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The map label for this gene is nqo12 [H]

Identifier: 110633387

GI number: 110633387

Start: 1133471

End: 1135459

Strand: Direct

Name: nqo12 [H]

Synonym: Meso_1033

Alternate gene names: 110633387

Gene position: 1133471-1135459 (Clockwise)

Preceding gene: 110633386

Following gene: 110633388

Centisome position: 25.69

GC content: 61.09

Gene sequence:

>1989_bases
ATGTATCAAGCAATCGTCTTCCTTCCGCTTGCGGGCTTCCTGATCGCCGGGCTCTTCGGCCGCTCGATCGGCGCCAAAGG
GTCGGAATACATCACGTCCGGCCTGCTGGTGGTCTCAGCCTTCCTGTCATGGATCGCTTTCTTTCAGGTGGGCCTGGGCG
ACGGCGAGGCAATCACCATACCGCTTCTGCGCTTCATCTCATCCGGCGCGCTGGATGTGGACTGGGCGCTTAGGATCGAC
ACGCTGACGGCAGTGATGCTGGTGGTGGTCAACACCGTCTCGGCGCTGGTGCACATCTATTCCATCGGCTACATGCACCA
CGACCCCGACCGGCCGCGCTTCTTCGCCTACCTGTCGCTCTTCACTTTCGCCATGCTCATGCTGGTGACATCCGACAACC
TGGTGCAGATGTTCTTCGGCTGGGAAGGCGTGGGCCTGGCCTCCTATCTGCTTATCGGCTTCTGGTACAAGAAGCCCTCC
GCCAATGCCGCGGCCATGAAAGCCTTTATCGTCAACCGCGTGGGCGATTTCGGCTTTGCGCTCGGCATTTTCGGCGTGTT
CGTCCTCTTCGGTTCGATCAATTTCGACACGATCTTTGCCAACACGGCGGCCTTCATGCCGGGTGAAGGCGGGGCGGAAG
CGGCCCAGCCGGTGCTGACCTTCCTGGGCTATGCCCTCGATCCGCATTCCGCGCTGACGGTCGTCTGCCTGCTCCTCTTC
CTGGGCGCGATGGGCAAGTCGGCGCAGGTGCCGCTCCACACCTGGCTTCCCGACGCCATGGAAGGCCCGACGCCGGTCTC
CGCCCTCATCCACGCCGCGACGATGGTGACGGCGGGCGTGTTCATGGTGGCGCGGCTGTCGCCCATTTTCGAGCTGTCGC
AAACCGCCCTGACGGTGGTGACGGCCGTGGGCGCCTTCACGGCCTTCTTCGCCGCGACCGTCGGCCTCGTGCAAAACGAC
ATCAAGCGCGTTATCGCCTATTCCACCTGCTCTCAGCTCGGCTACATGTTCGTGGCGCTCGGCACGGGCTTCTATAGCGC
GGCGATCTTCCACCTCTTCACGCACGCCTTCTTCAAGGCGTTGCTCTTCCTGGGCTCAGGCTCGGTTATCCATGCGGTCT
CCGACGAGCAGGACATGCGTAAGATGGGCGGCCTGAGGAAACTCATTCCGCAGACCTACTGGATGATGATCATCGGCACG
CTTGCGCTGACGGGTGTCGGCATTCCCGGCACGCTTATCGGCACGGCGGGCTTCTTTTCGAAGGACGCTATCATCGAAGG
CTCCTTCGTAGCCCACAACGCGGTGGCGCCCATCGCCTTCACATTGCTGGTGGTGGCCGCCGTCTTCACCAGTTTCTATT
CCTGGCGGCTGATCTTCATGACCTTTCACGGCAAGCCGCGCGCCTCTTCGGACGTCATGCACCATGTGCATGAATCACCC
TATGTGATGCTGGTGCCGCTCTTCCTGCTGGCGATCGGCGCCATCTTCGCCGGTCTCGTTTTCGAAGGCTTCTTCGTCGG
CCACGAATACGACCACTTCTGGAAGGGCGCACTCTTTACGCTGCCAGACAATCATATGGTGGAGGAGTTCCATCATGTGC
CGCTGTGGGTGAAGCTCTCGCCATTCGTGGCGATGCTGTTTGGGCTTCTTGTTGCCTGGCAGTTCTACATCCGCTCGCCG
GAAAGCCCGAAGCGGCTCGCCGAACGGCACCGCGCTCTTTATGCCTTCCTGCTGAACAAGTGGTACTTCGACGAAGTATA
CGACTTCCTGTTCGTGCGCCCGGCGCAGCGCCTCGGCCGCTTTCTTTGGAAAAAGGGCGACGGCTGGTTCATTGACGGCT
TCGGCCCCGACGGCATTTCTGCGCGGGTGGTCGACGTTGCCAATCGCGTGGTCAAGCTGCAGACCGGCTATCTCTATCAT
TACGCCTTCGCGATGCTGATCGGCATCGCTGCCTTCGTGACCTGGATGATGCTCGGGAGCTCCTTCTAA

Upstream 100 bases:

>100_bases
GAAGGGCTGAGGCGACTGCCTTGGTTGGATTTGCACCTATGGAAACGATCACGCCCGGCACCATGCCTGAACACAAGATG
CTTTAGAGGTCGGCGAAAAC

Downstream 100 bases:

>100_bases
ATGACCGACTGGCCCATTCTTTCCACGGTCACTTTCCTGCCGCTCGTCGGCGCATTCCTCATCCTGCTTATCAGGGATGA
CGGGCAGGGCGCGCGCCGCA

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 12; NDH-1, chain 12 [H]

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MYQAIVFLPLAGFLIAGLFGRSIGAKGSEYITSGLLVVSAFLSWIAFFQVGLGDGEAITIPLLRFISSGALDVDWALRID
TLTAVMLVVVNTVSALVHIYSIGYMHHDPDRPRFFAYLSLFTFAMLMLVTSDNLVQMFFGWEGVGLASYLLIGFWYKKPS
ANAAAMKAFIVNRVGDFGFALGIFGVFVLFGSINFDTIFANTAAFMPGEGGAEAAQPVLTFLGYALDPHSALTVVCLLLF
LGAMGKSAQVPLHTWLPDAMEGPTPVSALIHAATMVTAGVFMVARLSPIFELSQTALTVVTAVGAFTAFFAATVGLVQND
IKRVIAYSTCSQLGYMFVALGTGFYSAAIFHLFTHAFFKALLFLGSGSVIHAVSDEQDMRKMGGLRKLIPQTYWMMIIGT
LALTGVGIPGTLIGTAGFFSKDAIIEGSFVAHNAVAPIAFTLLVVAAVFTSFYSWRLIFMTFHGKPRASSDVMHHVHESP
YVMLVPLFLLAIGAIFAGLVFEGFFVGHEYDHFWKGALFTLPDNHMVEEFHHVPLWVKLSPFVAMLFGLLVAWQFYIRSP
ESPKRLAERHRALYAFLLNKWYFDEVYDFLFVRPAQRLGRFLWKKGDGWFIDGFGPDGISARVVDVANRVVKLQTGYLYH
YAFAMLIGIAAFVTWMMLGSSF

Sequences:

>Translated_662_residues
MYQAIVFLPLAGFLIAGLFGRSIGAKGSEYITSGLLVVSAFLSWIAFFQVGLGDGEAITIPLLRFISSGALDVDWALRID
TLTAVMLVVVNTVSALVHIYSIGYMHHDPDRPRFFAYLSLFTFAMLMLVTSDNLVQMFFGWEGVGLASYLLIGFWYKKPS
ANAAAMKAFIVNRVGDFGFALGIFGVFVLFGSINFDTIFANTAAFMPGEGGAEAAQPVLTFLGYALDPHSALTVVCLLLF
LGAMGKSAQVPLHTWLPDAMEGPTPVSALIHAATMVTAGVFMVARLSPIFELSQTALTVVTAVGAFTAFFAATVGLVQND
IKRVIAYSTCSQLGYMFVALGTGFYSAAIFHLFTHAFFKALLFLGSGSVIHAVSDEQDMRKMGGLRKLIPQTYWMMIIGT
LALTGVGIPGTLIGTAGFFSKDAIIEGSFVAHNAVAPIAFTLLVVAAVFTSFYSWRLIFMTFHGKPRASSDVMHHVHESP
YVMLVPLFLLAIGAIFAGLVFEGFFVGHEYDHFWKGALFTLPDNHMVEEFHHVPLWVKLSPFVAMLFGLLVAWQFYIRSP
ESPKRLAERHRALYAFLLNKWYFDEVYDFLFVRPAQRLGRFLWKKGDGWFIDGFGPDGISARVVDVANRVVKLQTGYLYH
YAFAMLIGIAAFVTWMMLGSSF
>Mature_662_residues
MYQAIVFLPLAGFLIAGLFGRSIGAKGSEYITSGLLVVSAFLSWIAFFQVGLGDGEAITIPLLRFISSGALDVDWALRID
TLTAVMLVVVNTVSALVHIYSIGYMHHDPDRPRFFAYLSLFTFAMLMLVTSDNLVQMFFGWEGVGLASYLLIGFWYKKPS
ANAAAMKAFIVNRVGDFGFALGIFGVFVLFGSINFDTIFANTAAFMPGEGGAEAAQPVLTFLGYALDPHSALTVVCLLLF
LGAMGKSAQVPLHTWLPDAMEGPTPVSALIHAATMVTAGVFMVARLSPIFELSQTALTVVTAVGAFTAFFAATVGLVQND
IKRVIAYSTCSQLGYMFVALGTGFYSAAIFHLFTHAFFKALLFLGSGSVIHAVSDEQDMRKMGGLRKLIPQTYWMMIIGT
LALTGVGIPGTLIGTAGFFSKDAIIEGSFVAHNAVAPIAFTLLVVAAVFTSFYSWRLIFMTFHGKPRASSDVMHHVHESP
YVMLVPLFLLAIGAIFAGLVFEGFFVGHEYDHFWKGALFTLPDNHMVEEFHHVPLWVKLSPFVAMLFGLLVAWQFYIRSP
ESPKRLAERHRALYAFLLNKWYFDEVYDFLFVRPAQRLGRFLWKKGDGWFIDGFGPDGISARVVDVANRVVKLQTGYLYH
YAFAMLIGIAAFVTWMMLGSSF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=404, Percent_Identity=42.5742574257426, Blast_Score=301, Evalue=2e-81,
Organism=Escherichia coli, GI1788614, Length=600, Percent_Identity=40.1666666666667, Blast_Score=353, Evalue=3e-98,
Organism=Escherichia coli, GI1788831, Length=344, Percent_Identity=33.1395348837209, Blast_Score=132, Evalue=1e-31,
Organism=Escherichia coli, GI1788827, Length=447, Percent_Identity=29.3064876957494, Blast_Score=130, Evalue=4e-31,
Organism=Escherichia coli, GI1788829, Length=393, Percent_Identity=32.0610687022901, Blast_Score=129, Evalue=7e-31,
Organism=Escherichia coli, GI1788613, Length=429, Percent_Identity=26.5734265734266, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI2367154, Length=215, Percent_Identity=27.4418604651163, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI145693160, Length=279, Percent_Identity=25.4480286738351, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 72747; Mature: 72747

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQAIVFLPLAGFLIAGLFGRSIGAKGSEYITSGLLVVSAFLSWIAFFQVGLGDGEAITI
CCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHH
PLLRFISSGALDVDWALRIDTLTAVMLVVVNTVSALVHIYSIGYMHHDPDRPRFFAYLSL
HHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHH
FTFAMLMLVTSDNLVQMFFGWEGVGLASYLLIGFWYKKPSANAAAMKAFIVNRVGDFGFA
HHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LGIFGVFVLFGSINFDTIFANTAAFMPGEGGAEAAQPVLTFLGYALDPHSALTVVCLLLF
HHHHHHHHHHCCCCCHHEEECCEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LGAMGKSAQVPLHTWLPDAMEGPTPVSALIHAATMVTAGVFMVARLSPIFELSQTALTVV
HCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAVGAFTAFFAATVGLVQNDIKRVIAYSTCSQLGYMFVALGTGFYSAAIFHLFTHAFFKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLFLGSGSVIHAVSDEQDMRKMGGLRKLIPQTYWMMIIGTLALTGVGIPGTLIGTAGFFS
HHHHCCCCEEEECCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCC
KDAIIEGSFVAHNAVAPIAFTLLVVAAVFTSFYSWRLIFMTFHGKPRASSDVMHHVHESP
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHCCCC
YVMLVPLFLLAIGAIFAGLVFEGFFVGHEYDHFWKGALFTLPDNHMVEEFHHVPLWVKLS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEECCCCHHHHHHHCCCEEEEHH
PFVAMLFGLLVAWQFYIRSPESPKRLAERHRALYAFLLNKWYFDEVYDFLFVRPAQRLGR
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLWKKGDGWFIDGFGPDGISARVVDVANRVVKLQTGYLYHYAFAMLIGIAAFVTWMMLGS
HHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
SF
CC
>Mature Secondary Structure
MYQAIVFLPLAGFLIAGLFGRSIGAKGSEYITSGLLVVSAFLSWIAFFQVGLGDGEAITI
CCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHH
PLLRFISSGALDVDWALRIDTLTAVMLVVVNTVSALVHIYSIGYMHHDPDRPRFFAYLSL
HHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHH
FTFAMLMLVTSDNLVQMFFGWEGVGLASYLLIGFWYKKPSANAAAMKAFIVNRVGDFGFA
HHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LGIFGVFVLFGSINFDTIFANTAAFMPGEGGAEAAQPVLTFLGYALDPHSALTVVCLLLF
HHHHHHHHHHCCCCCHHEEECCEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LGAMGKSAQVPLHTWLPDAMEGPTPVSALIHAATMVTAGVFMVARLSPIFELSQTALTVV
HCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAVGAFTAFFAATVGLVQNDIKRVIAYSTCSQLGYMFVALGTGFYSAAIFHLFTHAFFKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLFLGSGSVIHAVSDEQDMRKMGGLRKLIPQTYWMMIIGTLALTGVGIPGTLIGTAGFFS
HHHHCCCCEEEECCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCC
KDAIIEGSFVAHNAVAPIAFTLLVVAAVFTSFYSWRLIFMTFHGKPRASSDVMHHVHESP
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHCCCC
YVMLVPLFLLAIGAIFAGLVFEGFFVGHEYDHFWKGALFTLPDNHMVEEFHHVPLWVKLS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEECCCCHHHHHHHCCCEEEEHH
PFVAMLFGLLVAWQFYIRSPESPKRLAERHRALYAFLLNKWYFDEVYDFLFVRPAQRLGR
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLWKKGDGWFIDGFGPDGISARVVDVANRVVKLQTGYLYHYAFAMLIGIAAFVTWMMLGS
HHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
SF
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]