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The map label for this gene is gcvT [H]

Identifier: 110678550

GI number: 110678550

Start: 1187893

End: 1189017

Strand: Direct

Name: gcvT [H]

Synonym: RD1_1222

Alternate gene names: 110678550

Gene position: 1187893-1189017 (Clockwise)

Preceding gene: 110678548

Following gene: 110678551

Centisome position: 28.74

GC content: 62.93

Gene sequence:

>1125_bases
ATGACACGTCTGAAACGGACGCCACTTTTTGATCTGCATGCAGAGCTTGGCGCGAAGATGGTGCCCTTTGCAGGCTACGA
GATGCCCGTTCAATACCCGATGGGGGTCATGAAAGAGCATCTGCACACGCGCGGCCGTGCCGGGCTTTTCGATGTCAGCC
ATATGGGGCAGGTGCTCCTGTCTGGTCCCTCATGGGACGCGGTTGCGCTTGCCTTTGAGGCTTTGGTGCCCGTGGATGTG
CTGGGCCTTGCGGATGGGCGGCAACGCTATGGGTTTTTCACCAATGACGCAGGCGGTATCGAGGATGATCTGATGTTTTC
CCGACGCGGCGATGCCCTGTTTGTGGTGATCAATGCCGGGTGCAAGGACGCGGATCTGGCCCTGATGCGCGCGGGTTTGC
CCGATGACATCACCCTTACCGAGTTGAGCGACCGGGCCTTGCTGGCCCTGCAGGGACCTGCGGCGGGCAGTGTGATCGCG
TCTCTGGATGCGCGCGCAGCTGCGATGCGTTTCATGGACACATGCGAGTTATCGCTCTGCGGGCATACGGTCTGGGCCTC
CCGGTCCGGGTACACGGGCGAGGACGGTTTTGAAATCTCCGTTCACGCGGACGAAGCCGTGGCGCTGGCGCAGCGGCTTG
TTGAGGACGCAGAGGTTGCGCCCATCGGACTTGGCGCGCGGGATTCCCTGCGGCTTGAAGCGGGTCTGTGCCTTTACGGA
AATGATATAGATGCGGCGACAGGTCCGGTTGGTGCCGGTCTGTCCTGGGCCATTCAGAAAGTGCGCCGTCCCGGTGGCGC
ACGCGCTGGCGGCTTTCCCGGCAGCAAGGCGATCTTTGATGAAATAGCCCAAGGCCCGGCGACAAAACGCGTCGGATTGC
GCCCCGAAGGGCGCGCGCCCATGCGTCAGGGCGTGGCGCTGTTTGCCAGCGCCGAAGGGGGCGCGCAGATCGGCTCGGTC
ACCTCGGGCGGTTTTGGCCCCTCGGTGCAGGGTCCGGTTGCGATGGGATATGTCGATACCGATTTTGCCACCACCGGCAC
CGCGCTCTGGGGTGAGGTGCGCAGCAAGCGCATGGGGCTGAAGGTCGTTGACCTGCCGTTCGTTCCCGCAGGATTTAAAC
GTTAG

Upstream 100 bases:

>100_bases
GGCGAAAAGACAGAGGGGGCATTCAGGCGCAGGTCACAGGGCTGCGCGGGGGATGCCGTTGTTTGTCTGATTGCAGCACC
GGCGACGAATTGGAGGCCGG

Downstream 100 bases:

>100_bases
AAAACAGGAGACAGGCCATGAAATTCACAGAAGAGCACGAATGGTTGCGCCCGGACGGTGACGAAATCATCGTGGGCATC
ACGACACATGCCGCCGAACA

Product: aminomethyltransferase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MTRLKRTPLFDLHAELGAKMVPFAGYEMPVQYPMGVMKEHLHTRGRAGLFDVSHMGQVLLSGPSWDAVALAFEALVPVDV
LGLADGRQRYGFFTNDAGGIEDDLMFSRRGDALFVVINAGCKDADLALMRAGLPDDITLTELSDRALLALQGPAAGSVIA
SLDARAAAMRFMDTCELSLCGHTVWASRSGYTGEDGFEISVHADEAVALAQRLVEDAEVAPIGLGARDSLRLEAGLCLYG
NDIDAATGPVGAGLSWAIQKVRRPGGARAGGFPGSKAIFDEIAQGPATKRVGLRPEGRAPMRQGVALFASAEGGAQIGSV
TSGGFGPSVQGPVAMGYVDTDFATTGTALWGEVRSKRMGLKVVDLPFVPAGFKR

Sequences:

>Translated_374_residues
MTRLKRTPLFDLHAELGAKMVPFAGYEMPVQYPMGVMKEHLHTRGRAGLFDVSHMGQVLLSGPSWDAVALAFEALVPVDV
LGLADGRQRYGFFTNDAGGIEDDLMFSRRGDALFVVINAGCKDADLALMRAGLPDDITLTELSDRALLALQGPAAGSVIA
SLDARAAAMRFMDTCELSLCGHTVWASRSGYTGEDGFEISVHADEAVALAQRLVEDAEVAPIGLGARDSLRLEAGLCLYG
NDIDAATGPVGAGLSWAIQKVRRPGGARAGGFPGSKAIFDEIAQGPATKRVGLRPEGRAPMRQGVALFASAEGGAQIGSV
TSGGFGPSVQGPVAMGYVDTDFATTGTALWGEVRSKRMGLKVVDLPFVPAGFKR
>Mature_373_residues
TRLKRTPLFDLHAELGAKMVPFAGYEMPVQYPMGVMKEHLHTRGRAGLFDVSHMGQVLLSGPSWDAVALAFEALVPVDVL
GLADGRQRYGFFTNDAGGIEDDLMFSRRGDALFVVINAGCKDADLALMRAGLPDDITLTELSDRALLALQGPAAGSVIAS
LDARAAAMRFMDTCELSLCGHTVWASRSGYTGEDGFEISVHADEAVALAQRLVEDAEVAPIGLGARDSLRLEAGLCLYGN
DIDAATGPVGAGLSWAIQKVRRPGGARAGGFPGSKAIFDEIAQGPATKRVGLRPEGRAPMRQGVALFASAEGGAQIGSVT
SGGFGPSVQGPVAMGYVDTDFATTGTALWGEVRSKRMGLKVVDLPFVPAGFKR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=378, Percent_Identity=45.2380952380952, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI257796258, Length=361, Percent_Identity=45.4293628808864, Blast_Score=248, Evalue=8e-66,
Organism=Homo sapiens, GI257796254, Length=371, Percent_Identity=40.4312668463612, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI257796256, Length=316, Percent_Identity=43.9873417721519, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI197927446, Length=332, Percent_Identity=25.9036144578313, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI21361378, Length=332, Percent_Identity=25.9036144578313, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI24797151, Length=351, Percent_Identity=23.3618233618234, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1789272, Length=373, Percent_Identity=32.9758713136729, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17560118, Length=382, Percent_Identity=39.2670157068063, Blast_Score=228, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6320222, Length=391, Percent_Identity=37.5959079283887, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI20129441, Length=384, Percent_Identity=40.3645833333333, Blast_Score=254, Evalue=9e-68,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39296; Mature: 39165

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLKRTPLFDLHAELGAKMVPFAGYEMPVQYPMGVMKEHLHTRGRAGLFDVSHMGQVLL
CCCCCCCCCCHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEHHHHCCEEE
SGPSWDAVALAFEALVPVDVLGLADGRQRYGFFTNDAGGIEDDLMFSRRGDALFVVINAG
CCCCCHHHHHHHHHHCCCCEEECCCCCHHCCEEECCCCCCCHHHHEECCCCEEEEEEECC
CKDADLALMRAGLPDDITLTELSDRALLALQGPAAGSVIASLDARAAAMRFMDTCELSLC
CCCHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GHTVWASRSGYTGEDGFEISVHADEAVALAQRLVEDAEVAPIGLGARDSLRLEAGLCLYG
CCEEECCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCEECCCCCCCEEEEEEEEEEC
NDIDAATGPVGAGLSWAIQKVRRPGGARAGGFPGSKAIFDEIAQGPATKRVGLRPEGRAP
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCH
MRQGVALFASAEGGAQIGSVTSGGFGPSVQGPVAMGYVDTDFATTGTALWGEVRSKRMGL
HHCCEEEEEECCCCCEECCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCC
KVVDLPFVPAGFKR
EEEECCCCCCCCCC
>Mature Secondary Structure 
TRLKRTPLFDLHAELGAKMVPFAGYEMPVQYPMGVMKEHLHTRGRAGLFDVSHMGQVLL
CCCCCCCCCHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEHHHHCCEEE
SGPSWDAVALAFEALVPVDVLGLADGRQRYGFFTNDAGGIEDDLMFSRRGDALFVVINAG
CCCCCHHHHHHHHHHCCCCEEECCCCCHHCCEEECCCCCCCHHHHEECCCCEEEEEEECC
CKDADLALMRAGLPDDITLTELSDRALLALQGPAAGSVIASLDARAAAMRFMDTCELSLC
CCCHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GHTVWASRSGYTGEDGFEISVHADEAVALAQRLVEDAEVAPIGLGARDSLRLEAGLCLYG
CCEEECCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCEECCCCCCCEEEEEEEEEEC
NDIDAATGPVGAGLSWAIQKVRRPGGARAGGFPGSKAIFDEIAQGPATKRVGLRPEGRAP
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCH
MRQGVALFASAEGGAQIGSVTSGGFGPSVQGPVAMGYVDTDFATTGTALWGEVRSKRMGL
HHCCEEEEEECCCCCEECCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCC
KVVDLPFVPAGFKR
EEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA