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The map label for this gene is nuoE1 [H]

Identifier: 110633380

GI number: 110633380

Start: 1126256

End: 1127293

Strand: Direct

Name: nuoE1 [H]

Synonym: Meso_1026

Alternate gene names: 110633380

Gene position: 1126256-1127293 (Clockwise)

Preceding gene: 110633379

Following gene: 110633381

Centisome position: 25.52

GC content: 66.67

Gene sequence:

>1038_bases
ATGGCAGTCCGCCGTCTCGCAGACGAAGCCGTCCAGCCCCAGGGCTTTGCCTTCACCAGGGAAAACGAGGCCTGGGCGCA
TCATACGATCCGCAAATACCCCCCTGGGCGCCAGCAGTCGGCGGTGATCCCGCTTTTGATGCGCGCGCAGGAACAGGAAG
GCTGGGTCACGCGCGCGGCGATCGAGCATGTCGCCAAAATGCTCGACATGCCGTTGATCCGCGTCCTGGAGGTCGCGACC
TTCTATACCCAGTTCCAGCTGGCACCGGTCGGCACGCGCGCCCATGTGCAGGTCTGCGGCACCACGCCCTGCATGCTGCG
CGGGGCAGGCGACCTGATCGAGGTTTGCAAGAGCAGGATCCATCCCGAGCCCTTCCACACCAATGAGGGCGGCACGCTCT
CCTGGGAAGAGGTGGAGTGCCAGGGCGCCTGCGTGAACGCGCCCATGATCATGATCTCCAAGGATAGCTACGAGGATCTG
ACGCCAGAGCGGCTGGAAGAGATCATCGATGCGTTCGAGGCGGGCAAGGGCGACACGATCAAGCCGGGCACGCAGATCGA
CCGCCTGACCTCGGCGCCTGCTTCCGGTCTGACCTCGCTCACCGACGAGAGCGTTATCCTGAAGTTCCCCAATGGTGGCA
AGAAGGTTGCCAAGCGCGCGGCCAAGGCCGGTGACAGCGCGGCCGTTCCCCCGACGCGGGCCGGCAGGCCGAAGACCGAT
GCCCTGGAGACCGATGCGGCAATCAAGTCGCCCTCGCCCGTCAAGGCGCGTAGCGGCGGCGAGAAGCGCGTCAGCGTGCG
AGGGCCAAAGGAAAACCCCGTGCAGGCGGATCGTGTGGCCGAGGAGACGGAAGTTGCCTCCCGCACACGCCGTCACAGCG
ATGCGCCAAAGACCGAGGAGCCGTCGCTGCGCTCGCCGGAGCTGAAAAAGCGCAAGGCGCCACGCAACAAAATGGATGTC
GGGCCGGAATCGCCCGAGCGCGGCGTCGACCCCGCGGGACCTGCGGGCGGTCCGGGGTCGGGCAGGAAGCGGCGCTGA

Upstream 100 bases:

>100_bases
ATCTTCAGGCCATGGATTTCATGTGCCGCGGCCATCTTCTTGCCGACGTAACCGCCGTGCTCGGCTCCCTCGATATCGTG
TTTGGTGAGGTAGACAGATA

Downstream 100 bases:

>100_bases
GGAGAGCTAGATGCTTCAGGACAAGGACCGCATCTTCACCAATATTTACGGCCAGTTCGACCGGTCGCTCCACGGTGCCA
TGGCGCGCGGCCACTGGGAC

Product: NADH-quinone oxidoreductase, E subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E 1; NDH-1 subunit E 1 [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MAVRRLADEAVQPQGFAFTRENEAWAHHTIRKYPPGRQQSAVIPLLMRAQEQEGWVTRAAIEHVAKMLDMPLIRVLEVAT
FYTQFQLAPVGTRAHVQVCGTTPCMLRGAGDLIEVCKSRIHPEPFHTNEGGTLSWEEVECQGACVNAPMIMISKDSYEDL
TPERLEEIIDAFEAGKGDTIKPGTQIDRLTSAPASGLTSLTDESVILKFPNGGKKVAKRAAKAGDSAAVPPTRAGRPKTD
ALETDAAIKSPSPVKARSGGEKRVSVRGPKENPVQADRVAEETEVASRTRRHSDAPKTEEPSLRSPELKKRKAPRNKMDV
GPESPERGVDPAGPAGGPGSGRKRR

Sequences:

>Translated_345_residues
MAVRRLADEAVQPQGFAFTRENEAWAHHTIRKYPPGRQQSAVIPLLMRAQEQEGWVTRAAIEHVAKMLDMPLIRVLEVAT
FYTQFQLAPVGTRAHVQVCGTTPCMLRGAGDLIEVCKSRIHPEPFHTNEGGTLSWEEVECQGACVNAPMIMISKDSYEDL
TPERLEEIIDAFEAGKGDTIKPGTQIDRLTSAPASGLTSLTDESVILKFPNGGKKVAKRAAKAGDSAAVPPTRAGRPKTD
ALETDAAIKSPSPVKARSGGEKRVSVRGPKENPVQADRVAEETEVASRTRRHSDAPKTEEPSLRSPELKKRKAPRNKMDV
GPESPERGVDPAGPAGGPGSGRKRR
>Mature_344_residues
AVRRLADEAVQPQGFAFTRENEAWAHHTIRKYPPGRQQSAVIPLLMRAQEQEGWVTRAAIEHVAKMLDMPLIRVLEVATF
YTQFQLAPVGTRAHVQVCGTTPCMLRGAGDLIEVCKSRIHPEPFHTNEGGTLSWEEVECQGACVNAPMIMISKDSYEDLT
PERLEEIIDAFEAGKGDTIKPGTQIDRLTSAPASGLTSLTDESVILKFPNGGKKVAKRAAKAGDSAAVPPTRAGRPKTDA
LETDAAIKSPSPVKARSGGEKRVSVRGPKENPVQADRVAEETEVASRTRRHSDAPKTEEPSLRSPELKKRKAPRNKMDVG
PESPERGVDPAGPAGGPGSGRKRR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=187, Percent_Identity=45.4545454545455, Blast_Score=164, Evalue=8e-41,
Organism=Escherichia coli, GI1788621, Length=168, Percent_Identity=32.1428571428571, Blast_Score=74, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17561328, Length=189, Percent_Identity=45.5026455026455, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI18859877, Length=188, Percent_Identity=43.6170212765958, Blast_Score=157, Evalue=8e-39,
Organism=Drosophila melanogaster, GI21355353, Length=186, Percent_Identity=34.9462365591398, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 37427; Mature: 37296

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVRRLADEAVQPQGFAFTRENEAWAHHTIRKYPPGRQQSAVIPLLMRAQEQEGWVTRAA
CCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHH
IEHVAKMLDMPLIRVLEVATFYTQFQLAPVGTRAHVQVCGTTPCMLRGAGDLIEVCKSRI
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCHHHCCCHHHHHHHHHHC
HPEPFHTNEGGTLSWEEVECQGACVNAPMIMISKDSYEDLTPERLEEIIDAFEAGKGDTI
CCCCCCCCCCCEECHHHHCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCC
KPGTQIDRLTSAPASGLTSLTDESVILKFPNGGKKVAKRAAKAGDSAAVPPTRAGRPKTD
CCCCHHHHHHCCCCCCHHHCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
ALETDAAIKSPSPVKARSGGEKRVSVRGPKENPVQADRVAEETEVASRTRRHSDAPKTEE
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PSLRSPELKKRKAPRNKMDVGPESPERGVDPAGPAGGPGSGRKRR
CCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AVRRLADEAVQPQGFAFTRENEAWAHHTIRKYPPGRQQSAVIPLLMRAQEQEGWVTRAA
CHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHH
IEHVAKMLDMPLIRVLEVATFYTQFQLAPVGTRAHVQVCGTTPCMLRGAGDLIEVCKSRI
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCHHHCCCHHHHHHHHHHC
HPEPFHTNEGGTLSWEEVECQGACVNAPMIMISKDSYEDLTPERLEEIIDAFEAGKGDTI
CCCCCCCCCCCEECHHHHCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCC
KPGTQIDRLTSAPASGLTSLTDESVILKFPNGGKKVAKRAAKAGDSAAVPPTRAGRPKTD
CCCCHHHHHHCCCCCCHHHCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
ALETDAAIKSPSPVKARSGGEKRVSVRGPKENPVQADRVAEETEVASRTRRHSDAPKTEE
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PSLRSPELKKRKAPRNKMDVGPESPERGVDPAGPAGGPGSGRKRR
CCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]