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The map label for this gene is nudA

Identifier: 109948125

GI number: 109948125

Start: 1433836

End: 1434309

Strand: Reverse

Name: nudA

Synonym: Hac_1647

Alternate gene names: 109948125

Gene position: 1434309-1433836 (Counterclockwise)

Preceding gene: 109948126

Following gene: 109948124

Centisome position: 92.3

GC content: 40.51

Gene sequence:

>474_bases
ATGTTGCATAAGAAATATCGTCCTAATGTTGCGGCTATTATTATGTCGCCAAACTACCCTAATACATGCGAAGTTTTTAT
CGCTGAGCGTGTGGATATTGAAGGGGCTTGGCAATTCCCCCAAGGGGGCATTGACGAGGGCGAGACCCCTTTAGAAGCGC
TTTATAGGGAATTGTTAGAAGAAATTGGCACCAATGAAATAGAGGTTTTAGCGCAATACCCTAGATGGATCGCCTATGAT
TTCCCAAGCAACATGGAACATAACTTCTATTCCTTTGATGGGCAAAAACAACGCTATTTTTTAGTGCGCCTAAAGCATGC
GAATAGCATTGATTTAAACAAACACACGCCAGAATTTAGGACTTATCAGTTCATTCATTTAAAGGATTTGCTTAAAAAAA
TTGTTCCCTTTAAGCGTCAAGTGTATCGCCAAGTCATCGCTTATTTTAGAAGAGAGGGGTATTTGGGGTGTTAA

Upstream 100 bases:

>100_bases
TTCTTATTCTTGTTTTTCATTGCATTCTTAACCCTACTTAAAGCTAGCATACACTATAATACGATCTTAATCAAACAAGA
AAGAGCTGAAACCAAGACCT

Downstream 100 bases:

>100_bases
TCGTTCAAAAATATGGCGGCACGAGCATGGGCAGTGTGGAAAGGATCCACAATGTCGCCCAAAGGGTTTTAGAAAGCGTT
AAGTTAGGGCATCAGGTGGT

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MLHKKYRPNVAAIIMSPNYPNTCEVFIAERVDIEGAWQFPQGGIDEGETPLEALYRELLEEIGTNEIEVLAQYPRWIAYD
FPSNMEHNFYSFDGQKQRYFLVRLKHANSIDLNKHTPEFRTYQFIHLKDLLKKIVPFKRQVYRQVIAYFRREGYLGC

Sequences:

>Translated_157_residues
MLHKKYRPNVAAIIMSPNYPNTCEVFIAERVDIEGAWQFPQGGIDEGETPLEALYRELLEEIGTNEIEVLAQYPRWIAYD
FPSNMEHNFYSFDGQKQRYFLVRLKHANSIDLNKHTPEFRTYQFIHLKDLLKKIVPFKRQVYRQVIAYFRREGYLGC
>Mature_157_residues
MLHKKYRPNVAAIIMSPNYPNTCEVFIAERVDIEGAWQFPQGGIDEGETPLEALYRELLEEIGTNEIEVLAQYPRWIAYD
FPSNMEHNFYSFDGQKQRYFLVRLKHANSIDLNKHTPEFRTYQFIHLKDLLKKIVPFKRQVYRQVIAYFRREGYLGC

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=154, Percent_Identity=35.0649350649351, Blast_Score=90, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_HELAH (Q17VH2)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_665353.1
- ProteinModelPortal:   Q17VH2
- SMR:   Q17VH2
- STRING:   Q17VH2
- GeneID:   4177451
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_1647
- NMPDR:   fig|382638.8.peg.1594
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- PhylomeDB:   Q17VH2
- ProtClustDB:   PRK00714
- BioCyc:   HACI382638:HAC_1647-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18697; Mature: 18697

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHKKYRPNVAAIIMSPNYPNTCEVFIAERVDIEGAWQFPQGGIDEGETPLEALYRELLE
CCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCEECCCCCCCCCCCHHHHHHHHHHH
EIGTNEIEVLAQYPRWIAYDFPSNMEHNFYSFDGQKQRYFLVRLKHANSIDLNKHTPEFR
HHCCCHHHHHHHCCCEEEECCCCCCCCCEEECCCCCCEEEEEEEECCCCCCCCCCCCCCC
TYQFIHLKDLLKKIVPFKRQVYRQVIAYFRREGYLGC
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLHKKYRPNVAAIIMSPNYPNTCEVFIAERVDIEGAWQFPQGGIDEGETPLEALYRELLE
CCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCEECCCCCCCCCCCHHHHHHHHHHH
EIGTNEIEVLAQYPRWIAYDFPSNMEHNFYSFDGQKQRYFLVRLKHANSIDLNKHTPEFR
HHCCCHHHHHHHCCCEEEECCCCCCCCCEEECCCCCCEEEEEEEECCCCCCCCCCCCCCC
TYQFIHLKDLLKKIVPFKRQVYRQVIAYFRREGYLGC
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA