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The map label for this gene is phbA [H]

Identifier: 110680565

GI number: 110680565

Start: 3261042

End: 3262262

Strand: Direct

Name: phbA [H]

Synonym: RD1_3394

Alternate gene names: 110680565

Gene position: 3261042-3262262 (Clockwise)

Preceding gene: 110680564

Following gene: 110680566

Centisome position: 78.9

GC content: 59.87

Gene sequence:

>1221_bases
TTGCACGTCTGGTCTTTTCGAGAACTGGCAAAGGACCAAAAAACCATGACGAACGTCGTAATCGCCTCCGCCGCAAGAAC
TGCCGTCGGCAGCTTTGGTGGGTCATTCGCAAACACTCCGGCCCATGATCTTGGGGCAGCAATGCTCAAGGAAATCGTGG
CACGCGCGGGCGTTGACCCTTCGGAAGTGTCCGAAACGATCCTCGGCCAGGTGCTGACAGCCGCGCAGGGGCAGAACCCG
GCGCGCCAAGCGCATATCAATGCGGGCCTGCCACAGGAAAGCTCTGCCTGGACCATCAACCAGGTGTGCGGATCCGGGTT
GCGCACCGTTGCCCTCGCCGCTCAGCACATCCAATTGGGCGATGCTTCGATTGTGGCTGCGGGTGGTCAGGAAAACATGA
CACTTTCCCCCCATGCAGCCCCGCTGCGCGCAGGTCACAAGATGGGCGACATGAAATACATCGACACCATGATTCGCGAC
GGGCTGTGGGATGCGTTTAACGGCTACCACATGGGTCAAACCGCCGAAAACGTCGCTGAAAAATGGCAGATCAGCCGTGA
GCAACAGGATGAATTCGCGGTTGCCTCCCAAAACAAGGCGGAGGCCGCTCAAAAGGCCGGTAAGTTTGATGACGAGGTTT
TCGCCTATACCATCAGCACGCGCAAAGGCGATATCGTCGTCGATAAAGATGAGTACATCCGCCATGGCGCCACCATCGAA
GCCATGCAAAAGCTGCGCCCTGCCTTCACAAAGGACGGGTCGGTGACTGCGGCGAATGCCTCGGGTCTGAACGACGGCGC
TGCCGGGGCGCTGCTGATGTCGGTGGATGAGGCCGAAAAACGCGGCATCGAACCGCTGGCGCGCATTGCAAGCTATGCGA
CCGTGGGCCTTGATCCTTCGATCATGGGTGCAGGACCGATCTTTGCCAGCCGCAAAGCGCTGGAGAAGGCTGGCTGGAAG
CCAGAAGACCTCGACCTGGTCGAAGCCAACGAAGCCTTTGCCGCGCAGGCCTGTGCGGTCAACAAGGACATGGGTTGGGA
CCCTGCTGTGGTAAACGTCAACGGCGGTGCCATTGCGATCGGCCACCCTATCGGTGCATCCGGCGCGCGCATTCTCAACA
CGCTGCTGTTCGAAATGAAACGCCGCGACGCCAAGAAAGGTCTCGCGACACTGTGCATCGGCGGCGGCATGGGCGTTGCC
ATGTGCCTCGAGCGCGACTAA

Upstream 100 bases:

>100_bases
CATGTTTGCGGTGCTGTGTCACAGCTTTGAGATGTTGCCCGGTTCTTAATGTTACGTTAACAGTTGCCCACATCGCAGAA
AGGGCTAGGTCGTTGCGGTT

Downstream 100 bases:

>100_bases
CCCAGACCGAAGCGGCGCCCTGGGGCGCCGCATGATACACCACCGTGCTGGGCTTCAGGCTCAGCACGCCCAACCTGAAC
AAAGATTCCAGATCACTTGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MHVWSFRELAKDQKTMTNVVIASAARTAVGSFGGSFANTPAHDLGAAMLKEIVARAGVDPSEVSETILGQVLTAAQGQNP
ARQAHINAGLPQESSAWTINQVCGSGLRTVALAAQHIQLGDASIVAAGGQENMTLSPHAAPLRAGHKMGDMKYIDTMIRD
GLWDAFNGYHMGQTAENVAEKWQISREQQDEFAVASQNKAEAAQKAGKFDDEVFAYTISTRKGDIVVDKDEYIRHGATIE
AMQKLRPAFTKDGSVTAANASGLNDGAAGALLMSVDEAEKRGIEPLARIASYATVGLDPSIMGAGPIFASRKALEKAGWK
PEDLDLVEANEAFAAQACAVNKDMGWDPAVVNVNGGAIAIGHPIGASGARILNTLLFEMKRRDAKKGLATLCIGGGMGVA
MCLERD

Sequences:

