDVAA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEECHHHHH
LAFRLIDPAISVKIERPDGSAIAPGDVIASVSGPARGLLIAERTALNFLCHLCGIATATA
HHHHHHCCEEEEEEECCCCCCCCCCCEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
GIVEVVRGHKAQIVCTRKTTPGLRALEKYAVRAGGGSNHRFGLDDAILIKDNHIAIAGGI
HHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEECCC
RPAIERARAHAGHMVKIEVEVDTLAQLEEVLARKVDAVLLDNMSPEQLARAVELTAGRAI
HHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEE
TEASGRVTRETAPAIAASGVDLISVGWITHSAPVLDIGLDYRA
ECCCCCEEHHHCCHHHHCCCCEEEEEEEECCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]