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The map label for this gene is nqo3 [H]

Identifier: 110633382

GI number: 110633382

Start: 1128663

End: 1130744

Strand: Direct

Name: nqo3 [H]

Synonym: Meso_1028

Alternate gene names: 110633382

Gene position: 1128663-1130744 (Clockwise)

Preceding gene: 110633381

Following gene: 110633383

Centisome position: 25.58

GC content: 64.46

Gene sequence:

>2082_bases
ATGGCAAGGTTGAAAGTCGACGGCACGGAGATCGAGGTACCCGATCACTACACGCTGCTGCAGGCTGCCGAGGAGGCGGG
GGCGGAGATCCCGCGTTTCTGCTTCCACGAGCGGCTCTCCGTTGCCGGCAATTGCCGCATGTGCCTGGTCGAGGTGAAGG
GCGGTCCGCCCAAGCCGCAGGCCTCCTGCGCCATGGGCGTGCGCGACCTGCGCCCCGGCCCCAATGGCGAACTGCCGGAA
GTCTTCACCAAGAGCCCAATGGTGAAGAAGGCGCGCGAAGGCGTGATGGAGTTCCTGCTCATCAACCACCCGCTTGACTG
CCCGATCTGCGATCAGGGCGGCGAGTGCGACCTGCAGGACCAGGCCATGGCCTACGGCGTGGATTCCTCGCGTTTCTACG
AGAACAAGCGCGCCGTTGAGGACAAATATATCGGCCCGCTCGTCAAGACGATCATGACGCGCTGCATCCACTGCACGCGC
TGTGTGCGCTTCACGACCGAGGTGGCGGGCGTCTCCGAGCTCGGCGCCACTGGCCGCGGAGAGGATATGGAGATCACCAC
CTATCTGGAGCGGGCGATAACGTCCGAGCTTCAGGGCAATGTGATCGACCTCTGCCCCGTGGGCGCGCTGACTTCGAAAC
CCTATGCCTTCCAGGCTCGCCCGTGGGAGCTCGGCAAGACGCAGTCCATCGACGTAATGGACGCGGTAGGCTCCGCCATC
CGTGTCGACACGCGTGGCCGCGAGGTGATGCGCATTCTGCCGATCGTCAATGAATTCGTGAATGAGGAGTGGATCTCCGA
CAAAACCCGATTCGTTTGGGATGGTCTTCGCACGCAGCGCCTCGACCGGCCTTATGTCCGCAAGGGCAAGCGCCTGCAGC
CGGCGACATGGAGCGAGGCGTTCGATGCGATCGCCAAGGCGGTGAAGAAGGCAGCGCCCGAAAAGATCGGCGCGATTGCC
GGCGACCTCGCCAGCGTGGAAGAGATGTATGCGCTGAAGAAGCTCATGCAGTCGCTCGGCTCGCCCAATATCGACTGCCG
GCAGGACGGCACGGCACTAGACCCGAAATTCGGCCGCGCAAGCTACCTCTTCAATCCGACGATCGAAGGGATCGAGCGCT
CCGACGCGCTCCTCATCATCGGCGCCAATCCACGCATCGAGGCGGCGGTGCTCAACGCCCGCATCCTCAAGCGCTGGCGC
ATGGGCGAGTTCCCCATCGGCGTCATCGGCGAGGGTGGAGAACTGCGCTACGGCTACACCCATCTCGGTACCGGACCCGA
AACGCTTTCGGACCTGGCCGAAGGCAAGGGAAGCTTCCTGTCGGTGCTCGAGAAGGCAGAGCGTCCGATGGTCATCGTGG
GGCAGGGCGCTCTGGCCCGGCCGGACGGCGCGGCGGTGCTCGGCCGCGCGGCGAAGCTTGCAAACGATATCGGCGCGGTC
ACGCCGGAGTGGAACGGCTTTGCCGTGCTTCACACGGCAGCGGCGCGTGTGGGGGGTCTCGATCTCGGCTTCGTGCCGAA
TAAGGGCGGGAAGGCCGTCGCCGGCATGATGGGCGCAATGGACGTGCTCTTCCTGCTCGGCGCCGACGAGATCGATATGA
ACCAGATCGGCGATGCCTTCACGGTTTATATCGGCACTCATGGTGATGCCGGCGCCCATCGTGCCGACGTGATCCTGCCG
GGCGCGACCTATACGGAGAAATCCGCCACTTACGTGAACACGGAAGGCCGCGTTCAGATGACCAACCGCGCCGGCTTCGC
TCCGGGCGACGCCCGCGAGGATTGGGCGATCCTGCGCGCGCTCTCGGATGTGCTCGGCCACAGGTTGCCCTTCGATTCGC
TTCAGCAGTTGCGTGCGAAGCTTTATGCGGAGCATCCGCATTTCGCGGGCCTCGACGCGATCGAGCCCGGCAGCGCGGAC
GAGGTGCTGGCGCTCGCCAGACTCTCCGGCAAGCTGAATCCCATGCCGTTCCTTTCGACGGTGACGGATTTCTATCTCAC
CAACCCGATCGCGCGCGCATCCGCCATCATGGCGGAATGCTCCGCGCTTGCGCGTGGCGAATTGAAACAGGCGGCCGAGT
AG

Upstream 100 bases:

>100_bases
CCGCAACGCCCACCGCGCGGAGCCCGCGCTGGTGGCTGCGGAATAGAGTAAAACGAAAACGGATCTTGCTTCACAGGCAA
GCAGTTAGCGGACGGCGATA

Downstream 100 bases:

>100_bases
GGGCGAGAAACGATGGAATCCTTTGTCACGCTCTACGTTCTTCCGGGGCTTCTGATCCTGCTGAAGTCGGTCGCGCTGAT
CGTCATCCTGCTGGTGGGGG

Product: NADH dehydrogenase subunit G

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 3; NDH-1, chain 3 [H]

Number of amino acids: Translated: 693; Mature: 692

Protein sequence:

>693_residues
MARLKVDGTEIEVPDHYTLLQAAEEAGAEIPRFCFHERLSVAGNCRMCLVEVKGGPPKPQASCAMGVRDLRPGPNGELPE
VFTKSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAYGVDSSRFYENKRAVEDKYIGPLVKTIMTRCIHCTR
CVRFTTEVAGVSELGATGRGEDMEITTYLERAITSELQGNVIDLCPVGALTSKPYAFQARPWELGKTQSIDVMDAVGSAI
RVDTRGREVMRILPIVNEFVNEEWISDKTRFVWDGLRTQRLDRPYVRKGKRLQPATWSEAFDAIAKAVKKAAPEKIGAIA
GDLASVEEMYALKKLMQSLGSPNIDCRQDGTALDPKFGRASYLFNPTIEGIERSDALLIIGANPRIEAAVLNARILKRWR
MGEFPIGVIGEGGELRYGYTHLGTGPETLSDLAEGKGSFLSVLEKAERPMVIVGQGALARPDGAAVLGRAAKLANDIGAV
TPEWNGFAVLHTAAARVGGLDLGFVPNKGGKAVAGMMGAMDVLFLLGADEIDMNQIGDAFTVYIGTHGDAGAHRADVILP
GATYTEKSATYVNTEGRVQMTNRAGFAPGDAREDWAILRALSDVLGHRLPFDSLQQLRAKLYAEHPHFAGLDAIEPGSAD
EVLALARLSGKLNPMPFLSTVTDFYLTNPIARASAIMAECSALARGELKQAAE

Sequences:

>Translated_693_residues
MARLKVDGTEIEVPDHYTLLQAAEEAGAEIPRFCFHERLSVAGNCRMCLVEVKGGPPKPQASCAMGVRDLRPGPNGELPE
VFTKSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAYGVDSSRFYENKRAVEDKYIGPLVKTIMTRCIHCTR
CVRFTTEVAGVSELGATGRGEDMEITTYLERAITSELQGNVIDLCPVGALTSKPYAFQARPWELGKTQSIDVMDAVGSAI
RVDTRGREVMRILPIVNEFVNEEWISDKTRFVWDGLRTQRLDRPYVRKGKRLQPATWSEAFDAIAKAVKKAAPEKIGAIA
GDLASVEEMYALKKLMQSLGSPNIDCRQDGTALDPKFGRASYLFNPTIEGIERSDALLIIGANPRIEAAVLNARILKRWR
MGEFPIGVIGEGGELRYGYTHLGTGPETLSDLAEGKGSFLSVLEKAERPMVIVGQGALARPDGAAVLGRAAKLANDIGAV
TPEWNGFAVLHTAAARVGGLDLGFVPNKGGKAVAGMMGAMDVLFLLGADEIDMNQIGDAFTVYIGTHGDAGAHRADVILP
GATYTEKSATYVNTEGRVQMTNRAGFAPGDAREDWAILRALSDVLGHRLPFDSLQQLRAKLYAEHPHFAGLDAIEPGSAD
EVLALARLSGKLNPMPFLSTVTDFYLTNPIARASAIMAECSALARGELKQAAE
>Mature_692_residues
ARLKVDGTEIEVPDHYTLLQAAEEAGAEIPRFCFHERLSVAGNCRMCLVEVKGGPPKPQASCAMGVRDLRPGPNGELPEV
FTKSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAYGVDSSRFYENKRAVEDKYIGPLVKTIMTRCIHCTRC
VRFTTEVAGVSELGATGRGEDMEITTYLERAITSELQGNVIDLCPVGALTSKPYAFQARPWELGKTQSIDVMDAVGSAIR
VDTRGREVMRILPIVNEFVNEEWISDKTRFVWDGLRTQRLDRPYVRKGKRLQPATWSEAFDAIAKAVKKAAPEKIGAIAG
DLASVEEMYALKKLMQSLGSPNIDCRQDGTALDPKFGRASYLFNPTIEGIERSDALLIIGANPRIEAAVLNARILKRWRM
GEFPIGVIGEGGELRYGYTHLGTGPETLSDLAEGKGSFLSVLEKAERPMVIVGQGALARPDGAAVLGRAAKLANDIGAVT
PEWNGFAVLHTAAARVGGLDLGFVPNKGGKAVAGMMGAMDVLFLLGADEIDMNQIGDAFTVYIGTHGDAGAHRADVILPG
ATYTEKSATYVNTEGRVQMTNRAGFAPGDAREDWAILRALSDVLGHRLPFDSLQQLRAKLYAEHPHFAGLDAIEPGSADE
VLALARLSGKLNPMPFLSTVTDFYLTNPIARASAIMAECSALARGELKQAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1034

COG function: function code C; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI33519475, Length=696, Percent_Identity=52.1551724137931, Blast_Score=674, Evalue=0.0,
Organism=Escherichia coli, GI145693161, Length=387, Percent_Identity=29.7157622739018, Blast_Score=183, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17565758, Length=692, Percent_Identity=48.2658959537572, Blast_Score=611, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI32566231, Length=589, Percent_Identity=50.2546689303905, Blast_Score=552, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI193209088, Length=332, Percent_Identity=50.6024096385542, Blast_Score=318, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24640559, Length=684, Percent_Identity=51.9005847953216, Blast_Score=632, Evalue=0.0,
Organism=Drosophila melanogaster, GI24640557, Length=684, Percent_Identity=51.9005847953216, Blast_Score=632, Evalue=0.0,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR006656
- InterPro:   IPR000283
- InterPro:   IPR010228
- InterPro:   IPR019574
- InterPro:   IPR015405 [H]

Pfam domain/function: PF09326 DUF1982; PF00111 Fer2; PF00384 Molybdopterin; PF10588 NADH-G_4Fe-4S_3 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 75038; Mature: 74907

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00642 COMPLEX1_75K_2 ; PS00643 COMPLEX1_75K_3 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLKVDGTEIEVPDHYTLLQAAEEAGAEIPRFCFHERLSVAGNCRMCLVEVKGGPPKPQ
CCEEEECCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCC
ASCAMGVRDLRPGPNGELPEVFTKSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQD
HHHHHCHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
QAMAYGVDSSRFYENKRAVEDKYIGPLVKTIMTRCIHCTRCVRFTTEVAGVSELGATGRG
CHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCC
EDMEITTYLERAITSELQGNVIDLCPVGALTSKPYAFQARPWELGKTQSIDVMDAVGSAI
CCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEECCCCCCCCCCCCCHHHHHCCCEE
RVDTRGREVMRILPIVNEFVNEEWISDKTRFVWDGLRTQRLDRPYVRKGKRLQPATWSEA
EECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCHHHHHCCCHHHHCCCCCCCCHHHHH
FDAIAKAVKKAAPEKIGAIAGDLASVEEMYALKKLMQSLGSPNIDCRQDGTALDPKFGRA
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
SYLFNPTIEGIERSDALLIIGANPRIEAAVLNARILKRWRMGEFPIGVIGEGGELRYGYT
EEEECCCHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCEEECEE
HLGTGPETLSDLAEGKGSFLSVLEKAERPMVIVGQGALARPDGAAVLGRAAKLANDIGAV
ECCCCHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
TPEWNGFAVLHTAAARVGGLDLGFVPNKGGKAVAGMMGAMDVLFLLGADEIDMNQIGDAF
CCCCCCEEEEEHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCEE
TVYIGTHGDAGAHRADVILPGATYTEKSATYVNTEGRVQMTNRAGFAPGDAREDWAILRA
EEEEECCCCCCCCCCCEEECCCCCCCCCCEEECCCCCEEECCCCCCCCCCCCHHHHHHHH
LSDVLGHRLPFDSLQQLRAKLYAEHPHFAGLDAIEPGSADEVLALARLSGKLNPMPFLST
HHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHH
VTDFYLTNPIARASAIMAECSALARGELKQAAE
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARLKVDGTEIEVPDHYTLLQAAEEAGAEIPRFCFHERLSVAGNCRMCLVEVKGGPPKPQ
CEEEECCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCC
ASCAMGVRDLRPGPNGELPEVFTKSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQD
HHHHHCHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
QAMAYGVDSSRFYENKRAVEDKYIGPLVKTIMTRCIHCTRCVRFTTEVAGVSELGATGRG
CHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCC
EDMEITTYLERAITSELQGNVIDLCPVGALTSKPYAFQARPWELGKTQSIDVMDAVGSAI
CCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEECCCCCCCCCCCCCHHHHHCCCEE
RVDTRGREVMRILPIVNEFVNEEWISDKTRFVWDGLRTQRLDRPYVRKGKRLQPATWSEA
EECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCHHHHHCCCHHHHCCCCCCCCHHHHH
FDAIAKAVKKAAPEKIGAIAGDLASVEEMYALKKLMQSLGSPNIDCRQDGTALDPKFGRA
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
SYLFNPTIEGIERSDALLIIGANPRIEAAVLNARILKRWRMGEFPIGVIGEGGELRYGYT
EEEECCCHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCEEECEE
HLGTGPETLSDLAEGKGSFLSVLEKAERPMVIVGQGALARPDGAAVLGRAAKLANDIGAV
ECCCCHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
TPEWNGFAVLHTAAARVGGLDLGFVPNKGGKAVAGMMGAMDVLFLLGADEIDMNQIGDAF
CCCCCCEEEEEHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCEE
TVYIGTHGDAGAHRADVILPGATYTEKSATYVNTEGRVQMTNRAGFAPGDAREDWAILRA
EEEEECCCCCCCCCCCEEECCCCCCCCCCEEECCCCCEEECCCCCCCCCCCCHHHHHHHH
LSDVLGHRLPFDSLQQLRAKLYAEHPHFAGLDAIEPGSADEVLALARLSGKLNPMPFLST
HHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHH
VTDFYLTNPIARASAIMAECSALARGELKQAAE
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1605643; 8422400 [H]