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The map label for this gene is phoQ [H]

Identifier: 110633249

GI number: 110633249

Start: 985111

End: 986496

Strand: Direct

Name: phoQ [H]

Synonym: Meso_0895

Alternate gene names: 110633249

Gene position: 985111-986496 (Clockwise)

Preceding gene: 110633248

Following gene: 110633250

Centisome position: 22.33

GC content: 60.25

Gene sequence:

>1386_bases
ATGCAGGCTTGGCTTACGAGCCTGCCGCGCCGGCTCACTTTCCGTGTCGTGCTCTTTTCGTCCGTTTGGGCGATAATCGC
GCTTGTGGTAATCGCGACGGTTATCTCAACCCTGTTCCGGCAGGTGAGCGAGCGCGGTTTCGACAATGTGCTTTCCGCGC
ATCTCTTCAACCTGATCGCTTCGGTGAGTGCGACCGAAGACGGCCGCCTGGTGGGGAGCCCCAACCTGGGCGATCTCAGG
TTTTCCGAACCGTTGTCGGGCTGGTATTGGTCCGTGGAACCAATCTCGACGGCGTTGCGCAATCAATTGCGCTCATCGTC
TCTGGTGATGCCGGTCAGATCCCCTTCCACTGCCGATGTTCAATTCGACCGCAACTTCCAGCGCAGCTATGTGGAGGAAG
GCCCGGGCGGGGAGCAGATCGAGGTTCTGGAAGCTGAAGTCGTGCTGGACCAGCTTGACCGCATCGCCCGCTTTCGCGTG
ATGGGCAATCGCAGCGAACTTGAACGGGAAATTTCGGATTTTGCTGGCCGACTCTATGCGTATCTCGGCATCTTCGGCCT
CGGAATGATCGCAATCAACGTCTTCGCTATTCTCATTGCGTTAAGGCCGTTGGGAAGCATCAGGAGCGCGCTTGCGAATA
TTCGGGCCGGAACGGCCGAACGGCTTTCCGGCCCTTTCCCGGCGGAAATCGCTCCGCTCGCTGAGGAGACGAATGCCCTG
ATCGAAAGCAATCGGCGCATCATCGAGCGGGCACGCACGCAAGTTGGGAATCTGGCCCACTCGCTGAAGACCCCGCTTGC
CGTGCTGATGAATGAGGGCAGGGCTCTCGGGGGGGAGCAGGGCGCACTCATCACCGGCCATACGGAGGCCATGCAGAAGC
AGATCGATCACTATCTGCAGCGTGCTCGCGCCGCGGCGCAGCGCAGTACGCTTGCAGCGCGAAGTCCCGTAAACCAGACA
CTGGCCCGCATGGCGCGCGTCGCCGAGAAGCTCAACCCGGACAAGAAGCTCCAGACGACGATGCCCGACACGGAAGTGGT
GTTCGCGGGCGAGCGAGAGGATTTGGAAGAGATCATCGGAAATCTTCTCGAAAACGCCATGAAATGGGCCGATCGGAATG
TGGTTCTTTGGTTGCAGCCGCTGCGGCTGGCTGATTCGCGAGGGCTTGGTTTTCGCGTCATGATCGAGGATGACGGACCT
GGAATTCCCGAAGACCAGGCGCGACAGGCGCTGAAACGCGGCCGCAGGCTCGACGAAAGTAAGCCGGGCACGGGTCTTGG
TCTCGCAATCGCCGCTGATCTGGTGAAGGAATATGGGGGAACGCTCGCCTTGGAGCGTTCCAGGCTTGGAGGACTCCGGG
CTGAAGTTGTATTGCCCGCGGCATGA

Upstream 100 bases:

>100_bases
GGCGTGGACCTGATAGAAACTGTGCGAGGCATGGGATACCGTATGCGCGAGCCGAATGACGGATGAGGCAGATCACGCGG
TAGCTCGCCCGGTGGCACGA

Downstream 100 bases:

>100_bases
GGTGGAGGCGGGAACGCGTGGACAAAATTCGGTCAAACATGAGCTATAGTCGCGGCGCTGTTTCGGCGGCGGAGGGTGAG
AGCGTATGAAGATATCAGCT

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MQAWLTSLPRRLTFRVVLFSSVWAIIALVVIATVISTLFRQVSERGFDNVLSAHLFNLIASVSATEDGRLVGSPNLGDLR
FSEPLSGWYWSVEPISTALRNQLRSSSLVMPVRSPSTADVQFDRNFQRSYVEEGPGGEQIEVLEAEVVLDQLDRIARFRV
MGNRSELEREISDFAGRLYAYLGIFGLGMIAINVFAILIALRPLGSIRSALANIRAGTAERLSGPFPAEIAPLAEETNAL
IESNRRIIERARTQVGNLAHSLKTPLAVLMNEGRALGGEQGALITGHTEAMQKQIDHYLQRARAAAQRSTLAARSPVNQT
LARMARVAEKLNPDKKLQTTMPDTEVVFAGEREDLEEIIGNLLENAMKWADRNVVLWLQPLRLADSRGLGFRVMIEDDGP
GIPEDQARQALKRGRRLDESKPGTGLGLAIAADLVKEYGGTLALERSRLGGLRAEVVLPAA

Sequences:

>Translated_461_residues
MQAWLTSLPRRLTFRVVLFSSVWAIIALVVIATVISTLFRQVSERGFDNVLSAHLFNLIASVSATEDGRLVGSPNLGDLR
FSEPLSGWYWSVEPISTALRNQLRSSSLVMPVRSPSTADVQFDRNFQRSYVEEGPGGEQIEVLEAEVVLDQLDRIARFRV
MGNRSELEREISDFAGRLYAYLGIFGLGMIAINVFAILIALRPLGSIRSALANIRAGTAERLSGPFPAEIAPLAEETNAL
IESNRRIIERARTQVGNLAHSLKTPLAVLMNEGRALGGEQGALITGHTEAMQKQIDHYLQRARAAAQRSTLAARSPVNQT
LARMARVAEKLNPDKKLQTTMPDTEVVFAGEREDLEEIIGNLLENAMKWADRNVVLWLQPLRLADSRGLGFRVMIEDDGP
GIPEDQARQALKRGRRLDESKPGTGLGLAIAADLVKEYGGTLALERSRLGGLRAEVVLPAA
>Mature_461_residues
MQAWLTSLPRRLTFRVVLFSSVWAIIALVVIATVISTLFRQVSERGFDNVLSAHLFNLIASVSATEDGRLVGSPNLGDLR
FSEPLSGWYWSVEPISTALRNQLRSSSLVMPVRSPSTADVQFDRNFQRSYVEEGPGGEQIEVLEAEVVLDQLDRIARFRV
MGNRSELEREISDFAGRLYAYLGIFGLGMIAINVFAILIALRPLGSIRSALANIRAGTAERLSGPFPAEIAPLAEETNAL
IESNRRIIERARTQVGNLAHSLKTPLAVLMNEGRALGGEQGALITGHTEAMQKQIDHYLQRARAAAQRSTLAARSPVNQT
LARMARVAEKLNPDKKLQTTMPDTEVVFAGEREDLEEIIGNLLENAMKWADRNVVLWLQPLRLADSRGLGFRVMIEDDGP
GIPEDQARQALKRGRRLDESKPGTGLGLAIAADLVKEYGGTLALERSRLGGLRAEVVLPAA

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=268, Percent_Identity=31.3432835820896, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1788393, Length=268, Percent_Identity=27.2388059701493, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1787894, Length=235, Percent_Identity=26.8085106382979, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790346, Length=247, Percent_Identity=26.7206477732794, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50635; Mature: 50635

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAWLTSLPRRLTFRVVLFSSVWAIIALVVIATVISTLFRQVSERGFDNVLSAHLFNLIA
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SVSATEDGRLVGSPNLGDLRFSEPLSGWYWSVEPISTALRNQLRSSSLVMPVRSPSTADV
HHCCCCCCEEECCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCE
QFDRNFQRSYVEEGPGGEQIEVLEAEVVLDQLDRIARFRVMGNRSELEREISDFAGRLYA
EECCCHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
YLGIFGLGMIAINVFAILIALRPLGSIRSALANIRAGTAERLSGPFPAEIAPLAEETNAL
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHH
IESNRRIIERARTQVGNLAHSLKTPLAVLMNEGRALGGEQGALITGHTEAMQKQIDHYLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECHHHHHHHHHHHHHH
RARAAAQRSTLAARSPVNQTLARMARVAEKLNPDKKLQTTMPDTEVVFAGEREDLEEIIG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEECCCHHHHHHHHH
NLLENAMKWADRNVVLWLQPLRLADSRGLGFRVMIEDDGPGIPEDQARQALKRGRRLDES
HHHHHHHHHCCCCEEEEEECHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCC
KPGTGLGLAIAADLVKEYGGTLALERSRLGGLRAEVVLPAA
CCCCCHHHHHHHHHHHHHCCCEEEEHHHHCCCEEEEEECCC
>Mature Secondary Structure
MQAWLTSLPRRLTFRVVLFSSVWAIIALVVIATVISTLFRQVSERGFDNVLSAHLFNLIA
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SVSATEDGRLVGSPNLGDLRFSEPLSGWYWSVEPISTALRNQLRSSSLVMPVRSPSTADV
HHCCCCCCEEECCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCE
QFDRNFQRSYVEEGPGGEQIEVLEAEVVLDQLDRIARFRVMGNRSELEREISDFAGRLYA
EECCCHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
YLGIFGLGMIAINVFAILIALRPLGSIRSALANIRAGTAERLSGPFPAEIAPLAEETNAL
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHH
IESNRRIIERARTQVGNLAHSLKTPLAVLMNEGRALGGEQGALITGHTEAMQKQIDHYLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECHHHHHHHHHHHHHH
RARAAAQRSTLAARSPVNQTLARMARVAEKLNPDKKLQTTMPDTEVVFAGEREDLEEIIG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEECCCHHHHHHHHH
NLLENAMKWADRNVVLWLQPLRLADSRGLGFRVMIEDDGPGIPEDQARQALKRGRRLDES
HHHHHHHHHCCCCEEEEEECHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCC
KPGTGLGLAIAADLVKEYGGTLALERSRLGGLRAEVVLPAA
CCCCCHHHHHHHHHHHHHCCCEEEEHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]