>Translated_406_residues
MHVWSFRELAKDQKTMTNVVIASAARTAVGSFGGSFANTPAHDLGAAMLKEIVARAGVDPSEVSETILGQVLTAAQGQNP
ARQAHINAGLPQESSAWTINQVCGSGLRTVALAAQHIQLGDASIVAAGGQENMTLSPHAAPLRAGHKMGDMKYIDTMIRD
GLWDAFNGYHMGQTAENVAEKWQISREQQDEFAVASQNKAEAAQKAGKFDDEVFAYTISTRKGDIVVDKDEYIRHGATIE
AMQKLRPAFTKDGSVTAANASGLNDGAAGALLMSVDEAEKRGIEPLARIASYATVGLDPSIMGAGPIFASRKALEKAGWK
PEDLDLVEANEAFAAQACAVNKDMGWDPAVVNVNGGAIAIGHPIGASGARILNTLLFEMKRRDAKKGLATLCIGGGMGVA
MCLERD
>Mature_406_residues
MHVWSFRELAKDQKTMTNVVIASAARTAVGSFGGSFANTPAHDLGAAMLKEIVARAGVDPSEVSETILGQVLTAAQGQNP
ARQAHINAGLPQESSAWTINQVCGSGLRTVALAAQHIQLGDASIVAAGGQENMTLSPHAAPLRAGHKMGDMKYIDTMIRD
GLWDAFNGYHMGQTAENVAEKWQISREQQDEFAVASQNKAEAAQKAGKFDDEVFAYTISTRKGDIVVDKDEYIRHGATIE
AMQKLRPAFTKDGSVTAANASGLNDGAAGALLMSVDEAEKRGIEPLARIASYATVGLDPSIMGAGPIFASRKALEKAGWK
PEDLDLVEANEAFAAQACAVNKDMGWDPAVVNVNGGAIAIGHPIGASGARILNTLLFEMKRRDAKKGLATLCIGGGMGVA
MCLERD

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=57.1794871794872, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI167614485, Length=395, Percent_Identity=41.2658227848101, Blast_Score=301, Evalue=5e-82,
Organism=Homo sapiens, GI4557237, Length=396, Percent_Identity=40.4040404040404, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI4501853, Length=400, Percent_Identity=39.75, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI4504327, Length=439, Percent_Identity=31.4350797266515, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI194353979, Length=399, Percent_Identity=31.5789473684211, Blast_Score=145, Evalue=6e-35,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=53.0612244897959, Blast_Score=418, Evalue=1e-118,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=55.1020408163265, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=40.5, Blast_Score=281, Evalue=8e-77,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=41.5, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=32.6241134751773, Blast_Score=188, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=42.4164524421594, Blast_Score=313, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=39.2207792207792, Blast_Score=274, Evalue=8e-74,
Organism=Caenorhabditis elegans, GI17535921, Length=391, Percent_Identity=37.8516624040921, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=30.1401869158879, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=30.5555555555556, Blast_Score=160, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6325229, Length=395, Percent_Identity=42.2784810126582, Blast_Score=278, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=37.7215189873418, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=55.8974358974359, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=41.5816326530612, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=39.5886889460154, Blast_Score=278, Evalue=7e-75,
Organism=Drosophila melanogaster, GI17137578, Length=429, Percent_Identity=31.2354312354312, Blast_Score=179, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42802; Mature: 42802

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVWSFRELAKDQKTMTNVVIASAARTAVGSFGGSFANTPAHDLGAAMLKEIVARAGVDP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCH
SEVSETILGQVLTAAQGQNPARQAHINAGLPQESSAWTINQVCGSGLRTVALAAQHIQLG
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCEEHHHHHCCCHHHHHHHHHHHCCC
DASIVAAGGQENMTLSPHAAPLRAGHKMGDMKYIDTMIRDGLWDAFNGYHMGQTAENVAE
CCEEEEECCCCCCEECCCCCHHHCCCCCCCHHHHHHHHHHCHHHHHCCCCCCCHHHHHHH
KWQISREQQDEFAVASQNKAEAAQKAGKFDDEVFAYTISTRKGDIVVDKDEYIRHGATIE
HHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEECCHHHHHCCCHHH
AMQKLRPAFTKDGSVTAANASGLNDGAAGALLMSVDEAEKRGIEPLARIASYATVGLDPS
HHHHHHHHHCCCCCEEECCCCCCCCCCCCEEEEECCHHHHCCCHHHHHHHHHHHCCCCCC
IMGAGPIFASRKALEKAGWKPEDLDLVEANEAFAAQACAVNKDMGWDPAVVNVNGGAIAI
CCCCCCHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHCCCCCCCCCEEEEECCCEEEE
GHPIGASGARILNTLLFEMKRRDAKKGLATLCIGGGMGVAMCLERD
CCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECC
>Mature Secondary Structure
MHVWSFRELAKDQKTMTNVVIASAARTAVGSFGGSFANTPAHDLGAAMLKEIVARAGVDP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCH
SEVSETILGQVLTAAQGQNPARQAHINAGLPQESSAWTINQVCGSGLRTVALAAQHIQLG
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCEEHHHHHCCCHHHHHHHHHHHCCC
DASIVAAGGQENMTLSPHAAPLRAGHKMGDMKYIDTMIRDGLWDAFNGYHMGQTAENVAE
CCEEEEECCCCCCEECCCCCHHHCCCCCCCHHHHHHHHHHCHHHHHCCCCCCCHHHHHHH
KWQISREQQDEFAVASQNKAEAAQKAGKFDDEVFAYTISTRKGDIVVDKDEYIRHGATIE
HHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEECCHHHHHCCCHHH
AMQKLRPAFTKDGSVTAANASGLNDGAAGALLMSVDEAEKRGIEPLARIASYATVGLDPS
HHHHHHHHHCCCCCEEECCCCCCCCCCCCEEEEECCHHHHCCCHHHHHHHHHHHCCCCCC
IMGAGPIFASRKALEKAGWKPEDLDLVEANEAFAAQACAVNKDMGWDPAVVNVNGGAIAI
CCCCCCHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHCCCCCCCCCEEEEECCCEEEE
GHPIGASGARILNTLLFEMKRRDAKKGLATLCIGGGMGVAMCLERD
CCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566717 [H]