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The map label for this gene is nuoF1 [H]

Identifier: 110633381

GI number: 110633381

Start: 1127304

End: 1128608

Strand: Direct

Name: nuoF1 [H]

Synonym: Meso_1027

Alternate gene names: 110633381

Gene position: 1127304-1128608 (Clockwise)

Preceding gene: 110633380

Following gene: 110633382

Centisome position: 25.55

GC content: 64.9

Gene sequence:

>1305_bases
ATGCTTCAGGACAAGGACCGCATCTTCACCAATATTTACGGCCAGTTCGACCGGTCGCTCCACGGTGCCATGGCGCGCGG
CCACTGGGACGGCACAAAAGCCATCCTGGAAAAGGGCCGCGACTGGATCATCAACGAGATGAAGGCCTCCGGCCTGCGCG
GACGCGGCGGCGCCGGCTTTCCGACCGGCCTGAAATGGTCCTTCATGCCGAAAGCGCCGACGGACCGGCCGCATTACCTC
GTCGTCAATGCCGACGAGTCGGAACCCGGCACCTGCAAGGATCGCGACATCCTGCGCCACGAGCCGCACACGCTGGTGGA
GGGCTGCCTCATCGCCGGCTTCGCCATGGGCGCGCATGCCGCCTACATCTATGTGCGCGGTGAGTTCATCCGCGAGCGCG
AGGCGCTGCAGGCGGCCATCGACGAGTGTTACGCGCATGGTCTGCTGGGCAAGAACAACATCCATGGCTGGGACTTTGAC
GTAATCGTCCATCACGGCGCCGGCGCCTATATCTGCGGCGAGGAGACCGCGCTGCTCGAAAGCCTGGAAGGCAAGAAAGG
CCAGCCGCGCCTGAAGCCGCCATTCCCGGCGAATATGGGTCTCTACGGCTGCCCGACCACGGTGAACAACGTGGAGTCCA
TTGCCGTGGCGCCCACGATCCTTCGCCGCGGCGCCGCCTGGTTCTCCTCATTCGGGCGCGAGAACAACAAGGGCACGAAG
CTCTTCTGCATCTCCGGCCATGTTAACAACCCGTGCACGGTGGAGGAGGAGATGTCGATCCCCTTCCGCGAGCTCATCGA
CCGCCATTGCGGCGGCATTCGCGGCGGCTGGGACAATCTGCTTGCTGTGATCCCCGGCGGCTCCTCGGTGCCGCTGGTGC
CGGCCGAGCAGATCATCGACGCGCCGATGGATTTCGATTCGCTGCGCGACCTGAAATCGGGTCTCGGCACGGCGGCGGTG
ATCGTGATGGACAAGTCCACCGACATCGTGAAGGCCATCGCGCGGCTTTCCTATTTCTACAAGCACGAAAGCTGCGGCCA
ATGCACGCCGTGCCGTGAAGGCACCGGCTGGATGTGGCGCGTCATGGAGCGGCTGGTGCGCGGTGAGGCGCACAAGCACG
AGATCGATATGCTGCTCGACGTCACGAAGCAGGTGGAAGGGCACACGATCTGCGCGTTGGGTGACGCGGCCGCGTGGCCG
ATCCAGGGCCTGATCCGGCACTTCCGCCCGGAGATCGAGCGGCGCATCGACGAATTCACCCGCAACGCCCACCGCGCGGA
GCCCGCGCTGGTGGCTGCGGAATAG

Upstream 100 bases:

>100_bases
AAAATGGATGTCGGGCCGGAATCGCCCGAGCGCGGCGTCGACCCCGCGGGACCTGCGGGCGGTCCGGGGTCGGGCAGGAA
GCGGCGCTGAGGAGAGCTAG

Downstream 100 bases:

>100_bases
AGTAAAACGAAAACGGATCTTGCTTCACAGGCAAGCAGTTAGCGGACGGCGATAATGGCAAGGTTGAAAGTCGACGGCAC
GGAGATCGAGGTACCCGATC

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MLQDKDRIFTNIYGQFDRSLHGAMARGHWDGTKAILEKGRDWIINEMKASGLRGRGGAGFPTGLKWSFMPKAPTDRPHYL
VVNADESEPGTCKDRDILRHEPHTLVEGCLIAGFAMGAHAAYIYVRGEFIREREALQAAIDECYAHGLLGKNNIHGWDFD
VIVHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSFGRENNKGTK
LFCISGHVNNPCTVEEEMSIPFRELIDRHCGGIRGGWDNLLAVIPGGSSVPLVPAEQIIDAPMDFDSLRDLKSGLGTAAV
IVMDKSTDIVKAIARLSYFYKHESCGQCTPCREGTGWMWRVMERLVRGEAHKHEIDMLLDVTKQVEGHTICALGDAAAWP
IQGLIRHFRPEIERRIDEFTRNAHRAEPALVAAE

Sequences:

>Translated_434_residues
MLQDKDRIFTNIYGQFDRSLHGAMARGHWDGTKAILEKGRDWIINEMKASGLRGRGGAGFPTGLKWSFMPKAPTDRPHYL
VVNADESEPGTCKDRDILRHEPHTLVEGCLIAGFAMGAHAAYIYVRGEFIREREALQAAIDECYAHGLLGKNNIHGWDFD
VIVHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSFGRENNKGTK
LFCISGHVNNPCTVEEEMSIPFRELIDRHCGGIRGGWDNLLAVIPGGSSVPLVPAEQIIDAPMDFDSLRDLKSGLGTAAV
IVMDKSTDIVKAIARLSYFYKHESCGQCTPCREGTGWMWRVMERLVRGEAHKHEIDMLLDVTKQVEGHTICALGDAAAWP
IQGLIRHFRPEIERRIDEFTRNAHRAEPALVAAE
>Mature_434_residues
MLQDKDRIFTNIYGQFDRSLHGAMARGHWDGTKAILEKGRDWIINEMKASGLRGRGGAGFPTGLKWSFMPKAPTDRPHYL
VVNADESEPGTCKDRDILRHEPHTLVEGCLIAGFAMGAHAAYIYVRGEFIREREALQAAIDECYAHGLLGKNNIHGWDFD
VIVHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSFGRENNKGTK
LFCISGHVNNPCTVEEEMSIPFRELIDRHCGGIRGGWDNLLAVIPGGSSVPLVPAEQIIDAPMDFDSLRDLKSGLGTAAV
IVMDKSTDIVKAIARLSYFYKHESCGQCTPCREGTGWMWRVMERLVRGEAHKHEIDMLLDVTKQVEGHTICALGDAAAWP
IQGLIRHFRPEIERRIDEFTRNAHRAEPALVAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=419, Percent_Identity=69.6897374701671, Blast_Score=616, Evalue=1e-176,
Organism=Homo sapiens, GI260656005, Length=419, Percent_Identity=69.6897374701671, Blast_Score=615, Evalue=1e-176,
Organism=Escherichia coli, GI1788620, Length=400, Percent_Identity=43.75, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI17531727, Length=422, Percent_Identity=70.1421800947867, Blast_Score=631, Evalue=0.0,
Organism=Drosophila melanogaster, GI19920794, Length=417, Percent_Identity=70.2637889688249, Blast_Score=626, Evalue=1e-180,
Organism=Drosophila melanogaster, GI45550452, Length=418, Percent_Identity=66.7464114832536, Blast_Score=586, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24653819, Length=425, Percent_Identity=48.9411764705882, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24653817, Length=425, Percent_Identity=45.6470588235294, Blast_Score=378, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48034; Mature: 48034

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQDKDRIFTNIYGQFDRSLHGAMARGHWDGTKAILEKGRDWIINEMKASGLRGRGGAGF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKAPTDRPHYLVVNADESEPGTCKDRDILRHEPHTLVEGCLIAGFAMGAHA
CCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCE
AYIYVRGEFIREREALQAAIDECYAHGLLGKNNIHGWDFDVIVHHGAGAYICGEETALLE
EEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSFGRENNKGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LFCISGHVNNPCTVEEEMSIPFRELIDRHCGGIRGGWDNLLAVIPGGSSVPLVPAEQIID
EEEEECCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHC
APMDFDSLRDLKSGLGTAAVIVMDKSTDIVKAIARLSYFYKHESCGQCTPCREGTGWMWR
CCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VMERLVRGEAHKHEIDMLLDVTKQVEGHTICALGDAAAWPIQGLIRHFRPEIERRIDEFT
HHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
RNAHRAEPALVAAE
HHHHCCCCCEEECC
>Mature Secondary Structure
MLQDKDRIFTNIYGQFDRSLHGAMARGHWDGTKAILEKGRDWIINEMKASGLRGRGGAGF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKAPTDRPHYLVVNADESEPGTCKDRDILRHEPHTLVEGCLIAGFAMGAHA
CCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCE
AYIYVRGEFIREREALQAAIDECYAHGLLGKNNIHGWDFDVIVHHGAGAYICGEETALLE
EEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSFGRENNKGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LFCISGHVNNPCTVEEEMSIPFRELIDRHCGGIRGGWDNLLAVIPGGSSVPLVPAEQIID
EEEEECCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHC
APMDFDSLRDLKSGLGTAAVIVMDKSTDIVKAIARLSYFYKHESCGQCTPCREGTGWMWR
CCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VMERLVRGEAHKHEIDMLLDVTKQVEGHTICALGDAAAWPIQGLIRHFRPEIERRIDEFT
HHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
RNAHRAEPALVAAE
HHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]