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The map label for this gene is hemB [H]

Identifier: 110633482

GI number: 110633482

Start: 1236722

End: 1237753

Strand: Reverse

Name: hemB [H]

Synonym: Meso_1129

Alternate gene names: 110633482

Gene position: 1237753-1236722 (Counterclockwise)

Preceding gene: 110633495

Following gene: 110633481

Centisome position: 28.05

GC content: 59.98

Gene sequence:

>1032_bases
TTGAATAAGTTCAGCCGCCTCAAAATGGACCCGATCCGCAGTGTCGACGAGATCACCGGCAGCAGGCGTCTGAGGCGAAT
GCGCAAGGCTTCCTGGTCGCGGCGTCTGGTGCAGGAGAACCACCTCAGGGTGGAGGATCTCATCTGGCCGATCTTCCTGG
TGGAAGGTGAAAACCGGAAGGACCCGGTCGAAGCCATGCCCGGCGTCTACCGTTACTCGGTCGACCTTGCAGTGCGCGAA
GCCGAGCGGGCCGCGAAGCTTGGAATTCCGGCCATAGCGACCTTTCCCAATATCGGTATCAAAAAACGGGACGTGACCGG
ATCGGCCATTCTCGATCCGGACAATCTCATCAATCAGGCCAGCCGCGCCATCAAGGCTGCCGTGCCGGAGATCGGCATCA
TCACGGATGTTGCACTCGACCCCTTCACCAGCCATGGCCATGACGGCATCCTGCGCGACGGTGTCATCCTCAATGATGAG
ACGGTGGCGCAAGTGGCGGAGGCCGCCGTGCTTCAAGCGGCAGCCGGCGCGGACATAATCGCACCATCGGATATGATGGA
TGGCAGGATCGGCGCAATTCGCGACTCGCTCGACGCCAACGGCTTCCAGGACGTGGCGATCATGTCCTATGCGACCAAAT
TCGCTTCCGTCTTTTATGGGCCGTACCGGGAGGCGATCGGCACTGGAACCCTGCTTACGGGCGACAAGAAAACCTATTAC
GTCGACCCGGCCAATTCCGACGAAGCGGTGCGCGAAGCCGAGCAGGACCTGCTCGAAGGCGCCGACATGCTGATGGTGAA
GCCAGGCCTGCCTTATCTCGACATCATCAGGCGGCTGAAGGATGAGTTCGCCATGCCCACCTTCGCCTATCAGGTTTCGG
GCGAATATTCGATGATCAAGGCCGCGGCAGCCAATGGCTGGCTCGACGGCGAGAAGGCCATGCTCGAAACCCTGCTCGCA
TTCAAGCGTGCCGGTTGCGATGGCATCCTTACGTATTTCGCTCCGGAGGCAGCTCAACTTTTACGCGCTTAG

Upstream 100 bases:

>100_bases
CGGTCTCTCCCTTTCATCTCCTGCGGCGAAAACGTTCGGTCGCCCGCAGTTGTTCGCGGGCGCACGAGCGTGATAAAACG
CAACGAACAGGAGTATTGCC

Downstream 100 bases:

>100_bases
CGGCACTCACTTGAAAACGCCCGTAGGGTCCCCATCTGCTGAGCTTTGACCCGTTTTTGAAAGGCGTTGTTATGGTTGCA
AAAACGATCGATCTCCGCGA

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MNKFSRLKMDPIRSVDEITGSRRLRRMRKASWSRRLVQENHLRVEDLIWPIFLVEGENRKDPVEAMPGVYRYSVDLAVRE
AERAAKLGIPAIATFPNIGIKKRDVTGSAILDPDNLINQASRAIKAAVPEIGIITDVALDPFTSHGHDGILRDGVILNDE
TVAQVAEAAVLQAAAGADIIAPSDMMDGRIGAIRDSLDANGFQDVAIMSYATKFASVFYGPYREAIGTGTLLTGDKKTYY
VDPANSDEAVREAEQDLLEGADMLMVKPGLPYLDIIRRLKDEFAMPTFAYQVSGEYSMIKAAAANGWLDGEKAMLETLLA
FKRAGCDGILTYFAPEAAQLLRA

Sequences:

>Translated_343_residues
MNKFSRLKMDPIRSVDEITGSRRLRRMRKASWSRRLVQENHLRVEDLIWPIFLVEGENRKDPVEAMPGVYRYSVDLAVRE
AERAAKLGIPAIATFPNIGIKKRDVTGSAILDPDNLINQASRAIKAAVPEIGIITDVALDPFTSHGHDGILRDGVILNDE
TVAQVAEAAVLQAAAGADIIAPSDMMDGRIGAIRDSLDANGFQDVAIMSYATKFASVFYGPYREAIGTGTLLTGDKKTYY
VDPANSDEAVREAEQDLLEGADMLMVKPGLPYLDIIRRLKDEFAMPTFAYQVSGEYSMIKAAAANGWLDGEKAMLETLLA
FKRAGCDGILTYFAPEAAQLLRA
>Mature_343_residues
MNKFSRLKMDPIRSVDEITGSRRLRRMRKASWSRRLVQENHLRVEDLIWPIFLVEGENRKDPVEAMPGVYRYSVDLAVRE
AERAAKLGIPAIATFPNIGIKKRDVTGSAILDPDNLINQASRAIKAAVPEIGIITDVALDPFTSHGHDGILRDGVILNDE
TVAQVAEAAVLQAAAGADIIAPSDMMDGRIGAIRDSLDANGFQDVAIMSYATKFASVFYGPYREAIGTGTLLTGDKKTYY
VDPANSDEAVREAEQDLLEGADMLMVKPGLPYLDIIRRLKDEFAMPTFAYQVSGEYSMIKAAAANGWLDGEKAMLETLLA
FKRAGCDGILTYFAPEAAQLLRA

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. Required for nodule development [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=304, Percent_Identity=39.1447368421053, Blast_Score=221, Evalue=9e-58,
Organism=Escherichia coli, GI87081728, Length=319, Percent_Identity=48.58934169279, Blast_Score=267, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6321398, Length=314, Percent_Identity=36.9426751592357, Blast_Score=181, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21358291, Length=304, Percent_Identity=36.8421052631579, Blast_Score=214, Evalue=9e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37613; Mature: 37613

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKFSRLKMDPIRSVDEITGSRRLRRMRKASWSRRLVQENHLRVEDLIWPIFLVEGENRK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEEECCCCC
DPVEAMPGVYRYSVDLAVREAERAAKLGIPAIATFPNIGIKKRDVTGSAILDPDNLINQA
CHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCEECCCCCCCEECCCCCCEEECHHHHHHHH
SRAIKAAVPEIGIITDVALDPFTSHGHDGILRDGVILNDETVAQVAEAAVLQAAAGADII
HHHHHHHCCCCCEEECCCCCCCCCCCCCCCEECCEEECCHHHHHHHHHHHHHHHCCCCCC
APSDMMDGRIGAIRDSLDANGFQDVAIMSYATKFASVFYGPYREAIGTGTLLTGDKKTYY
CCCHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEE
VDPANSDEAVREAEQDLLEGADMLMVKPGLPYLDIIRRLKDEFAMPTFAYQVSGEYSMIK
ECCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHH
AAAANGWLDGEKAMLETLLAFKRAGCDGILTYFAPEAAQLLRA
HHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHCC
>Mature Secondary Structure
MNKFSRLKMDPIRSVDEITGSRRLRRMRKASWSRRLVQENHLRVEDLIWPIFLVEGENRK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEEECCCCC
DPVEAMPGVYRYSVDLAVREAERAAKLGIPAIATFPNIGIKKRDVTGSAILDPDNLINQA
CHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCEECCCCCCCEECCCCCCEEECHHHHHHHH
SRAIKAAVPEIGIITDVALDPFTSHGHDGILRDGVILNDETVAQVAEAAVLQAAAGADII
HHHHHHHCCCCCEEECCCCCCCCCCCCCCCEECCEEECCHHHHHHHHHHHHHHHCCCCCC
APSDMMDGRIGAIRDSLDANGFQDVAIMSYATKFASVFYGPYREAIGTGTLLTGDKKTYY
CCCHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEE
VDPANSDEAVREAEQDLLEGADMLMVKPGLPYLDIIRRLKDEFAMPTFAYQVSGEYSMIK
ECCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHH
AAAANGWLDGEKAMLETLLAFKRAGCDGILTYFAPEAAQLLRA
HHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8226669; 12597275 [H]