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The map label for this gene is hemF [H]

Identifier: 110678607

GI number: 110678607

Start: 1244756

End: 1245649

Strand: Direct

Name: hemF [H]

Synonym: RD1_1282

Alternate gene names: 110678607

Gene position: 1244756-1245649 (Clockwise)

Preceding gene: 110678606

Following gene: 110678609

Centisome position: 30.12

GC content: 58.5

Gene sequence:

>894_bases
ATGACCACAGACTACGATACGGAAAAAACACGCGCCTCTGCCTGGTTTCGTGACCTGCGCGATCAGATCGTAGCAGCTTT
TGAAGAGCTGGAGCGGGATCACGCGACAGGCCCTCTCAGCGATGGAGAGGCGGCCGTTTTCGATGTAAGTGAAACCAAAC
GCCAGAGCGATGATGGTTCTGACGCCGGTGGTGGTTTGATGAGCGTGATGCGCGGCGGTCGTGTGTTCGAGAAGGTCGGC
GTGAATATATCCACCGTCTACGGCACCCTTGGCACCCGCGCGCAATCCGCGATGGCGGCGCGCAAGGGCATTCCGGGGAT
GAAGGATGATCCGCGCTTCTGGGCCTCTGGCATCAGCCTTGTCGCGCATATGCAAAATCCGCATGTGCCTGCGGTACATA
TGAACACGCGGATGTTCTGGACGCCCCATGCGTGGTGGTTCGGGGGTGGCTCCGATTTGAACCCTTGCATCGAATACGAC
GAGGACACCGCCCATTTTCACGCCCAGCAACAGGAAAAACTGGACCCACATGGGGCAGAGCTCTACCCGCGGCTGAAAGA
ATGGGCGGATGAGTATTTCTATATCCCGCACCGCAATCGGGCGCGCGGCGTGGGCGGGATTTTCATGGATGATCACTGCA
CGAACGATTGGGAACGGGACTTTGCCCTGACCCAGGACATCGGGCGCGCGTTCCTACCTGCCTATGTGCCACTGGTGCGC
AAACGTCGGACGCAAGACTGGACGGACGCGGACAAGGATGCGCAACTGGTGCATCGCGGCCTCTATGCCGAATACAACCT
GGTTTATGATCGTGGTACCAAGTTTGGATTGGAGACAGGCCACGACGCGAATGCCGTATTGATGAGCCTGCCGCCCTTGG
CAAAATGGGTGTGA

Upstream 100 bases:

>100_bases
ATGCGGTCGCGGTGCCGGCGCACTGACAATTGCGCTTGGAATGCCGTGGAAAAGCGGTTTAGAGATGGTGTCAGGATAAA
CTGACACATTAGGCTGCACT

Downstream 100 bases:

>100_bases
TGCAGTGAAACTGCCCCGGCGCGATGCCCTTTAGGGATCGCGCCGGGGAGTGAGATACATGGGCTAAAGCGTCATTCCAA
AAATCCTAACCACGTAACGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MTTDYDTEKTRASAWFRDLRDQIVAAFEELERDHATGPLSDGEAAVFDVSETKRQSDDGSDAGGGLMSVMRGGRVFEKVG
VNISTVYGTLGTRAQSAMAARKGIPGMKDDPRFWASGISLVAHMQNPHVPAVHMNTRMFWTPHAWWFGGGSDLNPCIEYD
EDTAHFHAQQQEKLDPHGAELYPRLKEWADEYFYIPHRNRARGVGGIFMDDHCTNDWERDFALTQDIGRAFLPAYVPLVR
KRRTQDWTDADKDAQLVHRGLYAEYNLVYDRGTKFGLETGHDANAVLMSLPPLAKWV

Sequences:

>Translated_297_residues
MTTDYDTEKTRASAWFRDLRDQIVAAFEELERDHATGPLSDGEAAVFDVSETKRQSDDGSDAGGGLMSVMRGGRVFEKVG
VNISTVYGTLGTRAQSAMAARKGIPGMKDDPRFWASGISLVAHMQNPHVPAVHMNTRMFWTPHAWWFGGGSDLNPCIEYD
EDTAHFHAQQQEKLDPHGAELYPRLKEWADEYFYIPHRNRARGVGGIFMDDHCTNDWERDFALTQDIGRAFLPAYVPLVR
KRRTQDWTDADKDAQLVHRGLYAEYNLVYDRGTKFGLETGHDANAVLMSLPPLAKWV
>Mature_296_residues
TTDYDTEKTRASAWFRDLRDQIVAAFEELERDHATGPLSDGEAAVFDVSETKRQSDDGSDAGGGLMSVMRGGRVFEKVGV
NISTVYGTLGTRAQSAMAARKGIPGMKDDPRFWASGISLVAHMQNPHVPAVHMNTRMFWTPHAWWFGGGSDLNPCIEYDE
DTAHFHAQQQEKLDPHGAELYPRLKEWADEYFYIPHRNRARGVGGIFMDDHCTNDWERDFALTQDIGRAFLPAYVPLVRK
RRTQDWTDADKDAQLVHRGLYAEYNLVYDRGTKFGLETGHDANAVLMSLPPLAKWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=243, Percent_Identity=45.679012345679, Blast_Score=216, Evalue=1e-56,
Organism=Escherichia coli, GI1788777, Length=240, Percent_Identity=44.5833333333333, Blast_Score=215, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6320249, Length=257, Percent_Identity=45.136186770428, Blast_Score=228, Evalue=9e-61,
Organism=Drosophila melanogaster, GI17864388, Length=243, Percent_Identity=46.5020576131687, Blast_Score=221, Evalue=6e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 33525; Mature: 33393

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDYDTEKTRASAWFRDLRDQIVAAFEELERDHATGPLSDGEAAVFDVSETKRQSDDGS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCCCCC
DAGGGLMSVMRGGRVFEKVGVNISTVYGTLGTRAQSAMAARKGIPGMKDDPRFWASGISL
CCCHHHHHHHHCCHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
VAHMQNPHVPAVHMNTRMFWTPHAWWFGGGSDLNPCIEYDEDTAHFHAQQQEKLDPHGAE
HHHCCCCCCCEEEECCEEEECCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHH
LYPRLKEWADEYFYIPHRNRARGVGGIFMDDHCTNDWERDFALTQDIGRAFLPAYVPLVR
HHHHHHHHHHHEEECCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KRRTQDWTDADKDAQLVHRGLYAEYNLVYDRGTKFGLETGHDANAVLMSLPPLAKWV
HHCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCEEEEECCCHHHCC
>Mature Secondary Structure 
TTDYDTEKTRASAWFRDLRDQIVAAFEELERDHATGPLSDGEAAVFDVSETKRQSDDGS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCCCCC
DAGGGLMSVMRGGRVFEKVGVNISTVYGTLGTRAQSAMAARKGIPGMKDDPRFWASGISL
CCCHHHHHHHHCCHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
VAHMQNPHVPAVHMNTRMFWTPHAWWFGGGSDLNPCIEYDEDTAHFHAQQQEKLDPHGAE
HHHCCCCCCCEEEECCEEEECCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHH
LYPRLKEWADEYFYIPHRNRARGVGGIFMDDHCTNDWERDFALTQDIGRAFLPAYVPLVR
HHHHHHHHHHHEEECCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KRRTQDWTDADKDAQLVHRGLYAEYNLVYDRGTKFGLETGHDANAVLMSLPPLAKWV
HHCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCEEEEECCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]