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The map label for this gene is uvrC

Identifier: 109947296

GI number: 109947296

Start: 634928

End: 636712

Strand: Direct

Name: uvrC

Synonym: Hac_0725

Alternate gene names: 109947296

Gene position: 634928-636712 (Clockwise)

Preceding gene: 109947295

Following gene: 109947297

Centisome position: 40.86

GC content: 36.19

Gene sequence:

>1785_bases
ATGGCTGATTTATTGTCCAGTTTAAAAAACCTTTCTAATGGCAGTGGGGTGTATCAATACTTTGATAAAAACCGCCAATT
ACTCTACATCGGTAAAGCAAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCTATCCATAATAATGAAATCACGCCCA
ATCATCGCACAAGTTTGCGCATTCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACAATTTTAGTAGAAAACGAGCAA
GACGCTTTGATTTTAGAGAATTCTTTAATCAAGCAACTCAAACCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTATATGGATTTTTCCACTGACTTTCCTATTCCTTTAATCACACGAAAAATTTTAAAACAGCTTGGCGTTA
AATATTTTGGCCCTTTTACTAGTGGGGCTAAAGATATTTTGGATAGCTTGTATGAATTGCTCCCTTTAGTTCAAAAGAAA
AATTGCATTAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCTCCATGCGAGAATAAAATCACCAA
AGAAGAATATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAGCTCATCAAAGAACTTCAATTAA
AAATGGATCGCCTTTCTAGTAACTTGCGTTTTGAAGAAGCTCTCATTTATAGAGACAGGATTTCTAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATGGCAAAAACAACAGGGCGGT
GTTAGTGAAAATGTTCATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTCAATGGGTTTGATG
CTGATGAAGCGATGAAACAAGCGATCATTAACCATTACCAATCGCATTTGCCTTTAATGCCTGAACAAATTCTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAGTTTATTTATCATAAACACTCTAAAAAAATCACTCTTAATATCCC
CAAAAAGGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ACGAAGAAGAAATCTTAGAAGAGGTGCGCTCGCTTTTAAATTTAGAGTGCGTGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATAGTGCATTCCAAAAAAACTCTTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACGCTCAAATGAGCGAATTGCTCACCAGAAGAGCCTTAGATTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTGATAGATGGAGGGAGGGTGCAATTAAACATCGCTTTAGAAACTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGATGAGCGATACTTTTAAATTGCTCCCTAGTGACAAACGCTTGCAATGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACCGATCCACTAAAATTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAAGAAAAAAA
CGCCGTTTTGAAAAAACGAAATTAA

Upstream 100 bases:

>100_bases
AGGGTTGTTCCATAACCCTATCAAAGACGCTCGTTTGCATGAATGTTTTGAAAAAGCGCGCTCTTTGATCCACTACCAAC
GCAGTTTTTTTGAGGAATGA

Downstream 100 bases:

>100_bases
AGGAAAAAGCATGAAAAAAAGATTAAATATAGGGCTTGTGGGTTTAGGGTGTGTGGGGAGTGCGGTCGCTAAAATCTTAC
AAGAAAATCAAGAAATTATA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MADLLSSLKNLSNGSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRTSLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQLGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELQLKMDRLSSNLRFEEALIYRDRISKIQKI
APFTCMDLAKLYDLDIFAFYGKNNRAVLVKMFMRGGKIISSAFEKIHSLNGFDADEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQEFIYHKHSKKITLNIPKKGDKLALIEIAMKNAQEIFSQEKTSNEEEILEEVRSLLNLECVPYRVEIFDT
SHHANSQCVGGMVVYENSAFQKNSYRRYHLKGSNEYAQMSELLTRRALDFAKEPPPNLWVIDGGRVQLNIALETLKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTMSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKIKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRN

Sequences:

>Translated_594_residues
MADLLSSLKNLSNGSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRTSLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQLGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELQLKMDRLSSNLRFEEALIYRDRISKIQKI
APFTCMDLAKLYDLDIFAFYGKNNRAVLVKMFMRGGKIISSAFEKIHSLNGFDADEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQEFIYHKHSKKITLNIPKKGDKLALIEIAMKNAQEIFSQEKTSNEEEILEEVRSLLNLECVPYRVEIFDT
SHHANSQCVGGMVVYENSAFQKNSYRRYHLKGSNEYAQMSELLTRRALDFAKEPPPNLWVIDGGRVQLNIALETLKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTMSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKIKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRN
>Mature_593_residues
ADLLSSLKNLSNGSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRTSLRIQMMVKQIAFLETILVENEQD
ALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQLGVKYFGPFTSGAKDILDSLYELLPLVQKKN
CIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELQLKMDRLSSNLRFEEALIYRDRISKIQKIA
PFTCMDLAKLYDLDIFAFYGKNNRAVLVKMFMRGGKIISSAFEKIHSLNGFDADEAMKQAIINHYQSHLPLMPEQILLNA
CSNETLKELQEFIYHKHSKKITLNIPKKGDKLALIEIAMKNAQEIFSQEKTSNEEEILEEVRSLLNLECVPYRVEIFDTS
HHANSQCVGGMVVYENSAFQKNSYRRYHLKGSNEYAQMSELLTRRALDFAKEPPPNLWVIDGGRVQLNIALETLKSSGSF
VEVIAISKEKRDSKAYRSKGGAKDIIHTMSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKIKNMKQIALLKEKGIG
EASVKKLLDYFGSFEAIEKASEQEKNAVLKKRN

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=609, Percent_Identity=29.5566502463054, Blast_Score=240, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_HELAH (Q17XV1)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664524.1
- ProteinModelPortal:   Q17XV1
- STRING:   Q17XV1
- GeneID:   4176696
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0725
- NMPDR:   fig|382638.8.peg.703
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   HACI382638:HAC_0725-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 68803; Mature: 68672

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLLSSLKNLSNGSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRTSLR
CHHHHHHHHHCCCCCCHHHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCHHHH
IQMMVKQIAFLETILVENEQDALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPI
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCH
PLITRKILKQLGVKYFGPFTSGAKDILDSLYELLPLVQKKNCIKDKKACMFYQIERCKAP
HHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CENKITKEEYLKIAKECLEMIENKDKLIKELQLKMDRLSSNLRFEEALIYRDRISKIQKI
CCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
APFTCMDLAKLYDLDIFAFYGKNNRAVLVKMFMRGGKIISSAFEKIHSLNGFDADEAMKQ
CCHHHHHHHHHHCCEEEEEECCCCCEEHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
AIINHYQSHLPLMPEQILLNACSNETLKELQEFIYHKHSKKITLNIPKKGDKLALIEIAM
HHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEHHHHH
KNAQEIFSQEKTSNEEEILEEVRSLLNLECVPYRVEIFDTSHHANSQCVGGMVVYENSAF
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCC
QKNSYRRYHLKGSNEYAQMSELLTRRALDFAKEPPPNLWVIDGGRVQLNIALETLKSSGS
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEEEEEEHHHCCCC
FVEVIAISKEKRDSKAYRSKGGAKDIIHTMSDTFKLLPSDKRLQWVQKLRDESHRYAINF
EEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEE
HRSTKIKNMKQIALLKEKGIGEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRN
ECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ADLLSSLKNLSNGSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRTSLR
HHHHHHHHHCCCCCCHHHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCHHHH
IQMMVKQIAFLETILVENEQDALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPI
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCH
PLITRKILKQLGVKYFGPFTSGAKDILDSLYELLPLVQKKNCIKDKKACMFYQIERCKAP
HHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CENKITKEEYLKIAKECLEMIENKDKLIKELQLKMDRLSSNLRFEEALIYRDRISKIQKI
CCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
APFTCMDLAKLYDLDIFAFYGKNNRAVLVKMFMRGGKIISSAFEKIHSLNGFDADEAMKQ
CCHHHHHHHHHHCCEEEEEECCCCCEEHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
AIINHYQSHLPLMPEQILLNACSNETLKELQEFIYHKHSKKITLNIPKKGDKLALIEIAM
HHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEHHHHH
KNAQEIFSQEKTSNEEEILEEVRSLLNLECVPYRVEIFDTSHHANSQCVGGMVVYENSAF
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCC
QKNSYRRYHLKGSNEYAQMSELLTRRALDFAKEPPPNLWVIDGGRVQLNIALETLKSSGS
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEEEEEEHHHCCCC
FVEVIAISKEKRDSKAYRSKGGAKDIIHTMSDTFKLLPSDKRLQWVQKLRDESHRYAINF
EEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEE
HRSTKIKNMKQIALLKEKGIGEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRN
ECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA