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The map label for this gene is rnc [H]

Identifier: 110633304

GI number: 110633304

Start: 1047238

End: 1047954

Strand: Direct

Name: rnc [H]

Synonym: Meso_0950

Alternate gene names: 110633304

Gene position: 1047238-1047954 (Clockwise)

Preceding gene: 110633303

Following gene: 110633305

Centisome position: 23.73

GC content: 65.27

Gene sequence:

>717_bases
ATGACGCGGAGGCGTCCAAAAGGGCATGAACTGGCTGAGGCCGTGAACGAGCGGATCGGCCTTTCCTTCCGTGATGCCGA
GCTGCTTGAACGCGCGCTCACCCATTCGAGCGCGCGCGGCAAGGGAGGGGACTATCAGCGCCTGGAATTCCTTGGCGACC
GGGTGTTGGGGCTCGCTGTCGCCGAGATGCTTTACGAAGCCTATCCAGACGCTTCCGAGGGCGAGCTCTCGCTGCGCCTC
AATTCCTTGGTCAACGCCGAAACACTGGCGGAAATCACCGAAGAACTCGGCCTCGACACGCTGATCCGGACCGGCAGCGA
CTTGAAGGCCCTCGCCATGCGCAAGCAAGTCAACCTGCGGGCCGATGTGCTTGAAGCGCTGATTGCCGTGATCTACCTGC
AGGACGGGTTGGACGGCGCGCGCCAGTTCATCCGCACCCACTGGACGGAGCGTTCCACCGCCGAGGGGGCGGCCCGCGCC
GATGCGAAGACCGCGCTTCAGGAATGGGCGCACCGGGTATCGAGCGCCACGCCGGATTACGTGATCGAGAGTCGCGAGGG
GCCGGACCACGATCCTGTGTTCACCGCCGTGGTGCGCATCGCCGGCTTCCAGGAAGGGCGCGGCCGGGGGCGCTCCAAGC
GTGAGGCGGAACAGGCTGCTGCGACCGAGGTTTTGATTCGCGAGGCCGTATGGACGCCGATGGAAAGCCTGCCATGA

Upstream 100 bases:

>100_bases
CTTCTTCTCGATTGCTGGCGGGGCCAGCCCCCTGGAGCTTTGGCGCTGGCCATCCGAAATCCGGCTGTCGCGTATGTTAA
GCTGGATCGATTGAGGAGTG

Downstream 100 bases:

>100_bases
CCGAAACCGGAGAGCCTTCGCCGGGCACACGCTCCGGCTTCGTCGCGTTGATCGGTGCGCCGAACGCTGGAAAATCGACG
CTGCTCAACCAATTGGTAGG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MTRRRPKGHELAEAVNERIGLSFRDAELLERALTHSSARGKGGDYQRLEFLGDRVLGLAVAEMLYEAYPDASEGELSLRL
NSLVNAETLAEITEELGLDTLIRTGSDLKALAMRKQVNLRADVLEALIAVIYLQDGLDGARQFIRTHWTERSTAEGAARA
DAKTALQEWAHRVSSATPDYVIESREGPDHDPVFTAVVRIAGFQEGRGRGRSKREAEQAAATEVLIREAVWTPMESLP

Sequences:

>Translated_238_residues
MTRRRPKGHELAEAVNERIGLSFRDAELLERALTHSSARGKGGDYQRLEFLGDRVLGLAVAEMLYEAYPDASEGELSLRL
NSLVNAETLAEITEELGLDTLIRTGSDLKALAMRKQVNLRADVLEALIAVIYLQDGLDGARQFIRTHWTERSTAEGAARA
DAKTALQEWAHRVSSATPDYVIESREGPDHDPVFTAVVRIAGFQEGRGRGRSKREAEQAAATEVLIREAVWTPMESLP
>Mature_237_residues
TRRRPKGHELAEAVNERIGLSFRDAELLERALTHSSARGKGGDYQRLEFLGDRVLGLAVAEMLYEAYPDASEGELSLRLN
SLVNAETLAEITEELGLDTLIRTGSDLKALAMRKQVNLRADVLEALIAVIYLQDGLDGARQFIRTHWTERSTAEGAARAD
AKTALQEWAHRVSSATPDYVIESREGPDHDPVFTAVVRIAGFQEGRGRGRSKREAEQAAATEVLIREAVWTPMESLP

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=220, Percent_Identity=33.1818181818182, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI155030236, Length=220, Percent_Identity=33.1818181818182, Blast_Score=91, Evalue=8e-19,
Organism=Escherichia coli, GI1788920, Length=205, Percent_Identity=33.6585365853659, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI193202651, Length=226, Percent_Identity=33.1858407079646, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17506883, Length=226, Percent_Identity=33.1858407079646, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137682, Length=220, Percent_Identity=31.3636363636364, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26323; Mature: 26192

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRRPKGHELAEAVNERIGLSFRDAELLERALTHSSARGKGGDYQRLEFLGDRVLGLAV
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AEMLYEAYPDASEGELSLRLNSLVNAETLAEITEELGLDTLIRTGSDLKALAMRKQVNLR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHH
ADVLEALIAVIYLQDGLDGARQFIRTHWTERSTAEGAARADAKTALQEWAHRVSSATPDY
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VIESREGPDHDPVFTAVVRIAGFQEGRGRGRSKREAEQAAATEVLIREAVWTPMESLP
EEECCCCCCCCHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCC
>Mature Secondary Structure 
TRRRPKGHELAEAVNERIGLSFRDAELLERALTHSSARGKGGDYQRLEFLGDRVLGLAV
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AEMLYEAYPDASEGELSLRLNSLVNAETLAEITEELGLDTLIRTGSDLKALAMRKQVNLR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHH
ADVLEALIAVIYLQDGLDGARQFIRTHWTERSTAEGAARADAKTALQEWAHRVSSATPDY
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VIESREGPDHDPVFTAVVRIAGFQEGRGRGRSKREAEQAAATEVLIREAVWTPMESLP
EEECCCCCCCCHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA