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The map label for this gene is dapA

Identifier: 110633295

GI number: 110633295

Start: 1039165

End: 1040046

Strand: Direct

Name: dapA

Synonym: Meso_0941

Alternate gene names: 110633295

Gene position: 1039165-1040046 (Clockwise)

Preceding gene: 110633293

Following gene: 110633296

Centisome position: 23.55

GC content: 62.02

Gene sequence:

>882_bases
ATGTTCAGGGGTTCCATCACAGCGCTCGTGACGCCTTTCCGTCAGGATGGAAGCCTGGACAAAAAGGCTTTCGGTGCGCT
GGTAGAATGGCAGATCGCGGAAGGCTCGAGCGGCCTTGTTCCGGTCGGCACGACCGGTGAATCTCCAACACTCACCCATG
ATGAGCATCAGGAAGTGATCCGCCTCTGCGTAGAGGCGGCGAACAAGCGCGTGCCTGTGATTGCCGGCGCCGGCTCCAAT
TCCACGCGTGAGGCGATCAGCTTCGCAGAACATGCGGAGAAGGTGGGCGCCGATGCGCTTCTGGTCGTCACGCCTTACTA
CAACAAGCCCAATCAGCGCGGGCTCTACGAGCATTTTGCAGCCATTGCACGGTCCACCAGCCTGCCGATCTTCATCTACA
ACATACCGCCGCGTTCGGTGGTCGACATGCTGCCCGAAACCATGGCCAGACTCGCAGCAGACTTTAAGAACATCGTCGGC
GTGAAGGATGCGACCGCCAAGCTCGACCGGGTGTCGGAGCAGCGGGAGGCCTGCGGGCCCGATTTCATCCAGCTCTCGGG
CGAGGATGCTACGGCGCTGGGCTTCAACGCCCATGGCGGGGTGGGGTGCATCTCGGTGACGGCAAATGTGGCGCCTCGCC
TGTGTGCGGAGTTCCAGGCCGCTTCGCTCCGCGGCGACGGTGCGCGCGCCATCGAACTTCAGGATCGGCTGTTTCCGCTT
CATAAGGCGCTCTTTCTGGAGCCCAACCCCGCCGGCGCAAAATATGCATTGTCCCGACTGGGCAGGCTTGAGAATGTGCT
GCGCTCGCCGCTGGTCACGGTCGAGGCATCGACGGCCGAGAAGATTGATGCGGCGATGAAGCACGCGGGGCTCTTGAACT
GA

Upstream 100 bases:

>100_bases
TTTTCCTGCAATTTCGCACGAATGTGGCTAAGCAAATTCGGCGCGGCTGCCCGGGCTTTGCCTGGCGGAAGCCGCCCAAA
AGGAGATCGGAGTTTTCTCG

Downstream 100 bases:

>100_bases
CGCGCCGATGCAGGCATTCCCTTCCTCATGGCCAAGAACACGAACATCACGACGGTTGCCGACAACCGTAAGGCGCGTTT
CTCCTATGAGGTGATCGACA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MFRGSITALVTPFRQDGSLDKKAFGALVEWQIAEGSSGLVPVGTTGESPTLTHDEHQEVIRLCVEAANKRVPVIAGAGSN
STREAISFAEHAEKVGADALLVVTPYYNKPNQRGLYEHFAAIARSTSLPIFIYNIPPRSVVDMLPETMARLAADFKNIVG
VKDATAKLDRVSEQREACGPDFIQLSGEDATALGFNAHGGVGCISVTANVAPRLCAEFQAASLRGDGARAIELQDRLFPL
HKALFLEPNPAGAKYALSRLGRLENVLRSPLVTVEASTAEKIDAAMKHAGLLN

Sequences:

>Translated_293_residues
MFRGSITALVTPFRQDGSLDKKAFGALVEWQIAEGSSGLVPVGTTGESPTLTHDEHQEVIRLCVEAANKRVPVIAGAGSN
STREAISFAEHAEKVGADALLVVTPYYNKPNQRGLYEHFAAIARSTSLPIFIYNIPPRSVVDMLPETMARLAADFKNIVG
VKDATAKLDRVSEQREACGPDFIQLSGEDATALGFNAHGGVGCISVTANVAPRLCAEFQAASLRGDGARAIELQDRLFPL
HKALFLEPNPAGAKYALSRLGRLENVLRSPLVTVEASTAEKIDAAMKHAGLLN
>Mature_293_residues
MFRGSITALVTPFRQDGSLDKKAFGALVEWQIAEGSSGLVPVGTTGESPTLTHDEHQEVIRLCVEAANKRVPVIAGAGSN
STREAISFAEHAEKVGADALLVVTPYYNKPNQRGLYEHFAAIARSTSLPIFIYNIPPRSVVDMLPETMARLAADFKNIVG
VKDATAKLDRVSEQREACGPDFIQLSGEDATALGFNAHGGVGCISVTANVAPRLCAEFQAASLRGDGARAIELQDRLFPL
HKALFLEPNPAGAKYALSRLGRLENVLRSPLVTVEASTAEKIDAAMKHAGLLN

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=293, Percent_Identity=27.3037542662116, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI13540533, Length=241, Percent_Identity=25.7261410788382, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788823, Length=293, Percent_Identity=48.122866894198, Blast_Score=278, Evalue=2e-76,
Organism=Escherichia coli, GI87082415, Length=299, Percent_Identity=33.7792642140468, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1786463, Length=233, Percent_Identity=33.9055793991416, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1789620, Length=205, Percent_Identity=32.1951219512195, Blast_Score=98, Evalue=7e-22,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_MESSB (Q11JT7)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673503.1
- ProteinModelPortal:   Q11JT7
- SMR:   Q11JT7
- STRING:   Q11JT7
- GeneID:   4180318
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0941
- NMPDR:   fig|266779.1.peg.3911
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   YYNRPSD
- PhylomeDB:   Q11JT7
- ProtClustDB:   PRK03170
- BioCyc:   MSP266779:MESO_0941-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31303; Mature: 31303

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 162-162 BINDING 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRGSITALVTPFRQDGSLDKKAFGALVEWQIAEGSSGLVPVGTTGESPTLTHDEHQEVI
CCCCCEEEEECCCCCCCCCCHHHHHHEEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHH
RLCVEAANKRVPVIAGAGSNSTREAISFAEHAEKVGADALLVVTPYYNKPNQRGLYEHFA
HHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHH
AIARSTSLPIFIYNIPPRSVVDMLPETMARLAADFKNIVGVKDATAKLDRVSEQREACGP
HHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
DFIQLSGEDATALGFNAHGGVGCISVTANVAPRLCAEFQAASLRGDGARAIELQDRLFPL
CEEEECCCCCEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHH
HKALFLEPNPAGAKYALSRLGRLENVLRSPLVTVEASTAEKIDAAMKHAGLLN
HHHEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFRGSITALVTPFRQDGSLDKKAFGALVEWQIAEGSSGLVPVGTTGESPTLTHDEHQEVI
CCCCCEEEEECCCCCCCCCCHHHHHHEEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHH
RLCVEAANKRVPVIAGAGSNSTREAISFAEHAEKVGADALLVVTPYYNKPNQRGLYEHFA
HHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHH
AIARSTSLPIFIYNIPPRSVVDMLPETMARLAADFKNIVGVKDATAKLDRVSEQREACGP
HHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
DFIQLSGEDATALGFNAHGGVGCISVTANVAPRLCAEFQAASLRGDGARAIELQDRLFPL
CEEEECCCCCEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHH
HKALFLEPNPAGAKYALSRLGRLENVLRSPLVTVEASTAEKIDAAMKHAGLLN
HHHEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA