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The map label for this gene is hom [H]

Identifier: 109947297

GI number: 109947297

Start: 636723

End: 637988

Strand: Direct

Name: hom [H]

Synonym: Hac_0726

Alternate gene names: 109947297

Gene position: 636723-637988 (Clockwise)

Preceding gene: 109947296

Following gene: 109947298

Centisome position: 40.98

GC content: 38.31

Gene sequence:

>1266_bases
ATGAAAAAAAGATTAAATATAGGGCTTGTGGGTTTAGGGTGTGTGGGGAGTGCGGTCGCTAAAATCTTACAAGAAAATCA
AGAAATTATAAAAGATAGGGCCGGTGTAGAAATAGTCATTAAAAAAGCGGTGGTGCGAGATGTTCAAAAACACAAGGGCT
ATCCTTTTGAAATCAGTAATGATTTAGAAAGTTTGGTAGAAGATAAAGAGATTGATATTATCGTGGAGCTTATGGGTGGG
GTTGAAGCACCTTATCTTTTAGCTAAAAAAACTTTAGCCAAACAAAAAGCTTTCGTTACAGCCAATAAGGCTATGTTAGC
GTATCACCGCTACGAATTAGAACAAATCGCTAAAAACACCCCCATAGGCTTTGAAGCGAGCGTGTGTGGGGGTATCCCTA
TTATCAAGGCTTTAAAAGACGGCTTGAGCGCTAATCATATCCTTTCTTTTAAGGGCATTTTAAACGGCACAAGCAATTAT
ATTTTAAGCCAGATGTTTAAAAATCAAGCGAGTTTTAAAGACGCTTTGAAAGATGCGCAACATTTAGGTTATGCGGAATT
AAACCCTGAATTTGATATTAAGGGCATTGATGCAGCTCACAAGCTCTTGATTTTAGCGTCTTTAGCGTATGGTATTGATG
CGAAATTAGAAGAAATTTTAATTGAAGGTATTGAAAAAATAGAGCCAGATGACATGGAGTTTGCAAAAGAGTTTGGTTAT
AGCATTAAACTTTTAGGTATCGCTAAAAAACATCAAGATTGCATTGAATTAAGGGTGCATCCAAGCATGATTAGAAATGA
ATCCATGCTTTCTAAAGTGGATGGGGTGATGAACGCTATAAGCGTCATAGGGGATAAGGTGGGCGAGACTTTGTATTATG
GGGCTGGGGCTGGGGGAGAGCCTACAGCAAGCGCGGTCATTAGCGATATTATAGAAATCGCAAGGAAAAAAAGCTCTTTG
ATGCTAGGCTTTGAAACCCCCCAAAAACTCCCCTTAAAACCCAAAGAAGAAATACAATGCGCTTATTATACGCGTTTGTT
AGTGAGCGATGAAAAGGGGGTTTTTTCTCAAATCAGCGCGATTTTAGCCCAAAATGATATTTCGCTCAACAATGTCTTAC
AAAAAGAAATCCCGCATTTTAACAAGGCTAAAATTTTATTTTCCACGCACACCACGAATGAAAAATCGCTTTTAAACGCC
CTAAAAGAGCTTGAAAATTTAAAAAGCGTGTTGGATACCCCTAAAATGATCCGCTTGGAAAATTGA

Upstream 100 bases:

>100_bases
AAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAAGAAAAAAACGCCGTTTTGAAAAA
ACGAAATTAAAGGAAAAAGC

Downstream 100 bases:

>100_bases
ATGCGTTTTTTCAATAACAAGCATAAAGAAAAGGGCTTAAAGGCTGAAGAAGAAGCTTGCGAGTTTTTAAAAACGCTGGG
TTTTGAAATAATAGAAAGGA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVEIVIKKAVVRDVQKHKGYPFEISNDLESLVEDKEIDIIVELMGG
VEAPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQIAKNTPIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNY
ILSQMFKNQASFKDALKDAQHLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGY
SIKLLGIAKKHQDCIELRVHPSMIRNESMLSKVDGVMNAISVIGDKVGETLYYGAGAGGEPTASAVISDIIEIARKKSSL
MLGFETPQKLPLKPKEEIQCAYYTRLLVSDEKGVFSQISAILAQNDISLNNVLQKEIPHFNKAKILFSTHTTNEKSLLNA
LKELENLKSVLDTPKMIRLEN

Sequences:

>Translated_421_residues
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVEIVIKKAVVRDVQKHKGYPFEISNDLESLVEDKEIDIIVELMGG
VEAPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQIAKNTPIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNY
ILSQMFKNQASFKDALKDAQHLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGY
SIKLLGIAKKHQDCIELRVHPSMIRNESMLSKVDGVMNAISVIGDKVGETLYYGAGAGGEPTASAVISDIIEIARKKSSL
MLGFETPQKLPLKPKEEIQCAYYTRLLVSDEKGVFSQISAILAQNDISLNNVLQKEIPHFNKAKILFSTHTTNEKSLLNA
LKELENLKSVLDTPKMIRLEN
>Mature_421_residues
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVEIVIKKAVVRDVQKHKGYPFEISNDLESLVEDKEIDIIVELMGG
VEAPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQIAKNTPIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNY
ILSQMFKNQASFKDALKDAQHLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGY
SIKLLGIAKKHQDCIELRVHPSMIRNESMLSKVDGVMNAISVIGDKVGETLYYGAGAGGEPTASAVISDIIEIARKKSSL
MLGFETPQKLPLKPKEEIQCAYYTRLLVSDEKGVFSQISAILAQNDISLNNVLQKEIPHFNKAKILFSTHTTNEKSLLNA
LKELENLKSVLDTPKMIRLEN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=251, Percent_Identity=28.2868525896414, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=232, Percent_Identity=25.8620689655172, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46393; Mature: 46393

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVEIVIKKAVVRDVQKHKGYPFEISN
CCCCCEECEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEECH
DLESLVEDKEIDIIVELMGGVEAPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQIAKNT
HHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNYILSQMFKNQASFKDALKDAQ
CCCCCCHHHCCHHHHHHHHCCCCCCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
HLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGY
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCC
SIKLLGIAKKHQDCIELRVHPSMIRNESMLSKVDGVMNAISVIGDKVGETLYYGAGAGGE
EEEEEEEHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCC
PTASAVISDIIEIARKKSSLMLGFETPQKLPLKPKEEIQCAYYTRLLVSDEKGVFSQISA
HHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHH
ILAQNDISLNNVLQKEIPHFNKAKILFSTHTTNEKSLLNALKELENLKSVLDTPKMIRLE
HHHHCCCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEC
N
C
>Mature Secondary Structure
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVEIVIKKAVVRDVQKHKGYPFEISN
CCCCCEECEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEECH
DLESLVEDKEIDIIVELMGGVEAPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQIAKNT
HHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNYILSQMFKNQASFKDALKDAQ
CCCCCCHHHCCHHHHHHHHCCCCCCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
HLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGY
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCC
SIKLLGIAKKHQDCIELRVHPSMIRNESMLSKVDGVMNAISVIGDKVGETLYYGAGAGGE
EEEEEEEHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCC
PTASAVISDIIEIARKKSSLMLGFETPQKLPLKPKEEIQCAYYTRLLVSDEKGVFSQISA
HHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHH
ILAQNDISLNNVLQKEIPHFNKAKILFSTHTTNEKSLLNALKELENLKSVLDTPKMIRLE
HHHHCCCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]