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The map label for this gene is nadB [H]

Identifier: 110634897

GI number: 110634897

Start: 2744626

End: 2746179

Strand: Reverse

Name: nadB [H]

Synonym: Meso_2556

Alternate gene names: 110634897

Gene position: 2746179-2744626 (Counterclockwise)

Preceding gene: 110634898

Following gene: 110634896

Centisome position: 62.24

GC content: 67.37

Gene sequence:

>1554_bases
ATGAACGGCTTTGATCTTCACGACCTCAGCGGCCGCCCGGTCATTATCGGCGCTGGCCTTGCTGGGCTCGCAACCGCGCT
TCATCTTTCACCCATGCCTGTCGTGGTGCTTTCCAAGGCACCTCTCGGCGAGGAGGCATCGAGCGCCTGGGCGCAGGGCG
GGCTCGCGGCAGCCATGGGGCCGGACGATGATCCCGACCTTCATCTGGCCGATACGCTCGCCGCAGGGGACGGGCTTTGC
GATCCCGACATTGTCGGCAAGGTCGTCCGAGCAGCACCTCGGGCGATCGAGGACCTGGCACGCTTCGGCGTCCGCTTTGA
CAAGGCAGAGGACGGTCCGCTGCTCCTTGGACTTGAGGCGGCGCATAGCCGCCGCCGCATCATCCATGCGGAAGGAGACG
CCACGGGCCGCGAAATCATGCGCGCGCTTGTGGCCGCGGTGCGCCGGACTCCCTCGATCACCGTGCTGGAAGGTTTCGAA
GCGCGGCGGCTCCTCACGGAAGACGGTGCCATTTCCGGGGTTGTCGCCGCCGGGCCGGACAGTCCGGTGCTGCTTGCTAC
CAGCCGCGTTGTGATCGCCACCGGCAGTATCGGCGGTTTGTACGAGGATACCACAACGCCTTTGGGTTCCTTCGGCCAAG
GGCTTGCGCTTGCCGCACATGCCGGCGCGGCGCTTCGCGATCTGGAATTCGTGCAGTTCCATCCCACCGCGCTCGATGGG
ACCGGGCGTCCGATGCGCCTCGTCAGCGAGGCCGTGCGCGGGGAGGGCGCGGTTCTCATCGACGAGACTGGCCGTCGTTT
CCTCGAGGGCACGCCGGGCGCCGAGCTTGCGCCGCGCGACGTGGTGGCGCGCGCGGTGGCGTGGCATCTCTCCATGGGCC
ATCGCGTTTTTCTCGATGCGCGGGGGGCCATCGGGACCAGCTTCGCTCTCCGCTTTCCCAGTATTTACGCCTTCTGCAGA
GCCGCGGGCCTTGATCCGTCGCGTGTGCCGATCCCCATTCGCCCTGCCGTCCATTACCACATGGGCGGCATTGCCGTTAA
CGGCGAAGGCCGCAGCTCCGTGCGCGGCCTATGGGCGTGCGGCGAGGTAGCCTCGACCGGCCTTCACGGCGCGAACCGGC
TCGCCAGCAATTCGCTGATCGAGGCGGCCGTCTTTGGCCGTTGGGTGGCGGAAAGCATCGCCGGCGCGGGCGATGCGATG
CGCCATCGGCCGGGCTCCTTCGCCATGCCCGGCAGTGCGGATGCTTCAGTCGTGCGTCCGGTCGTCTCGCGTGCCTTGGG
CGTCATCCGCGATGCGGACACAATGCGGGATGCAATTGCTTCGCTCCTTCCTCTGGCCGAGCGCAAAGGACCCGCTTCTG
ATCCCGCGGCGGTCGCATTGATGATGGTTGTCTCCGCGCTGGCGCGCGAGGAAAGCCGGGGCGGGCATTTCCGCGCCGAT
TTCCCCCGGCGCAGTGAGTATGCGGTGCATTCGCGCCTTACGCTGGCCAACGCATTCGAGACGGCGCGGAGTCTCGTGCC
CGAGCCTGCAATCCCGATGGCCAGGAGCGCATGA

Upstream 100 bases:

>100_bases
ATATCCGCAAGGCGTTGGAGGAGAACCAGCACGTGGTGACGGTCGATCCTGAGGTGGCCGAGCGCGCGCGGCGCGCCGTG
GAGCGGATGCTCGCTGTCAA

Downstream 100 bases:

>100_bases
TGAATATTCCTCCGCTTCCCACCGTCATGTTCGAGCCGTTGGTTCGCTCAACGTTGCTGGAGGATCTTGGCCGCGCGGGC
GATCTCACCACGGATGCAGT

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO; Quinolinate synthase B [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MNGFDLHDLSGRPVIIGAGLAGLATALHLSPMPVVVLSKAPLGEEASSAWAQGGLAAAMGPDDDPDLHLADTLAAGDGLC
DPDIVGKVVRAAPRAIEDLARFGVRFDKAEDGPLLLGLEAAHSRRRIIHAEGDATGREIMRALVAAVRRTPSITVLEGFE
ARRLLTEDGAISGVVAAGPDSPVLLATSRVVIATGSIGGLYEDTTTPLGSFGQGLALAAHAGAALRDLEFVQFHPTALDG
TGRPMRLVSEAVRGEGAVLIDETGRRFLEGTPGAELAPRDVVARAVAWHLSMGHRVFLDARGAIGTSFALRFPSIYAFCR
AAGLDPSRVPIPIRPAVHYHMGGIAVNGEGRSSVRGLWACGEVASTGLHGANRLASNSLIEAAVFGRWVAESIAGAGDAM
RHRPGSFAMPGSADASVVRPVVSRALGVIRDADTMRDAIASLLPLAERKGPASDPAAVALMMVVSALAREESRGGHFRAD
FPRRSEYAVHSRLTLANAFETARSLVPEPAIPMARSA

Sequences:

>Translated_517_residues
MNGFDLHDLSGRPVIIGAGLAGLATALHLSPMPVVVLSKAPLGEEASSAWAQGGLAAAMGPDDDPDLHLADTLAAGDGLC
DPDIVGKVVRAAPRAIEDLARFGVRFDKAEDGPLLLGLEAAHSRRRIIHAEGDATGREIMRALVAAVRRTPSITVLEGFE
ARRLLTEDGAISGVVAAGPDSPVLLATSRVVIATGSIGGLYEDTTTPLGSFGQGLALAAHAGAALRDLEFVQFHPTALDG
TGRPMRLVSEAVRGEGAVLIDETGRRFLEGTPGAELAPRDVVARAVAWHLSMGHRVFLDARGAIGTSFALRFPSIYAFCR
AAGLDPSRVPIPIRPAVHYHMGGIAVNGEGRSSVRGLWACGEVASTGLHGANRLASNSLIEAAVFGRWVAESIAGAGDAM
RHRPGSFAMPGSADASVVRPVVSRALGVIRDADTMRDAIASLLPLAERKGPASDPAAVALMMVVSALAREESRGGHFRAD
FPRRSEYAVHSRLTLANAFETARSLVPEPAIPMARSA
>Mature_517_residues
MNGFDLHDLSGRPVIIGAGLAGLATALHLSPMPVVVLSKAPLGEEASSAWAQGGLAAAMGPDDDPDLHLADTLAAGDGLC
DPDIVGKVVRAAPRAIEDLARFGVRFDKAEDGPLLLGLEAAHSRRRIIHAEGDATGREIMRALVAAVRRTPSITVLEGFE
ARRLLTEDGAISGVVAAGPDSPVLLATSRVVIATGSIGGLYEDTTTPLGSFGQGLALAAHAGAALRDLEFVQFHPTALDG
TGRPMRLVSEAVRGEGAVLIDETGRRFLEGTPGAELAPRDVVARAVAWHLSMGHRVFLDARGAIGTSFALRFPSIYAFCR
AAGLDPSRVPIPIRPAVHYHMGGIAVNGEGRSSVRGLWACGEVASTGLHGANRLASNSLIEAAVFGRWVAESIAGAGDAM
RHRPGSFAMPGSADASVVRPVVSRALGVIRDADTMRDAIASLLPLAERKGPASDPAAVALMMVVSALAREESRGGHFRAD
FPRRSEYAVHSRLTLANAFETARSLVPEPAIPMARSA

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=514, Percent_Identity=31.5175097276265, Blast_Score=192, Evalue=7e-49,
Organism=Escherichia coli, GI1788928, Length=520, Percent_Identity=37.1153846153846, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI1790597, Length=494, Percent_Identity=32.3886639676113, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI1786942, Length=536, Percent_Identity=30.2238805970149, Blast_Score=180, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17550100, Length=518, Percent_Identity=30.3088803088803, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17505833, Length=509, Percent_Identity=30.8447937131631, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71986328, Length=460, Percent_Identity=27.6086956521739, Blast_Score=99, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6322416, Length=507, Percent_Identity=30.7692307692308, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6322701, Length=508, Percent_Identity=31.8897637795276, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320788, Length=478, Percent_Identity=27.4058577405858, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6322511, Length=489, Percent_Identity=27.4028629856851, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17137288, Length=510, Percent_Identity=31.9607843137255, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI24655642, Length=510, Percent_Identity=31.9607843137255, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI24655647, Length=510, Percent_Identity=31.9607843137255, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI24663005, Length=505, Percent_Identity=29.3069306930693, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 53817; Mature: 53817

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGFDLHDLSGRPVIIGAGLAGLATALHLSPMPVVVLSKAPLGEEASSAWAQGGLAAAMG
CCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCEEEECC
PDDDPDLHLADTLAAGDGLCDPDIVGKVVRAAPRAIEDLARFGVRFDKAEDGPLLLGLEA
CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEEEEHH
AHSRRRIIHAEGDATGREIMRALVAAVRRTPSITVLEGFEARRLLTEDGAISGVVAAGPD
CCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCCCCCCEEEECCCC
SPVLLATSRVVIATGSIGGLYEDTTTPLGSFGQGLALAAHAGAALRDLEFVQFHPTALDG
CCEEEEECEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHCCEEEEECCCEECC
TGRPMRLVSEAVRGEGAVLIDETGRRFLEGTPGAELAPRDVVARAVAWHLSMGHRVFLDA
CCCHHHHHHHHHCCCCEEEEECCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEC
RGAIGTSFALRFPSIYAFCRAAGLDPSRVPIPIRPAVHYHMGGIAVNGEGRSSVRGLWAC
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCEEECCCCCCHHHHHHHH
GEVASTGLHGANRLASNSLIEAAVFGRWVAESIAGAGDAMRHRPGSFAMPGSADASVVRP
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHH
VVSRALGVIRDADTMRDAIASLLPLAERKGPASDPAAVALMMVVSALAREESRGGHFRAD
HHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECC
FPRRSEYAVHSRLTLANAFETARSLVPEPAIPMARSA
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNGFDLHDLSGRPVIIGAGLAGLATALHLSPMPVVVLSKAPLGEEASSAWAQGGLAAAMG
CCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCEEEECC
PDDDPDLHLADTLAAGDGLCDPDIVGKVVRAAPRAIEDLARFGVRFDKAEDGPLLLGLEA
CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEEEEHH
AHSRRRIIHAEGDATGREIMRALVAAVRRTPSITVLEGFEARRLLTEDGAISGVVAAGPD
CCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCCCCCCEEEECCCC
SPVLLATSRVVIATGSIGGLYEDTTTPLGSFGQGLALAAHAGAALRDLEFVQFHPTALDG
CCEEEEECEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHCCEEEEECCCEECC
TGRPMRLVSEAVRGEGAVLIDETGRRFLEGTPGAELAPRDVVARAVAWHLSMGHRVFLDA
CCCHHHHHHHHHCCCCEEEEECCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEC
RGAIGTSFALRFPSIYAFCRAAGLDPSRVPIPIRPAVHYHMGGIAVNGEGRSSVRGLWAC
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCEEECCCCCCHHHHHHHH
GEVASTGLHGANRLASNSLIEAAVFGRWVAESIAGAGDAMRHRPGSFAMPGSADASVVRP
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHH
VVSRALGVIRDADTMRDAIASLLPLAERKGPASDPAAVALMMVVSALAREESRGGHFRAD
HHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECC
FPRRSEYAVHSRLTLANAFETARSLVPEPAIPMARSA
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]