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The map label for this gene is acdA [H]

Identifier: 110680833

GI number: 110680833

Start: 3548181

End: 3549326

Strand: Direct

Name: acdA [H]

Synonym: RD1_3681

Alternate gene names: 110680833

Gene position: 3548181-3549326 (Clockwise)

Preceding gene: 110680832

Following gene: 110680834

Centisome position: 85.85

GC content: 62.91

Gene sequence:

>1146_bases
ATGACCTTCATCTGGCATATGTTGAACGACGACGAGACCCTGTTTTGCGATGTGCTCGAACGGATCGTTGCGGACAAGAT
CGCGCCCCTTGCAACGCAAACGGACGAGACGTCGAATTTCGTCCACGCGCAACTCAAGGTGCTGGCAGAGGCGGGTATGA
TGGGGGCGAACCTGCCCGAAGCCTTTGGCGGCTCGAATATTTCCGCCCCTGCCCTGCTGCGCGCCGTTGAGATCGTGGCC
GGTGGATGCGGATCGACGGCCTCGGCACTCACCGCGCATTTTCTGGCCAGCGATTCCATTCTGATCGGCGCCACCGAGGC
GCAAAAAGCCCATTGGCTGCCCAGAATGGCCACAGGCGAAGCACTGGGTGCCTTTGCCCTGACCGAGCCTTCAGCGGGCA
GCGATCCGGCCGATATGAAAACCCGCGCAACCCGCGAGGGGGATGGATGGCACCTGACAGGGTCCAAGTGTTTCATCTCG
AACGGGGGCGTTGCGGATGTGCTCATTGTCTTTGCGGTCACCGATCCGACGGCGCGGCATCGCGGGATTTCCGCCTTCAT
CCTGCCCAAGCACACGCCCGGATTTACCGCCGGACCTGCGGAAAAAACCATGGGCCTCAAGGGCGGGCATGTGTTTTCGC
TGGCGCTGGATTGCCACCTGCCGGCAGAGGCCCTGCTGGGCGAGGAAGGGTCAGGTTTTCGCACGGCGATGAAAGTGCTG
GACAATGGGCGCGTCGAAGTTGCCGCGCAATGTATCGGCATGGCGCAAGCGGCCCTTGATGCGGCCAAAGCCTATGCCAG
TGATCGCGTCATCGGCGGCGAGGCGCTCAGCGCCAAACAGGGCATCCGCTGGATGCTCGCCGACATGGCGCTCGACCTAT
ACGGCGCGCGCCTCATGGCGCTTGAGGCGGCCCGGCAGCGCGATACGGGCGCGCGTTTCAGCGAAGCGGCGGCAATGGCC
AAGCTCAAGGCCAGCGAGGCTGCGGATCGTGTGGCCGACGCGGCGCTGCAAATCCACGGGGGCTATGGCTATACCCGTGA
TTTCCCGATCGAACGACTGACCCGCGATCTGCGCATCATGCGCATCTACGAAGGGTCCTCTGAAATTCAACGCAATATCA
TCGCCGGCCACCTGCTGGCGCACTGA

Upstream 100 bases:

>100_bases
CCGCACCGGGTTTGAGCGCGGATGCGACCCGCATCCTGTCGGATTTCTGCGATGTGGACGCGGCGCGGCTGGCCCATCTG
CGCGACAAGGGAGTGGTTCT

Downstream 100 bases:

>100_bases
AGGAGAAAACCATGACCAACGCCCGTCATAACCTGCGCGACATCTACCCCCCTACCGGGCCGGACATCACGGCCAAAAGC
TGGCTCACCGAGGCGCCCAT

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MTFIWHMLNDDETLFCDVLERIVADKIAPLATQTDETSNFVHAQLKVLAEAGMMGANLPEAFGGSNISAPALLRAVEIVA
GGCGSTASALTAHFLASDSILIGATEAQKAHWLPRMATGEALGAFALTEPSAGSDPADMKTRATREGDGWHLTGSKCFIS
NGGVADVLIVFAVTDPTARHRGISAFILPKHTPGFTAGPAEKTMGLKGGHVFSLALDCHLPAEALLGEEGSGFRTAMKVL
DNGRVEVAAQCIGMAQAALDAAKAYASDRVIGGEALSAKQGIRWMLADMALDLYGARLMALEAARQRDTGARFSEAAAMA
KLKASEAADRVADAALQIHGGYGYTRDFPIERLTRDLRIMRIYEGSSEIQRNIIAGHLLAH

Sequences:

>Translated_381_residues
MTFIWHMLNDDETLFCDVLERIVADKIAPLATQTDETSNFVHAQLKVLAEAGMMGANLPEAFGGSNISAPALLRAVEIVA
GGCGSTASALTAHFLASDSILIGATEAQKAHWLPRMATGEALGAFALTEPSAGSDPADMKTRATREGDGWHLTGSKCFIS
NGGVADVLIVFAVTDPTARHRGISAFILPKHTPGFTAGPAEKTMGLKGGHVFSLALDCHLPAEALLGEEGSGFRTAMKVL
DNGRVEVAAQCIGMAQAALDAAKAYASDRVIGGEALSAKQGIRWMLADMALDLYGARLMALEAARQRDTGARFSEAAAMA
KLKASEAADRVADAALQIHGGYGYTRDFPIERLTRDLRIMRIYEGSSEIQRNIIAGHLLAH
>Mature_380_residues
TFIWHMLNDDETLFCDVLERIVADKIAPLATQTDETSNFVHAQLKVLAEAGMMGANLPEAFGGSNISAPALLRAVEIVAG
GCGSTASALTAHFLASDSILIGATEAQKAHWLPRMATGEALGAFALTEPSAGSDPADMKTRATREGDGWHLTGSKCFISN
GGVADVLIVFAVTDPTARHRGISAFILPKHTPGFTAGPAEKTMGLKGGHVFSLALDCHLPAEALLGEEGSGFRTAMKVLD
NGRVEVAAQCIGMAQAALDAAKAYASDRVIGGEALSAKQGIRWMLADMALDLYGARLMALEAARQRDTGARFSEAAAMAK
LKASEAADRVADAALQIHGGYGYTRDFPIERLTRDLRIMRIYEGSSEIQRNIIAGHLLAH

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=374, Percent_Identity=41.1764705882353, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI4501859, Length=378, Percent_Identity=35.1851851851852, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI187960098, Length=372, Percent_Identity=34.1397849462366, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI4557231, Length=372, Percent_Identity=34.1397849462366, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI76496475, Length=381, Percent_Identity=37.007874015748, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4557235, Length=381, Percent_Identity=37.007874015748, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI21361497, Length=360, Percent_Identity=36.6666666666667, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=33.3333333333333, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI226958412, Length=373, Percent_Identity=32.7077747989276, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI226958414, Length=333, Percent_Identity=34.8348348348348, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4501857, Length=385, Percent_Identity=30.3896103896104, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4503943, Length=373, Percent_Identity=27.3458445040214, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI7669494, Length=363, Percent_Identity=27.2727272727273, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI211971008, Length=291, Percent_Identity=32.9896907216495, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI48976061, Length=291, Percent_Identity=32.9896907216495, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI38505218, Length=285, Percent_Identity=28.7719298245614, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI1786223, Length=365, Percent_Identity=30.958904109589, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI87081958, Length=372, Percent_Identity=29.0322580645161, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI87081702, Length=335, Percent_Identity=25.0746268656716, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082384, Length=270, Percent_Identity=28.5185185185185, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=36.5079365079365, Blast_Score=234, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI17506239, Length=372, Percent_Identity=33.8709677419355, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17569725, Length=378, Percent_Identity=33.8624338624339, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI71985184, Length=354, Percent_Identity=38.7005649717514, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI17534899, Length=365, Percent_Identity=34.7945205479452, Blast_Score=217, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=32.7956989247312, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17538396, Length=371, Percent_Identity=33.4231805929919, Blast_Score=210, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI17533517, Length=369, Percent_Identity=33.0623306233062, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI71985192, Length=303, Percent_Identity=36.3036303630363, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71990804, Length=327, Percent_Identity=31.8042813455657, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17505929, Length=376, Percent_Identity=30.8510638297872, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17551932, Length=377, Percent_Identity=28.3819628647215, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17534353, Length=368, Percent_Identity=29.3478260869565, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI32563615, Length=225, Percent_Identity=33.7777777777778, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=29.7794117647059, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17531909, Length=238, Percent_Identity=31.0924369747899, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17562446, Length=281, Percent_Identity=29.5373665480427, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17531913, Length=177, Percent_Identity=28.2485875706215, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356377, Length=355, Percent_Identity=40.2816901408451, Blast_Score=251, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=37.5335120643432, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24660351, Length=375, Percent_Identity=34.4, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=36.1185983827493, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI281363737, Length=373, Percent_Identity=36.9973190348526, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=34.1269841269841, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI19920834, Length=375, Percent_Identity=26.4, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 40260; Mature: 40129

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFIWHMLNDDETLFCDVLERIVADKIAPLATQTDETSNFVHAQLKVLAEAGMMGANLPE
CEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCH
AFGGSNISAPALLRAVEIVAGGCGSTASALTAHFLASDSILIGATEAQKAHWLPRMATGE
HCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCCC
ALGAFALTEPSAGSDPADMKTRATREGDGWHLTGSKCFISNGGVADVLIVFAVTDPTARH
HHCEEEECCCCCCCCCCHHHHHCCCCCCCEEECCCEEEECCCCCEEEEEEEEECCCHHHH
RGISAFILPKHTPGFTAGPAEKTMGLKGGHVFSLALDCHLPAEALLGEEGSGFRTAMKVL
CCCEEEEECCCCCCCCCCCHHHHCCCCCCEEEEEEEECCCCHHHHCCCCCCCHHHHHHHH
DNGRVEVAAQCIGMAQAALDAAKAYASDRVIGGEALSAKQGIRWMLADMALDLYGARLMA
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LEAARQRDTGARFSEAAAMAKLKASEAADRVADAALQIHGGYGYTRDFPIERLTRDLRIM
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHEEE
RIYEGSSEIQRNIIAGHLLAH
EEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TFIWHMLNDDETLFCDVLERIVADKIAPLATQTDETSNFVHAQLKVLAEAGMMGANLPE
EEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCH
AFGGSNISAPALLRAVEIVAGGCGSTASALTAHFLASDSILIGATEAQKAHWLPRMATGE
HCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCCC
ALGAFALTEPSAGSDPADMKTRATREGDGWHLTGSKCFISNGGVADVLIVFAVTDPTARH
HHCEEEECCCCCCCCCCHHHHHCCCCCCCEEECCCEEEECCCCCEEEEEEEEECCCHHHH
RGISAFILPKHTPGFTAGPAEKTMGLKGGHVFSLALDCHLPAEALLGEEGSGFRTAMKVL
CCCEEEEECCCCCCCCCCCHHHHCCCCCCEEEEEEEECCCCHHHHCCCCCCCHHHHHHHH
DNGRVEVAAQCIGMAQAALDAAKAYASDRVIGGEALSAKQGIRWMLADMALDLYGARLMA
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LEAARQRDTGARFSEAAAMAKLKASEAADRVADAALQIHGGYGYTRDFPIERLTRDLRIM
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHEEE
RIYEGSSEIQRNIIAGHLLAH
EEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]