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The map label for this gene is capL [H]

Identifier: 108801607

GI number: 108801607

Start: 4918768

End: 4920078

Strand: Reverse

Name: capL [H]

Synonym: Mmcs_4644

Alternate gene names: 108801607

Gene position: 4920078-4918768 (Counterclockwise)

Preceding gene: 108801608

Following gene: 108801606

Centisome position: 86.23

GC content: 69.49

Gene sequence:

>1311_bases
ATGACCACGTTCTGCGAACCGACTGTCAGCGACCATCTCCGCAGTGACGTGGCGCAGCCACTACACGGCGTGGGCATCGT
CGGACTCGGCTATGTCGGACTGCCCACCGCGCTCGCGATCGCCGAATCCGGTGTCGCCGTCCTCGGCTGCGACATCAGCG
AGTCGCGGATCGCGGCGATCAAGGCCCAGCGGGTCGACCTCCTGGCCGGCGACCTCATGAGCCTGAACCGCCTACTCGAC
ACCGACCTGTTGACGCTGACCACCGAGGTCGCCGGACTCGCGGCGGTGGACACCGTCCTGATCTGTGTGCCGACGCCGGT
CGACACCCATCTGGTCCCCGATCTGACCGCGCTGCGCGCCGCATGCGCCACCGTCGTCGATGCGGCTCGGCCCGGGCAGA
CGATCGTGTTGACCTCCACCACCTATGTGGGGTGCACCCGCGAACTGTTGGTCGAGCCCCTCGCGCGGCGCGGTCTGGTC
GCCGGCCGTGACGTGTTCGTCGCCTTCAGCCCCGAGCGGATCGACCCCGGCTCACCGGCCCATGTCCCCGAGCGGACACC
GCGCGTGGTCGGTGGTGTGACCGATGCGTGCGCCGTCCAGGCGACGCGGACGCTCGTCCGGTCCGCCGCATCTGTGCACC
AGGTGTCCAGCCCCGAGGCCGCCGAGCTGACCAAGCTGCTCGAGAACACCTTTCGGGCCGTGAACATCGCGCTGGCCAAC
GAGTTCTCCGACGTCGCAAAGAACTTCGGCGTCGACGTCATGGAGGTGATCTCCGCGGCGGCGACCAAGCCCTACGGTTT
CATGCCGTTCCGCCCCGGCCCGGGCGTCGGCGGACACTGCATCCCGTGCGATCCGCACTACCTGCTGTGGCAGCTGAAAG
CCACCAGGCTGCCGTCACCCGTCACCGAAGCCGCCATGGCATCCATCGCCTCGCGTCCGCAGGCGGTGGTCAACCGGGCG
CAGGAACTGCTCGCGGAGGAGGGTCGGCCGCTGGCCGGGTCGCGGATCCTCGTCGTCGGCGTCGCATACAAACCGGCCGT
CGCCGACGTGCGCGAGTCGCCCGCCCTGCACATCCTCGAAGAACTGCACCGCCGCGGCGCCGAGGTCGCCTTCACCGACG
CGATGGTGGAGAGCGTGTGGACCGAGTCCGGGCACCTCGCGCGGGAAACCGATCCGGCGCAGGGCGATTGGGATCTGGTC
ATCGCGCACACGCTGCACCCGGCGGCTGATCACACCTGGTTGTCCACGGTCCCCCTGCTGCTCGACGCCGCCTACGGCCT
GCCCGACCTGCCTCAGCGGAGGGTGCTTTGA

Upstream 100 bases:

>100_bases
CGCAGGGTCAGGGGAGGGGGCACATGGCACGGTCCGACTTCCTCTATCGCCGGGCCGGCGATTTCGCCGCCCGCGTCCAC
CGCTTCCCCGAAGGGACGTC

Downstream 100 bases:

>100_bases
GCACGGCCGACACCTTGGCGCCACCGTCGGTGCGGGAGCCCCGGAGCCTCGCATTCGCCGGATGGCTCGACTCCAGACCG
GCGGAGGTGCGTCGCGGACT

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MTTFCEPTVSDHLRSDVAQPLHGVGIVGLGYVGLPTALAIAESGVAVLGCDISESRIAAIKAQRVDLLAGDLMSLNRLLD
TDLLTLTTEVAGLAAVDTVLICVPTPVDTHLVPDLTALRAACATVVDAARPGQTIVLTSTTYVGCTRELLVEPLARRGLV
AGRDVFVAFSPERIDPGSPAHVPERTPRVVGGVTDACAVQATRTLVRSAASVHQVSSPEAAELTKLLENTFRAVNIALAN
EFSDVAKNFGVDVMEVISAAATKPYGFMPFRPGPGVGGHCIPCDPHYLLWQLKATRLPSPVTEAAMASIASRPQAVVNRA
QELLAEEGRPLAGSRILVVGVAYKPAVADVRESPALHILEELHRRGAEVAFTDAMVESVWTESGHLARETDPAQGDWDLV
IAHTLHPAADHTWLSTVPLLLDAAYGLPDLPQRRVL

Sequences:

>Translated_436_residues
MTTFCEPTVSDHLRSDVAQPLHGVGIVGLGYVGLPTALAIAESGVAVLGCDISESRIAAIKAQRVDLLAGDLMSLNRLLD
TDLLTLTTEVAGLAAVDTVLICVPTPVDTHLVPDLTALRAACATVVDAARPGQTIVLTSTTYVGCTRELLVEPLARRGLV
AGRDVFVAFSPERIDPGSPAHVPERTPRVVGGVTDACAVQATRTLVRSAASVHQVSSPEAAELTKLLENTFRAVNIALAN
EFSDVAKNFGVDVMEVISAAATKPYGFMPFRPGPGVGGHCIPCDPHYLLWQLKATRLPSPVTEAAMASIASRPQAVVNRA
QELLAEEGRPLAGSRILVVGVAYKPAVADVRESPALHILEELHRRGAEVAFTDAMVESVWTESGHLARETDPAQGDWDLV
IAHTLHPAADHTWLSTVPLLLDAAYGLPDLPQRRVL
>Mature_435_residues
TTFCEPTVSDHLRSDVAQPLHGVGIVGLGYVGLPTALAIAESGVAVLGCDISESRIAAIKAQRVDLLAGDLMSLNRLLDT
DLLTLTTEVAGLAAVDTVLICVPTPVDTHLVPDLTALRAACATVVDAARPGQTIVLTSTTYVGCTRELLVEPLARRGLVA
GRDVFVAFSPERIDPGSPAHVPERTPRVVGGVTDACAVQATRTLVRSAASVHQVSSPEAAELTKLLENTFRAVNIALANE
FSDVAKNFGVDVMEVISAAATKPYGFMPFRPGPGVGGHCIPCDPHYLLWQLKATRLPSPVTEAAMASIASRPQAVVNRAQ
ELLAEEGRPLAGSRILVVGVAYKPAVADVRESPALHILEELHRRGAEVAFTDAMVESVWTESGHLARETDPAQGDWDLVI
AHTLHPAADHTWLSTVPLLLDAAYGLPDLPQRRVL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=377, Percent_Identity=24.4031830238727, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI48994968, Length=358, Percent_Identity=32.9608938547486, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788340, Length=409, Percent_Identity=22.9828850855746, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17560350, Length=385, Percent_Identity=24.1558441558442, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17136908, Length=385, Percent_Identity=24.1558441558442, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46169; Mature: 46038

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFCEPTVSDHLRSDVAQPLHGVGIVGLGYVGLPTALAIAESGVAVLGCDISESRIAAI
CCCCCCCHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHH
KAQRVDLLAGDLMSLNRLLDTDLLTLTTEVAGLAAVDTVLICVPTPVDTHLVPDLTALRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHH
ACATVVDAARPGQTIVLTSTTYVGCTRELLVEPLARRGLVAGRDVFVAFSPERIDPGSPA
HHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCC
HVPERTPRVVGGVTDACAVQATRTLVRSAASVHQVSSPEAAELTKLLENTFRAVNIALAN
CCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
EFSDVAKNFGVDVMEVISAAATKPYGFMPFRPGPGVGGHCIPCDPHYLLWQLKATRLPSP
HHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHCCCCH
VTEAAMASIASRPQAVVNRAQELLAEEGRPLAGSRILVVGVAYKPAVADVRESPALHILE
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHCCCHHHHHH
ELHRRGAEVAFTDAMVESVWTESGHLARETDPAQGDWDLVIAHTLHPAADHTWLSTVPLL
HHHHCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHH
LDAAYGLPDLPQRRVL
HHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TTFCEPTVSDHLRSDVAQPLHGVGIVGLGYVGLPTALAIAESGVAVLGCDISESRIAAI
CCCCCCHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHH
KAQRVDLLAGDLMSLNRLLDTDLLTLTTEVAGLAAVDTVLICVPTPVDTHLVPDLTALRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHH
ACATVVDAARPGQTIVLTSTTYVGCTRELLVEPLARRGLVAGRDVFVAFSPERIDPGSPA
HHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCC
HVPERTPRVVGGVTDACAVQATRTLVRSAASVHQVSSPEAAELTKLLENTFRAVNIALAN
CCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
EFSDVAKNFGVDVMEVISAAATKPYGFMPFRPGPGVGGHCIPCDPHYLLWQLKATRLPSP
HHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHCCCCH
VTEAAMASIASRPQAVVNRAQELLAEEGRPLAGSRILVVGVAYKPAVADVRESPALHILE
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHCCCHHHHHH
ELHRRGAEVAFTDAMVESVWTESGHLARETDPAQGDWDLVIAHTLHPAADHTWLSTVPLL
HHHHCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHH
LDAAYGLPDLPQRRVL
HHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]