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The map label for this gene is purL

Identifier: 110680413

GI number: 110680413

Start: 3099884

End: 3102043

Strand: Direct

Name: purL

Synonym: RD1_3232

Alternate gene names: 110680413

Gene position: 3099884-3102043 (Clockwise)

Preceding gene: 110680412

Following gene: 110680416

Centisome position: 75.0

GC content: 60.46

Gene sequence:

>2160_bases
ATGCAAGAGCCTGCCATCACACCAGACCTGATCGCGAGCCACGGGCTTAGTCCGGATGAATACGACCGCATTCTCAATAT
CGTCGGGCGCACCCCGACCTTTACCGAACTCGGCATTTTCTCAGCCATGTGGAACGAACACTGTTCCTACAAGTCGTCGA
AAAAATGGCTGCGCACATTGCCCACGACTGGACCTCAGGTGATTTGCGGACCGGGAGAGAACGCAGGCGTTGTGGACATC
GGCGATGGCCAGGCGGTCGTCTTCAAGATGGAGAGCCACAACCACCCCAGCTATATCGAGCCCTATCAGGGTGCCGCCAC
CGGTGTCGGCGGCATTCTGCGCGATGTCTTTACCATGGGTGCGCGTCCGATCGCGGCGATGAACTCTCTCAGTTTCGGCG
AAATCAGCCACCCCAAGACACGGCAACTGGTCAACGGCGTGGTTGCGGGCGTGGGCGGATATGGCAATTGCTTTGGCGTT
CCGACAGTCGGGGGCGAGGTGCGGTTTGATCCGGCCTATAACGGCAACTGCCTTGTGAATGCCTTTGCCGCCGGTTTGGC
CGACGCGGACAAGATTTTCTATTCCGCCGCATCAGGCGTTGGCATGCCCGTGGTCTATCTGGGGGCCAAGACGGGGCGCG
ACGGGGTCGGTGGTGCCACCATGGCCTCCGCCGAATTCGACGACACCATCGAGGAAAAGCGGCCCACGGTGCAGGTCGGT
GACCCGTTCACGGAAAAGCGCCTGATGGAAGCTACGCTGGAATTGATGCAGACCGGGGCCGTTATCTCAATTCAGGATAT
GGGGGCCGCCGGGCTGACCTGTTCCGCGGTTGAGATGGGCGACAAGGGCAATCTGGGCGTTCGACTCGATCTGGAAAAAG
TACCGGTGCGCGAAGAGGCGATGACCGCCTATGAAATGATGCTGTCGGAAAGTCAGGAACGCATGCTGATGGTGCTGCGC
CCCGAGTTGGAACAGGAAGCCAAAGCAGTCTTCGACAAATGGGATCTTGATTTCGCCATCGTCGGTGAAACCATTGCCGA
GGATCGGTTTCTCATCGTCCACAACGGCGAGGTCAAGGCGGACCTGCCGCTCAAGACGCTGGCAGGCACTGCGCCGGAAT
ATGACCGGCCGTGGGTTGCGACGCCCGCTGCAGATCCGCTTGGTGATGTACCGGATGTGGACCCGATTGACGGTCTGCGC
GCCTTGATCAGCAGCCCCAATTACGCCTCCAAGGACTGGGTGTTTACCCAATATGACACGATGGTCATGGCCGATACGGT
GCGCATTCCCGGCATTGGCGCGGGCATTGTGCGCGTGCATGGCACCGACAAGGCGCTCGCCTTTACCTCGGATGTGACGC
CGCGTTATGTGCAGGCCAACCCGGTTGAGGGCGGCAAACAGGCTGTGGCAGAAGCCTACCGCAACCTCTCTGCGGTCGGG
GCCACCCCCCTTGCGACGACCGACAACATGAATTTCGGCAACCCCGAAAAGCCCGAGATCATGGGCCAGTTCGTCGGCGC
GATCAAAGGCATCTCCGCAGCGGTCGCGGCACTGGATATGCCCATCGTGTCGGGCAATGTGTCCTTATATAATGAAACCG
ATGGCACCGCGATCCTGCCCACACCGACGATTGGAGCCGTTGGCCTGATCGCGCACCTCGATGACGTGATCGGTTGCGAT
GTGCGCGACGGACACGTGGCCCTGGTATTGGGCGAGACGCACGGCCACCTTGGTCAGTCCGCGATCCTGTCCGAGGTCTA
CAACCGTGCGGAGGGCGACGCCCCGCCGGTGGACCTTGATCAGGAAAAGGCGCACGGCGATTTCATCCGGGCAAACCGCG
CCTACATCAAGGCCTGCACGGATTTATCCGACGGCGGGTTGGCGTTGGCCGCGTTTGAAATGGCGGAAAATGCCGGGGTG
GGTGTCTGCCTTGACGCCAGTGATACCGCAACGCTTTTCGGCGAAGATCAGGGCAGATACCTGATCGCCTGCAACTTTGA
TCAAGCCGAAGCACTGATGATCGCGGCAAGTCAGGCGGGTCTGACCCTGACATCGGTCGGGAAATTCACCGGCCAGGCGG
TGCGGTTTGGTGCCTCCAGCGCACCCTTGGCCGAACTATCCGACGTCTATCGCCAGAGTTTTGGCGCGGCACTAGCCTAA

Upstream 100 bases:

>100_bases
TGCGGCGCGGGCATCCGCACCACAGGATCGCCCCTTTCCCCCGCGCGCGCAGACCTGTAAGAGAGCGCCAAGTTTTGCCA
GCCGGGGGACAATAAGGCCT

Downstream 100 bases:

>100_bases
AGCATCACGCGAAAAACCTGAACCACGTAACGTTGCCTGAAATCAATAATTTCAGCGCGTTACGTGATAGTTTATGTGTT
TCGTCAGACGCCCTGCACCC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 719; Mature: 719

Protein sequence:

>719_residues
MQEPAITPDLIASHGLSPDEYDRILNIVGRTPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTTGPQVICGPGENAGVVDI
GDGQAVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNSLSFGEISHPKTRQLVNGVVAGVGGYGNCFGV
PTVGGEVRFDPAYNGNCLVNAFAAGLADADKIFYSAASGVGMPVVYLGAKTGRDGVGGATMASAEFDDTIEEKRPTVQVG
DPFTEKRLMEATLELMQTGAVISIQDMGAAGLTCSAVEMGDKGNLGVRLDLEKVPVREEAMTAYEMMLSESQERMLMVLR
PELEQEAKAVFDKWDLDFAIVGETIAEDRFLIVHNGEVKADLPLKTLAGTAPEYDRPWVATPAADPLGDVPDVDPIDGLR
ALISSPNYASKDWVFTQYDTMVMADTVRIPGIGAGIVRVHGTDKALAFTSDVTPRYVQANPVEGGKQAVAEAYRNLSAVG
ATPLATTDNMNFGNPEKPEIMGQFVGAIKGISAAVAALDMPIVSGNVSLYNETDGTAILPTPTIGAVGLIAHLDDVIGCD
VRDGHVALVLGETHGHLGQSAILSEVYNRAEGDAPPVDLDQEKAHGDFIRANRAYIKACTDLSDGGLALAAFEMAENAGV
GVCLDASDTATLFGEDQGRYLIACNFDQAEALMIAASQAGLTLTSVGKFTGQAVRFGASSAPLAELSDVYRQSFGAALA

Sequences:

>Translated_719_residues
MQEPAITPDLIASHGLSPDEYDRILNIVGRTPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTTGPQVICGPGENAGVVDI
GDGQAVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNSLSFGEISHPKTRQLVNGVVAGVGGYGNCFGV
PTVGGEVRFDPAYNGNCLVNAFAAGLADADKIFYSAASGVGMPVVYLGAKTGRDGVGGATMASAEFDDTIEEKRPTVQVG
DPFTEKRLMEATLELMQTGAVISIQDMGAAGLTCSAVEMGDKGNLGVRLDLEKVPVREEAMTAYEMMLSESQERMLMVLR
PELEQEAKAVFDKWDLDFAIVGETIAEDRFLIVHNGEVKADLPLKTLAGTAPEYDRPWVATPAADPLGDVPDVDPIDGLR
ALISSPNYASKDWVFTQYDTMVMADTVRIPGIGAGIVRVHGTDKALAFTSDVTPRYVQANPVEGGKQAVAEAYRNLSAVG
ATPLATTDNMNFGNPEKPEIMGQFVGAIKGISAAVAALDMPIVSGNVSLYNETDGTAILPTPTIGAVGLIAHLDDVIGCD
VRDGHVALVLGETHGHLGQSAILSEVYNRAEGDAPPVDLDQEKAHGDFIRANRAYIKACTDLSDGGLALAAFEMAENAGV
GVCLDASDTATLFGEDQGRYLIACNFDQAEALMIAASQAGLTLTSVGKFTGQAVRFGASSAPLAELSDVYRQSFGAALA
>Mature_719_residues
MQEPAITPDLIASHGLSPDEYDRILNIVGRTPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTTGPQVICGPGENAGVVDI
GDGQAVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNSLSFGEISHPKTRQLVNGVVAGVGGYGNCFGV
PTVGGEVRFDPAYNGNCLVNAFAAGLADADKIFYSAASGVGMPVVYLGAKTGRDGVGGATMASAEFDDTIEEKRPTVQVG
DPFTEKRLMEATLELMQTGAVISIQDMGAAGLTCSAVEMGDKGNLGVRLDLEKVPVREEAMTAYEMMLSESQERMLMVLR
PELEQEAKAVFDKWDLDFAIVGETIAEDRFLIVHNGEVKADLPLKTLAGTAPEYDRPWVATPAADPLGDVPDVDPIDGLR
ALISSPNYASKDWVFTQYDTMVMADTVRIPGIGAGIVRVHGTDKALAFTSDVTPRYVQANPVEGGKQAVAEAYRNLSAVG
ATPLATTDNMNFGNPEKPEIMGQFVGAIKGISAAVAALDMPIVSGNVSLYNETDGTAILPTPTIGAVGLIAHLDDVIGCD
VRDGHVALVLGETHGHLGQSAILSEVYNRAEGDAPPVDLDQEKAHGDFIRANRAYIKACTDLSDGGLALAAFEMAENAGV
GVCLDASDTATLFGEDQGRYLIACNFDQAEALMIAASQAGLTLTSVGKFTGQAVRFGASSAPLAELSDVYRQSFGAALA

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=730, Percent_Identity=25.4794520547945, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI48994899, Length=808, Percent_Identity=25.2475247524752, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321498, Length=789, Percent_Identity=23.574144486692, Blast_Score=113, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24582111, Length=649, Percent_Identity=23.4206471494607, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24582109, Length=649, Percent_Identity=23.4206471494607, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137292, Length=649, Percent_Identity=23.4206471494607, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_ROSDO (Q163V9)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_683420.1
- STRING:   Q163V9
- GeneID:   4198582
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_3232
- NMPDR:   fig|375451.6.peg.3002
- eggNOG:   COG0046
- HOGENOM:   HBG311214
- OMA:   ADYGNSI
- ProtClustDB:   PRK01213
- BioCyc:   RDEN375451:RD1_3232-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 75828; Mature: 75828

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEPAITPDLIASHGLSPDEYDRILNIVGRTPTFTELGIFSAMWNEHCSYKSSKKWLRTL
CCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHC
PTTGPQVICGPGENAGVVDIGDGQAVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMG
CCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHC
ARPIAAMNSLSFGEISHPKTRQLVNGVVAGVGGYGNCFGVPTVGGEVRFDPAYNGNCLVN
CCCHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCEEEECCCCCCCEEEE
AFAAGLADADKIFYSAASGVGMPVVYLGAKTGRDGVGGATMASAEFDDTIEEKRPTVQVG
HHHHCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCCHHHHHHCCCEEEEC
DPFTEKRLMEATLELMQTGAVISIQDMGAAGLTCSAVEMGDKGNLGVRLDLEKVPVREEA
CCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCEEEEEHHHCCCHHHH
MTAYEMMLSESQERMLMVLRPELEQEAKAVFDKWDLDFAIVGETIAEDRFLIVHNGEVKA
HHHHHHHHHCCHHHEEEEECCCHHHHHHHHHHHCCCCEEEECCHHCCCCEEEEECCCEEE
DLPLKTLAGTAPEYDRPWVATPAADPLGDVPDVDPIDGLRALISSPNYASKDWVFTQYDT
CCCHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCC
MVMADTVRIPGIGAGIVRVHGTDKALAFTSDVTPRYVQANPVEGGKQAVAEAYRNLSAVG
EEEEEEEECCCCCCCEEEEECCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHCC
ATPLATTDNMNFGNPEKPEIMGQFVGAIKGISAAVAALDMPIVSGNVSLYNETDGTAILP
CCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCCCCEEEC
TPTIGAVGLIAHLDDVIGCDVRDGHVALVLGETHGHLGQSAILSEVYNRAEGDAPPVDLD
CCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCC
QEKAHGDFIRANRAYIKACTDLSDGGLALAAFEMAENAGVGVCLDASDTATLFGEDQGRY
CHHCCCCEEECCCCEEEEECCCCCCCEEEEEEEHHCCCCCEEEECCCCCEEEEECCCCCE
LIACNFDQAEALMIAASQAGLTLTSVGKFTGQAVRFGASSAPLAELSDVYRQSFGAALA
EEEECCCCCCEEEEEECCCCEEEEHHHHHCCHHEEECCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQEPAITPDLIASHGLSPDEYDRILNIVGRTPTFTELGIFSAMWNEHCSYKSSKKWLRTL
CCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHC
PTTGPQVICGPGENAGVVDIGDGQAVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMG
CCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHC
ARPIAAMNSLSFGEISHPKTRQLVNGVVAGVGGYGNCFGVPTVGGEVRFDPAYNGNCLVN
CCCHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCEEEECCCCCCCEEEE
AFAAGLADADKIFYSAASGVGMPVVYLGAKTGRDGVGGATMASAEFDDTIEEKRPTVQVG
HHHHCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCCHHHHHHCCCEEEEC
DPFTEKRLMEATLELMQTGAVISIQDMGAAGLTCSAVEMGDKGNLGVRLDLEKVPVREEA
CCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCEEEEEHHHCCCHHHH
MTAYEMMLSESQERMLMVLRPELEQEAKAVFDKWDLDFAIVGETIAEDRFLIVHNGEVKA
HHHHHHHHHCCHHHEEEEECCCHHHHHHHHHHHCCCCEEEECCHHCCCCEEEEECCCEEE
DLPLKTLAGTAPEYDRPWVATPAADPLGDVPDVDPIDGLRALISSPNYASKDWVFTQYDT
CCCHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCC
MVMADTVRIPGIGAGIVRVHGTDKALAFTSDVTPRYVQANPVEGGKQAVAEAYRNLSAVG
EEEEEEEECCCCCCCEEEEECCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHCC
ATPLATTDNMNFGNPEKPEIMGQFVGAIKGISAAVAALDMPIVSGNVSLYNETDGTAILP
CCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCCCCEEEC
TPTIGAVGLIAHLDDVIGCDVRDGHVALVLGETHGHLGQSAILSEVYNRAEGDAPPVDLD
CCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCC
QEKAHGDFIRANRAYIKACTDLSDGGLALAAFEMAENAGVGVCLDASDTATLFGEDQGRY
CHHCCCCEEECCCCEEEEECCCCCCCEEEEEEEHHCCCCCEEEECCCCCEEEEECCCCCE
LIACNFDQAEALMIAASQAGLTLTSVGKFTGQAVRFGASSAPLAELSDVYRQSFGAALA
EEEECCCCCCEEEEEECCCCEEEEHHHHHCCHHEEECCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA