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The map label for this gene is dppA [H]

Identifier: 110632429

GI number: 110632429

Start: 90516

End: 92144

Strand: Reverse

Name: dppA [H]

Synonym: Meso_0067

Alternate gene names: 110632429

Gene position: 92144-90516 (Counterclockwise)

Preceding gene: 110632432

Following gene: 110632428

Centisome position: 2.09

GC content: 58.5

Gene sequence:

>1629_bases
ATGGCTCCAAATAAAGTTCGGGAGGTAATCCGCATGAAACCGAAAATGACGTTCGCTGCTGTACTTCTTGCCGCCACGAC
ATTGAGCGGCATGGCCGGCGCGAAGACCTTTGTCTACTGTTCGGAGGGCTCGCCCGAAGGATTCGATCCAGGTCTCTACA
CGGCTGGTACCACTTTCGATGCCGCGGCTCACACCGTCTATAACCGGCTGCTTGAATTTAAGCCGGGCACGACTGAAACC
GTGCCCGGGCTTGCCGAGAGCTGGGAAATTTCGGACGACGGCCTGCAATATACCTTCAAGCTGCGGCCGGGAGTGAAGTT
CCAGACGACAGATTTCTTCACCCCTACGCGCGACCTCAATGCCGATGACGTGATCTTCTCCTACGAGCGTCAGTGGAAAA
GCGATAACCCCTGGCATCAATACGTGACTGGCGCCTCCTGGGAATATTTCAACGGCATGGGCTTTCCGGACCTTATCGAG
TCGATCGAGAAGATCGATGACATGACGGTTCGCTTCACGCTCAAGCAACCGGAAGCGCCGTTCCTCGCCAATGTGGCGAT
GCCCTTCGCTTCGATCATGTCCAAGGAATACGCCGACAAGCTCGAAGCCGACGGCAAGATGCAGATGCTGAACCAGCAGC
CGCTTGGCACCGGCCCCTACGAGTTTGTCGCCTACCAGCAAGATGCTGTGATCCGATACCGGGCGCATGAAGACTATTGG
AATGGCCAGCAGAAGATCGACGACCTGGTTTTCGCAATCACGCCGGACGCTTCGGTGCGCTATCAGAAACTGACAGCCGG
CGAATGCCACCTCATGCCCTATCCGAACGCGGCCGACGTGGAGGACATGAAGGCGGATTCCAACCTGAAGGTGATGGAGC
AGGAGGGGCTGAACATCGCCTATCTCGCCTACAACACCACACAGGCGCCCTTCGATAAGCCGGAAGTGCGCAAGGCGTTG
AACATGGCGATCAACAAGCAGGCGATCGTCCATGCGGTGTTCCAGGGCATGGCGACGCCTGCAAAGAACCCAATTCCGCC
GACGATGTGGTCCTATAACGACTCCATCGAGGACGATCCCTACGATCCGGAAGCAGCCAAGAAGATGCTCGAAGAGGCGG
GCGTCAGCAATCTTTCCATGAAGGTGTGGGCGATGCCGGTGAGCCGGCCCTACATGCTGAACGCGCGCCGGGCGGCCGAG
CTTATCCAGTCCGACTTCCAGAAAGTCGGCGTGAATGTCGAGATCGTTTCCTATGAGTGGGCCGAATATCTCGACCGCTC
GAAGGAGAAGGACCGCGACGGAGCGGTGATCCTCGGCTGGACGGGCGACAACGGCGATCCCGACAACTTCCTGCACACCC
TGCTCGGCTGCGATGCCGTGGGCGGAAACAACCGCGCACAATGGTGCAACGAGGAGTTCAACAACCTCGTGATGCAGGCA
AAGCAGGCTTCCGATCAGGCGGAACGCACCAGACTCTACGAAGAGGCTCAGGTGGTCTTCAAGCGCGAGGCACCGTGGGC
GACGCTCGACCACTCGCTGTCGATCGTGCCGATGCGCAAGGAGGTTGAAGGTTTCGTGCAGAGTCCGCTCGGCGATTTCG
CCTTCGAAGGCGTCGACCTGGCCGAATAA

Upstream 100 bases:

>100_bases
AAAATTTACGCCGCAGAATGATTTTGTAGGCTGCTATTCTAGAGGGAGTTTTCCTACCGGAAAAATCTTGCTTATATTGC
TTCAGGGGGCCGCGTGGGAA

Downstream 100 bases:

>100_bases
ATTGCTTTGCGAGGCAAATGTGAGGCGCGTCGGGAAACCGGCGCGCTTCTTTTCGATTATGACTGAGAAGCAGCCCTTTT
CGGGCCTATGGTTCTGACCA

Product: extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MAPNKVREVIRMKPKMTFAAVLLAATTLSGMAGAKTFVYCSEGSPEGFDPGLYTAGTTFDAAAHTVYNRLLEFKPGTTET
VPGLAESWEISDDGLQYTFKLRPGVKFQTTDFFTPTRDLNADDVIFSYERQWKSDNPWHQYVTGASWEYFNGMGFPDLIE
SIEKIDDMTVRFTLKQPEAPFLANVAMPFASIMSKEYADKLEADGKMQMLNQQPLGTGPYEFVAYQQDAVIRYRAHEDYW
NGQQKIDDLVFAITPDASVRYQKLTAGECHLMPYPNAADVEDMKADSNLKVMEQEGLNIAYLAYNTTQAPFDKPEVRKAL
NMAINKQAIVHAVFQGMATPAKNPIPPTMWSYNDSIEDDPYDPEAAKKMLEEAGVSNLSMKVWAMPVSRPYMLNARRAAE
LIQSDFQKVGVNVEIVSYEWAEYLDRSKEKDRDGAVILGWTGDNGDPDNFLHTLLGCDAVGGNNRAQWCNEEFNNLVMQA
KQASDQAERTRLYEEAQVVFKREAPWATLDHSLSIVPMRKEVEGFVQSPLGDFAFEGVDLAE

Sequences:

>Translated_542_residues
MAPNKVREVIRMKPKMTFAAVLLAATTLSGMAGAKTFVYCSEGSPEGFDPGLYTAGTTFDAAAHTVYNRLLEFKPGTTET
VPGLAESWEISDDGLQYTFKLRPGVKFQTTDFFTPTRDLNADDVIFSYERQWKSDNPWHQYVTGASWEYFNGMGFPDLIE
SIEKIDDMTVRFTLKQPEAPFLANVAMPFASIMSKEYADKLEADGKMQMLNQQPLGTGPYEFVAYQQDAVIRYRAHEDYW
NGQQKIDDLVFAITPDASVRYQKLTAGECHLMPYPNAADVEDMKADSNLKVMEQEGLNIAYLAYNTTQAPFDKPEVRKAL
NMAINKQAIVHAVFQGMATPAKNPIPPTMWSYNDSIEDDPYDPEAAKKMLEEAGVSNLSMKVWAMPVSRPYMLNARRAAE
LIQSDFQKVGVNVEIVSYEWAEYLDRSKEKDRDGAVILGWTGDNGDPDNFLHTLLGCDAVGGNNRAQWCNEEFNNLVMQA
KQASDQAERTRLYEEAQVVFKREAPWATLDHSLSIVPMRKEVEGFVQSPLGDFAFEGVDLAE
>Mature_541_residues
APNKVREVIRMKPKMTFAAVLLAATTLSGMAGAKTFVYCSEGSPEGFDPGLYTAGTTFDAAAHTVYNRLLEFKPGTTETV
PGLAESWEISDDGLQYTFKLRPGVKFQTTDFFTPTRDLNADDVIFSYERQWKSDNPWHQYVTGASWEYFNGMGFPDLIES
IEKIDDMTVRFTLKQPEAPFLANVAMPFASIMSKEYADKLEADGKMQMLNQQPLGTGPYEFVAYQQDAVIRYRAHEDYWN
GQQKIDDLVFAITPDASVRYQKLTAGECHLMPYPNAADVEDMKADSNLKVMEQEGLNIAYLAYNTTQAPFDKPEVRKALN
MAINKQAIVHAVFQGMATPAKNPIPPTMWSYNDSIEDDPYDPEAAKKMLEEAGVSNLSMKVWAMPVSRPYMLNARRAAEL
IQSDFQKVGVNVEIVSYEWAEYLDRSKEKDRDGAVILGWTGDNGDPDNFLHTLLGCDAVGGNNRAQWCNEEFNNLVMQAK
QASDQAERTRLYEEAQVVFKREAPWATLDHSLSIVPMRKEVEGFVQSPLGDFAFEGVDLAE

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=530, Percent_Identity=53.3962264150943, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI1787551, Length=541, Percent_Identity=36.2292051756007, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1787052, Length=469, Percent_Identity=32.409381663113, Blast_Score=203, Evalue=3e-53,
Organism=Escherichia coli, GI1787762, Length=544, Percent_Identity=26.4705882352941, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789397, Length=514, Percent_Identity=25.6809338521401, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1789887, Length=520, Percent_Identity=22.8846153846154, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787495, Length=481, Percent_Identity=24.7401247401247, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 60904; Mature: 60773

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPNKVREVIRMKPKMTFAAVLLAATTLSGMAGAKTFVYCSEGSPEGFDPGLYTAGTTFD
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEECCCCHH
AAAHTVYNRLLEFKPGTTETVPGLAESWEISDDGLQYTFKLRPGVKFQTTDFFTPTRDLN
HHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCC
ADDVIFSYERQWKSDNPWHQYVTGASWEYFNGMGFPDLIESIEKIDDMTVRFTLKQPEAP
CCCEEEEEHHHCCCCCCHHHHHCCCCCHHHCCCCCHHHHHHHHHHCCEEEEEEECCCCCC
FLANVAMPFASIMSKEYADKLEADGKMQMLNQQPLGTGPYEFVAYQQDAVIRYRAHEDYW
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCHHEEEECCCCEEEEECCCCCC
NGQQKIDDLVFAITPDASVRYQKLTAGECHLMPYPNAADVEDMKADSNLKVMEQEGLNIA
CCHHHHCCEEEEECCCCCCEEEEECCCCEEEECCCCCCCHHHHCCCCCCEEECCCCCEEE
YLAYNTTQAPFDKPEVRKALNMAINKQAIVHAVFQGMATPAKNPIPPTMWSYNDSIEDDP
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
YDPEAAKKMLEEAGVSNLSMKVWAMPVSRPYMLNARRAAELIQSDFQKVGVNVEIVSYEW
CCHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECHHHHHHHHHHHHHHHCCCEEEEEEHH
AEYLDRSKEKDRDGAVILGWTGDNGDPDNFLHTLLGCDAVGGNNRAQWCNEEFNNLVMQA
HHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
KQASDQAERTRLYEEAQVVFKREAPWATLDHSLSIVPMRKEVEGFVQSPLGDFAFEGVDL
HHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEECHHHHHHHHHCCCHHHHCCCCCC
AE
CC
>Mature Secondary Structure 
APNKVREVIRMKPKMTFAAVLLAATTLSGMAGAKTFVYCSEGSPEGFDPGLYTAGTTFD
CCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEECCCCHH
AAAHTVYNRLLEFKPGTTETVPGLAESWEISDDGLQYTFKLRPGVKFQTTDFFTPTRDLN
HHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCC
ADDVIFSYERQWKSDNPWHQYVTGASWEYFNGMGFPDLIESIEKIDDMTVRFTLKQPEAP
CCCEEEEEHHHCCCCCCHHHHHCCCCCHHHCCCCCHHHHHHHHHHCCEEEEEEECCCCCC
FLANVAMPFASIMSKEYADKLEADGKMQMLNQQPLGTGPYEFVAYQQDAVIRYRAHEDYW
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCHHEEEECCCCEEEEECCCCCC
NGQQKIDDLVFAITPDASVRYQKLTAGECHLMPYPNAADVEDMKADSNLKVMEQEGLNIA
CCHHHHCCEEEEECCCCCCEEEEECCCCEEEECCCCCCCHHHHCCCCCCEEECCCCCEEE
YLAYNTTQAPFDKPEVRKALNMAINKQAIVHAVFQGMATPAKNPIPPTMWSYNDSIEDDP
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
YDPEAAKKMLEEAGVSNLSMKVWAMPVSRPYMLNARRAAELIQSDFQKVGVNVEIVSYEW
CCHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECHHHHHHHHHHHHHHHCCCEEEEEEHH
AEYLDRSKEKDRDGAVILGWTGDNGDPDNFLHTLLGCDAVGGNNRAQWCNEEFNNLVMQA
HHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
KQASDQAERTRLYEEAQVVFKREAPWATLDHSLSIVPMRKEVEGFVQSPLGDFAFEGVDL
HHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEECHHHHHHHHHCCCHHHHCCCCCC
AE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]