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The map label for this gene is norM [H]

Identifier: 110633651

GI number: 110633651

Start: 1389736

End: 1391139

Strand: Reverse

Name: norM [H]

Synonym: Meso_1298

Alternate gene names: 110633651

Gene position: 1391139-1389736 (Counterclockwise)

Preceding gene: 110633655

Following gene: 110633649

Centisome position: 31.53

GC content: 63.46

Gene sequence:

>1404_bases
ATGGTTATGACAGCGCTGGCTACGGGCGCGAGTGCGCCCCCGGTCAATCTTTGGCTTTCCGAAGCGCGGGCGACACTGTC
GCTTGCCTGGCCCATGATTTTGACCAATCTCGCCCAGACGGCGATGACCATGACCGATGTGATGATGCTGGGCCGCCTCT
CGCCCGAGGCGCTCGCCGCCGGCACGCTCGGCCATAACCTTTATTTTATGCTGGTCATATTCGGTCTCGGCCTGCTTGCT
GCCGCGTCACCCATGATGGCGAGCGCCATCGGCCGAAAGCTGCGCTATGTGCGGGACGTGCGGCGGACCGCCCGGCAAGG
GCTGTGGCTTGCCTTGGTAATCTCCGTTCCCATCTGGCTCATCCTTTGGAACACGGAAAGCATCCTCCTGGCGATGGGCC
AGGACCCGGCGCTGAGCAGGGGCGCGGCTTCCTATATGAACGCGCTGCAATGGGCGGCCTTGCCCTTTTTCGGCTATATC
GTGCTGCGCTCCTTCATCTCGGCGCTGGAGCGGCCGGGCTGGGCGCTGCTGGTGGCTTTCATCTGCGTGGGCTTCAACGT
GCTCGCCAACTGGTGCCTGATCTACGGCAATCTCGGTTTTCCGGCACTCGGCCTTCAGGGCGCGGGCCTGGCCACCACGC
TTTCAAGCATCTTCATGTTTCTCGGGCTCGTGGCGGTGGTCACGCTCGTGCGCCAGTTCCGCCGGTTCAGCCTGTTCGGC
CGCCTCTGGCGCTCGGACTGGCCGCGCTTTAAAGCCATGTTGCGGCTGGGATTGCCGATCGCGGGCATTCTCACCTTTGA
AGTGTCGATCTTCAATATCGCCGCCCTGCTCATGGGCCTTATCGATGCGGTTTCACTCGCCGCCCATGCAATCGCCATCC
AGATCGCCTCGGCGAGCTTCATGGTGCCGATGGGCCTCGGCCAGGCAGTAACGGTGCGCGTGGGCCGCGCATATGGTGCG
AGGGATGCGGAGGCCATCACGCGCGCGGGCTGGACGGCTTTCGTTATGGGCGTGAGCTTCATGGGCATGATGGCGCTTTT
GATGTATTTCGCGCCCCGCCTGCTCATCGCCGGCTTCCTGGACCTGAACGCCCCGGAAAACCAGCCGGTCATCTCCACGG
CCGTTACCTTCCTTGCCTTCGCCGCCCTCTTCCAGATCGCCGATGGCGCTCAAGCCGTGGGAAGCGGCATGCTGCGCGGA
CTGCACGACACGACGGTGCCAATGATCTATGCGGCGCTCGGATATTGGGGCATCGGACTGCCGCTCAGCATCGTCCTGGG
TTTCCCGCTGGGCTATCGCGGCGTCGGCATTTGGACCGGCCTTTGCGCCGGGCTTGCCGTGGTGGCCGTGATGCTTCTTT
GGCGGTGGCTGCGTCGAGAAAAGCTCATGCCTTTTTCAGCCTGA

Upstream 100 bases:

>100_bases
GTCCGCCCGGTTGCGGGCGCTATTAAGCATCCGGCAGGCAATCTGAACCGGATTTGCTGCAATCGATGCGGCTGCCAGCC
GCACACCGCACAAAGAAAGC

Downstream 100 bases:

>100_bases
GCCGCCGCCGCTTCGCCTCGTCGATCAGCATATTTGCGACCTGCATGCGAATCACCGCGCGGGCACGCAGATGCTCCGGA
ACGCGGTCGGGATGGTTGCG

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MVMTALATGASAPPVNLWLSEARATLSLAWPMILTNLAQTAMTMTDVMMLGRLSPEALAAGTLGHNLYFMLVIFGLGLLA
AASPMMASAIGRKLRYVRDVRRTARQGLWLALVISVPIWLILWNTESILLAMGQDPALSRGAASYMNALQWAALPFFGYI
VLRSFISALERPGWALLVAFICVGFNVLANWCLIYGNLGFPALGLQGAGLATTLSSIFMFLGLVAVVTLVRQFRRFSLFG
RLWRSDWPRFKAMLRLGLPIAGILTFEVSIFNIAALLMGLIDAVSLAAHAIAIQIASASFMVPMGLGQAVTVRVGRAYGA
RDAEAITRAGWTAFVMGVSFMGMMALLMYFAPRLLIAGFLDLNAPENQPVISTAVTFLAFAALFQIADGAQAVGSGMLRG
LHDTTVPMIYAALGYWGIGLPLSIVLGFPLGYRGVGIWTGLCAGLAVVAVMLLWRWLRREKLMPFSA

Sequences:

>Translated_467_residues
MVMTALATGASAPPVNLWLSEARATLSLAWPMILTNLAQTAMTMTDVMMLGRLSPEALAAGTLGHNLYFMLVIFGLGLLA
AASPMMASAIGRKLRYVRDVRRTARQGLWLALVISVPIWLILWNTESILLAMGQDPALSRGAASYMNALQWAALPFFGYI
VLRSFISALERPGWALLVAFICVGFNVLANWCLIYGNLGFPALGLQGAGLATTLSSIFMFLGLVAVVTLVRQFRRFSLFG
RLWRSDWPRFKAMLRLGLPIAGILTFEVSIFNIAALLMGLIDAVSLAAHAIAIQIASASFMVPMGLGQAVTVRVGRAYGA
RDAEAITRAGWTAFVMGVSFMGMMALLMYFAPRLLIAGFLDLNAPENQPVISTAVTFLAFAALFQIADGAQAVGSGMLRG
LHDTTVPMIYAALGYWGIGLPLSIVLGFPLGYRGVGIWTGLCAGLAVVAVMLLWRWLRREKLMPFSA
>Mature_467_residues
MVMTALATGASAPPVNLWLSEARATLSLAWPMILTNLAQTAMTMTDVMMLGRLSPEALAAGTLGHNLYFMLVIFGLGLLA
AASPMMASAIGRKLRYVRDVRRTARQGLWLALVISVPIWLILWNTESILLAMGQDPALSRGAASYMNALQWAALPFFGYI
VLRSFISALERPGWALLVAFICVGFNVLANWCLIYGNLGFPALGLQGAGLATTLSSIFMFLGLVAVVTLVRQFRRFSLFG
RLWRSDWPRFKAMLRLGLPIAGILTFEVSIFNIAALLMGLIDAVSLAAHAIAIQIASASFMVPMGLGQAVTVRVGRAYGA
RDAEAITRAGWTAFVMGVSFMGMMALLMYFAPRLLIAGFLDLNAPENQPVISTAVTFLAFAALFQIADGAQAVGSGMLRG
LHDTTVPMIYAALGYWGIGLPLSIVLGFPLGYRGVGIWTGLCAGLAVVAVMLLWRWLRREKLMPFSA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=430, Percent_Identity=26.9767441860465, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI153792564, Length=432, Percent_Identity=25.9259259259259, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI38261960, Length=467, Percent_Identity=25.4817987152034, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI48994890, Length=447, Percent_Identity=35.1230425055928, Blast_Score=216, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6320545, Length=458, Percent_Identity=22.707423580786, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 50352; Mature: 50352

Theoretical pI: Translated: 10.74; Mature: 10.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMTALATGASAPPVNLWLSEARATLSLAWPMILTNLAQTAMTMTDVMMLGRLSPEALAA
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GTLGHNLYFMLVIFGLGLLAAASPMMASAIGRKLRYVRDVRRTARQGLWLALVISVPIWL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEE
ILWNTESILLAMGQDPALSRGAASYMNALQWAALPFFGYIVLRSFISALERPGWALLVAF
EEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ICVGFNVLANWCLIYGNLGFPALGLQGAGLATTLSSIFMFLGLVAVVTLVRQFRRFSLFG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLWRSDWPRFKAMLRLGLPIAGILTFEVSIFNIAALLMGLIDAVSLAAHAIAIQIASASF
HHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCE
MVPMGLGQAVTVRVGRAYGARDAEAITRAGWTAFVMGVSFMGMMALLMYFAPRLLIAGFL
EEECCCCCEEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLNAPENQPVISTAVTFLAFAALFQIADGAQAVGSGMLRGLHDTTVPMIYAALGYWGIGL
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCH
PLSIVLGFPLGYRGVGIWTGLCAGLAVVAVMLLWRWLRREKLMPFSA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVMTALATGASAPPVNLWLSEARATLSLAWPMILTNLAQTAMTMTDVMMLGRLSPEALAA
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GTLGHNLYFMLVIFGLGLLAAASPMMASAIGRKLRYVRDVRRTARQGLWLALVISVPIWL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEE
ILWNTESILLAMGQDPALSRGAASYMNALQWAALPFFGYIVLRSFISALERPGWALLVAF
EEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ICVGFNVLANWCLIYGNLGFPALGLQGAGLATTLSSIFMFLGLVAVVTLVRQFRRFSLFG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLWRSDWPRFKAMLRLGLPIAGILTFEVSIFNIAALLMGLIDAVSLAAHAIAIQIASASF
HHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCE
MVPMGLGQAVTVRVGRAYGARDAEAITRAGWTAFVMGVSFMGMMALLMYFAPRLLIAGFL
EEECCCCCEEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLNAPENQPVISTAVTFLAFAALFQIADGAQAVGSGMLRGLHDTTVPMIYAALGYWGIGL
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCH
PLSIVLGFPLGYRGVGIWTGLCAGLAVVAVMLLWRWLRREKLMPFSA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]