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The map label for this gene is moeA [H]

Identifier: 110634771

GI number: 110634771

Start: 2606023

End: 2607279

Strand: Reverse

Name: moeA [H]

Synonym: Meso_2430

Alternate gene names: 110634771

Gene position: 2607279-2606023 (Counterclockwise)

Preceding gene: 110634774

Following gene: 110634770

Centisome position: 59.09

GC content: 63.48

Gene sequence:

>1257_bases
ATGGTGCAACTCTCGGATGATTGCTTCGCTTTCGGCGGACCGATGCGGTCCATTGCCGAGACGGCCGCGCTGATAGCCTC
CAAGCTAAGCGCCGTGGAAGAGGCCGAGACAGTGCCCCTCGTGCTTGCGGATGGGCGCGTGCTTGCAAGGGAAATGACAG
CGCCGCTGCCGCTGCCGCCCTTCACCAATTCGGCAGTCGATGGTTATGCCATACGAGGCGCAGACTTGCCGCAGACCGTC
GAGAAGGCCTTTGCCGTGGTCGGGAGGGTTCAGGCAGGGATGGTTCCAGACATACCAGTATCGCCCGGCCAAACGGTTCG
CATCTTCACCGGTGCTCCAATGCCCGAGCAGGCCGACACGGTGTTCATGCAGGAAGACGTGCGTGTGAACGACTCTGGCA
AGGTCATCCTTCCGCCCGGGCTGAAAAGGGGCGCCAATGTACGGCCCGCAGGTGAGGATATCGCCCTGGGCGACACGGTT
CTGCCGGCAGGCCATCGAATGCGGCCGCAAGATGTCGCTCTTGCTGCCGCGCTTGGTTTCACCGGGGTCGAAGTCCGGCG
CAGGATACGCGTCGCGGTGTTCTCGACCGGAGACGAGATCGTCGCGCCGGGAGAAAAGCGCGGCCAGGCGCAGCTTTTTG
ATTCGAACCGCTTCATGTTGATGGCGATGGTCATGCGCCTCGGCTGCGACGTCACCGATCTCGGCATACTGCCAGATAAC
ATGGGGATGATCGCCGGCCGATTGAGCGACGCGGCCTCGACGCATGATCTGATCCTCACCTCGGGCGGCGTGTCGACCGG
CGAGGCGGATTGCGTGAGGGCCGCCGTCGAGAGCGTCGGAACCCTGGTGTTCTGGCGTGTGGCGATCAAACCGGGTCGGC
CCGTCGCCATGGGTGTGATCAAGGGAACCCCGCTCATCGGACTTCCCGGTAATCCGGTGGCGAGTTTCGTCACCTTTGCT
CATATTGCCCGTCCGGCAATCCTCGCCCTTGCGGGAGCGCAGCCGGAGCAGTCGGTTTCGACTGCTGTGCGGGCGGCTTT
CTCTTATCGCAAGAAGCAGGGGCGGCGCGAATATGTGCGGGCAAGCCTTCGTGCGGCTGAAGACGGCTCGTTCGAGGCGG
TCAAGTTCCCGCGCGAGGGTGCGGGGCTGCTGTCGTCTCTCGTTGCCACCGATGGTTTGATCGAGCTCGGCGAGGAGACC
ACTCGGGTGGAGCCGGGCGATACGGTGCAGTTTCTCGGCTATTCGAGCCTGCTCTAA

Upstream 100 bases:

>100_bases
ACCCTATACCTTATAGCCTGTTCAAACGAAGGACCAAAGTGCCATAGGATTGGTACGCGATGGTAACGGGCTCCACTTCC
TGATGGGCTGAAGAAGCTAG

Downstream 100 bases:

>100_bases
ACTGCACCATGCCAAGCTGTGGCGTGATTGACGATGGCGCGCCGGGTAGGGCATCATGCCTGCATCATGGTGACGACGAT
CAAGCTCGACCTGACGGGAC

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MVQLSDDCFAFGGPMRSIAETAALIASKLSAVEEAETVPLVLADGRVLAREMTAPLPLPPFTNSAVDGYAIRGADLPQTV
EKAFAVVGRVQAGMVPDIPVSPGQTVRIFTGAPMPEQADTVFMQEDVRVNDSGKVILPPGLKRGANVRPAGEDIALGDTV
LPAGHRMRPQDVALAAALGFTGVEVRRRIRVAVFSTGDEIVAPGEKRGQAQLFDSNRFMLMAMVMRLGCDVTDLGILPDN
MGMIAGRLSDAASTHDLILTSGGVSTGEADCVRAAVESVGTLVFWRVAIKPGRPVAMGVIKGTPLIGLPGNPVASFVTFA
HIARPAILALAGAQPEQSVSTAVRAAFSYRKKQGRREYVRASLRAAEDGSFEAVKFPREGAGLLSSLVATDGLIELGEET
TRVEPGDTVQFLGYSSLL

Sequences:

>Translated_418_residues
MVQLSDDCFAFGGPMRSIAETAALIASKLSAVEEAETVPLVLADGRVLAREMTAPLPLPPFTNSAVDGYAIRGADLPQTV
EKAFAVVGRVQAGMVPDIPVSPGQTVRIFTGAPMPEQADTVFMQEDVRVNDSGKVILPPGLKRGANVRPAGEDIALGDTV
LPAGHRMRPQDVALAAALGFTGVEVRRRIRVAVFSTGDEIVAPGEKRGQAQLFDSNRFMLMAMVMRLGCDVTDLGILPDN
MGMIAGRLSDAASTHDLILTSGGVSTGEADCVRAAVESVGTLVFWRVAIKPGRPVAMGVIKGTPLIGLPGNPVASFVTFA
HIARPAILALAGAQPEQSVSTAVRAAFSYRKKQGRREYVRASLRAAEDGSFEAVKFPREGAGLLSSLVATDGLIELGEET
TRVEPGDTVQFLGYSSLL
>Mature_418_residues
MVQLSDDCFAFGGPMRSIAETAALIASKLSAVEEAETVPLVLADGRVLAREMTAPLPLPPFTNSAVDGYAIRGADLPQTV
EKAFAVVGRVQAGMVPDIPVSPGQTVRIFTGAPMPEQADTVFMQEDVRVNDSGKVILPPGLKRGANVRPAGEDIALGDTV
LPAGHRMRPQDVALAAALGFTGVEVRRRIRVAVFSTGDEIVAPGEKRGQAQLFDSNRFMLMAMVMRLGCDVTDLGILPDN
MGMIAGRLSDAASTHDLILTSGGVSTGEADCVRAAVESVGTLVFWRVAIKPGRPVAMGVIKGTPLIGLPGNPVASFVTFA
HIARPAILALAGAQPEQSVSTAVRAAFSYRKKQGRREYVRASLRAAEDGSFEAVKFPREGAGLLSSLVATDGLIELGEET
TRVEPGDTVQFLGYSSLL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=333, Percent_Identity=37.5375375375375, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI66932975, Length=333, Percent_Identity=37.8378378378378, Blast_Score=169, Evalue=5e-42,
Organism=Escherichia coli, GI1787049, Length=371, Percent_Identity=37.7358490566038, Blast_Score=251, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI25147659, Length=373, Percent_Identity=29.2225201072386, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17562606, Length=306, Percent_Identity=27.7777777777778, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136978, Length=400, Percent_Identity=30.25, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24638841, Length=400, Percent_Identity=30.25, Blast_Score=159, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43962; Mature: 43962

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQLSDDCFAFGGPMRSIAETAALIASKLSAVEEAETVPLVLADGRVLAREMTAPLPLPP
CCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCCCC
FTNSAVDGYAIRGADLPQTVEKAFAVVGRVQAGMVPDIPVSPGQTVRIFTGAPMPEQADT
CCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCE
VFMQEDVRVNDSGKVILPPGLKRGANVRPAGEDIALGDTVLPAGHRMRPQDVALAAALGF
EEEECCEEECCCCCEEECCCCCCCCCCCCCCCCEECCCEECCCCCCCCHHHHHHHHHHCC
TGVEVRRRIRVAVFSTGDEIVAPGEKRGQAQLFDSNRFMLMAMVMRLGCDVTDLGILPDN
CCHHHHHEEEEEEEECCCCEECCCCCCCCEEEECCCCHHHHHHHHHHCCCEEECCCCCCC
MGMIAGRLSDAASTHDLILTSGGVSTGEADCVRAAVESVGTLVFWRVAIKPGRPVAMGVI
CCHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHEEEEEEEECCCCCEEEEEE
KGTPLIGLPGNPVASFVTFAHIARPAILALAGAQPEQSVSTAVRAAFSYRKKQGRREYVR
CCCCEEECCCCHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ASLRAAEDGSFEAVKFPREGAGLLSSLVATDGLIELGEETTRVEPGDTVQFLGYSSLL
HHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCHHHCCCHHCCCCCCCCEEECCHHCCC
>Mature Secondary Structure
MVQLSDDCFAFGGPMRSIAETAALIASKLSAVEEAETVPLVLADGRVLAREMTAPLPLPP
CCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCCCC
FTNSAVDGYAIRGADLPQTVEKAFAVVGRVQAGMVPDIPVSPGQTVRIFTGAPMPEQADT
CCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCE
VFMQEDVRVNDSGKVILPPGLKRGANVRPAGEDIALGDTVLPAGHRMRPQDVALAAALGF
EEEECCEEECCCCCEEECCCCCCCCCCCCCCCCEECCCEECCCCCCCCHHHHHHHHHHCC
TGVEVRRRIRVAVFSTGDEIVAPGEKRGQAQLFDSNRFMLMAMVMRLGCDVTDLGILPDN
CCHHHHHEEEEEEEECCCCEECCCCCCCCEEEECCCCHHHHHHHHHHCCCEEECCCCCCC
MGMIAGRLSDAASTHDLILTSGGVSTGEADCVRAAVESVGTLVFWRVAIKPGRPVAMGVI
CCHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHEEEEEEEECCCCCEEEEEE
KGTPLIGLPGNPVASFVTFAHIARPAILALAGAQPEQSVSTAVRAAFSYRKKQGRREYVR
CCCCEEECCCCHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ASLRAAEDGSFEAVKFPREGAGLLSSLVATDGLIELGEETTRVEPGDTVQFLGYSSLL
HHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCHHHCCCHHCCCCCCCCEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]