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The map label for this gene is glpK [H]

Identifier: 108801836

GI number: 108801836

Start: 5161940

End: 5163472

Strand: Reverse

Name: glpK [H]

Synonym: Mmcs_4873

Alternate gene names: 108801836

Gene position: 5163472-5161940 (Counterclockwise)

Preceding gene: 108801841

Following gene: 108801830

Centisome position: 90.5

GC content: 67.84

Gene sequence:

>1533_bases
ATGAGGGAGAGCGCATTGGCCGAGTTCGTCGCCGCCATCGATCAGGGGACCACCAGTACCCGGTGCATGATCTTCGACCA
CGACGGCGCCGAGGTCGGCCGGCACCAGCTCGAACACGAGCAGATCCTGCCCAGGGCCGGCTGGGTCGAACACAACCCGG
TGGAGATCTGGGAGCGCACCGCATCGGTCCTCATGTCGGCGCTCAACCGCACCGACCTCTCGGCCGGGGACCTGTGCGCG
CTCGGTATCACCAACCAGCGGGAGACGGCGCTGGTGTGGAACCGTCGCACCGGGCGGCCGTACTACAACGCGATCGTGTG
GCAGGACACCCGCACCGACCGCATCGCCACGGCGCTCGACCGGGACGGGCGCGGAGACGTGATCCGCCGCAAGGCCGGGT
TGCCGCCGGCGACGTACTTCTCCGCGGGCAAGGTGCAGTGGATCCTCGACAACGTCGACGGTGTGCGCGAGGCCGCCGAC
AAGGGTGACGCGATCTTCGGCACCGCCGACAGCTGGGTGGTGTGGAACCTGACCGGCGGACCGCGCGGCGGCGTGCACGT
CACCGACGTGACCAACGCCAGCCGCACCATGCTGATGGATCTGGAGACGCTGGACTGGGACGATGAACTGTTGTCGTTCT
TCGGGATTCCGCGCCAGATGATGCCCGAGATCAAACCGTCGTCGTGCCCGGACTGCCACGGTGTCACCCGGGAGGACGGA
CCGCTCGGCGGTGAGGTGCCGATCGCCGGCATCCTCGGTGACCAGCAGGCCGCGATGGTCGGGCAGGTGTGCCTGTCGGC
GGGCGAGGCCAAGAACACCTACGGCACAGGCAATTTCCTGCTGCTCAACACCGGCGAGAAGATCGTCCGCTCCGAGAACG
GTCTGCTCACCACGGTCTGCTACCAGTTCGGTGACGCGAAACCCGTTTACGCCCTTGAGGGTTCGATCGCGGTGACGGGG
TCGGCCGTGCAATGGCTGCGCGATCAGCTCGGCATCATCAGCGGTGCCTCGCAGAGCGAGTCGCTGGCGCGTCAGGTCGA
GGACAACGGCGGGGTGTACTTCGTGCCGGCGTTCTCCGGGCTGTTCGCACCGTACTGGCGCTCGGATGCCCGCGGCGCCA
TCGTCGGCCTGTCCCGGTTCAACACCAACGCCCACGTCGCGCGGGCGACGCTGGAGGCGATCTGCTACCAGAGCCGCGAT
GTCGTCGACGCGATGGAGGCCGACTCAGGTGTGCATCTCGAGGTGCTCAAGGTCGACGGCGGCATCACCGTCAACGATCT
GTGCATGCAGATCCAGGCCGATGTGCTCGGCGTCGACGTGGTCCGGCCGGTGGTGGCCGAAACCACCGCTCTCGGTGCAG
GTTACGCGGCCGGGTTGGCGGTCGGGTTCTGGGACGGCGCCGACGATCTGCGGCGCAACTGGCAGGAGGACAAGCGCTGG
ACTCCGCAGTGGAGCGACGATCAGCGCGCCGAGGGGTACGCCGGCTGGCAGAAGGCCGTACAGCGCACCCTGGACTGGGT
CGACGTCGAGTGA

Upstream 100 bases:

>100_bases
CGGTCCAGACACGAGGCGCGGGGACCGCCGCGGGGCATCCGGTCGATGTCGGCGATCTTCGTTCCCATGTAGACCATGAT
GGACGACGGGAGCCGCCGTC

Downstream 100 bases:

>100_bases
GCGGCTAAGCGACGGCGTTCAACTGCTCGACGACCTCGGCGGGGAGTTCGATGTCACGGACGGCGGTGTTCTCCCCGAGG
TGAGCCACCGACGAGGTGCC

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MRESALAEFVAAIDQGTTSTRCMIFDHDGAEVGRHQLEHEQILPRAGWVEHNPVEIWERTASVLMSALNRTDLSAGDLCA
LGITNQRETALVWNRRTGRPYYNAIVWQDTRTDRIATALDRDGRGDVIRRKAGLPPATYFSAGKVQWILDNVDGVREAAD
KGDAIFGTADSWVVWNLTGGPRGGVHVTDVTNASRTMLMDLETLDWDDELLSFFGIPRQMMPEIKPSSCPDCHGVTREDG
PLGGEVPIAGILGDQQAAMVGQVCLSAGEAKNTYGTGNFLLLNTGEKIVRSENGLLTTVCYQFGDAKPVYALEGSIAVTG
SAVQWLRDQLGIISGASQSESLARQVEDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHVARATLEAICYQSRD
VVDAMEADSGVHLEVLKVDGGITVNDLCMQIQADVLGVDVVRPVVAETTALGAGYAAGLAVGFWDGADDLRRNWQEDKRW
TPQWSDDQRAEGYAGWQKAVQRTLDWVDVE

Sequences:

>Translated_510_residues
MRESALAEFVAAIDQGTTSTRCMIFDHDGAEVGRHQLEHEQILPRAGWVEHNPVEIWERTASVLMSALNRTDLSAGDLCA
LGITNQRETALVWNRRTGRPYYNAIVWQDTRTDRIATALDRDGRGDVIRRKAGLPPATYFSAGKVQWILDNVDGVREAAD
KGDAIFGTADSWVVWNLTGGPRGGVHVTDVTNASRTMLMDLETLDWDDELLSFFGIPRQMMPEIKPSSCPDCHGVTREDG
PLGGEVPIAGILGDQQAAMVGQVCLSAGEAKNTYGTGNFLLLNTGEKIVRSENGLLTTVCYQFGDAKPVYALEGSIAVTG
SAVQWLRDQLGIISGASQSESLARQVEDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHVARATLEAICYQSRD
VVDAMEADSGVHLEVLKVDGGITVNDLCMQIQADVLGVDVVRPVVAETTALGAGYAAGLAVGFWDGADDLRRNWQEDKRW
TPQWSDDQRAEGYAGWQKAVQRTLDWVDVE
>Mature_510_residues
MRESALAEFVAAIDQGTTSTRCMIFDHDGAEVGRHQLEHEQILPRAGWVEHNPVEIWERTASVLMSALNRTDLSAGDLCA
LGITNQRETALVWNRRTGRPYYNAIVWQDTRTDRIATALDRDGRGDVIRRKAGLPPATYFSAGKVQWILDNVDGVREAAD
KGDAIFGTADSWVVWNLTGGPRGGVHVTDVTNASRTMLMDLETLDWDDELLSFFGIPRQMMPEIKPSSCPDCHGVTREDG
PLGGEVPIAGILGDQQAAMVGQVCLSAGEAKNTYGTGNFLLLNTGEKIVRSENGLLTTVCYQFGDAKPVYALEGSIAVTG
SAVQWLRDQLGIISGASQSESLARQVEDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHVARATLEAICYQSRD
VVDAMEADSGVHLEVLKVDGGITVNDLCMQIQADVLGVDVVRPVVAETTALGAGYAAGLAVGFWDGADDLRRNWQEDKRW
TPQWSDDQRAEGYAGWQKAVQRTLDWVDVE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=519, Percent_Identity=47.0134874759152, Blast_Score=484, Evalue=1e-137,
Organism=Homo sapiens, GI4504007, Length=519, Percent_Identity=47.0134874759152, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI42794763, Length=524, Percent_Identity=46.5648854961832, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI41393575, Length=515, Percent_Identity=45.6310679611651, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI88196792, Length=517, Percent_Identity=30.3675048355899, Blast_Score=287, Evalue=2e-77,
Organism=Escherichia coli, GI1790361, Length=500, Percent_Identity=52, Blast_Score=532, Evalue=1e-152,
Organism=Escherichia coli, GI1789987, Length=441, Percent_Identity=24.7165532879819, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17535599, Length=508, Percent_Identity=44.8818897637795, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71986140, Length=522, Percent_Identity=23.5632183908046, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71986147, Length=300, Percent_Identity=27.6666666666667, Blast_Score=112, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6321755, Length=558, Percent_Identity=39.6057347670251, Blast_Score=344, Evalue=2e-95,
Organism=Drosophila melanogaster, GI17864214, Length=508, Percent_Identity=47.0472440944882, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24655555, Length=520, Percent_Identity=41.9230769230769, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24655560, Length=520, Percent_Identity=41.9230769230769, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24655570, Length=520, Percent_Identity=41.9230769230769, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24655574, Length=520, Percent_Identity=41.9230769230769, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24655565, Length=520, Percent_Identity=41.9230769230769, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24654573, Length=436, Percent_Identity=48.8532110091743, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI19922058, Length=533, Percent_Identity=35.0844277673546, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24652871, Length=499, Percent_Identity=34.8697394789579, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI21357867, Length=534, Percent_Identity=29.7752808988764, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24656367, Length=515, Percent_Identity=29.9029126213592, Blast_Score=222, Evalue=5e-58,
Organism=Drosophila melanogaster, GI24656372, Length=369, Percent_Identity=31.1653116531165, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI45552909, Length=310, Percent_Identity=30, Blast_Score=128, Evalue=9e-30,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55582; Mature: 55582

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRESALAEFVAAIDQGTTSTRCMIFDHDGAEVGRHQLEHEQILPRAGWVEHNPVEIWERT
CCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
ASVLMSALNRTDLSAGDLCALGITNQRETALVWNRRTGRPYYNAIVWQDTRTDRIATALD
HHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHC
RDGRGDVIRRKAGLPPATYFSAGKVQWILDNVDGVREAADKGDAIFGTADSWVVWNLTGG
CCCCCCHHHHHCCCCCHHHCCCCCEEEEECCHHHHHHHHCCCCEEEECCCCEEEEEECCC
PRGGVHVTDVTNASRTMLMDLETLDWDDELLSFFGIPRQMMPEIKPSSCPDCHGVTREDG
CCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCC
PLGGEVPIAGILGDQQAAMVGQVCLSAGEAKNTYGTGNFLLLNTGEKIVRSENGLLTTVC
CCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHCCCCEEEEEH
YQFGDAKPVYALEGSIAVTGSAVQWLRDQLGIISGASQSESLARQVEDNGGVYFVPAFSG
HHCCCCCCEEEECCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCC
LFAPYWRSDARGAIVGLSRFNTNAHVARATLEAICYQSRDVVDAMEADSGVHLEVLKVDG
HHCHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEECC
GITVNDLCMQIQADVLGVDVVRPVVAETTALGAGYAAGLAVGFWDGADDLRRNWQEDKRW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEECCCHHHHHHCHHHHCCC
TPQWSDDQRAEGYAGWQKAVQRTLDWVDVE
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRESALAEFVAAIDQGTTSTRCMIFDHDGAEVGRHQLEHEQILPRAGWVEHNPVEIWERT
CCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
ASVLMSALNRTDLSAGDLCALGITNQRETALVWNRRTGRPYYNAIVWQDTRTDRIATALD
HHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHC
RDGRGDVIRRKAGLPPATYFSAGKVQWILDNVDGVREAADKGDAIFGTADSWVVWNLTGG
CCCCCCHHHHHCCCCCHHHCCCCCEEEEECCHHHHHHHHCCCCEEEECCCCEEEEEECCC
PRGGVHVTDVTNASRTMLMDLETLDWDDELLSFFGIPRQMMPEIKPSSCPDCHGVTREDG
CCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCC
PLGGEVPIAGILGDQQAAMVGQVCLSAGEAKNTYGTGNFLLLNTGEKIVRSENGLLTTVC
CCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHCCCCEEEEEH
YQFGDAKPVYALEGSIAVTGSAVQWLRDQLGIISGASQSESLARQVEDNGGVYFVPAFSG
HHCCCCCCEEEECCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCC
LFAPYWRSDARGAIVGLSRFNTNAHVARATLEAICYQSRDVVDAMEADSGVHLEVLKVDG
HHCHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEECC
GITVNDLCMQIQADVLGVDVVRPVVAETTALGAGYAAGLAVGFWDGADDLRRNWQEDKRW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEECCCHHHHHHCHHHHCCC
TPQWSDDQRAEGYAGWQKAVQRTLDWVDVE
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA