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The map label for this gene is lepB [H]

Identifier: 110633303

GI number: 110633303

Start: 1046482

End: 1047231

Strand: Direct

Name: lepB [H]

Synonym: Meso_0949

Alternate gene names: 110633303

Gene position: 1046482-1047231 (Clockwise)

Preceding gene: 110633302

Following gene: 110633304

Centisome position: 23.72

GC content: 56.8

Gene sequence:

>750_bases
ATGAGCGTGGCGGATAGATCCAAAAGAAAATCAGGCGGGGTGGGCGAGACCATTAGCGTCGTCGTTCAGGCACTGCTGAT
TGCCCTTGTTATCAGAACCTTTTTCTTTCAGCCCTTTTCAATTCCCTCCGGCTCCATGCGCCCGACCTTGCTGGAGGGTG
ATTATCTCTTCGTGACCAAATGGGCCTATGGCTATTCGCGCTATTCGTTTCCGTTCTCGCCGCCGCTGTTTTCGGGCCGG
ATCTGGGGAGCGGAACCGGAGCGCGGCGACGTCGTCGTCTTCAAATATCCGCCCGATCCTTCACTTGATTACATCAAGCG
CGTCATCGGCCTTCCGGGTGATCGCATCCAGATGCGCGACGGCCAGCTCTACATCAATGGGACAGCCGTTCCGCGTGAGA
AAATCGGGCAGATAGAGGATCAGGACATTACTGATCAGGCTCGGCCGGTGGATGTCTATCGCGAGACGCTTCCCAATGGC
GTCTCTTATGAAACGCTCGACCTTTCGCCCACAACGGTCGGTGACAATACGCGGGAATTCATCGTCCCCGAGGCGCATTA
TTTCATGATGGGCGACAATCGCGACAATTCCGCCGACAGTCGTTTCTCGGTCGGTTTCGTGCCGGTGGAGAACCTGGTGG
GCCGCGCCAATATCATCTTCTTCTCGATTGCTGGCGGGGCCAGCCCCCTGGAGCTTTGGCGCTGGCCATCCGAAATCCGG
CTGTCGCGTATGTTAAGCTGGATCGATTGA

Upstream 100 bases:

>100_bases
CTGCGAATGCCGCAGGTCGGTGCATTGCCGTAAAGGCCGCAAGCCGATAAGACGAATTGCAAAATGGGTCGCCTGGCGAG
GCGGCCGAACCGAGGACGAA

Downstream 100 bases:

>100_bases
GGAGTGATGACGCGGAGGCGTCCAAAAGGGCATGAACTGGCTGAGGCCGTGAACGAGCGGATCGGCCTTTCCTTCCGTGA
TGCCGAGCTGCTTGAACGCG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSVADRSKRKSGGVGETISVVVQALLIALVIRTFFFQPFSIPSGSMRPTLLEGDYLFVTKWAYGYSRYSFPFSPPLFSGR
IWGAEPERGDVVVFKYPPDPSLDYIKRVIGLPGDRIQMRDGQLYINGTAVPREKIGQIEDQDITDQARPVDVYRETLPNG
VSYETLDLSPTTVGDNTREFIVPEAHYFMMGDNRDNSADSRFSVGFVPVENLVGRANIIFFSIAGGASPLELWRWPSEIR
LSRMLSWID

Sequences:

>Translated_249_residues
MSVADRSKRKSGGVGETISVVVQALLIALVIRTFFFQPFSIPSGSMRPTLLEGDYLFVTKWAYGYSRYSFPFSPPLFSGR
IWGAEPERGDVVVFKYPPDPSLDYIKRVIGLPGDRIQMRDGQLYINGTAVPREKIGQIEDQDITDQARPVDVYRETLPNG
VSYETLDLSPTTVGDNTREFIVPEAHYFMMGDNRDNSADSRFSVGFVPVENLVGRANIIFFSIAGGASPLELWRWPSEIR
LSRMLSWID
>Mature_248_residues
SVADRSKRKSGGVGETISVVVQALLIALVIRTFFFQPFSIPSGSMRPTLLEGDYLFVTKWAYGYSRYSFPFSPPLFSGRI
WGAEPERGDVVVFKYPPDPSLDYIKRVIGLPGDRIQMRDGQLYINGTAVPREKIGQIEDQDITDQARPVDVYRETLPNGV
SYETLDLSPTTVGDNTREFIVPEAHYFMMGDNRDNSADSRFSVGFVPVENLVGRANIIFFSIAGGASPLELWRWPSEIRL
SRMLSWID

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=271, Percent_Identity=36.1623616236162, Blast_Score=144, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 28016; Mature: 27885

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVADRSKRKSGGVGETISVVVQALLIALVIRTFFFQPFSIPSGSMRPTLLEGDYLFVTK
CCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCEEEEEE
WAYGYSRYSFPFSPPLFSGRIWGAEPERGDVVVFKYPPDPSLDYIKRVIGLPGDRIQMRD
EECCCEECCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEC
GQLYINGTAVPREKIGQIEDQDITDQARPVDVYRETLPNGVSYETLDLSPTTVGDNTREF
CEEEEECCCCCHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCEE
IVPEAHYFMMGDNRDNSADSRFSVGFVPVENLVGRANIIFFSIAGGASPLELWRWPSEIR
EECCCEEEEEECCCCCCCCCEEEEEEEEHHHHCCCCEEEEEEECCCCCHHHHHCCCHHHH
LSRMLSWID
HHHHHHHCC
>Mature Secondary Structure 
SVADRSKRKSGGVGETISVVVQALLIALVIRTFFFQPFSIPSGSMRPTLLEGDYLFVTK
CCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCEEEEEE
WAYGYSRYSFPFSPPLFSGRIWGAEPERGDVVVFKYPPDPSLDYIKRVIGLPGDRIQMRD
EECCCEECCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEC
GQLYINGTAVPREKIGQIEDQDITDQARPVDVYRETLPNGVSYETLDLSPTTVGDNTREF
CEEEEECCCCCHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCEE
IVPEAHYFMMGDNRDNSADSRFSVGFVPVENLVGRANIIFFSIAGGASPLELWRWPSEIR
EECCCEEEEEECCCCCCCCCEEEEEEEEHHHHCCCCEEEEEEECCCCCHHHHHCCCHHHH
LSRMLSWID
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA