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The map label for this gene is fabF [H]

Identifier: 110633671

GI number: 110633671

Start: 1408535

End: 1409803

Strand: Reverse

Name: fabF [H]

Synonym: Meso_1318

Alternate gene names: 110633671

Gene position: 1409803-1408535 (Counterclockwise)

Preceding gene: 110633672

Following gene: 110633670

Centisome position: 31.95

GC content: 64.54

Gene sequence:

>1269_bases
ATGAAGACCACCGACAGTTTCGGACGCCCGCTCGTCGCCGTTACCGGCATGGGTGTCGTCACCTCGCTCGGCCAGGGCAA
GAAGGACAATTGGCGAGCCCTGACCGGCGGCCAGTCCGGAATCCATCCGATCACGCGCTTTCCGACGGATCACCTGGCGA
CGACCATAAGCGGCATGGTGGATTTTCTGCCGGAGAGCAGCCGCGGCGCAAGCGCTCTTACCTTTGCGCTGGCGGACTCG
GCCGCAGAGGAAGCCATCGGCGAGGCAGGTTTCTCAACGAGCGATTTCGGCGGCCCGCTGTTCCTCGCAGCGCCACCCGT
CGAGCTCGACTGGCACAACCGCCTGCGGCTTTACGCGCAATCCGATCGCGCCAATGGCTGGCGCAGCCTGATCGAGGCGG
CGCGGAAGGCAAGCGAACGCGCCCTTTTCGATGAGAGCCAGTTCGCCGCGATTGCCGACCGGCTGGCTGAAAAATACGGC
ACGCGCGGCCTTCCGATCACACTTTCGACCGCCTGCGCCTCCGGCGCCACGGCGATCCAACTCGGGACGGAGGCGATCCG
CCGCGGAGAGTGCGAGCGGGCGCTCGCCATAGGCGCGGATGGCTCGGCCACCGCCGAGGCGCTGATTCGCTTCTCGCTTC
TTTCCGCGCTCTCGACGCAAAACGAGCGGCCGGAAAAAGCTTCCAAGCCCTTCTCCAAGGATCGCGACGGTTTCGTGCTG
GCGGAAGGTTCGGGCGCGCTTGTGCTGGAATCGCTGGAGAACGCTTTGGCGCGCGGCGCCGAGATCCTCGGCATTATCCG
CGGCTGCGGCGAAAAGGCGGACGATTTTCACCGCACACGCTCAAAGCCTGACGGATCGCCGGCCATCGCCGCCGTGCGCG
CCGCGCTCAGCGATGCCGGGATGTCGGAGGACGAGATCGGCTATGTCAACGCGCATGGCACCTCGACGCCCGAGAACGAC
AAGATGGAGCATCTCTCGCTCTCGACCGTCTTTGGGGAGCGCATGCGCACGATTCCCATTTCGTCCAACAAATCCATGAT
CGGCCATACGCTCTCGGCCGCGGGCGCCGTGGAGGCCGTCTTCTCCATTTTGACCATGCGCGAGAACACCATCCCGCCGA
CCATCAACTACGAGAACCCGGACCCTGCAATCGAGCTTGACGTGGTGCCAAACGTAAAGCGCGAAGCAGAGGTGGCCAGC
GTGCTTTCGAACTCGTTCGGCTTCGGCGGCCAGAACACTTGCCTTGTCATGGCGCGCGAAGCGGGTTAA

Upstream 100 bases:

>100_bases
AGCCTTTCGAAAGCGCGCCCAAGGCAGCGCTTGCCACCGCCATCGGCTATGACTGCTTCGAGGGCATGGGGCTCATCGTA
GAGGCCTAAGGAGAGCGTCC

Downstream 100 bases:

>100_bases
GCGACCGGCCTGTCTAAAGGACCGGCATTCATGCGTGCATTGCAACTCGTCGCGGACCGCAAGCTCGAAATCGCGGACGT
ATCCCCACCCCCTCCCCCCG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKTTDSFGRPLVAVTGMGVVTSLGQGKKDNWRALTGGQSGIHPITRFPTDHLATTISGMVDFLPESSRGASALTFALADS
AAEEAIGEAGFSTSDFGGPLFLAAPPVELDWHNRLRLYAQSDRANGWRSLIEAARKASERALFDESQFAAIADRLAEKYG
TRGLPITLSTACASGATAIQLGTEAIRRGECERALAIGADGSATAEALIRFSLLSALSTQNERPEKASKPFSKDRDGFVL
AEGSGALVLESLENALARGAEILGIIRGCGEKADDFHRTRSKPDGSPAIAAVRAALSDAGMSEDEIGYVNAHGTSTPEND
KMEHLSLSTVFGERMRTIPISSNKSMIGHTLSAAGAVEAVFSILTMRENTIPPTINYENPDPAIELDVVPNVKREAEVAS
VLSNSFGFGGQNTCLVMAREAG

Sequences:

>Translated_422_residues
MKTTDSFGRPLVAVTGMGVVTSLGQGKKDNWRALTGGQSGIHPITRFPTDHLATTISGMVDFLPESSRGASALTFALADS
AAEEAIGEAGFSTSDFGGPLFLAAPPVELDWHNRLRLYAQSDRANGWRSLIEAARKASERALFDESQFAAIADRLAEKYG
TRGLPITLSTACASGATAIQLGTEAIRRGECERALAIGADGSATAEALIRFSLLSALSTQNERPEKASKPFSKDRDGFVL
AEGSGALVLESLENALARGAEILGIIRGCGEKADDFHRTRSKPDGSPAIAAVRAALSDAGMSEDEIGYVNAHGTSTPEND
KMEHLSLSTVFGERMRTIPISSNKSMIGHTLSAAGAVEAVFSILTMRENTIPPTINYENPDPAIELDVVPNVKREAEVAS
VLSNSFGFGGQNTCLVMAREAG
>Mature_422_residues
MKTTDSFGRPLVAVTGMGVVTSLGQGKKDNWRALTGGQSGIHPITRFPTDHLATTISGMVDFLPESSRGASALTFALADS
AAEEAIGEAGFSTSDFGGPLFLAAPPVELDWHNRLRLYAQSDRANGWRSLIEAARKASERALFDESQFAAIADRLAEKYG
TRGLPITLSTACASGATAIQLGTEAIRRGECERALAIGADGSATAEALIRFSLLSALSTQNERPEKASKPFSKDRDGFVL
AEGSGALVLESLENALARGAEILGIIRGCGEKADDFHRTRSKPDGSPAIAAVRAALSDAGMSEDEIGYVNAHGTSTPEND
KMEHLSLSTVFGERMRTIPISSNKSMIGHTLSAAGAVEAVFSILTMRENTIPPTINYENPDPAIELDVVPNVKREAEVAS
VLSNSFGFGGQNTCLVMAREAG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=429, Percent_Identity=32.1678321678322, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=40.5405405405405, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI41872631, Length=281, Percent_Identity=29.1814946619217, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1787337, Length=418, Percent_Identity=37.0813397129187, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1788663, Length=414, Percent_Identity=31.8840579710145, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71983541, Length=273, Percent_Identity=36.996336996337, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=36.8821292775665, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI212642053, Length=277, Percent_Identity=26.7148014440433, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=274, Percent_Identity=27.007299270073, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=463, Percent_Identity=30.0215982721382, Blast_Score=156, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24644341, Length=431, Percent_Identity=33.6426914153132, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24581345, Length=281, Percent_Identity=28.8256227758007, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19920632, Length=348, Percent_Identity=27.0114942528736, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221330659, Length=348, Percent_Identity=27.0114942528736, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44517; Mature: 44517

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTDSFGRPLVAVTGMGVVTSLGQGKKDNWRALTGGQSGIHPITRFPTDHLATTISGMV
CCCCCCCCCCEEEEECCHHHHHCCCCCCCCCEEECCCCCCCCCHHCCCHHHHHHHHHHHH
DFLPESSRGASALTFALADSAAEEAIGEAGFSTSDFGGPLFLAAPPVELDWHNRLRLYAQ
HHCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEE
SDRANGWRSLIEAARKASERALFDESQFAAIADRLAEKYGTRGLPITLSTACASGATAIQ
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCCCEEH
LGTEAIRRGECERALAIGADGSATAEALIRFSLLSALSTQNERPEKASKPFSKDRDGFVL
HCHHHHHCCCCHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEE
AEGSGALVLESLENALARGAEILGIIRGCGEKADDFHRTRSKPDGSPAIAAVRAALSDAG
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCC
MSEDEIGYVNAHGTSTPENDKMEHLSLSTVFGERMRTIPISSNKSMIGHTLSAAGAVEAV
CCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHH
FSILTMRENTIPPTINYENPDPAIELDVVPNVKREAEVASVLSNSFGFGGQNTCLVMARE
HHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEC
AG
CC
>Mature Secondary Structure
MKTTDSFGRPLVAVTGMGVVTSLGQGKKDNWRALTGGQSGIHPITRFPTDHLATTISGMV
CCCCCCCCCCEEEEECCHHHHHCCCCCCCCCEEECCCCCCCCCHHCCCHHHHHHHHHHHH
DFLPESSRGASALTFALADSAAEEAIGEAGFSTSDFGGPLFLAAPPVELDWHNRLRLYAQ
HHCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEE
SDRANGWRSLIEAARKASERALFDESQFAAIADRLAEKYGTRGLPITLSTACASGATAIQ
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCCCEEH
LGTEAIRRGECERALAIGADGSATAEALIRFSLLSALSTQNERPEKASKPFSKDRDGFVL
HCHHHHHCCCCHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEE
AEGSGALVLESLENALARGAEILGIIRGCGEKADDFHRTRSKPDGSPAIAAVRAALSDAG
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCC
MSEDEIGYVNAHGTSTPENDKMEHLSLSTVFGERMRTIPISSNKSMIGHTLSAAGAVEAV
CCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHH
FSILTMRENTIPPTINYENPDPAIELDVVPNVKREAEVASVLSNSFGFGGQNTCLVMARE
HHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEC
AG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]