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The map label for this gene is pgi

Identifier: 110632432

GI number: 110632432

Start: 95315

End: 96952

Strand: Reverse

Name: pgi

Synonym: Meso_0070

Alternate gene names: 110632432

Gene position: 96952-95315 (Counterclockwise)

Preceding gene: 110632434

Following gene: 110632429

Centisome position: 2.2

GC content: 63.0

Gene sequence:

>1638_bases
ATGAGCGCCTACGCCCGAGCCCTGGACGCGCTGCGGCAACATCGTCGCGAGACCGAGGACTTCGATCTGCGGCAGGCATT
TGGTGCCGACCCCGACCGCTTCTCCCGCTGCTCGGCTGCGCTCGACGACATGCTTCTCGATTATTCCAAATGCGCGGTGA
GCGACGAAACGCTGGCATTGCTCGACAAGATCGCGGAGGCGGCGGGCGTGATCGAGCGGCGCGAGGAGATGTTTTCGGCC
AAGCGAATCAACGTCACCGAGAACCGGGCCGTGCTGCACACGGCGCTTCGCAATGATTCAACCCGGCCAGTAATGCTCGA
CGGCAAGGACGTGATGCCGGATGTGGAGGCCGTGCTTGCTGCGATGAGCACTTTTTCCGAGGGCATCCGCAGCGGGACGA
TCAAGGCTGCAACCGGCAAGTCCTTCACCGACGTGGTGAATATCGGCATCGGCGGGTCCGATCTTGGGCCGGCCATGGCA
ACGCTGGCGCTCGCCCCTTATCATGACGGGCCGCGGCTCCATTACGTCTCCAATGTGGACGGGGCGCATATCCACGACAC
CCTGAAAGCGCTCGACCCGGATACGACGCTATTCATCATCGCGTCGAAGACCTTCACGACCATCGAGACAATGACGAATG
CCGGCACCGCGCGCTCGTGGATCGCGGAGAAGCTGGGGCAGGATGCGGTAGGCTCGCATTTTGCGGCCGTTTCGACCGCA
CTCGACAAGGTGGCGGCCTTCGGCATCGACGAGAGCCGCGTCTTTGGCTTCTGGGATTGGGTGGGCGGCCGTTATTCGCT
CTGGTCGGCGATCGGCCTGCCCATCATGATCGCCATAGGGCCGGAAAACTTCCGGCGGTTCCTGGACGGCGCGGAGCTGA
TGGACCGGCATTTCCGCGAGGCGCCGTCGCGCGAGAACTTGCCGATGATGCTGGGCCTGATCGGCTTTTGGCATCGGGTG
ATCTGCGGCTATCCGGCACGCGCGGTCATCCCATACGATCAGCGGCTCGCGCGGCTGCCGGCCTATCTGCAGCAACTCGA
TATGGAATCGAACGGCAAACGCGTCACCTTCGAGGGTGAGTCGGTGACTGTTCCGACTGGGCCGCTTGTCTGGGGCGAGC
CCGGCACCAACGGCCAGCACGCCTTTTTCCAGCTCCTGCATCAAGGCACGGACATCATTCCCGTGGAGTTCATGATTGCC
GCAAGGGGGCATGAGCCGGAACTGAAGCATCACCACGACCTGCTTATCGCCAACTGCCTGGCGCAATCGGAAGCATTGAT
GAAGGGCCGGACGCTGCAGGAGGCCAAGGCGCAGCTCCTGGCGAAAGGCATGAGCGAGGCGGAGGCAGACAAGCTAGCCC
CGCACCGCGTCTTCCCCGGCAACCGGCCCTCTGTCACCATCATCTATGAGAAGCTCGACCCCTTTACACTCGGCCGCCTG
ATCGCGCTCTACGAGCACAGGGTGTTCGTCGAAGCGGCGCTCTTCCGCATCAATGCCTTCGATCAATGGGGCGTGGAGCT
GGGCAAGGAGCTTGCGACCGAGCTTCTGCCCGTCGTGGAAGGAAAGAAGGATGCGTCCGGGCGTGATTCCTCGACGGCGG
GGCTCGTCGCCCAGATCGCGGCATTACGTGATTCATAG

Upstream 100 bases:

>100_bases
ACCGCAACCCTGGTCCAAGCGATTAAGCCAGAGGGCTGCTTCACTTTTGCCGTTCGGCCCCCTAAGTTTCGGCTCCACCC
AGAAGAGGAGATCGACGTTC

Downstream 100 bases:

>100_bases
TCTGGAGGTCAGCCGGCCCCTTGGCAGAAAAAAGCCGTTCAACATGTTAGCTTAAAGTGAAACTAAGCTAAGGGTTGGAT
CGCGAGTGAAGGGGGCTTAC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MSAYARALDALRQHRRETEDFDLRQAFGADPDRFSRCSAALDDMLLDYSKCAVSDETLALLDKIAEAAGVIERREEMFSA
KRINVTENRAVLHTALRNDSTRPVMLDGKDVMPDVEAVLAAMSTFSEGIRSGTIKAATGKSFTDVVNIGIGGSDLGPAMA
TLALAPYHDGPRLHYVSNVDGAHIHDTLKALDPDTTLFIIASKTFTTIETMTNAGTARSWIAEKLGQDAVGSHFAAVSTA
LDKVAAFGIDESRVFGFWDWVGGRYSLWSAIGLPIMIAIGPENFRRFLDGAELMDRHFREAPSRENLPMMLGLIGFWHRV
ICGYPARAVIPYDQRLARLPAYLQQLDMESNGKRVTFEGESVTVPTGPLVWGEPGTNGQHAFFQLLHQGTDIIPVEFMIA
ARGHEPELKHHHDLLIANCLAQSEALMKGRTLQEAKAQLLAKGMSEAEADKLAPHRVFPGNRPSVTIIYEKLDPFTLGRL
IALYEHRVFVEAALFRINAFDQWGVELGKELATELLPVVEGKKDASGRDSSTAGLVAQIAALRDS

Sequences:

>Translated_545_residues
MSAYARALDALRQHRRETEDFDLRQAFGADPDRFSRCSAALDDMLLDYSKCAVSDETLALLDKIAEAAGVIERREEMFSA
KRINVTENRAVLHTALRNDSTRPVMLDGKDVMPDVEAVLAAMSTFSEGIRSGTIKAATGKSFTDVVNIGIGGSDLGPAMA
TLALAPYHDGPRLHYVSNVDGAHIHDTLKALDPDTTLFIIASKTFTTIETMTNAGTARSWIAEKLGQDAVGSHFAAVSTA
LDKVAAFGIDESRVFGFWDWVGGRYSLWSAIGLPIMIAIGPENFRRFLDGAELMDRHFREAPSRENLPMMLGLIGFWHRV
ICGYPARAVIPYDQRLARLPAYLQQLDMESNGKRVTFEGESVTVPTGPLVWGEPGTNGQHAFFQLLHQGTDIIPVEFMIA
ARGHEPELKHHHDLLIANCLAQSEALMKGRTLQEAKAQLLAKGMSEAEADKLAPHRVFPGNRPSVTIIYEKLDPFTLGRL
IALYEHRVFVEAALFRINAFDQWGVELGKELATELLPVVEGKKDASGRDSSTAGLVAQIAALRDS
>Mature_544_residues
SAYARALDALRQHRRETEDFDLRQAFGADPDRFSRCSAALDDMLLDYSKCAVSDETLALLDKIAEAAGVIERREEMFSAK
RINVTENRAVLHTALRNDSTRPVMLDGKDVMPDVEAVLAAMSTFSEGIRSGTIKAATGKSFTDVVNIGIGGSDLGPAMAT
LALAPYHDGPRLHYVSNVDGAHIHDTLKALDPDTTLFIIASKTFTTIETMTNAGTARSWIAEKLGQDAVGSHFAAVSTAL
DKVAAFGIDESRVFGFWDWVGGRYSLWSAIGLPIMIAIGPENFRRFLDGAELMDRHFREAPSRENLPMMLGLIGFWHRVI
CGYPARAVIPYDQRLARLPAYLQQLDMESNGKRVTFEGESVTVPTGPLVWGEPGTNGQHAFFQLLHQGTDIIPVEFMIAA
RGHEPELKHHHDLLIANCLAQSEALMKGRTLQEAKAQLLAKGMSEAEADKLAPHRVFPGNRPSVTIIYEKLDPFTLGRLI
ALYEHRVFVEAALFRINAFDQWGVELGKELATELLPVVEGKKDASGRDSSTAGLVAQIAALRDS

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=541, Percent_Identity=51.7560073937153, Blast_Score=576, Evalue=1e-164,
Organism=Homo sapiens, GI296080693, Length=541, Percent_Identity=48.2439926062847, Blast_Score=522, Evalue=1e-148,
Organism=Escherichia coli, GI1790457, Length=539, Percent_Identity=51.9480519480519, Blast_Score=575, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI71996708, Length=536, Percent_Identity=52.2388059701493, Blast_Score=560, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI71996703, Length=536, Percent_Identity=52.2388059701493, Blast_Score=560, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6319673, Length=534, Percent_Identity=48.689138576779, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24651916, Length=530, Percent_Identity=52.8301886792453, Blast_Score=573, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24651914, Length=530, Percent_Identity=52.8301886792453, Blast_Score=573, Evalue=1e-163,
Organism=Drosophila melanogaster, GI17737445, Length=530, Percent_Identity=52.8301886792453, Blast_Score=573, Evalue=1e-163,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_MESSB (Q11MA0)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_672640.1
- ProteinModelPortal:   Q11MA0
- SMR:   Q11MA0
- STRING:   Q11MA0
- GeneID:   4179514
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0070
- NMPDR:   fig|266779.1.peg.3229
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   RIANEPA
- PhylomeDB:   Q11MA0
- ProtClustDB:   PRK00179
- BioCyc:   MSP266779:MESO_0070-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 59799; Mature: 59668

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 349-349 ACT_SITE 380-380 ACT_SITE 509-509

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAYARALDALRQHRRETEDFDLRQAFGADPDRFSRCSAALDDMLLDYSKCAVSDETLAL
CCHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LDKIAEAAGVIERREEMFSAKRINVTENRAVLHTALRNDSTRPVMLDGKDVMPDVEAVLA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
AMSTFSEGIRSGTIKAATGKSFTDVVNIGIGGSDLGPAMATLALAPYHDGPRLHYVSNVD
HHHHHHHHHHCCCEEECCCCCCHHHEEECCCCCCHHHHHHHHEECCCCCCCCEEEECCCC
GAHIHDTLKALDPDTTLFIIASKTFTTIETMTNAGTARSWIAEKLGQDAVGSHFAAVSTA
CCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHH
LDKVAAFGIDESRVFGFWDWVGGRYSLWSAIGLPIMIAIGPENFRRFLDGAELMDRHFRE
HHHHHHCCCCCCCEEEEHHCCCCCHHHHHHCCCCEEEEECHHHHHHHHCHHHHHHHHHHH
APSRENLPMMLGLIGFWHRVICGYPARAVIPYDQRLARLPAYLQQLDMESNGKRVTFEGE
CCCCCCCHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCC
SVTVPTGPLVWGEPGTNGQHAFFQLLHQGTDIIPVEFMIAARGHEPELKHHHDLLIANCL
EEECCCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHH
AQSEALMKGRTLQEAKAQLLAKGMSEAEADKLAPHRVFPGNRPSVTIIYEKLDPFTLGRL
HHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHH
IALYEHRVFVEAALFRINAFDQWGVELGKELATELLPVVEGKKDASGRDSSTAGLVAQIA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
ALRDS
HHHCC
>Mature Secondary Structure 
SAYARALDALRQHRRETEDFDLRQAFGADPDRFSRCSAALDDMLLDYSKCAVSDETLAL
CHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LDKIAEAAGVIERREEMFSAKRINVTENRAVLHTALRNDSTRPVMLDGKDVMPDVEAVLA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
AMSTFSEGIRSGTIKAATGKSFTDVVNIGIGGSDLGPAMATLALAPYHDGPRLHYVSNVD
HHHHHHHHHHCCCEEECCCCCCHHHEEECCCCCCHHHHHHHHEECCCCCCCCEEEECCCC
GAHIHDTLKALDPDTTLFIIASKTFTTIETMTNAGTARSWIAEKLGQDAVGSHFAAVSTA
CCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHH
LDKVAAFGIDESRVFGFWDWVGGRYSLWSAIGLPIMIAIGPENFRRFLDGAELMDRHFRE
HHHHHHCCCCCCCEEEEHHCCCCCHHHHHHCCCCEEEEECHHHHHHHHCHHHHHHHHHHH
APSRENLPMMLGLIGFWHRVICGYPARAVIPYDQRLARLPAYLQQLDMESNGKRVTFEGE
CCCCCCCHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCC
SVTVPTGPLVWGEPGTNGQHAFFQLLHQGTDIIPVEFMIAARGHEPELKHHHDLLIANCL
EEECCCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHH
AQSEALMKGRTLQEAKAQLLAKGMSEAEADKLAPHRVFPGNRPSVTIIYEKLDPFTLGRL
HHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHH
IALYEHRVFVEAALFRINAFDQWGVELGKELATELLPVVEGKKDASGRDSSTAGLVAQIA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
ALRDS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA