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The map label for this gene is rnc

Identifier: 110678686

GI number: 110678686

Start: 1313512

End: 1314198

Strand: Direct

Name: rnc

Synonym: RD1_1366

Alternate gene names: 110678686

Gene position: 1313512-1314198 (Clockwise)

Preceding gene: 110678685

Following gene: 110678687

Centisome position: 31.78

GC content: 63.61

Gene sequence:

>687_bases
GTGAAACTCTCGGCGGAACTGAAGTCCTTTCAAAAGCGGCTCGGGCATCAGTTTAACCAACCGGCGCTTTTGGCTCAGGC
GGTAACGCATGCCTCCATGTCCACGGCAAACCGGGGCGACAATCAGCGCATGGAGTTTCTGGGTGACCGGGTGCTGGGTC
TGGTCATGGCCGAAGCCTTGCTGAGGCTGGACAATAACGCCACCGAAGGGCAGCTTGCTCCGCGTTTCAATGCCCTCGTG
CGCAAAGAAACCTGCGCCGATGTTGCGCGCGAAATCGACCTTGGGGCGGTTTTGCGTCTGGGGCGTTCCGAGATGCTGTC
GGGCGGGCGGCGCAAGCAGGCACTCTTGGGCGATGCCATCGAGGCAGTGATTGCGGCCGTTTATCAGGATGCGGGATTTG
ATGCGGCGCGCGCTCTGATCCTGCGGCTCTGGGGCGACCGGGTTCACGAGGTCGAGGAAGACGCGCGCGATCCCAAAACC
GCGCTGCAGGAATGGGCGCAGGCCCGCGGTCTGCAGCCCCCCCGCTACGAAGAGGTGAGCCGCAAGGGCCCCGACCACGC
CCCGATTTTCACGATTTCCGTGCGGATCAGCACCGGGGAAACGGATCAGGCCACGGCCGGGTCAAAGCGGCAGGCCGAAC
AAGCCGCGGCACAGGCCTTGCTGGCCAAACTGGAGACAAGCGGATGA

Upstream 100 bases:

>100_bases
ATCTGATCGGGCGGGCAGACCGGGTGATGTTCTCCTCCGCGGGACGGTCCATGTTGTTTTTCTGGACATGGCGCGGTGAT
CGTTTCTTCAAGAGGGTGGA

Downstream 100 bases:

>100_bases
GTACACGTGCAGGATTTGTCGCACTGATCGGGGAGCCGAACGCGGGAAAGTCGACCTTGCTCAACCGCATGGTCGGGGCA
AAGGTGTCGATTGTCACGCA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKLSAELKSFQKRLGHQFNQPALLAQAVTHASMSTANRGDNQRMEFLGDRVLGLVMAEALLRLDNNATEGQLAPRFNALV
RKETCADVAREIDLGAVLRLGRSEMLSGGRRKQALLGDAIEAVIAAVYQDAGFDAARALILRLWGDRVHEVEEDARDPKT
ALQEWAQARGLQPPRYEEVSRKGPDHAPIFTISVRISTGETDQATAGSKRQAEQAAAQALLAKLETSG

Sequences:

>Translated_228_residues
MKLSAELKSFQKRLGHQFNQPALLAQAVTHASMSTANRGDNQRMEFLGDRVLGLVMAEALLRLDNNATEGQLAPRFNALV
RKETCADVAREIDLGAVLRLGRSEMLSGGRRKQALLGDAIEAVIAAVYQDAGFDAARALILRLWGDRVHEVEEDARDPKT
ALQEWAQARGLQPPRYEEVSRKGPDHAPIFTISVRISTGETDQATAGSKRQAEQAAAQALLAKLETSG
>Mature_228_residues
MKLSAELKSFQKRLGHQFNQPALLAQAVTHASMSTANRGDNQRMEFLGDRVLGLVMAEALLRLDNNATEGQLAPRFNALV
RKETCADVAREIDLGAVLRLGRSEMLSGGRRKQALLGDAIEAVIAAVYQDAGFDAARALILRLWGDRVHEVEEDARDPKT
ALQEWAQARGLQPPRYEEVSRKGPDHAPIFTISVRISTGETDQATAGSKRQAEQAAAQALLAKLETSG

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=227, Percent_Identity=29.9559471365639, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI155030236, Length=227, Percent_Identity=29.9559471365639, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1788920, Length=222, Percent_Identity=40.990990990991, Blast_Score=143, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17506883, Length=233, Percent_Identity=31.7596566523605, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=233, Percent_Identity=31.7596566523605, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17137682, Length=231, Percent_Identity=30.3030303030303, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_ROSDO (Q16AI6)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_681693.1
- ProteinModelPortal:   Q16AI6
- SMR:   Q16AI6
- STRING:   Q16AI6
- GeneID:   4197339
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_1366
- NMPDR:   fig|375451.6.peg.1279
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q16AI6
- ProtClustDB:   CLSK934087
- BioCyc:   RDEN375451:RD1_1366-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 24853; Mature: 24853

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSAELKSFQKRLGHQFNQPALLAQAVTHASMSTANRGDNQRMEFLGDRVLGLVMAEAL
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LRLDNNATEGQLAPRFNALVRKETCADVAREIDLGAVLRLGRSEMLSGGRRKQALLGDAI
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHH
EAVIAAVYQDAGFDAARALILRLWGDRVHEVEEDARDPKTALQEWAQARGLQPPRYEEVS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHH
RKGPDHAPIFTISVRISTGETDQATAGSKRQAEQAAAQALLAKLETSG
HCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLSAELKSFQKRLGHQFNQPALLAQAVTHASMSTANRGDNQRMEFLGDRVLGLVMAEAL
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LRLDNNATEGQLAPRFNALVRKETCADVAREIDLGAVLRLGRSEMLSGGRRKQALLGDAI
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHH
EAVIAAVYQDAGFDAARALILRLWGDRVHEVEEDARDPKTALQEWAQARGLQPPRYEEVS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHH
RKGPDHAPIFTISVRISTGETDQATAGSKRQAEQAAAQALLAKLETSG
HCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA