Click here to switch to the map view.

The map label for this gene is moeA [C]

Identifier: 110634774

GI number: 110634774

Start: 2608931

End: 2610880

Strand: Reverse

Name: moeA [C]

Synonym: Meso_2433

Alternate gene names: 110634774

Gene position: 2610880-2608931 (Counterclockwise)

Preceding gene: 110634775

Following gene: 110634771

Centisome position: 59.17

GC content: 67.28

Gene sequence:

>1950_bases
ATGTCTCAGTCTCCCAACTCCATCCGGCACGATTCCCATCAGGAGCAGTTCCTAACGATCTTGTCGCGCGAGGAGGCGCT
GGCCCGCTTTGAGGCAGCAGTGTTTCCATGGGCGATCCCGACCGAAGAACGGACCCTGGCCGGGGCACTTGGGCTGGCGC
TTGCCGGAGACGTGACAGCGCCGATCGACGTGCCGCCCTTCGACCGCTCCAACGTTGACGGCTTCGCCGTGCGCGCCGCC
GATCTCGCCGCCGCATCGGAAGCGCTTCCCGCCCGGCTCACGCTAAACGCGGAGTCCATCGCCTGCGGCACCGTTCCGCA
GCTGCCGGTACTGGCTGGCACCGCCACGGCCATCGCGACCGGCGGCCCAATGCCCCGTGGCGCCGACGCAATCATAATGG
TGGAGCACACCCAGCCGGCAGAGGCCGGCTTGATCGAGGTGAGGCGCGGCGTCTCCCCCGGCCAGTTCGTTTCAAACGCC
GGTTCGGATATGGCGCGAGGCGAGGTCGTGCTGCGCACCGGAACCGTAATCGGCGCGCGCGAGATCGGCATGCTTGCCGC
CTGCGGGGTCTCGCGGGTAACGGTGGCTCGCAGGCCGCGCGTCGCGATACTCTCCACCGGCGACGAGCTTGTCCAACCCG
GTGCGCCATTGCGTCAGGCCGGCATCTACGATGCCAATGGCCCGATCATTAGCGCGGCTGTCACTGAAAATGGTGGCGAG
GCGGACTTCCTCGGCGCCTTTCCGGACGACGAGGCTGCGCTCGAACGAGCCATGCGCGATGCGCTCGCGGCTCACGACAT
GCTGATCCTCTCGGGCGGCACGTCGAAGGGAGCAGGGGATGTCAGCTATCGCATTCTCGGCCGGCTCGGCAGCCCAGGCG
TTATCGCGCACGGCGTGGCGCTGAAACCGGGCAAGCCGCTTTGCCTCGCGGTCTGCGACGGCAAGCCGGTCGTCATCCTG
CCGGGTTTTCCCACTTCGGCGATGTTCACATTCCACGACATGATCGTGCCCGTGCTGCGGCGCATGGCCGGACTGCCGCC
GCGCGTCGACGCGCAGGTCGCGGCGCGGGTGCCGTTCCGCGTGGCGTCCGAGGTCGGACGCACCGAGTTCGTCATGGTCT
CGCTGGTTGAAGGGCAGGAAGGCCTCGCGGCCTACCCGACGGGCAAGGGCTCGGGGGCGATTACGTCCTTCACCCAGGCA
GATGGATTCATCCGCATCGAGGCCCTGGCAGATCACATTCCCGCGGGCAGTGAATTGCCGGTGACTTTGTTCACGCCGCA
GGTCCGCGTGCCCGACCTCGTCGTCATCGGCAGCCACTGCACGGGCCTCGACCTTGTTGTCGGGGCGCTCTCTCGCGGAG
GAACATCGGTCCGCTCCCTAGCGGTCGGGAGCCTGGGTGGGCTTGCCGCCGCGAAACGCGGCGAATGCGACCTCGCGCCG
ATCCATCTCTTCGACCCGAAGACGCAGAGCTACAACGCGCCGTTCCTCGGCGATGGCCTCGAACTGGTGCCGGGCTGGCG
GCGCATGCAGGGCTTTGCGTTCCGCCAGGGCGACAAGCGTTTTGGAGGGATGAGCGCGGAGGAGGCGATCCGCGCCGCGC
TCAGTAATCCCGATTGCATGATGGTCAACCGCAATCAAGGCTCGGGAACGCGCATCCTGATCGATCAACTGCTCGGCTCG
GCGCGCCCGGACGGCTACTGGAACCAGCCGCGCTCGCACAATGCCGTCGCTGCGGCGATCGCGCAGGAACGTGCCGACTG
GGGTGTCACCATCGCGCCGGTAGCGCATGCGGCGGGGCTTGCTTTCATACCGCTGACGGAAGAGCACTATGATTTCGCGC
TGGTCTCGGCCCGTAAGGAGCGGCCCGCGGTGCAGGCCTTTCTTGCCACTCTCCAGTTGCCGGAGATCCAAGCGGCGCTG
GAGGAGGCGGGCTTTACCCGCGCTGACTAG

Upstream 100 bases:

>100_bases
TGGCTGACGCCTGGCTTGCGGTGCCGGATGACAGCGAGGGATATGCCGCCGGCACGCCTGTCGCAGCTTTTCCGCTCCGC
AGCATGAATTGAGCCCGGAC

Downstream 100 bases:

>100_bases
TCGGCCTGCGTCGTCAGCCGCTCGGCCTCGGCAAGATCATCGAGCGTGTTCGCGTTGAAGAAGGGATCCACCGGCTCATG
CGGCCAGGAGACAGTCGCAA

Product: putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 649; Mature: 648

Protein sequence:

>649_residues
MSQSPNSIRHDSHQEQFLTILSREEALARFEAAVFPWAIPTEERTLAGALGLALAGDVTAPIDVPPFDRSNVDGFAVRAA
DLAAASEALPARLTLNAESIACGTVPQLPVLAGTATAIATGGPMPRGADAIIMVEHTQPAEAGLIEVRRGVSPGQFVSNA
GSDMARGEVVLRTGTVIGAREIGMLAACGVSRVTVARRPRVAILSTGDELVQPGAPLRQAGIYDANGPIISAAVTENGGE
ADFLGAFPDDEAALERAMRDALAAHDMLILSGGTSKGAGDVSYRILGRLGSPGVIAHGVALKPGKPLCLAVCDGKPVVIL
PGFPTSAMFTFHDMIVPVLRRMAGLPPRVDAQVAARVPFRVASEVGRTEFVMVSLVEGQEGLAAYPTGKGSGAITSFTQA
DGFIRIEALADHIPAGSELPVTLFTPQVRVPDLVVIGSHCTGLDLVVGALSRGGTSVRSLAVGSLGGLAAAKRGECDLAP
IHLFDPKTQSYNAPFLGDGLELVPGWRRMQGFAFRQGDKRFGGMSAEEAIRAALSNPDCMMVNRNQGSGTRILIDQLLGS
ARPDGYWNQPRSHNAVAAAIAQERADWGVTIAPVAHAAGLAFIPLTEEHYDFALVSARKERPAVQAFLATLQLPEIQAAL
EEAGFTRAD

Sequences:

>Translated_649_residues
MSQSPNSIRHDSHQEQFLTILSREEALARFEAAVFPWAIPTEERTLAGALGLALAGDVTAPIDVPPFDRSNVDGFAVRAA
DLAAASEALPARLTLNAESIACGTVPQLPVLAGTATAIATGGPMPRGADAIIMVEHTQPAEAGLIEVRRGVSPGQFVSNA
GSDMARGEVVLRTGTVIGAREIGMLAACGVSRVTVARRPRVAILSTGDELVQPGAPLRQAGIYDANGPIISAAVTENGGE
ADFLGAFPDDEAALERAMRDALAAHDMLILSGGTSKGAGDVSYRILGRLGSPGVIAHGVALKPGKPLCLAVCDGKPVVIL
PGFPTSAMFTFHDMIVPVLRRMAGLPPRVDAQVAARVPFRVASEVGRTEFVMVSLVEGQEGLAAYPTGKGSGAITSFTQA
DGFIRIEALADHIPAGSELPVTLFTPQVRVPDLVVIGSHCTGLDLVVGALSRGGTSVRSLAVGSLGGLAAAKRGECDLAP
IHLFDPKTQSYNAPFLGDGLELVPGWRRMQGFAFRQGDKRFGGMSAEEAIRAALSNPDCMMVNRNQGSGTRILIDQLLGS
ARPDGYWNQPRSHNAVAAAIAQERADWGVTIAPVAHAAGLAFIPLTEEHYDFALVSARKERPAVQAFLATLQLPEIQAAL
EEAGFTRAD
>Mature_648_residues
SQSPNSIRHDSHQEQFLTILSREEALARFEAAVFPWAIPTEERTLAGALGLALAGDVTAPIDVPPFDRSNVDGFAVRAAD
LAAASEALPARLTLNAESIACGTVPQLPVLAGTATAIATGGPMPRGADAIIMVEHTQPAEAGLIEVRRGVSPGQFVSNAG
SDMARGEVVLRTGTVIGAREIGMLAACGVSRVTVARRPRVAILSTGDELVQPGAPLRQAGIYDANGPIISAAVTENGGEA
DFLGAFPDDEAALERAMRDALAAHDMLILSGGTSKGAGDVSYRILGRLGSPGVIAHGVALKPGKPLCLAVCDGKPVVILP
GFPTSAMFTFHDMIVPVLRRMAGLPPRVDAQVAARVPFRVASEVGRTEFVMVSLVEGQEGLAAYPTGKGSGAITSFTQAD
GFIRIEALADHIPAGSELPVTLFTPQVRVPDLVVIGSHCTGLDLVVGALSRGGTSVRSLAVGSLGGLAAAKRGECDLAPI
HLFDPKTQSYNAPFLGDGLELVPGWRRMQGFAFRQGDKRFGGMSAEEAIRAALSNPDCMMVNRNQGSGTRILIDQLLGSA
RPDGYWNQPRSHNAVAAAIAQERADWGVTIAPVAHAAGLAFIPLTEEHYDFALVSARKERPAVQAFLATLQLPEIQAALE
EAGFTRAD

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=414, Percent_Identity=34.5410628019324, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI66932975, Length=414, Percent_Identity=34.5410628019324, Blast_Score=156, Evalue=6e-38,
Organism=Escherichia coli, GI1787049, Length=400, Percent_Identity=35, Blast_Score=182, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI25147659, Length=342, Percent_Identity=32.1637426900585, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17562606, Length=320, Percent_Identity=25.625, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17136978, Length=380, Percent_Identity=26.8421052631579, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24638841, Length=380, Percent_Identity=26.8421052631579, Blast_Score=105, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 67768; Mature: 67637

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSPNSIRHDSHQEQFLTILSREEALARFEAAVFPWAIPTEERTLAGALGLALAGDVTA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEECCCCC
PIDVPPFDRSNVDGFAVRAADLAAASEALPARLTLNAESIACGTVPQLPVLAGTATAIAT
CCCCCCCCCCCCCCEEEEHHHHHHHHHCCCEEEEECCCCEECCCCCCCCEECCCHHHEEC
GGPMPRGADAIIMVEHTQPAEAGLIEVRRGVSPGQFVSNAGSDMARGEVVLRTGTVIGAR
CCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCHHHHCCCCCCCCCEEEEEECCEECHH
EIGMLAACGVSRVTVARRPRVAILSTGDELVQPGAPLRQAGIYDANGPIISAAVTENGGE
HHHHHHHCCCHHEEEECCCCEEEEECCHHHHCCCCCHHHCCCCCCCCCEEEEEEECCCCC
ADFLGAFPDDEAALERAMRDALAAHDMLILSGGTSKGAGDVSYRILGRLGSPGVIAHGVA
EEEECCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEEEECCCCCCEEEECEE
LKPGKPLCLAVCDGKPVVILPGFPTSAMFTFHDMIVPVLRRMAGLPPRVDAQVAARVPFR
ECCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHH
VASEVGRTEFVMVSLVEGQEGLAAYPTGKGSGAITSFTQADGFIRIEALADHIPAGSELP
HHHHCCCCEEEEEEEECCCCCCEECCCCCCCCCEEEEECCCCCEEEEEHHHCCCCCCCCC
VTLFTPQVRVPDLVVIGSHCTGLDLVVGALSRGGTSVRSLAVGSLGGLAAAKRGECDLAP
EEEECCCCCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCHHHCCCCCCCEEE
IHLFDPKTQSYNAPFLGDGLELVPGWRRMQGFAFRQGDKRFGGMSAEEAIRAALSNPDCM
EEEECCCCCCCCCCCCCCCHHCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEE
MVNRNQGSGTRILIDQLLGSARPDGYWNQPRSHNAVAAAIAQERADWGVTIAPVAHAAGL
EEECCCCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEHHHHHCCE
AFIPLTEEHYDFALVSARKERPAVQAFLATLQLPEIQAALEEAGFTRAD
EEEEECCCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SQSPNSIRHDSHQEQFLTILSREEALARFEAAVFPWAIPTEERTLAGALGLALAGDVTA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEECCCCC
PIDVPPFDRSNVDGFAVRAADLAAASEALPARLTLNAESIACGTVPQLPVLAGTATAIAT
CCCCCCCCCCCCCCEEEEHHHHHHHHHCCCEEEEECCCCEECCCCCCCCEECCCHHHEEC
GGPMPRGADAIIMVEHTQPAEAGLIEVRRGVSPGQFVSNAGSDMARGEVVLRTGTVIGAR
CCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCHHHHCCCCCCCCCEEEEEECCEECHH
EIGMLAACGVSRVTVARRPRVAILSTGDELVQPGAPLRQAGIYDANGPIISAAVTENGGE
HHHHHHHCCCHHEEEECCCCEEEEECCHHHHCCCCCHHHCCCCCCCCCEEEEEEECCCCC
ADFLGAFPDDEAALERAMRDALAAHDMLILSGGTSKGAGDVSYRILGRLGSPGVIAHGVA
EEEECCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEEEECCCCCCEEEECEE
LKPGKPLCLAVCDGKPVVILPGFPTSAMFTFHDMIVPVLRRMAGLPPRVDAQVAARVPFR
ECCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHH
VASEVGRTEFVMVSLVEGQEGLAAYPTGKGSGAITSFTQADGFIRIEALADHIPAGSELP
HHHHCCCCEEEEEEEECCCCCCEECCCCCCCCCEEEEECCCCCEEEEEHHHCCCCCCCCC
VTLFTPQVRVPDLVVIGSHCTGLDLVVGALSRGGTSVRSLAVGSLGGLAAAKRGECDLAP
EEEECCCCCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCHHHCCCCCCCEEE
IHLFDPKTQSYNAPFLGDGLELVPGWRRMQGFAFRQGDKRFGGMSAEEAIRAALSNPDCM
EEEECCCCCCCCCCCCCCCHHCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEE
MVNRNQGSGTRILIDQLLGSARPDGYWNQPRSHNAVAAAIAQERADWGVTIAPVAHAAGL
EEECCCCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEHHHHHCCE
AFIPLTEEHYDFALVSARKERPAVQAFLATLQLPEIQAALEEAGFTRAD
EEEEECCCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]