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The map label for this gene is nuoN1 [H]

Identifier: 110633389

GI number: 110633389

Start: 1136982

End: 1138421

Strand: Direct

Name: nuoN1 [H]

Synonym: Meso_1035

Alternate gene names: 110633389

Gene position: 1136982-1138421 (Clockwise)

Preceding gene: 110633388

Following gene: 110633390

Centisome position: 25.77

GC content: 61.53

Gene sequence:

>1440_bases
ATGAACTTTGATCTCGCATCGAGCCTGGCCCTCGCTTTTCCCGAAGTGGCGCTTGCCGTCGGCGCCATGGTGCTGCTGAT
GATCGGCGTCTTTTCTGGCGAGAGGGCGAACGCCACTGTGACGGGCCTTGCGGTGGCGCTGTTCCTCGCTGCCATCGCCT
GGATCGTGGTCTTCCCGGCCGATGGAGAGGCTTTCGGCGGCGCCTTCATCAGCGACCCCTTCTCCCGCTTCATGAAGCTA
TTGACCCTGATCGGCGCGGCCGTGACTCTCGTCATGTCTGTTGGCTTCGCCAAGGCGGAGAAGTTCGACAAGTTCGAGTA
TCCGGTCCTGATCATGCTGTCGACGCTCGGCATGCTGCTGATGATTTCGGCCAATGACATGATCTCGCTCTATCTTGGCC
TGGAGCTTCAGTCGCTTGCGCTTTACGTCGTGGCCGCGATTAACCGCGACAGCGTGCGCGCGACGGAGGCGGGACTGAAA
TATTTCGTCCTCGGCGCTCTCTCCTCGGGCATGCTGCTCTACGGCGTCTCGCTGGTCTACGGCTTTACCGGCAACACCGG
CTTCGAGGCTATCGCCACTGCCCTTTCGAGCGGCGGTGAGAGGCAGCTGGGCCTCGTCTTCGGGCTCGTGTTCGTTCTGG
CCGGCCTGGCCTTCAAGATCTCCGCCGTGCCGTTCCATATGTGGACGCCGGATGTCTACGAGGGTGCGCCAACGCCGGTG
ACGGCCTTTTTCGCCGCCGCGCCCAAGATGGCTGCCATCGCCCTGCTCATCCGCGTAACGATGCAGGCGTTCGAGCCCAT
CGCCGTCGATTGGCAGCAGATCGTGGTCTTCATTTCGATCGCGTCCATGCTTCTCGGCTCCTTCGCGGCCATAGGCCAGC
GCAACATCAAGCGTCTGATGGCCTATTCCTCCATCGGCCATATGGGCTTCGCTTTGGTCGGGCTTGCCGCCAATTCAGAG
GCCGGCGTGCGCGGCGTCATCATCTATATGCTCATCTACCTTGCGATGACGCTCGGCACCTTCGCCTTCATCCTTGCGAT
GCGCCGCAACGACACCAATGTCGAGCAGATCGACGATCTCGCTGGGCTTGCCTCCACAAATCCCATGATGGCCACCATCA
TGACGATCCTGATGTTCTCCATGGCCGGCATTCCGCCGCTCGCGGGCTTCTGGGCCAAGTGGTACGTCTTCCTCGCCGCC
ATCAATGCCGGGCTGGTGGCGCTGGCGGTCATCGGCGTCCTCGCCTCTGTGGTGGCCGCGTACTACTACCTGCGCATTAT
CAAGGTGATGTGGTTCGATGAGTCCGTCGGAGCCTTCCAGCCGATGGCGGGCGAACTGCGTCTTGTGCTTACTCTATCGG
GCGCTTTCGTGCTTCTTTACGTGTTCTTCGGCGGCCCTGTCGGCCGGCTGGCGGAAGCCGCAGCGTCGACGTTCTTTTAA

Upstream 100 bases:

>100_bases
GATACCACCACGGCCTCGGTGAGCGCGCTGCTTGACCACGTCAGCGCATCGCTTTCCACCGCGCAGGCCGCGGCGGCCAA
TTGAACGGGAAGACTGGCAA

Downstream 100 bases:

>100_bases
GATGTTCGCGCTCGCGGCTTCGGCTTCTGCCGCAGGGTACCGGCTGGAGGCGCATGAGAGCGTCGGGTCGACAAATGTCT
TGGCGCTCGAAAGGGCTGTG

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N 1; NDH-1 subunit N 1 [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MNFDLASSLALAFPEVALAVGAMVLLMIGVFSGERANATVTGLAVALFLAAIAWIVVFPADGEAFGGAFISDPFSRFMKL
LTLIGAAVTLVMSVGFAKAEKFDKFEYPVLIMLSTLGMLLMISANDMISLYLGLELQSLALYVVAAINRDSVRATEAGLK
YFVLGALSSGMLLYGVSLVYGFTGNTGFEAIATALSSGGERQLGLVFGLVFVLAGLAFKISAVPFHMWTPDVYEGAPTPV
TAFFAAAPKMAAIALLIRVTMQAFEPIAVDWQQIVVFISIASMLLGSFAAIGQRNIKRLMAYSSIGHMGFALVGLAANSE
AGVRGVIIYMLIYLAMTLGTFAFILAMRRNDTNVEQIDDLAGLASTNPMMATIMTILMFSMAGIPPLAGFWAKWYVFLAA
INAGLVALAVIGVLASVVAAYYYLRIIKVMWFDESVGAFQPMAGELRLVLTLSGAFVLLYVFFGGPVGRLAEAAASTFF

Sequences:

>Translated_479_residues
MNFDLASSLALAFPEVALAVGAMVLLMIGVFSGERANATVTGLAVALFLAAIAWIVVFPADGEAFGGAFISDPFSRFMKL
LTLIGAAVTLVMSVGFAKAEKFDKFEYPVLIMLSTLGMLLMISANDMISLYLGLELQSLALYVVAAINRDSVRATEAGLK
YFVLGALSSGMLLYGVSLVYGFTGNTGFEAIATALSSGGERQLGLVFGLVFVLAGLAFKISAVPFHMWTPDVYEGAPTPV
TAFFAAAPKMAAIALLIRVTMQAFEPIAVDWQQIVVFISIASMLLGSFAAIGQRNIKRLMAYSSIGHMGFALVGLAANSE
AGVRGVIIYMLIYLAMTLGTFAFILAMRRNDTNVEQIDDLAGLASTNPMMATIMTILMFSMAGIPPLAGFWAKWYVFLAA
INAGLVALAVIGVLASVVAAYYYLRIIKVMWFDESVGAFQPMAGELRLVLTLSGAFVLLYVFFGGPVGRLAEAAASTFF
>Mature_479_residues
MNFDLASSLALAFPEVALAVGAMVLLMIGVFSGERANATVTGLAVALFLAAIAWIVVFPADGEAFGGAFISDPFSRFMKL
LTLIGAAVTLVMSVGFAKAEKFDKFEYPVLIMLSTLGMLLMISANDMISLYLGLELQSLALYVVAAINRDSVRATEAGLK
YFVLGALSSGMLLYGVSLVYGFTGNTGFEAIATALSSGGERQLGLVFGLVFVLAGLAFKISAVPFHMWTPDVYEGAPTPV
TAFFAAAPKMAAIALLIRVTMQAFEPIAVDWQQIVVFISIASMLLGSFAAIGQRNIKRLMAYSSIGHMGFALVGLAANSE
AGVRGVIIYMLIYLAMTLGTFAFILAMRRNDTNVEQIDDLAGLASTNPMMATIMTILMFSMAGIPPLAGFWAKWYVFLAA
INAGLVALAVIGVLASVVAAYYYLRIIKVMWFDESVGAFQPMAGELRLVLTLSGAFVLLYVFFGGPVGRLAEAAASTFF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=326, Percent_Identity=23.6196319018405, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI251831117, Length=216, Percent_Identity=28.7037037037037, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI145693160, Length=362, Percent_Identity=36.1878453038674, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1788831, Length=399, Percent_Identity=27.0676691729323, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788613, Length=275, Percent_Identity=27.6363636363636, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788614, Length=313, Percent_Identity=23.961661341853, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788827, Length=334, Percent_Identity=26.9461077844311, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788829, Length=254, Percent_Identity=24.4094488188976, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 50911; Mature: 50911

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDLASSLALAFPEVALAVGAMVLLMIGVFSGERANATVTGLAVALFLAAIAWIVVFPA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEEECC
DGEAFGGAFISDPFSRFMKLLTLIGAAVTLVMSVGFAKAEKFDKFEYPVLIMLSTLGMLL
CCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHE
MISANDMISLYLGLELQSLALYVVAAINRDSVRATEAGLKYFVLGALSSGMLLYGVSLVY
EECCCCCEEHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
GFTGNTGFEAIATALSSGGERQLGLVFGLVFVLAGLAFKISAVPFHMWTPDVYEGAPTPV
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECEEECCCCHHCCCCCCCH
TAFFAAAPKMAAIALLIRVTMQAFEPIAVDWQQIVVFISIASMLLGSFAAIGQRNIKRLM
HHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYSSIGHMGFALVGLAANSEAGVRGVIIYMLIYLAMTLGTFAFILAMRRNDTNVEQIDDL
HHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AGLASTNPMMATIMTILMFSMAGIPPLAGFWAKWYVFLAAINAGLVALAVIGVLASVVAA
HCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YYYLRIIKVMWFDESVGAFQPMAGELRLVLTLSGAFVLLYVFFGGPVGRLAEAAASTFF
HHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNFDLASSLALAFPEVALAVGAMVLLMIGVFSGERANATVTGLAVALFLAAIAWIVVFPA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEEECC
DGEAFGGAFISDPFSRFMKLLTLIGAAVTLVMSVGFAKAEKFDKFEYPVLIMLSTLGMLL
CCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHE
MISANDMISLYLGLELQSLALYVVAAINRDSVRATEAGLKYFVLGALSSGMLLYGVSLVY
EECCCCCEEHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
GFTGNTGFEAIATALSSGGERQLGLVFGLVFVLAGLAFKISAVPFHMWTPDVYEGAPTPV
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECEEECCCCHHCCCCCCCH
TAFFAAAPKMAAIALLIRVTMQAFEPIAVDWQQIVVFISIASMLLGSFAAIGQRNIKRLM
HHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYSSIGHMGFALVGLAANSEAGVRGVIIYMLIYLAMTLGTFAFILAMRRNDTNVEQIDDL
HHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AGLASTNPMMATIMTILMFSMAGIPPLAGFWAKWYVFLAAINAGLVALAVIGVLASVVAA
HCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YYYLRIIKVMWFDESVGAFQPMAGELRLVLTLSGAFVLLYVFFGGPVGRLAEAAASTFF
HHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]