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The map label for this gene is pdhA [H]

Identifier: 110680207

GI number: 110680207

Start: 2886826

End: 2887836

Strand: Direct

Name: pdhA [H]

Synonym: RD1_3011

Alternate gene names: 110680207

Gene position: 2886826-2887836 (Clockwise)

Preceding gene: 110680206

Following gene: 110680208

Centisome position: 69.85

GC content: 57.96

Gene sequence:

>1011_bases
ATGGCAGCGCGAAAAGCGGCAAAAAAACCAAACGTCTCAGCCGAAGAACTCACGGCATATTACAAGGATATGCTCCTGAT
CAGACGGTTCGAGGAAAAAGCAGGCCAGCTGTACGGCATGGGCCTGATCGGCGGCTTTTGCCATCTCTACATCGGTCAGG
AAGCGGTTGTTGTCGGCCTTGAGGCCGCCGCCGAAGAGGGCGACAAACGCATCACGTCCTACCGTGATCACGGCCACATG
CTGGCCTGTGGGATGGACCCCAACGGCGTGATGGCCGAATTGACCGGACGCGAGGGTGGCTATTCCAAAGGCAAAGGCGG
CTCCATGCATATGTTCTCCAAGGAGAAGCATTTCTACGGGGGCCACGGAATCGTGGCCGCTCAGGTTCCGCTGGGCGCGG
GTCTGGCTTTCGCGGACAAATACCTCGACAACAAGCGCGTGACCTTCACCTATTTCGGCGATGGTGCGGCCAATCAGGGG
CAGGTCTACGAGGCTTTCAACATGGCTGCCCTGTGGGACCTGCCGTGTATCTTTGTGATTGAAAACAACCAATACGCCAT
GGGCACCTCGCAGCAGCGCTCCACCTCATCGGATGAGATATATGAGCGCGGACGCGCCTTTGGCATTCCGGGCGAAGCTG
TTGACGGCATGGATGTCATTGCGGTCAAGGCCGCCGGTGACACCGCCGTCGCGCACTGCCGGTCTGGCAAGGGGCCCTAT
ATTCTTGAGATCAAAACCTATCGCTATCGCGGCCACTCCATGTCCGATCCGGCGAAATACCGGACCCGCGAAGAGGTGCA
GAAAATGCGCGACGAGCGCGATCCGATCGAACAGGTGCGCTCGATGCTGCTGACAGGCAAGCACGCAACCGAAGACGATT
TGAAAGCCATCGACAAGGAAATCAAAGCCATCGTGAACGAGAGCGCGGAGTTTGCAAAAACATCCCCCGAGCCGGACCTG
AAAGAGCTTTGGACCGACATCTACGCCACAGAAGTTCCGCAGGAGGCTTGA

Upstream 100 bases:

>100_bases
GTTTGTATTCAGTCTCGCAATACGCCACCGAATCCGATAATAGATAGTTTAATGCTAAACTATCTACCCCACGGCGGGTT
GCGGAAAGGAAGTGTGACCG

Downstream 100 bases:

>100_bases
TCAATGGCTACTGAAATACTCATGCCCGCCCTATCGCCCACCATGGAAGAAGGCACACTCGCCAAATGGCTGGTCAAGGA
AGGAGACACGGTTTCCTCCG

Product: pyruvate dehydrogenase complex, E1 component, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAARKAAKKPNVSAEELTAYYKDMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGLEAAAEEGDKRITSYRDHGHM
LACGMDPNGVMAELTGREGGYSKGKGGSMHMFSKEKHFYGGHGIVAAQVPLGAGLAFADKYLDNKRVTFTYFGDGAANQG
QVYEAFNMAALWDLPCIFVIENNQYAMGTSQQRSTSSDEIYERGRAFGIPGEAVDGMDVIAVKAAGDTAVAHCRSGKGPY
ILEIKTYRYRGHSMSDPAKYRTREEVQKMRDERDPIEQVRSMLLTGKHATEDDLKAIDKEIKAIVNESAEFAKTSPEPDL
KELWTDIYATEVPQEA

Sequences:

>Translated_336_residues
MAARKAAKKPNVSAEELTAYYKDMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGLEAAAEEGDKRITSYRDHGHM
LACGMDPNGVMAELTGREGGYSKGKGGSMHMFSKEKHFYGGHGIVAAQVPLGAGLAFADKYLDNKRVTFTYFGDGAANQG
QVYEAFNMAALWDLPCIFVIENNQYAMGTSQQRSTSSDEIYERGRAFGIPGEAVDGMDVIAVKAAGDTAVAHCRSGKGPY
ILEIKTYRYRGHSMSDPAKYRTREEVQKMRDERDPIEQVRSMLLTGKHATEDDLKAIDKEIKAIVNESAEFAKTSPEPDL
KELWTDIYATEVPQEA
>Mature_335_residues
AARKAAKKPNVSAEELTAYYKDMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGLEAAAEEGDKRITSYRDHGHML
ACGMDPNGVMAELTGREGGYSKGKGGSMHMFSKEKHFYGGHGIVAAQVPLGAGLAFADKYLDNKRVTFTYFGDGAANQGQ
VYEAFNMAALWDLPCIFVIENNQYAMGTSQQRSTSSDEIYERGRAFGIPGEAVDGMDVIAVKAAGDTAVAHCRSGKGPYI
LEIKTYRYRGHSMSDPAKYRTREEVQKMRDERDPIEQVRSMLLTGKHATEDDLKAIDKEIKAIVNESAEFAKTSPEPDLK
ELWTDIYATEVPQEA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=313, Percent_Identity=54.6325878594249, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI291084742, Length=326, Percent_Identity=52.1472392638037, Blast_Score=322, Evalue=5e-88,
Organism=Homo sapiens, GI4505685, Length=326, Percent_Identity=52.1472392638037, Blast_Score=321, Evalue=5e-88,
Organism=Homo sapiens, GI291084744, Length=333, Percent_Identity=51.0510510510511, Blast_Score=314, Evalue=6e-86,
Organism=Homo sapiens, GI291084757, Length=326, Percent_Identity=46.319018404908, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI11386135, Length=330, Percent_Identity=31.8181818181818, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI258645172, Length=330, Percent_Identity=31.8181818181818, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI32564172, Length=331, Percent_Identity=52.5679758308157, Blast_Score=333, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI17536047, Length=331, Percent_Identity=52.5679758308157, Blast_Score=332, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI86563355, Length=329, Percent_Identity=30.6990881458967, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI86563357, Length=329, Percent_Identity=30.6990881458967, Blast_Score=127, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6321026, Length=333, Percent_Identity=50.1501501501502, Blast_Score=313, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24639744, Length=327, Percent_Identity=49.2354740061162, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI28571106, Length=327, Percent_Identity=49.2354740061162, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24639740, Length=327, Percent_Identity=49.2354740061162, Blast_Score=324, Evalue=5e-89,
Organism=Drosophila melanogaster, GI24639746, Length=310, Percent_Identity=50.9677419354839, Blast_Score=318, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24639748, Length=322, Percent_Identity=50.3105590062112, Blast_Score=299, Evalue=2e-81,
Organism=Drosophila melanogaster, GI21355903, Length=329, Percent_Identity=27.6595744680851, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37026; Mature: 36895

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARKAAKKPNVSAEELTAYYKDMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHEECCCEEEEEH
EAAAEEGDKRITSYRDHGHMLACGMDPNGVMAELTGREGGYSKGKGGSMHMFSKEKHFYG
HHHHHCCHHHHHHCCCCCCEEEECCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCEEC
GHGIVAAQVPLGAGLAFADKYLDNKRVTFTYFGDGAANQGQVYEAFNMAALWDLPCIFVI
CCEEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCHHEEECCCEEEEE
ENNQYAMGTSQQRSTSSDEIYERGRAFGIPGEAVDGMDVIAVKAAGDTAVAHCRSGKGPY
ECCEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHCCCCCCE
ILEIKTYRYRGHSMSDPAKYRTREEVQKMRDERDPIEQVRSMLLTGKHATEDDLKAIDKE
EEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
IKAIVNESAEFAKTSPEPDLKELWTDIYATEVPQEA
HHHHHCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AARKAAKKPNVSAEELTAYYKDMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHEECCCEEEEEH
EAAAEEGDKRITSYRDHGHMLACGMDPNGVMAELTGREGGYSKGKGGSMHMFSKEKHFYG
HHHHHCCHHHHHHCCCCCCEEEECCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCEEC
GHGIVAAQVPLGAGLAFADKYLDNKRVTFTYFGDGAANQGQVYEAFNMAALWDLPCIFVI
CCEEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCHHEEECCCEEEEE
ENNQYAMGTSQQRSTSSDEIYERGRAFGIPGEAVDGMDVIAVKAAGDTAVAHCRSGKGPY
ECCEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHCCCCCCE
ILEIKTYRYRGHSMSDPAKYRTREEVQKMRDERDPIEQVRSMLLTGKHATEDDLKAIDKE
EEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
IKAIVNESAEFAKTSPEPDLKELWTDIYATEVPQEA
HHHHHCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]