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The map label for this gene is ccmE

Identifier: 110633252

GI number: 110633252

Start: 988269

End: 988703

Strand: Direct

Name: ccmE

Synonym: Meso_0898

Alternate gene names: 110633252

Gene position: 988269-988703 (Clockwise)

Preceding gene: 110633251

Following gene: 110633253

Centisome position: 22.4

GC content: 62.3

Gene sequence:

>435_bases
ATGACGCGCAAGCAGAAGCGGCTGGCGGTCATCGGTTCGGGAATGGGCTTTCTCGCCCTGGCCGCGGCATTGACCTTTTA
TGCGCTGGGGCAGCAGACGTCCTATTTCTACATGCCCTCGGACCTGCTGTCGCAGCCCGCGGCGGCGCAGGAACGCATCC
GGCTCGGCGGCCTTGTTCAGCAAGGTTCCGTCGAGCGAGGCCAGGGAACGCATGTGAGCTTTGTGGTGGCCGATGGCCAG
AACGGGGTGCCAGTGGTCTATGACGGCATTCTGCCTGACCTGTTCCGGGAGGAGCAAGGTGTCGTAATCGAGGGCAGGAT
GGGGCCCGACGGGGTCTTTGTCGCGGATACCGTCCTTGCGAAGCACGACGAGACCTATATGCCCCGTGAAGTGGCGGACA
GGCTGAAAAAGGACGGCCTTTGGCAGGAACAATGA

Upstream 100 bases:

>100_bases
TGGACCGGGGACTTTCCGCCCTTGGACCCGACTCGCCGGACGGCAAGGCTTTAAGTGAATTGGCCGGGACGCTCGGCCTC
ACAGACACGCAGGTGAATAA

Downstream 100 bases:

>100_bases
GAAAGGTCCGATGAGCGTCGAACTTGGCCATTTCGCACTCGTGCTGGCGCTGGCGCTGGCCTTGGTGCAGGCGCTGGTGC
CGCTCCTCGGCGCGCGCTTG

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 144; Mature: 143

Protein sequence:

>144_residues
MTRKQKRLAVIGSGMGFLALAAALTFYALGQQTSYFYMPSDLLSQPAAAQERIRLGGLVQQGSVERGQGTHVSFVVADGQ
NGVPVVYDGILPDLFREEQGVVIEGRMGPDGVFVADTVLAKHDETYMPREVADRLKKDGLWQEQ

Sequences:

>Translated_144_residues
MTRKQKRLAVIGSGMGFLALAAALTFYALGQQTSYFYMPSDLLSQPAAAQERIRLGGLVQQGSVERGQGTHVSFVVADGQ
NGVPVVYDGILPDLFREEQGVVIEGRMGPDGVFVADTVLAKHDETYMPREVADRLKKDGLWQEQ
>Mature_143_residues
TRKQKRLAVIGSGMGFLALAAALTFYALGQQTSYFYMPSDLLSQPAAAQERIRLGGLVQQGSVERGQGTHVSFVVADGQN
GVPVVYDGILPDLFREEQGVVIEGRMGPDGVFVADTVLAKHDETYMPREVADRLKKDGLWQEQ

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=143, Percent_Identity=39.1608391608392, Blast_Score=101, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_MESSB (Q11JY0)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673460.1
- ProteinModelPortal:   Q11JY0
- SMR:   Q11JY0
- STRING:   Q11JY0
- GeneID:   4182729
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0898
- NMPDR:   fig|266779.1.peg.3871
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- PhylomeDB:   Q11JY0
- ProtClustDB:   PRK13254
- BioCyc:   MSP266779:MESO_0898-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 15730; Mature: 15599

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: BINDING 122-122

Signals:

None

Transmembrane regions:

HASH(0x17a0b434)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRKQKRLAVIGSGMGFLALAAALTFYALGQQTSYFYMPSDLLSQPAAAQERIRLGGLVQ
CCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCHHHHCCCHHHHHHHHHCCEEC
QGSVERGQGTHVSFVVADGQNGVPVVYDGILPDLFREEQGVVIEGRMGPDGVFVADTVLA
CCCCCCCCCCEEEEEEECCCCCCCEEECCCCHHHHHCCCCEEEECCCCCCCEEEHHHHHH
KHDETYMPREVADRLKKDGLWQEQ
CCCCCCCCHHHHHHHHHCCCCCCH
>Mature Secondary Structure 
TRKQKRLAVIGSGMGFLALAAALTFYALGQQTSYFYMPSDLLSQPAAAQERIRLGGLVQ
CCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCHHHHCCCHHHHHHHHHCCEEC
QGSVERGQGTHVSFVVADGQNGVPVVYDGILPDLFREEQGVVIEGRMGPDGVFVADTVLA
CCCCCCCCCCEEEEEEECCCCCCCEEECCCCHHHHHCCCCEEEECCCCCCCEEEHHHHHH
KHDETYMPREVADRLKKDGLWQEQ
CCCCCCCCHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA