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The map label for this gene is glyA [H]

Identifier: 110681120

GI number: 110681120

Start: 3849125

End: 3850420

Strand: Direct

Name: glyA [H]

Synonym: RD1_3991

Alternate gene names: 110681120

Gene position: 3849125-3850420 (Clockwise)

Preceding gene: 110681116

Following gene: 110681126

Centisome position: 93.13

GC content: 63.35

Gene sequence:

>1296_bases
ATGAACGCCCCCCACCGCGCCCCTGGCTTTTTCACGCAATCGCTGGCTGACAGCGATCCTGAGCTTTTCGGCTCGATCAC
GGATGAGCTGGGCCGCCAGCGTGACGAGATCGAGTTGATCGCGTCGGAAAACATCGTTTCTGCCGCCGTGCTTGAGGCGC
AGGGCTCGATCATGACCAACAAATACGCCGAAGGCTATCCCGGACGGCGCTATTATGGCGGCTGCCAGTTCGTCGATGTG
GCCGAAAACCTCGCCATCGAGCGCGCCTGCAAACTCTTTGGTTGCGGCTTTGCCAATGTGCAGCCCAATTCCGGCAGCCA
GGCCAATCAGGGCGTGTTCACTGCCCTCTTGCAGCCCGGCGACACCATCCTCGGCATGAGCCTTGATGCGGGCGGGCACC
TGACGCATGGCGCCAAGCCCAACCAGTCCGGCAAGTGGTTCAACGCCGTGCAATACGGTGTGCGCCGCGAAGACAACCTG
CTGGATTATGACCAGGTCGAAGCGCTCGCCAAGGAGCACCAGCCCAAGCTGATCATCGCCGGCGGCTCGGCCATCCCGCG
CCAGATCGACTTTGCCCGCATGCGCGAAATCGCCGATATGGTCGGGGCGTATCTGCACGTGGACATGGCGCATTTCGCAG
GCCTCGTGGCGGCGGGCGAACACCCAAGCCCCTTCCCGCACGCCCATGTGGCCACCACCACGACGCATAAGACCCTGCGC
GGCCCGCGCGGCGGCATGATCCTGACGAACGACGAGGCGCTGGCGAAAAAGTTCAACTCCGCCATCTTCCCCGGCATTCA
GGGCGGCCCGCTGATGCATGTGATCGCTGCCAAGGCCGTGGCCTTTGGCGAGGCGCTGCGGCCCGATTTCAAATCCTACA
CCAAGCAGGTCATCGCCAACGCGCAGGCCCTGAGCGACCAGCTGATCAAGGGCGGGCTGGACACGATCACGCATGGCACC
GACACCCATGTGGTGCTGGTCGACCTGCGCCCCAAGGGCGTGAAGGGCAATGCGACCGAAAAGGCGCTGGGGCGTGCGCA
TATCACCTGCAACAAGAACGGCGTGCCCTTTGATCCGGAAAAGCCGATGGTGACCTCCGGCATCCGTCTGGGCAGCCCTG
CCGGGACGACGCGCGGGTTCGGCGAGCCGGAGTTCCGCCAGATCGCCGACTGGATCATCGAAGTGGTCGACGGCCTCGCC
GCCAACGGCGAAGACAACAACAGCGCCGTCGAAGCCAAGGTCAAAGCAGAAGTCGCACAACTCTGCGCAAGATTCCCAAT
GTATCCGAACCTCTAA

Upstream 100 bases:

>100_bases
ACGCATATTTCTGCTCGAGCGTCGCTTTACCGGCTTTGCCCGCGCTCTAGTTTCCGATACGAAACCGATCGAAACCTCAT
CATTCAAGGGAGATGCCCTC

Downstream 100 bases:

>100_bases
GCACCTCACGGCCCCGCATGATCACATGCGGGGCCGGACCGGTTCAGCCCGCAACCCAGTTTGGCAAGGTCAGCGAGATG
GCGGGCACAAAGGTAATCAG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNAPHRAPGFFTQSLADSDPELFGSITDELGRQRDEIELIASENIVSAAVLEAQGSIMTNKYAEGYPGRRYYGGCQFVDV
AENLAIERACKLFGCGFANVQPNSGSQANQGVFTALLQPGDTILGMSLDAGGHLTHGAKPNQSGKWFNAVQYGVRREDNL
LDYDQVEALAKEHQPKLIIAGGSAIPRQIDFARMREIADMVGAYLHVDMAHFAGLVAAGEHPSPFPHAHVATTTTHKTLR
GPRGGMILTNDEALAKKFNSAIFPGIQGGPLMHVIAAKAVAFGEALRPDFKSYTKQVIANAQALSDQLIKGGLDTITHGT
DTHVVLVDLRPKGVKGNATEKALGRAHITCNKNGVPFDPEKPMVTSGIRLGSPAGTTRGFGEPEFRQIADWIIEVVDGLA
ANGEDNNSAVEAKVKAEVAQLCARFPMYPNL

Sequences:

>Translated_431_residues
MNAPHRAPGFFTQSLADSDPELFGSITDELGRQRDEIELIASENIVSAAVLEAQGSIMTNKYAEGYPGRRYYGGCQFVDV
AENLAIERACKLFGCGFANVQPNSGSQANQGVFTALLQPGDTILGMSLDAGGHLTHGAKPNQSGKWFNAVQYGVRREDNL
LDYDQVEALAKEHQPKLIIAGGSAIPRQIDFARMREIADMVGAYLHVDMAHFAGLVAAGEHPSPFPHAHVATTTTHKTLR
GPRGGMILTNDEALAKKFNSAIFPGIQGGPLMHVIAAKAVAFGEALRPDFKSYTKQVIANAQALSDQLIKGGLDTITHGT
DTHVVLVDLRPKGVKGNATEKALGRAHITCNKNGVPFDPEKPMVTSGIRLGSPAGTTRGFGEPEFRQIADWIIEVVDGLA
ANGEDNNSAVEAKVKAEVAQLCARFPMYPNL
>Mature_431_residues
MNAPHRAPGFFTQSLADSDPELFGSITDELGRQRDEIELIASENIVSAAVLEAQGSIMTNKYAEGYPGRRYYGGCQFVDV
AENLAIERACKLFGCGFANVQPNSGSQANQGVFTALLQPGDTILGMSLDAGGHLTHGAKPNQSGKWFNAVQYGVRREDNL
LDYDQVEALAKEHQPKLIIAGGSAIPRQIDFARMREIADMVGAYLHVDMAHFAGLVAAGEHPSPFPHAHVATTTTHKTLR
GPRGGMILTNDEALAKKFNSAIFPGIQGGPLMHVIAAKAVAFGEALRPDFKSYTKQVIANAQALSDQLIKGGLDTITHGT
DTHVVLVDLRPKGVKGNATEKALGRAHITCNKNGVPFDPEKPMVTSGIRLGSPAGTTRGFGEPEFRQIADWIIEVVDGLA
ANGEDNNSAVEAKVKAEVAQLCARFPMYPNL

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=453, Percent_Identity=44.8123620309051, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI261862350, Length=453, Percent_Identity=44.8123620309051, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI261862348, Length=453, Percent_Identity=44.8123620309051, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI19923315, Length=453, Percent_Identity=44.8123620309051, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI22547186, Length=462, Percent_Identity=45.2380952380952, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI261862346, Length=453, Percent_Identity=43.9293598233996, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI22547189, Length=445, Percent_Identity=43.3707865168539, Blast_Score=306, Evalue=2e-83,
Organism=Escherichia coli, GI1788902, Length=417, Percent_Identity=57.0743405275779, Blast_Score=460, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=48.5, Blast_Score=346, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=48.5, Blast_Score=346, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6323087, Length=411, Percent_Identity=45.0121654501217, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6319739, Length=442, Percent_Identity=41.4027149321267, Blast_Score=336, Evalue=5e-93,
Organism=Drosophila melanogaster, GI24640005, Length=400, Percent_Identity=47.75, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI221329721, Length=400, Percent_Identity=47.75, Blast_Score=345, Evalue=3e-95,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 46137; Mature: 46137

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPHRAPGFFTQSLADSDPELFGSITDELGRQRDEIELIASENIVSAAVLEAQGSIMTN
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCEEEC
KYAEGYPGRRYYGGCQFVDVAENLAIERACKLFGCGFANVQPNSGSQANQGVFTALLQPG
CCCCCCCCCEECCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCC
DTILGMSLDAGGHLTHGAKPNQSGKWFNAVQYGVRREDNLLDYDQVEALAKEHQPKLIIA
CEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEE
GGSAIPRQIDFARMREIADMVGAYLHVDMAHFAGLVAAGEHPSPFPHAHVATTTTHKTLR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHC
GPRGGMILTNDEALAKKFNSAIFPGIQGGPLMHVIAAKAVAFGEALRPDFKSYTKQVIAN
CCCCCEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
AQALSDQLIKGGLDTITHGTDTHVVLVDLRPKGVKGNATEKALGRAHITCNKNGVPFDPE
HHHHHHHHHHCCHHHHCCCCCCEEEEEEECCCCCCCCCHHHHCCCEEEEECCCCCCCCCC
KPMVTSGIRLGSPAGTTRGFGEPEFRQIADWIIEVVDGLAANGEDNNSAVEAKVKAEVAQ
CCHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LCARFPMYPNL
HHHHCCCCCCC
>Mature Secondary Structure
MNAPHRAPGFFTQSLADSDPELFGSITDELGRQRDEIELIASENIVSAAVLEAQGSIMTN
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCEEEC
KYAEGYPGRRYYGGCQFVDVAENLAIERACKLFGCGFANVQPNSGSQANQGVFTALLQPG
CCCCCCCCCEECCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCC
DTILGMSLDAGGHLTHGAKPNQSGKWFNAVQYGVRREDNLLDYDQVEALAKEHQPKLIIA
CEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEE
GGSAIPRQIDFARMREIADMVGAYLHVDMAHFAGLVAAGEHPSPFPHAHVATTTTHKTLR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHC
GPRGGMILTNDEALAKKFNSAIFPGIQGGPLMHVIAAKAVAFGEALRPDFKSYTKQVIAN
CCCCCEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
AQALSDQLIKGGLDTITHGTDTHVVLVDLRPKGVKGNATEKALGRAHITCNKNGVPFDPE
HHHHHHHHHHCCHHHHCCCCCCEEEEEEECCCCCCCCCHHHHCCCEEEEECCCCCCCCCC
KPMVTSGIRLGSPAGTTRGFGEPEFRQIADWIIEVVDGLAANGEDNNSAVEAKVKAEVAQ
CCHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LCARFPMYPNL
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA