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The map label for this gene is hemE

Identifier: 110678609

GI number: 110678609

Start: 1246857

End: 1247891

Strand: Direct

Name: hemE

Synonym: RD1_1284

Alternate gene names: 110678609

Gene position: 1246857-1247891 (Clockwise)

Preceding gene: 110678607

Following gene: 110678610

Centisome position: 30.17

GC content: 60.77

Gene sequence:

>1035_bases
ATGGCCGCGGCAAAAACCATCCTGCGCTCTTTGGCAGGCGAAACACTTCCCACCCCTCCGATCTGGATGATGCGTCAGGC
AGGGCGATATCTGCCCGAATACAAAGCGACGCGCGCGCAGGCCGGTGATTTTCTGTCGCTGTGCTATAACCCGGAATTGG
CCGCCGAGGTGACGTTGCAGCCGATCCGTCGCTATGGGTTCGACGCGGCCATCCTTTTTGCCGATATCCTGCTGTTGCCG
CAGGCGCTGGGGGCGGATTTGTGGTTTGTCACCGGCGAGGGGCCGAGGTTGTCCACCATCACAACCCAAGCGGATTTCGA
CAAGCTCAAGCCCGTGGACGAGATCGACGCGGTTCTGAATCCGATCTACGAAACCGTGCGTATTCTGCGCCGCGAGTTGC
CGCAGGAAACGACGCTCATTGGTTTTGCCGGGGCACCCTGGACGGTGGCGACCTATATGATTGCCGGGCGCGGCACGCCT
GATCAGGCACCTGCGCATGCGCTGAAAGATGAAAACCGGGAATTGTTCGAGGCACTTCTGGCGCGGATCACGCAGGGCAC
CATCGAATATCTGTCCCGACAGATCGAAGCCGGCGCAGAGGTGGTCAAGATTTTTGACAGTTGGGCCGGGTCGCTGAAAG
GCGCGGATTTCCAGAGATACGCGCTGGAACCTGCGCGCGAGATCACCGCCGCGATCAAGGCGCGTCATCCGGATATTCCG
GTCATCGGCTTCCCGCGCGAGGCAGGGGATGGATACATCGGCTTCGCAAAAGCCACCGGCGTGGATTGCGTCGCCCTCGA
CAACTCGGTCAGCGCGGAATGGGCGGCGGCCAATGTTCAGGTCGATGGCTGCGTGCAGGGTAATCTGGCGTCAAGCCATA
TGGTCACGGGCGGGCAGGCGTTGATTGATGAGACGCGCGCGATCGTAAAGGCGTTTTCTGGCGGCCCGCACATCTTTAAC
CTCGGTCACGGAATCACACCGGATGCTGACCCGGACAATGTGCAGCGCATGATTGACGCGGTTCGGGGGCAGTAA

Upstream 100 bases:

>100_bases
CACATCTTTAAGCGCGTCAATTTACCCTGACAACCCGTCTGTGACTTGACAATACCGCCTGAGACGAAGACCAACGTTTT
GAGTTACCAAGAGGACGAAC

Downstream 100 bases:

>100_bases
ACGCGGATTGTGCCTTGACGGTCAGAGCGGGCTGGAATAACTGACGCTTCGATGGCGTTATAGCTCAGTTGGTTAGAGCG
AACGACTCATAATCGTTAGG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MAAAKTILRSLAGETLPTPPIWMMRQAGRYLPEYKATRAQAGDFLSLCYNPELAAEVTLQPIRRYGFDAAILFADILLLP
QALGADLWFVTGEGPRLSTITTQADFDKLKPVDEIDAVLNPIYETVRILRRELPQETTLIGFAGAPWTVATYMIAGRGTP
DQAPAHALKDENRELFEALLARITQGTIEYLSRQIEAGAEVVKIFDSWAGSLKGADFQRYALEPAREITAAIKARHPDIP
VIGFPREAGDGYIGFAKATGVDCVALDNSVSAEWAAANVQVDGCVQGNLASSHMVTGGQALIDETRAIVKAFSGGPHIFN
LGHGITPDADPDNVQRMIDAVRGQ

Sequences:

>Translated_344_residues
MAAAKTILRSLAGETLPTPPIWMMRQAGRYLPEYKATRAQAGDFLSLCYNPELAAEVTLQPIRRYGFDAAILFADILLLP
QALGADLWFVTGEGPRLSTITTQADFDKLKPVDEIDAVLNPIYETVRILRRELPQETTLIGFAGAPWTVATYMIAGRGTP
DQAPAHALKDENRELFEALLARITQGTIEYLSRQIEAGAEVVKIFDSWAGSLKGADFQRYALEPAREITAAIKARHPDIP
VIGFPREAGDGYIGFAKATGVDCVALDNSVSAEWAAANVQVDGCVQGNLASSHMVTGGQALIDETRAIVKAFSGGPHIFN
LGHGITPDADPDNVQRMIDAVRGQ
>Mature_343_residues
AAAKTILRSLAGETLPTPPIWMMRQAGRYLPEYKATRAQAGDFLSLCYNPELAAEVTLQPIRRYGFDAAILFADILLLPQ
ALGADLWFVTGEGPRLSTITTQADFDKLKPVDEIDAVLNPIYETVRILRRELPQETTLIGFAGAPWTVATYMIAGRGTPD
QAPAHALKDENRELFEALLARITQGTIEYLSRQIEAGAEVVKIFDSWAGSLKGADFQRYALEPAREITAAIKARHPDIPV
IGFPREAGDGYIGFAKATGVDCVALDNSVSAEWAAANVQVDGCVQGNLASSHMVTGGQALIDETRAIVKAFSGGPHIFNL
GHGITPDADPDNVQRMIDAVRGQ

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=345, Percent_Identity=36.5217391304348, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI2367337, Length=343, Percent_Identity=43.4402332361516, Blast_Score=259, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=34.4729344729345, Blast_Score=200, Evalue=3e-52,
Organism=Drosophila melanogaster, GI221330099, Length=343, Percent_Identity=34.9854227405248, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI19921920, Length=343, Percent_Identity=34.9854227405248, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_ROSDO (Q16AR3)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_681616.1
- ProteinModelPortal:   Q16AR3
- SMR:   Q16AR3
- STRING:   Q16AR3
- GeneID:   4197416
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_1284
- NMPDR:   fig|375451.6.peg.1201
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q16AR3
- ProtClustDB:   PRK00115
- BioCyc:   RDEN375451:RD1_1284-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37204; Mature: 37073

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 75-75 BINDING 152-152 BINDING 207-207 BINDING 323-323

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAKTILRSLAGETLPTPPIWMMRQAGRYLPEYKATRAQAGDFLSLCYNPELAAEVTLQ
CCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCHHHHHCCCCHHHHHHHH
PIRRYGFDAAILFADILLLPQALGADLWFVTGEGPRLSTITTQADFDKLKPVDEIDAVLN
HHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCHHHCCCHHHHHHHHH
PIYETVRILRRELPQETTLIGFAGAPWTVATYMIAGRGTPDQAPAHALKDENRELFEALL
HHHHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHH
ARITQGTIEYLSRQIEAGAEVVKIFDSWAGSLKGADFQRYALEPAREITAAIKARHPDIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHHHHCCCCCC
VIGFPREAGDGYIGFAKATGVDCVALDNSVSAEWAAANVQVDGCVQGNLASSHMVTGGQA
EEECCCCCCCCEEEEHHCCCCEEEEECCCCCCCEEEEEEEECCEECCCCCCCCEECCCHH
LIDETRAIVKAFSGGPHIFNLGHGITPDADPDNVQRMIDAVRGQ
HHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAAKTILRSLAGETLPTPPIWMMRQAGRYLPEYKATRAQAGDFLSLCYNPELAAEVTLQ
CHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCHHHHHCCCCHHHHHHHH
PIRRYGFDAAILFADILLLPQALGADLWFVTGEGPRLSTITTQADFDKLKPVDEIDAVLN
HHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCHHHCCCHHHHHHHHH
PIYETVRILRRELPQETTLIGFAGAPWTVATYMIAGRGTPDQAPAHALKDENRELFEALL
HHHHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHH
ARITQGTIEYLSRQIEAGAEVVKIFDSWAGSLKGADFQRYALEPAREITAAIKARHPDIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHHHHCCCCCC
VIGFPREAGDGYIGFAKATGVDCVALDNSVSAEWAAANVQVDGCVQGNLASSHMVTGGQA
EEECCCCCCCCEEEEHHCCCCEEEEECCCCCCCEEEEEEEECCEECCCCCCCCEECCCHH
LIDETRAIVKAFSGGPHIFNLGHGITPDADPDNVQRMIDAVRGQ
HHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA