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The map label for this gene is lysC [H]

Identifier: 109948124

GI number: 109948124

Start: 1432625

End: 1433842

Strand: Reverse

Name: lysC [H]

Synonym: Hac_1646

Alternate gene names: 109948124

Gene position: 1433842-1432625 (Counterclockwise)

Preceding gene: 109948125

Following gene: 109948123

Centisome position: 92.27

GC content: 43.76

Gene sequence:

>1218_bases
GTGTTAATCGTTCAAAAATATGGCGGCACGAGCATGGGCAGTGTGGAAAGGATCCACAATGTCGCCCAAAGGGTTTTAGA
AAGCGTTAAGTTAGGGCATCAGGTGGTGGTAATCGTTTCTGCGATGAGCGGCGAAACGGACCGGCTTTTAGAATTTGGCA
AGAATTTTAGCCATAACCCTAGCAAGCGAGAAATGGATAGGATCGTAAGCGTGGGGGAATTGATTTCAAGTGCGGCTTTG
AGCATGGCGTTAGAGAGATATGGGTATAAAGCCATTTCATTGAGTGGGAAAGAAGCGGGCATTCTAACCAACTCGCATTT
TCAAAGCGCTGTGATCCAATCCATTGATAACAAACGCATTAGAGAACTTTTGGAAAAAAACTACATTGTGGTGATCGCTG
GGTTTCAAGGTGCTGATACTCATGGCGAAACGACGACTTTAGGGCGTGGGGGGAGCGATTTGAGTGCGGTCGCTTTAGCT
GGGGCTTTAAAAGCGGATTTGTGTGAAATTTATACCGATGTGGATGGCGTTTATACCACCGATCCGCGCATTGAAGAAAA
GGCTCAAAAAATCGCGCAAATCAGCTATGATGAAATGCTTGAATTGGCTTCTATGGGGGCTAAAGTTTTGTTAAACCGAT
CAGTGGAATTAGCTAAAAAACTCAGCGTGAAATTAGTGACTCGCAACTCGTTTAATCATAGCGAAGGCACGCTCATTGTG
GCTGAAAAAGACTTTAAAGGAGAACGCATGGAAACCCCTATTGTGAGTGGGATCGCACTGGATAAAAATCAAGCTCGTGT
GAGCATGGAGGGCGTGGAAGACAGGCCTGGCATTGCCGCAGAAATCTTTGGTGCTTTAGCGGAGTATCGCATCAATGTGG
ATATGATAGTCCAAACGATCGGCAGAGACGGCAAAACGGATTTGGATTTCACTATCGTTAAAACCCAAATAGAAGAGACC
AAATACGCCCTAAAGCCTTTTTTATCGCAGATTGACTCCATTGATTATGATGAAAATATCGCTAAAGTTTCCATAGTGGG
CGTGGGCATGAAATCGCATTCTGGGGTGGCGAGCACCGCTTTTAAAGCCCTAGCAAAAGACAATATCAATATCATGATGA
TTTCTACAAGCGAAATTAAAATTTCTGTTTTAATTGATATTAAATACGCGGAATTAGCCGTTAGAACTTTGCATGCGGTG
TATGAATTAGACAAATGA

Upstream 100 bases:

>100_bases
AGTTCATTCATTTAAAGGATTTGCTTAAAAAAATTGTTCCCTTTAAGCGTCAAGTGTATCGCCAAGTCATCGCTTATTTT
AGAAGAGAGGGGTATTTGGG

Downstream 100 bases:

>100_bases
AAGATTTCTATGATTGGATCAGGGAATTTGTGCGCGATCAGGGTGAGTTTATTGCCCAACAAAGTGGGTGGTTAGAATTA
GAGCGTTCAAGCTATGCAAA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MLIVQKYGGTSMGSVERIHNVAQRVLESVKLGHQVVVIVSAMSGETDRLLEFGKNFSHNPSKREMDRIVSVGELISSAAL
SMALERYGYKAISLSGKEAGILTNSHFQSAVIQSIDNKRIRELLEKNYIVVIAGFQGADTHGETTTLGRGGSDLSAVALA
GALKADLCEIYTDVDGVYTTDPRIEEKAQKIAQISYDEMLELASMGAKVLLNRSVELAKKLSVKLVTRNSFNHSEGTLIV
AEKDFKGERMETPIVSGIALDKNQARVSMEGVEDRPGIAAEIFGALAEYRINVDMIVQTIGRDGKTDLDFTIVKTQIEET
KYALKPFLSQIDSIDYDENIAKVSIVGVGMKSHSGVASTAFKALAKDNINIMMISTSEIKISVLIDIKYAELAVRTLHAV
YELDK

Sequences:

>Translated_405_residues
MLIVQKYGGTSMGSVERIHNVAQRVLESVKLGHQVVVIVSAMSGETDRLLEFGKNFSHNPSKREMDRIVSVGELISSAAL
SMALERYGYKAISLSGKEAGILTNSHFQSAVIQSIDNKRIRELLEKNYIVVIAGFQGADTHGETTTLGRGGSDLSAVALA
GALKADLCEIYTDVDGVYTTDPRIEEKAQKIAQISYDEMLELASMGAKVLLNRSVELAKKLSVKLVTRNSFNHSEGTLIV
AEKDFKGERMETPIVSGIALDKNQARVSMEGVEDRPGIAAEIFGALAEYRINVDMIVQTIGRDGKTDLDFTIVKTQIEET
KYALKPFLSQIDSIDYDENIAKVSIVGVGMKSHSGVASTAFKALAKDNINIMMISTSEIKISVLIDIKYAELAVRTLHAV
YELDK
>Mature_405_residues
MLIVQKYGGTSMGSVERIHNVAQRVLESVKLGHQVVVIVSAMSGETDRLLEFGKNFSHNPSKREMDRIVSVGELISSAAL
SMALERYGYKAISLSGKEAGILTNSHFQSAVIQSIDNKRIRELLEKNYIVVIAGFQGADTHGETTTLGRGGSDLSAVALA
GALKADLCEIYTDVDGVYTTDPRIEEKAQKIAQISYDEMLELASMGAKVLLNRSVELAKKLSVKLVTRNSFNHSEGTLIV
AEKDFKGERMETPIVSGIALDKNQARVSMEGVEDRPGIAAEIFGALAEYRINVDMIVQTIGRDGKTDLDFTIVKTQIEET
KYALKPFLSQIDSIDYDENIAKVSIVGVGMKSHSGVASTAFKALAKDNINIMMISTSEIKISVLIDIKYAELAVRTLHAV
YELDK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=345, Percent_Identity=33.9130434782609, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1790455, Length=273, Percent_Identity=31.5018315018315, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790376, Length=172, Percent_Identity=29.6511627906977, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320893, Length=500, Percent_Identity=27, Blast_Score=101, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44211; Mature: 44211

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIVQKYGGTSMGSVERIHNVAQRVLESVKLGHQVVVIVSAMSGETDRLLEFGKNFSHNP
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHCCCCCCCC
SKREMDRIVSVGELISSAALSMALERYGYKAISLSGKEAGILTNSHFQSAVIQSIDNKRI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEECHHHHHHHHHHHCHHHH
RELLEKNYIVVIAGFQGADTHGETTTLGRGGSDLSAVALAGALKADLCEIYTDVDGVYTT
HHHHHCCEEEEEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEC
DPRIEEKAQKIAQISYDEMLELASMGAKVLLNRSVELAKKLSVKLVTRNSFNHSEGTLIV
CCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHCCHHHHHHCEEEEEEECCCCCCCCEEEE
AEKDFKGERMETPIVSGIALDKNQARVSMEGVEDRPGIAAEIFGALAEYRINVDMIVQTI
EECCCCCCCCCCCCCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
GRDGKTDLDFTIVKTQIEETKYALKPFLSQIDSIDYDENIAKVSIVGVGMKSHSGVASTA
CCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHH
FKALAKDNINIMMISTSEIKISVLIDIKYAELAVRTLHAVYELDK
HHHHHHCCCEEEEEECCCEEEEEEEEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLIVQKYGGTSMGSVERIHNVAQRVLESVKLGHQVVVIVSAMSGETDRLLEFGKNFSHNP
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHCCCCCCCC
SKREMDRIVSVGELISSAALSMALERYGYKAISLSGKEAGILTNSHFQSAVIQSIDNKRI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEECHHHHHHHHHHHCHHHH
RELLEKNYIVVIAGFQGADTHGETTTLGRGGSDLSAVALAGALKADLCEIYTDVDGVYTT
HHHHHCCEEEEEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEC
DPRIEEKAQKIAQISYDEMLELASMGAKVLLNRSVELAKKLSVKLVTRNSFNHSEGTLIV
CCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHCCHHHHHHCEEEEEEECCCCCCCCEEEE
AEKDFKGERMETPIVSGIALDKNQARVSMEGVEDRPGIAAEIFGALAEYRINVDMIVQTI
EECCCCCCCCCCCCCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
GRDGKTDLDFTIVKTQIEETKYALKPFLSQIDSIDYDENIAKVSIVGVGMKSHSGVASTA
CCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHH
FKALAKDNINIMMISTSEIKISVLIDIKYAELAVRTLHAVYELDK
HHHHHHCCCEEEEEECCCEEEEEEEEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]