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The map label for this gene is nqo13 [H]

Identifier: 110633388

GI number: 110633388

Start: 1135460

End: 1136965

Strand: Direct

Name: nqo13 [H]

Synonym: Meso_1034

Alternate gene names: 110633388

Gene position: 1135460-1136965 (Clockwise)

Preceding gene: 110633387

Following gene: 110633389

Centisome position: 25.73

GC content: 60.03

Gene sequence:

>1506_bases
ATGACCGACTGGCCCATTCTTTCCACGGTCACTTTCCTGCCGCTCGTCGGCGCATTCCTCATCCTGCTTATCAGGGATGA
CGGGCAGGGCGCGCGCCGCAACATCCGCAACGTGGCGCTGCTGACGACGGTCTTCACCTTCATCCTGTCGCTCTTCATCT
GGATCGGCTTCGATTACACGACGCCCGGCTTCCAGATGGTCGAAAAGAGGGAGTGGCTGGACTCCGGCATTTCCTACCAT
ATGGGGGTGGACGGCATTTCGATGCTGTTCGTGATCCTCACCACTTTCCTGATGCCCTTCTGCATCCTGGCAAGCTGGGA
GGCGATCGACAGCCGTGTCAAGGAATACATGATCGCGTTTCTGATCCTGGAAACGCTGATGATCGGCGTCTTCTGCGCGC
TCGATATCGTGCTCTTCTACGTGTTCTTCGAGGCTGGCCTCATTCCGATGTTCATCATCATCGGCGTGTGGGGCGGCAAG
CGCCGGGTCTATGCGAGCTTCAAGTTCTTCCTCTATACGCTCGCCGGCTCCGTGCTCATGCTACTGGCCATGATGGCCAT
GTTCTGGCAGTCCGGCACGACGGACATTCCGACGCTGCTCACGCATGCCTTCCCCGTCCAGATGCAATATTGGCTTTGGA
TCGCCTTCTTCGCCTCCTTCGCGGTGAAGATGCCCATGTGGCCGGTGCACACCTGGCTGCCGGACGCCCACGTCGAGGCG
CCGACGGCAGGCTCCGTGATCCTGGCGGGCATCCTCCTGAAAATGGGCGGCTACGGTTTTCTCCGCTTCTCCTTGCCGAT
GTTCCCCGAGGCGTCGGCGGAATTCGCTCCATTCGTCTTCACGCTCTCCGTTGTCGCCATCATCTACACCTCGCTGGTGG
CGATGATGCAGGATGACATCAAGAAGCTCATCGCATATTCGTCCGTGGCCCATATGGGCTTCGTCACCATGGGCATTTTC
GCCATGAACGAGCAGGGCGTGCAAGGCGCCATCTTCCAGATGCTCTCCCACGGCCTCGTCTCAGGCGCGCTCTTTCTGTG
CGTGGGCGTGATCTACGACCGTATGCACACCCGCGAGATCTCTGCCTATGGCGGCCTCGTCAACAACATGCCGAAATATG
CGGTGGCCTTCATGGTCTTCACCATGGCCAATGTGGGCCTGCCCGGTACGAGCGGCTTCGTCGGCGAGTTCCTGACGCTT
TTTGCCGCCTTCCAGGTGAACACATGGGTGGCATTCTTCGCCACCACCGGCGTGGTGCTCTCTGCCGCTTATGCGCTATG
GCTCTACCGCCGCGTGATTTTCGGTGCCCTGACCAAGGAGAGCCTGAAGGGACTGACGGACCTTTCGCTGCGCGAGAAGA
CGATCCTCTATCCGCTGGTGGCGCTGGTCATCTTCTTCGGCGTTTATCCCTCCGCACTCATCGATACCACCACGGCCTCG
GTGAGCGCGCTGCTTGACCACGTCAGCGCATCGCTTTCCACCGCGCAGGCCGCGGCGGCCAATTGA

Upstream 100 bases:

>100_bases
GGTCAAGCTGCAGACCGGCTATCTCTATCATTACGCCTTCGCGATGCTGATCGGCATCGCTGCCTTCGTGACCTGGATGA
TGCTCGGGAGCTCCTTCTAA

Downstream 100 bases:

>100_bases
ACGGGAAGACTGGCAAATGAACTTTGATCTCGCATCGAGCCTGGCCCTCGCTTTTCCCGAAGTGGCGCTTGCCGTCGGCG
CCATGGTGCTGCTGATGATC

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MTDWPILSTVTFLPLVGAFLILLIRDDGQGARRNIRNVALLTTVFTFILSLFIWIGFDYTTPGFQMVEKREWLDSGISYH
MGVDGISMLFVILTTFLMPFCILASWEAIDSRVKEYMIAFLILETLMIGVFCALDIVLFYVFFEAGLIPMFIIIGVWGGK
RRVYASFKFFLYTLAGSVLMLLAMMAMFWQSGTTDIPTLLTHAFPVQMQYWLWIAFFASFAVKMPMWPVHTWLPDAHVEA
PTAGSVILAGILLKMGGYGFLRFSLPMFPEASAEFAPFVFTLSVVAIIYTSLVAMMQDDIKKLIAYSSVAHMGFVTMGIF
AMNEQGVQGAIFQMLSHGLVSGALFLCVGVIYDRMHTREISAYGGLVNNMPKYAVAFMVFTMANVGLPGTSGFVGEFLTL
FAAFQVNTWVAFFATTGVVLSAAYALWLYRRVIFGALTKESLKGLTDLSLREKTILYPLVALVIFFGVYPSALIDTTTAS
VSALLDHVSASLSTAQAAAAN

Sequences:

>Translated_501_residues
MTDWPILSTVTFLPLVGAFLILLIRDDGQGARRNIRNVALLTTVFTFILSLFIWIGFDYTTPGFQMVEKREWLDSGISYH
MGVDGISMLFVILTTFLMPFCILASWEAIDSRVKEYMIAFLILETLMIGVFCALDIVLFYVFFEAGLIPMFIIIGVWGGK
RRVYASFKFFLYTLAGSVLMLLAMMAMFWQSGTTDIPTLLTHAFPVQMQYWLWIAFFASFAVKMPMWPVHTWLPDAHVEA
PTAGSVILAGILLKMGGYGFLRFSLPMFPEASAEFAPFVFTLSVVAIIYTSLVAMMQDDIKKLIAYSSVAHMGFVTMGIF
AMNEQGVQGAIFQMLSHGLVSGALFLCVGVIYDRMHTREISAYGGLVNNMPKYAVAFMVFTMANVGLPGTSGFVGEFLTL
FAAFQVNTWVAFFATTGVVLSAAYALWLYRRVIFGALTKESLKGLTDLSLREKTILYPLVALVIFFGVYPSALIDTTTAS
VSALLDHVSASLSTAQAAAAN
>Mature_500_residues
TDWPILSTVTFLPLVGAFLILLIRDDGQGARRNIRNVALLTTVFTFILSLFIWIGFDYTTPGFQMVEKREWLDSGISYHM
GVDGISMLFVILTTFLMPFCILASWEAIDSRVKEYMIAFLILETLMIGVFCALDIVLFYVFFEAGLIPMFIIIGVWGGKR
RVYASFKFFLYTLAGSVLMLLAMMAMFWQSGTTDIPTLLTHAFPVQMQYWLWIAFFASFAVKMPMWPVHTWLPDAHVEAP
TAGSVILAGILLKMGGYGFLRFSLPMFPEASAEFAPFVFTLSVVAIIYTSLVAMMQDDIKKLIAYSSVAHMGFVTMGIFA
MNEQGVQGAIFQMLSHGLVSGALFLCVGVIYDRMHTREISAYGGLVNNMPKYAVAFMVFTMANVGLPGTSGFVGEFLTLF
AAFQVNTWVAFFATTGVVLSAAYALWLYRRVIFGALTKESLKGLTDLSLREKTILYPLVALVIFFGVYPSALIDTTTASV
SALLDHVSASLSTAQAAAAN

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=365, Percent_Identity=33.972602739726, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI251831117, Length=410, Percent_Identity=23.4146341463415, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI1788613, Length=510, Percent_Identity=39.2156862745098, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1788827, Length=282, Percent_Identity=27.3049645390071, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788831, Length=302, Percent_Identity=27.4834437086093, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI145693160, Length=371, Percent_Identity=26.4150943396226, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1788614, Length=411, Percent_Identity=25.3041362530414, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788829, Length=346, Percent_Identity=24.5664739884393, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI2367154, Length=340, Percent_Identity=22.6470588235294, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55426; Mature: 55295

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDWPILSTVTFLPLVGAFLILLIRDDGQGARRNIRNVALLTTVFTFILSLFIWIGFDYT
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TPGFQMVEKREWLDSGISYHMGVDGISMLFVILTTFLMPFCILASWEAIDSRVKEYMIAF
CCHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILETLMIGVFCALDIVLFYVFFEAGLIPMFIIIGVWGGKRRVYASFKFFLYTLAGSVLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LLAMMAMFWQSGTTDIPTLLTHAFPVQMQYWLWIAFFASFAVKMPMWPVHTWLPDAHVEA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCC
PTAGSVILAGILLKMGGYGFLRFSLPMFPEASAEFAPFVFTLSVVAIIYTSLVAMMQDDI
CCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KKLIAYSSVAHMGFVTMGIFAMNEQGVQGAIFQMLSHGLVSGALFLCVGVIYDRMHTREI
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAYGGLVNNMPKYAVAFMVFTMANVGLPGTSGFVGEFLTLFAAFQVNTWVAFFATTGVVL
HHHCCHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAAYALWLYRRVIFGALTKESLKGLTDLSLREKTILYPLVALVIFFGVYPSALIDTTTAS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VSALLDHVSASLSTAQAAAAN
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]