Click here to switch to the map view.

The map label for this gene is bhbD [H]

Identifier: 110678704

GI number: 110678704

Start: 1328799

End: 1329674

Strand: Reverse

Name: bhbD [H]

Synonym: RD1_1385

Alternate gene names: 110678704

Gene position: 1329674-1328799 (Counterclockwise)

Preceding gene: 110678706

Following gene: 110678696

Centisome position: 32.17

GC content: 56.16

Gene sequence:

>876_bases
GTGGAAATCAAATCAATTGGAATCGTGGGTGCGGGTCAGATGGGCAATGGGATTGCGCATGTCATGGCCTTGGCAGGGTA
TGATGTGATGCTGAATGACATCAATCAGGAAACACTGACTGCCGCGATGGAGACCATGACGCGCAACATGGACCGGCAAG
TCAGCCGTGAGAAGATCTCCGCCGACGCGCAGAAAGACGCCCTCGGGCGGATCATCACGACAACCACACTCACGGATCTG
GGTCAGACCGATCTGGTGATCGAGGCTGCGACTGAACGAGAAACCGTCAAACAGGCGATTTTCGAAGACCTCATTCCACA
TCTGAAACCGAACACGATCCTCACTTCCAACACCTCATCCATCTCGATCACGCGCCTGGCCAGCCGGACAGACCGGCCAG
AAAGGTTCATGGGCTTTCATTTCATGAACCCCGTACCCGTGATGAAACTGGTTGAACTGATCCGTGGGATTGCGACAGAT
GAAGAAACCTATGCGGCCTGCAAGGCTGTTGTGGACCGGCTGGATAAAACCGCCGCCTCCGCCGAGGACTTCCCCGGATT
TATCGTGAACCGGATATTGATGCCGATGATCAACGAGGCCGTCTACACGCTGTACGAGGGTGTCGGAAATGTCCAATCCA
TCGACAGTTCGATGAAGCTCGGCGCGAACCATCCGATGGGGCCCCTCGAACTGGCCGATTTCATTGGCCTTGATACCTGC
CTTGCGATCATGAACGTGCTGCATGACGGGCTGGCGGATACCAAATACCGTCCCTGCCCCCTGCTCACGAAATATGTGGA
GGCGGGGTGGCTGGGCCGAAAAACCCAGCGCGGGTTTTACGATTACCGTGGCGACACGCCCGTTCCAACGCGATAG

Upstream 100 bases:

>100_bases
TTTCTTAATGCTGGAATTTTAGACAATGCTGCTGTGCCGCATTGCACTTGCAGCTACCTGCCCCAAAGCCCTAGAATGGC
GGTGTACAAAGGGGACTTCC

Downstream 100 bases:

>100_bases
GGGTTAATCCGTCAACGACAGGGTGTGATCGCGCAACCATGCCATGAAGGCGCGCGGGTCATCCTGCCGCTTGATGATCT
CATCAGGGTCTATCGGATGC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MEIKSIGIVGAGQMGNGIAHVMALAGYDVMLNDINQETLTAAMETMTRNMDRQVSREKISADAQKDALGRIITTTTLTDL
GQTDLVIEAATERETVKQAIFEDLIPHLKPNTILTSNTSSISITRLASRTDRPERFMGFHFMNPVPVMKLVELIRGIATD
EETYAACKAVVDRLDKTAASAEDFPGFIVNRILMPMINEAVYTLYEGVGNVQSIDSSMKLGANHPMGPLELADFIGLDTC
LAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRKTQRGFYDYRGDTPVPTR

Sequences:

>Translated_291_residues
MEIKSIGIVGAGQMGNGIAHVMALAGYDVMLNDINQETLTAAMETMTRNMDRQVSREKISADAQKDALGRIITTTTLTDL
GQTDLVIEAATERETVKQAIFEDLIPHLKPNTILTSNTSSISITRLASRTDRPERFMGFHFMNPVPVMKLVELIRGIATD
EETYAACKAVVDRLDKTAASAEDFPGFIVNRILMPMINEAVYTLYEGVGNVQSIDSSMKLGANHPMGPLELADFIGLDTC
LAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRKTQRGFYDYRGDTPVPTR
>Mature_291_residues
MEIKSIGIVGAGQMGNGIAHVMALAGYDVMLNDINQETLTAAMETMTRNMDRQVSREKISADAQKDALGRIITTTTLTDL
GQTDLVIEAATERETVKQAIFEDLIPHLKPNTILTSNTSSISITRLASRTDRPERFMGFHFMNPVPVMKLVELIRGIATD
EETYAACKAVVDRLDKTAASAEDFPGFIVNRILMPMINEAVYTLYEGVGNVQSIDSSMKLGANHPMGPLELADFIGLDTC
LAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRKTQRGFYDYRGDTPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=38.7543252595156, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=37.4592833876222, Blast_Score=193, Evalue=1e-49,
Organism=Homo sapiens, GI261878539, Length=296, Percent_Identity=31.0810810810811, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI68989263, Length=296, Percent_Identity=31.0810810810811, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=29.3286219081272, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI1787661, Length=286, Percent_Identity=39.8601398601399, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI1790281, Length=267, Percent_Identity=33.7078651685393, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI1788682, Length=266, Percent_Identity=34.5864661654135, Blast_Score=143, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=41.6666666666667, Blast_Score=217, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17549919, Length=290, Percent_Identity=38.6206896551724, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=35.8885017421603, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17558304, Length=286, Percent_Identity=32.8671328671329, Blast_Score=143, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17508951, Length=286, Percent_Identity=32.1678321678322, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI25144276, Length=286, Percent_Identity=32.1678321678322, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17508953, Length=286, Percent_Identity=32.1678321678322, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71985923, Length=288, Percent_Identity=27.4305555555556, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71985930, Length=285, Percent_Identity=25.9649122807018, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI193203623, Length=209, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=209, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI19921000, Length=292, Percent_Identity=32.1917808219178, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24583077, Length=292, Percent_Identity=32.1917808219178, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24583079, Length=292, Percent_Identity=32.1917808219178, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=28.3333333333333, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI20129993, Length=243, Percent_Identity=26.3374485596708, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 32034; Mature: 32034

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKSIGIVGAGQMGNGIAHVMALAGYDVMLNDINQETLTAAMETMTRNMDRQVSREKIS
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
ADAQKDALGRIITTTTLTDLGQTDLVIEAATERETVKQAIFEDLIPHLKPNTILTSNTSS
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ISITRLASRTDRPERFMGFHFMNPVPVMKLVELIRGIATDEETYAACKAVVDRLDKTAAS
EEHHHHHHCCCCHHHHHCHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
AEDFPGFIVNRILMPMINEAVYTLYEGVGNVQSIDSSMKLGANHPMGPLELADFIGLDTC
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRKTQRGFYDYRGDTPVPTR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEIKSIGIVGAGQMGNGIAHVMALAGYDVMLNDINQETLTAAMETMTRNMDRQVSREKIS
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
ADAQKDALGRIITTTTLTDLGQTDLVIEAATERETVKQAIFEDLIPHLKPNTILTSNTSS
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ISITRLASRTDRPERFMGFHFMNPVPVMKLVELIRGIATDEETYAACKAVVDRLDKTAAS
EEHHHHHHCCCCHHHHHCHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
AEDFPGFIVNRILMPMINEAVYTLYEGVGNVQSIDSSMKLGANHPMGPLELADFIGLDTC
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRKTQRGFYDYRGDTPVPTR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]