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The map label for this gene is dppE [H]

Identifier: 110634412

GI number: 110634412

Start: 2213637

End: 2215289

Strand: Reverse

Name: dppE [H]

Synonym: Meso_2062

Alternate gene names: 110634412

Gene position: 2215289-2213637 (Counterclockwise)

Preceding gene: 110634419

Following gene: 110634411

Centisome position: 50.21

GC content: 60.68

Gene sequence:

>1653_bases
ATGAAGTTCTTCAGGAGCAACGACGGAGCTGTCCCCACCCGCATAAAAGCTTTGGCCGAGAAGGCACGAGCCGGCCGAAT
CGACCGCCGGGAGTTCCTGGCCCTTGCCAGCACCTTCGGCGCCACCGCGGCCGGTGCGTATGCGATGGCCGGCCTTACGC
TGCCCCGTCCCGCATTGGCGCAGGAGCCGAAGAAGGGCGGCGTGCTCAAGATGGCCATGTGGGTCAAAGACCCCAAGGAT
CCGCGAACGGCGGACTGGTCCGAGATCGCCAACGCCATGCGGCAGACGCTGGAGCCGCTCGTCAAATATACCGCCGACTT
TACGTTCGAAGGGCGGCTGCTCGAAAGCTGGGAGGTGAACGAAGAGGCGACGGAATATGTCCTCCATGTCCGCAAGGGCG
TGACCTGGAACAATGGCGATCCGTTCACCGCTGACGATGTGATCTACAACATTGCCCGCTGGTGCGACGAAACCGCCGAG
GGCAATTCCATGGCCGCCCGGCTGACGTCGCTGATCGATTCTGAAACGAAGAAGGTTCGTGATGGAGCGGTGGAGAGAGT
GGACGACCACACGGTGCGTCTCGTCCTGCAAAAGCCGGAAATCTCCATCATCGCCAGCTTCACCGATTATCCGGCGCTCG
TGGTGCACCGGAGCTTTGACGAAACCGGCGCCAATTTCGTCGCCAACCCGATCGGCACCGGCCCGTTCGAGCTCGTCTCT
TATGAGGTGGGCAATCGCGTTGTGGTGAAGCGCCGCGAGGACGGTAAGTGGTGGGGCGGGGACATATATCTCGACGGCGT
GGAATTCATCGACTACGGCACGGACCCTTCCGCGATGGTTTCTGCCTTCGAGGCGGGCGAAATCCACACCAATTACGAGA
CCAGCGCCGATTATGTGGAAATTCTGGACGGTCTGGGCCTGGTGAAGAGCGAGGCTCTTACCGCTGCGACGATTCTCGCG
CGAACCAATGTCAACAACAAGCCTTACGACGATCAGCGCGTGCGAAGGGCGCTGCAGCTTGCGGTGGACAATGCCACCGT
GCTCGCGCTCGGCTATGGCGGGGCCGGCGAGGTGGCGGAGAACCATCATGTCTGCCCAATCCATCCGGAATATGCGAAGC
TTCCGACGGTTGCGCGCAATGCCGACCAGGCCAAGCGGCTCATGCAGGAAGCCGGGCAGACCGATTACGAGCATGTGCTT
ATCACCGTCGATGAGGACTGGCACAAGAACACCGGCGATGTGATCGCCGCGCAGATCCGCGAGTCGGGCTTCAAGGTGAG
GCGCGAGGTGCTGCCAGGCCCGACCTTCTGGAACGACTGGATGAAATATCCCTTTTCCATGACGAACTGGGCGATGCGCC
CGCTGGGAATTCAGACCATTGCGCTCGCCTACCGCTCTGATGGATCGTGGAACGAGTCCGGCTACTCAAACCCGGACCTC
GACGCGCTCATCGACGAGGCGCTCACCATCCCGGATCCGGAGGAGCGCCAGGGCGTGATGAAGAATATCGAGCAGCATAT
TCAGAATTCCGGCATCATCATCCAGCCGTACTGGCGCAAGGTTTACAACCACTCGGTGGAAGCGGTGAAGAACCACAAGA
TTCATCCGAGTTTCGAGGTGGATTTCGGAAGGGTGTGGCTGGACGAAGCGTAG

Upstream 100 bases:

>100_bases
GTCAGGAGAATAGCGCTTTGACAATGCGGGCAGGGTAGCGGAATGTTAAGGCGTCACCGCGGTCGAGATGGCAGCGATAT
TCGTATCAAGGGGAGTGCCT

Downstream 100 bases:

>100_bases
GTTACGCTGAAAGGTCTGCCGGCAGAGGCAGCGGAGCGGATATTTGGCAGGCTTCATAATCCGCCGCCTAGGGACCATGG
CGCTTGCGATGTTGTGCCTA

Product: twin-arginine translocation pathway signal

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MKFFRSNDGAVPTRIKALAEKARAGRIDRREFLALASTFGATAAGAYAMAGLTLPRPALAQEPKKGGVLKMAMWVKDPKD
PRTADWSEIANAMRQTLEPLVKYTADFTFEGRLLESWEVNEEATEYVLHVRKGVTWNNGDPFTADDVIYNIARWCDETAE
GNSMAARLTSLIDSETKKVRDGAVERVDDHTVRLVLQKPEISIIASFTDYPALVVHRSFDETGANFVANPIGTGPFELVS
YEVGNRVVVKRREDGKWWGGDIYLDGVEFIDYGTDPSAMVSAFEAGEIHTNYETSADYVEILDGLGLVKSEALTAATILA
RTNVNNKPYDDQRVRRALQLAVDNATVLALGYGGAGEVAENHHVCPIHPEYAKLPTVARNADQAKRLMQEAGQTDYEHVL
ITVDEDWHKNTGDVIAAQIRESGFKVRREVLPGPTFWNDWMKYPFSMTNWAMRPLGIQTIALAYRSDGSWNESGYSNPDL
DALIDEALTIPDPEERQGVMKNIEQHIQNSGIIIQPYWRKVYNHSVEAVKNHKIHPSFEVDFGRVWLDEA

Sequences:

>Translated_550_residues
MKFFRSNDGAVPTRIKALAEKARAGRIDRREFLALASTFGATAAGAYAMAGLTLPRPALAQEPKKGGVLKMAMWVKDPKD
PRTADWSEIANAMRQTLEPLVKYTADFTFEGRLLESWEVNEEATEYVLHVRKGVTWNNGDPFTADDVIYNIARWCDETAE
GNSMAARLTSLIDSETKKVRDGAVERVDDHTVRLVLQKPEISIIASFTDYPALVVHRSFDETGANFVANPIGTGPFELVS
YEVGNRVVVKRREDGKWWGGDIYLDGVEFIDYGTDPSAMVSAFEAGEIHTNYETSADYVEILDGLGLVKSEALTAATILA
RTNVNNKPYDDQRVRRALQLAVDNATVLALGYGGAGEVAENHHVCPIHPEYAKLPTVARNADQAKRLMQEAGQTDYEHVL
ITVDEDWHKNTGDVIAAQIRESGFKVRREVLPGPTFWNDWMKYPFSMTNWAMRPLGIQTIALAYRSDGSWNESGYSNPDL
DALIDEALTIPDPEERQGVMKNIEQHIQNSGIIIQPYWRKVYNHSVEAVKNHKIHPSFEVDFGRVWLDEA
>Mature_550_residues
MKFFRSNDGAVPTRIKALAEKARAGRIDRREFLALASTFGATAAGAYAMAGLTLPRPALAQEPKKGGVLKMAMWVKDPKD
PRTADWSEIANAMRQTLEPLVKYTADFTFEGRLLESWEVNEEATEYVLHVRKGVTWNNGDPFTADDVIYNIARWCDETAE
GNSMAARLTSLIDSETKKVRDGAVERVDDHTVRLVLQKPEISIIASFTDYPALVVHRSFDETGANFVANPIGTGPFELVS
YEVGNRVVVKRREDGKWWGGDIYLDGVEFIDYGTDPSAMVSAFEAGEIHTNYETSADYVEILDGLGLVKSEALTAATILA
RTNVNNKPYDDQRVRRALQLAVDNATVLALGYGGAGEVAENHHVCPIHPEYAKLPTVARNADQAKRLMQEAGQTDYEHVL
ITVDEDWHKNTGDVIAAQIRESGFKVRREVLPGPTFWNDWMKYPFSMTNWAMRPLGIQTIALAYRSDGSWNESGYSNPDL
DALIDEALTIPDPEERQGVMKNIEQHIQNSGIIIQPYWRKVYNHSVEAVKNHKIHPSFEVDFGRVWLDEA

Specific function: Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the binding of dipeptides with high affinity. Is expressed to facilitate adaptation to nutrient deficiency conditions, which also induce sporulation [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=296, Percent_Identity=28.7162162162162, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787551, Length=262, Percent_Identity=25.9541984732824, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1787495, Length=521, Percent_Identity=21.8809980806142, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787052, Length=457, Percent_Identity=22.3194748358862, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1789397, Length=474, Percent_Identity=22.3628691983122, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 61510; Mature: 61510

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFFRSNDGAVPTRIKALAEKARAGRIDRREFLALASTFGATAAGAYAMAGLTLPRPALA
CCCEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHH
QEPKKGGVLKMAMWVKDPKDPRTADWSEIANAMRQTLEPLVKYTADFTFEGRLLESWEVN
CCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCEEECCCCCC
EEATEYVLHVRKGVTWNNGDPFTADDVIYNIARWCDETAEGNSMAARLTSLIDSETKKVR
HHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
DGAVERVDDHTVRLVLQKPEISIIASFTDYPALVVHRSFDETGANFVANPIGTGPFELVS
HHHHHHCCCCEEEEEEECCCEEEEEECCCCCEEEEECCCCCCCCCEECCCCCCCCHHEEE
YEVGNRVVVKRREDGKWWGGDIYLDGVEFIDYGTDPSAMVSAFEAGEIHTNYETSADYVE
EECCCEEEEEECCCCCEECCEEEECCEEEEECCCCHHHHHHHHHCCCEECCCCCCHHHHH
ILDGLGLVKSEALTAATILARTNVNNKPYDDQRVRRALQLAVDNATVLALGYGGAGEVAE
HHHCCCHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
NHHVCPIHPEYAKLPTVARNADQAKRLMQEAGQTDYEHVLITVDEDWHKNTGDVIAAQIR
CCCCCCCCCCHHHCCHHHCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHH
ESGFKVRREVLPGPTFWNDWMKYPFSMTNWAMRPLGIQTIALAYRSDGSWNESGYSNPDL
HHHHHHHHHHCCCCCCHHHHHHCCCCHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCH
DALIDEALTIPDPEERQGVMKNIEQHIQNSGIIIQPYWRKVYNHSVEAVKNHKIHPSFEV
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHCCHHHHHHCCCCCCCEEE
DFGRVWLDEA
CCCEEEECCC
>Mature Secondary Structure
MKFFRSNDGAVPTRIKALAEKARAGRIDRREFLALASTFGATAAGAYAMAGLTLPRPALA
CCCEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHH
QEPKKGGVLKMAMWVKDPKDPRTADWSEIANAMRQTLEPLVKYTADFTFEGRLLESWEVN
CCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCEEECCCCCC
EEATEYVLHVRKGVTWNNGDPFTADDVIYNIARWCDETAEGNSMAARLTSLIDSETKKVR
HHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
DGAVERVDDHTVRLVLQKPEISIIASFTDYPALVVHRSFDETGANFVANPIGTGPFELVS
HHHHHHCCCCEEEEEEECCCEEEEEECCCCCEEEEECCCCCCCCCEECCCCCCCCHHEEE
YEVGNRVVVKRREDGKWWGGDIYLDGVEFIDYGTDPSAMVSAFEAGEIHTNYETSADYVE
EECCCEEEEEECCCCCEECCEEEECCEEEEECCCCHHHHHHHHHCCCEECCCCCCHHHHH
ILDGLGLVKSEALTAATILARTNVNNKPYDDQRVRRALQLAVDNATVLALGYGGAGEVAE
HHHCCCHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
NHHVCPIHPEYAKLPTVARNADQAKRLMQEAGQTDYEHVLITVDEDWHKNTGDVIAAQIR
CCCCCCCCCCHHHCCHHHCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHH
ESGFKVRREVLPGPTFWNDWMKYPFSMTNWAMRPLGIQTIALAYRSDGSWNESGYSNPDL
HHHHHHHHHHCCCCCCHHHHHHCCCCHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCH
DALIDEALTIPDPEERQGVMKNIEQHIQNSGIIIQPYWRKVYNHSVEAVKNHKIHPSFEV
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHCCHHHHHHCCCCCCCEEE
DFGRVWLDEA
CCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1766370; 9384377 [H]