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The map label for this gene is iclR [H]

Identifier: 110634191

GI number: 110634191

Start: 1977612

End: 1978397

Strand: Direct

Name: iclR [H]

Synonym: Meso_1841

Alternate gene names: 110634191

Gene position: 1977612-1978397 (Clockwise)

Preceding gene: 110634190

Following gene: 110634205

Centisome position: 44.82

GC content: 63.74

Gene sequence:

>786_bases
ATGGGTGCACCGGAATTCCCTGAGGAGGCCACCTCCAATGAACGGCTGGGGACCGTTCAATCCGTCGAGCGCGCCATCTC
CCTCCTGGAGGTGCTGGCGGAACACGGATCGGGAATGCGCCTGAGGGAGATCACCGCGGTCGCAGAGCTTTCCCGTTCGA
CCACTCACAGGCTGCTCACCACATTGGAAAAGCGGCATTTCGTGCAGTTCAATCGGCATGATGGACGCTGGTATATCGGC
CGCCAGGCCTATTTGGTGGCGAGCGCCTTCGTTCATAAGCGGGCCTTCGTCGCCTCCGCCATCCCATACATGCGCAGGCT
CAGGGACCTGACGCATGAGACCGCCAATCTCGGCATTGCCGAAGGCCACGACGTGGTCGTTCTGGCGCAGATCGAGAGCC
GCGAGGCAAGACTTTCGGTGGCCAAGGTGGGCGGCCGCATGCCCATCCACTGTTCGGGAATGGGCAAGGCCATCCTCGCC
GCCTATCCGGAGAAAGAGGTCAGAGCCGTCATCGCAAATATGGCGGTGAGCACGGATGCCCTGGGCCCCTGCTACAGTGA
CGACCTGCATGTCACCAGGCGTCGCGCCTACGCCATCGACGACGAAGGCTTGGCCCGGGGCGTGCGGTGCGTCGCCTCCG
TGGTTTACGGTGCCAACAGCGAACCTCTCTGCGCCATCTCCGTCTCCGGTCATGTCAGCCGCCTGACGGACGAGCGCATC
GAAGCGGTTGGCCCGCTCGTGTCGTCTGTCGCGCAGGAATTGACGGGAGCGCTCGGCGGACGCTGA

Upstream 100 bases:

>100_bases
TGTATGCAATTAAAAATATTGATTTGAATGTAGAAGTGTACTTTACTGAGGTGGTACCGATACCCGAGAGTTGGAAGCAT
TCTACGGAGGCATCGACGCG

Downstream 100 bases:

>100_bases
GCCACCGGAAAGATGCCATCACAGCCCCAGCAATGCTGCGGCATTGCGGAAGAAAATGCGCTCGAGCACCTCCGGACGGA
AACCGATTTGCTGCACGCTC

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MGAPEFPEEATSNERLGTVQSVERAISLLEVLAEHGSGMRLREITAVAELSRSTTHRLLTTLEKRHFVQFNRHDGRWYIG
RQAYLVASAFVHKRAFVASAIPYMRRLRDLTHETANLGIAEGHDVVVLAQIESREARLSVAKVGGRMPIHCSGMGKAILA
AYPEKEVRAVIANMAVSTDALGPCYSDDLHVTRRRAYAIDDEGLARGVRCVASVVYGANSEPLCAISVSGHVSRLTDERI
EAVGPLVSSVAQELTGALGGR

Sequences:

>Translated_261_residues
MGAPEFPEEATSNERLGTVQSVERAISLLEVLAEHGSGMRLREITAVAELSRSTTHRLLTTLEKRHFVQFNRHDGRWYIG
RQAYLVASAFVHKRAFVASAIPYMRRLRDLTHETANLGIAEGHDVVVLAQIESREARLSVAKVGGRMPIHCSGMGKAILA
AYPEKEVRAVIANMAVSTDALGPCYSDDLHVTRRRAYAIDDEGLARGVRCVASVVYGANSEPLCAISVSGHVSRLTDERI
EAVGPLVSSVAQELTGALGGR
>Mature_260_residues
GAPEFPEEATSNERLGTVQSVERAISLLEVLAEHGSGMRLREITAVAELSRSTTHRLLTTLEKRHFVQFNRHDGRWYIGR
QAYLVASAFVHKRAFVASAIPYMRRLRDLTHETANLGIAEGHDVVVLAQIESREARLSVAKVGGRMPIHCSGMGKAILAA
YPEKEVRAVIANMAVSTDALGPCYSDDLHVTRRRAYAIDDEGLARGVRCVASVVYGANSEPLCAISVSGHVSRLTDERIE
AVGPLVSSVAQELTGALGGR

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=251, Percent_Identity=37.4501992031873, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1786715, Length=245, Percent_Identity=34.6938775510204, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1786468, Length=251, Percent_Identity=29.0836653386454, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1788131, Length=259, Percent_Identity=23.1660231660232, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789999, Length=267, Percent_Identity=26.9662921348315, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788581, Length=249, Percent_Identity=25.7028112449799, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28342; Mature: 28211

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAPEFPEEATSNERLGTVQSVERAISLLEVLAEHGSGMRLREITAVAELSRSTTHRLLT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
TLEKRHFVQFNRHDGRWYIGRQAYLVASAFVHKRAFVASAIPYMRRLRDLTHETANLGIA
HHHHHHHHEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EGHDVVVLAQIESREARLSVAKVGGRMPIHCSGMGKAILAAYPEKEVRAVIANMAVSTDA
CCCCEEEEEEECCCHHHHHHHHHCCCCCEEECCCCCHHHHHCCHHHHHHHHHHHHHCCCC
LGPCYSDDLHVTRRRAYAIDDEGLARGVRCVASVVYGANSEPLCAISVSGHVSRLTDERI
CCCCCCCCHHHHHHHHEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHH
EAVGPLVSSVAQELTGALGGR
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GAPEFPEEATSNERLGTVQSVERAISLLEVLAEHGSGMRLREITAVAELSRSTTHRLLT
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
TLEKRHFVQFNRHDGRWYIGRQAYLVASAFVHKRAFVASAIPYMRRLRDLTHETANLGIA
HHHHHHHHEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EGHDVVVLAQIESREARLSVAKVGGRMPIHCSGMGKAILAAYPEKEVRAVIANMAVSTDA
CCCCEEEEEEECCCHHHHHHHHHCCCCCEEECCCCCHHHHHCCHHHHHHHHHHHHHCCCC
LGPCYSDDLHVTRRRAYAIDDEGLARGVRCVASVVYGANSEPLCAISVSGHVSRLTDERI
CCCCCCCCHHHHHHHHEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHH
EAVGPLVSSVAQELTGALGGR
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]