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The map label for this gene is gppA [H]

Identifier: 110680245

GI number: 110680245

Start: 2923383

End: 2924498

Strand: Reverse

Name: gppA [H]

Synonym: RD1_3053

Alternate gene names: 110680245

Gene position: 2924498-2923383 (Counterclockwise)

Preceding gene: 110680255

Following gene: 110680244

Centisome position: 70.76

GC content: 61.02

Gene sequence:

>1116_bases
ATGGCGCCACAGCGTCACAAAGGTGCGGGCGCGCTCAAAAGTAAGACGGCTCTGAGCCCCGCGCCAGTTCCGCCCCGGTC
AAGTGAGCTTTTCGCAGCCCTTGATCTGGGTACAAATAGTTGCCGCATGCTGATTGCGCAGCCGGAAGGCAGCGGCTTTC
ATGTGGTCGACAGTTTTTCCAAATCGGTGCAACTGGGCGCCGGTCTGGAGAAAACCGGGCGGTTGTCGCGCGGATCCATG
ACGCGCACCATTCAGGCATTGCGCGTGTGTCAGCAGAAACTGAAGCGCAACAAGGTGCGGTACATGCGTCTGGTCGCGAC
CGAAGCCTGTCGCCGCGCGCAAAACGCGGATGAATTCATCCGCCGTGTGCAGCGCGAAACGGGGCTGCGGCTGGATATCA
TCAAGGCGCAGGAAGAGGCGCAACTGGCCGTGATCTCCTGTGCGCCGCTGGTCAGTCGCTCGACCGAGAACCTGCTGGTG
GTGGATATTGGCGGTGGGTCGACGGAACTGGTCTGGATTGACCTCAAGGACGTGCCCAAGAACGAGCGGGCGCGCTCGAT
CATGCATCTCAATGCAGGCTTTGCCCGTGGGCTGGGGGATGTGCCCGCAGCGCGTGTGGTTGACTGGATTTCTGTGCCTT
TGGGCGTTGCGACCCTGCGCGATCAATTCAGTGATGTGGATGATGATGCGGCGCGCTTTGCGCTGATGAGCTGGTTTTTC
GAGGAAAACCTGTCAGATTTCGCACCCTATCACGACACGCAGCCGCAGGAGAAATTCCAGATCGTCGGCACCTCGGGCAC
GGTGACGACCGTTGCAGCGAGCCACCTCGGGCTGAAACGCTATGACCGCAAGAAAGTGGATGGTCTGCATATGACAACGG
ATCAGATTGACCGTGTCATCCGATCCTATCTGGCGCTGGGGCCGGACGGGCGGCGTGCCGATCCGCGCATCGGTGCGGAT
CGCCATGCGCTGATCATGTCGGGGGCGGCGATCCTTCAGGCTTTGATGCGCTGCTGGCCAACGGATCGGTTGTCGGTGGC
GGATCGTGGCCTGCGCGAAGGGCTGCTTTATGCGCAGATGAGTGCGCAGGGTGTGTTGGAAGACGGGGCGTTCTGA

Upstream 100 bases:

>100_bases
GACGCTCGGCGCGAAAACCACATGAAAGCGCGCGCCCGTGCTTGCGCAGCAGACGCACAGCCGTTAGCGTAAACCCAACT
CGAAATGAAAGGCGCAACCC

Downstream 100 bases:

>100_bases
TGGCGAAAAAACCGGGCAGTCAAAATACATCGGGGCGCGGGCAGCGTGATCTGAAGGTCAAGGTCAAGACCGCGCGCGGG
CGCAAGCTGAGTTCAACGCG

Product: Ppx/GppA family phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MAPQRHKGAGALKSKTALSPAPVPPRSSELFAALDLGTNSCRMLIAQPEGSGFHVVDSFSKSVQLGAGLEKTGRLSRGSM
TRTIQALRVCQQKLKRNKVRYMRLVATEACRRAQNADEFIRRVQRETGLRLDIIKAQEEAQLAVISCAPLVSRSTENLLV
VDIGGGSTELVWIDLKDVPKNERARSIMHLNAGFARGLGDVPAARVVDWISVPLGVATLRDQFSDVDDDAARFALMSWFF
EENLSDFAPYHDTQPQEKFQIVGTSGTVTTVAASHLGLKRYDRKKVDGLHMTTDQIDRVIRSYLALGPDGRRADPRIGAD
RHALIMSGAAILQALMRCWPTDRLSVADRGLREGLLYAQMSAQGVLEDGAF

Sequences:

>Translated_371_residues
MAPQRHKGAGALKSKTALSPAPVPPRSSELFAALDLGTNSCRMLIAQPEGSGFHVVDSFSKSVQLGAGLEKTGRLSRGSM
TRTIQALRVCQQKLKRNKVRYMRLVATEACRRAQNADEFIRRVQRETGLRLDIIKAQEEAQLAVISCAPLVSRSTENLLV
VDIGGGSTELVWIDLKDVPKNERARSIMHLNAGFARGLGDVPAARVVDWISVPLGVATLRDQFSDVDDDAARFALMSWFF
EENLSDFAPYHDTQPQEKFQIVGTSGTVTTVAASHLGLKRYDRKKVDGLHMTTDQIDRVIRSYLALGPDGRRADPRIGAD
RHALIMSGAAILQALMRCWPTDRLSVADRGLREGLLYAQMSAQGVLEDGAF
>Mature_370_residues
APQRHKGAGALKSKTALSPAPVPPRSSELFAALDLGTNSCRMLIAQPEGSGFHVVDSFSKSVQLGAGLEKTGRLSRGSMT
RTIQALRVCQQKLKRNKVRYMRLVATEACRRAQNADEFIRRVQRETGLRLDIIKAQEEAQLAVISCAPLVSRSTENLLVV
DIGGGSTELVWIDLKDVPKNERARSIMHLNAGFARGLGDVPAARVVDWISVPLGVATLRDQFSDVDDDAARFALMSWFFE
ENLSDFAPYHDTQPQEKFQIVGTSGTVTTVAASHLGLKRYDRKKVDGLHMTTDQIDRVIRSYLALGPDGRRADPRIGADR
HALIMSGAAILQALMRCWPTDRLSVADRGLREGLLYAQMSAQGVLEDGAF

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=337, Percent_Identity=28.1899109792285, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI48994966, Length=334, Percent_Identity=27.2455089820359, Blast_Score=92, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 40695; Mature: 40564

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPQRHKGAGALKSKTALSPAPVPPRSSELFAALDLGTNSCRMLIAQPEGSGFHVVDSFS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEHHHH
KSVQLGAGLEKTGRLSRGSMTRTIQALRVCQQKLKRNKVRYMRLVATEACRRAQNADEFI
HHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RRVQRETGLRLDIIKAQEEAQLAVISCAPLVSRSTENLLVVDIGGGSTELVWIDLKDVPK
HHHHHHCCCEEEEEECCCCCEEEEEEECHHHCCCCCCEEEEEECCCCEEEEEEECCCCCC
NERARSIMHLNAGFARGLGDVPAARVVDWISVPLGVATLRDQFSDVDDDAARFALMSWFF
CHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EENLSDFAPYHDTQPQEKFQIVGTSGTVTTVAASHLGLKRYDRKKVDGLHMTTDQIDRVI
HHCHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RSYLALGPDGRRADPRIGADRHALIMSGAAILQALMRCWPTDRLSVADRGLREGLLYAQM
HHHHHCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SAQGVLEDGAF
HHCCCCCCCCC
>Mature Secondary Structure 
APQRHKGAGALKSKTALSPAPVPPRSSELFAALDLGTNSCRMLIAQPEGSGFHVVDSFS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEHHHH
KSVQLGAGLEKTGRLSRGSMTRTIQALRVCQQKLKRNKVRYMRLVATEACRRAQNADEFI
HHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RRVQRETGLRLDIIKAQEEAQLAVISCAPLVSRSTENLLVVDIGGGSTELVWIDLKDVPK
HHHHHHCCCEEEEEECCCCCEEEEEEECHHHCCCCCCEEEEEECCCCEEEEEEECCCCCC
NERARSIMHLNAGFARGLGDVPAARVVDWISVPLGVATLRDQFSDVDDDAARFALMSWFF
CHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EENLSDFAPYHDTQPQEKFQIVGTSGTVTTVAASHLGLKRYDRKKVDGLHMTTDQIDRVI
HHCHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RSYLALGPDGRRADPRIGADRHALIMSGAAILQALMRCWPTDRLSVADRGLREGLLYAQM
HHHHHCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SAQGVLEDGAF
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA