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The map label for this gene is hasA [H]

Identifier: 108801606

GI number: 108801606

Start: 4917314

End: 4918771

Strand: Reverse

Name: hasA [H]

Synonym: Mmcs_4643

Alternate gene names: 108801606

Gene position: 4918771-4917314 (Counterclockwise)

Preceding gene: 108801607

Following gene: 108801605

Centisome position: 86.21

GC content: 68.04

Gene sequence:

>1458_bases
TTGAGCACGGCCGACACCTTGGCGCCACCGTCGGTGCGGGAGCCCCGGAGCCTCGCATTCGCCGGATGGCTCGACTCCAG
ACCGGCGGAGGTGCGTCGCGGACTGCGCAGGGTGCTGGTCCTGATCGGGCTGATGCCGCTGATCGTGCTGCTCGCCGTGC
AGGCGCCGCTGTTGTCGCACGGGGCGCTGCTGCTGGGATACGGGATGCTCGTCCTGACCGCCACCGTCTCGATGATGTAT
CTCGGCTTCGCGCGCTACGAGGATCCCAGCGTCCACCGTTCGACGGATGCCGGTGCGCGTGACCAGTGCGACTTCCCCGC
GCTGCCGCCCCTGCCGCGGGTGAGTCTGCTCGTCGCGGTCCGGGACGAGGTGGACGGTATCGAAGAGTGCGTCCGCACCA
TGGTCGGTTCGGCGTACCCCGACCTCGAAGTGATCGTCATCGACGACGCGTCGACCGACGGGACGCCCGACGTGCTCCGG
CGGTTGGCCGCCGAACTCGATGTGACCGTGATCTTCAAGGAGATCAACCAGGGCAAGAAACACGCCCTCACCGACGGGGT
GCGCGTCGCCTCCGGTGAGGTTCTGGCATTCACCGACTCCGACTGCGTGCTCGCACCCGACGCCCTGTCGCGCTGCGTGC
GCGCACTGGTCGAGAATCCGCGGCTGGGCGCGGTCAGCGGTCACGCACGCGCACTCAACGCCGCCGACACCGTGCTGACC
CGCGCCCAGGACACCTGGTACGACGGCCAGTTCAGGGTGGCCAAGGCCGCCGAGGCCACCTTCGGCAACGTCACCTGCGT
CTCGGGGCCACTGGCCGTGTTCCGCCGCGACGCGATCGTCAACTACCTGCCGGCGTGGGCCAACGACACGTTCCTCGGCC
GCGAATTCCGCTTCGCCACCGACCGGCAACTCACCGGATACGTGCTCGGCCAGGTGTGGAAGGGGCAGGCGCTCAAGCGC
CGCTACGCGGACGATCCGCTGGTCGCCGATCACGACCATCCCGAACGGCGTTGGCTGGTCGGCTATGTGCGCTCCGCGCA
TGTGTGGACGACGGTGCCCGCCCGGTTCCGGCCGTTCCTCAAACAGCAGGTGCGGTGGAAGAAGAGCTTCATCCGGAACC
TGTGCTTCACCGGGTCGTTCATGTGGCGGCGCGGGTTCGGTGCGGCGGCCCTGTTCTACGGTCACGTCCTGTTCGTGGCG
GTGGCGCCGTTGATGGCCGTGCGCCATCTGGTCTGGGCGCCGGCCAACGGCCTCTATTTCCTCACGCTGCTCTACCTGTG
CGGGGTGGTGACCAAAGGGTTCGCCTGGGCGCTCGCCTTCAAGATCTCCAACCCGGGCAACCCGCTGTGGCGTTACCGCC
TGTTGATGGCGGTCCTCGGCTCGATGCTGTTGTCCTGGTTGCTGCCCTATTCGCTGGCCACCATCCGCAAGGGCACATGG
GCGCGAGGTGCCCAATGA

Upstream 100 bases:

>100_bases
ACACGCTGCACCCGGCGGCTGATCACACCTGGTTGTCCACGGTCCCCCTGCTGCTCGACGCCGCCTACGGCCTGCCCGAC
CTGCCTCAGCGGAGGGTGCT

Downstream 100 bases:

>100_bases
GACTGCGCCGACTGCGCATCCGGCTCGTCGACCTGGTGTTCCTCGCCGCCGGCGCGCTGGTGTTCTTGATCGTCCTGACG
AATGGAATGTTCTGGTGACC

Product: glycosyl transferase family protein

Products: NA

Alternate protein names: Hyaluronate synthase; Hyaluronic acid synthase; HA synthase [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSTADTLAPPSVREPRSLAFAGWLDSRPAEVRRGLRRVLVLIGLMPLIVLLAVQAPLLSHGALLLGYGMLVLTATVSMMY
LGFARYEDPSVHRSTDAGARDQCDFPALPPLPRVSLLVAVRDEVDGIEECVRTMVGSAYPDLEVIVIDDASTDGTPDVLR
RLAAELDVTVIFKEINQGKKHALTDGVRVASGEVLAFTDSDCVLAPDALSRCVRALVENPRLGAVSGHARALNAADTVLT
RAQDTWYDGQFRVAKAAEATFGNVTCVSGPLAVFRRDAIVNYLPAWANDTFLGREFRFATDRQLTGYVLGQVWKGQALKR
RYADDPLVADHDHPERRWLVGYVRSAHVWTTVPARFRPFLKQQVRWKKSFIRNLCFTGSFMWRRGFGAAALFYGHVLFVA
VAPLMAVRHLVWAPANGLYFLTLLYLCGVVTKGFAWALAFKISNPGNPLWRYRLLMAVLGSMLLSWLLPYSLATIRKGTW
ARGAQ

Sequences:

>Translated_485_residues
MSTADTLAPPSVREPRSLAFAGWLDSRPAEVRRGLRRVLVLIGLMPLIVLLAVQAPLLSHGALLLGYGMLVLTATVSMMY
LGFARYEDPSVHRSTDAGARDQCDFPALPPLPRVSLLVAVRDEVDGIEECVRTMVGSAYPDLEVIVIDDASTDGTPDVLR
RLAAELDVTVIFKEINQGKKHALTDGVRVASGEVLAFTDSDCVLAPDALSRCVRALVENPRLGAVSGHARALNAADTVLT
RAQDTWYDGQFRVAKAAEATFGNVTCVSGPLAVFRRDAIVNYLPAWANDTFLGREFRFATDRQLTGYVLGQVWKGQALKR
RYADDPLVADHDHPERRWLVGYVRSAHVWTTVPARFRPFLKQQVRWKKSFIRNLCFTGSFMWRRGFGAAALFYGHVLFVA
VAPLMAVRHLVWAPANGLYFLTLLYLCGVVTKGFAWALAFKISNPGNPLWRYRLLMAVLGSMLLSWLLPYSLATIRKGTW
ARGAQ
>Mature_484_residues
STADTLAPPSVREPRSLAFAGWLDSRPAEVRRGLRRVLVLIGLMPLIVLLAVQAPLLSHGALLLGYGMLVLTATVSMMYL
GFARYEDPSVHRSTDAGARDQCDFPALPPLPRVSLLVAVRDEVDGIEECVRTMVGSAYPDLEVIVIDDASTDGTPDVLRR
LAAELDVTVIFKEINQGKKHALTDGVRVASGEVLAFTDSDCVLAPDALSRCVRALVENPRLGAVSGHARALNAADTVLTR
AQDTWYDGQFRVAKAAEATFGNVTCVSGPLAVFRRDAIVNYLPAWANDTFLGREFRFATDRQLTGYVLGQVWKGQALKRR
YADDPLVADHDHPERRWLVGYVRSAHVWTTVPARFRPFLKQQVRWKKSFIRNLCFTGSFMWRRGFGAAALFYGHVLFVAV
APLMAVRHLVWAPANGLYFLTLLYLCGVVTKGFAWALAFKISNPGNPLWRYRLLMAVLGSMLLSWLLPYSLATIRKGTWA
RGAQ

Specific function: Glycosaminoglycan synthesis. The hyaluronic acid capsule is involved in the pathogenicity of group A Streptococci; it may be the major virulence determinant [H]

COG id: COG1215

COG function: function code M; Glycosyltransferases, probably involved in cell wall biogenesis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nodC/HAS family [H]

Homologues:

Organism=Homo sapiens, GI20302153, Length=426, Percent_Identity=24.8826291079812, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI4885391, Length=345, Percent_Identity=25.5072463768116, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI167466171, Length=212, Percent_Identity=31.6037735849057, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1787259, Length=302, Percent_Identity=27.8145695364238, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: =2.4.1.212 [H]

Molecular weight: Translated: 53643; Mature: 53512

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTADTLAPPSVREPRSLAFAGWLDSRPAEVRRGLRRVLVLIGLMPLIVLLAVQAPLLSH
CCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GALLLGYGMLVLTATVSMMYLGFARYEDPSVHRSTDAGARDQCDFPALPPLPRVSLLVAV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEH
RDEVDGIEECVRTMVGSAYPDLEVIVIDDASTDGTPDVLRRLAAELDVTVIFKEINQGKK
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHH
HALTDGVRVASGEVLAFTDSDCVLAPDALSRCVRALVENPRLGAVSGHARALNAADTVLT
HHHHCCCEEECCCEEEEECCCCEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
RAQDTWYDGQFRVAKAAEATFGNVTCVSGPLAVFRRDAIVNYLPAWANDTFLGREFRFAT
HCCCCCCCCCEEEEHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCEEECCC
DRQLTGYVLGQVWKGQALKRRYADDPLVADHDHPERRWLVGYVRSAHVWTTVPARFRPFL
CCCHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCHHHHHHH
KQQVRWKKSFIRNLCFTGSFMWRRGFGAAALFYGHVLFVAVAPLMAVRHLVWAPANGLYF
HHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LTLLYLCGVVTKGFAWALAFKISNPGNPLWRYRLLMAVLGSMLLSWLLPYSLATIRKGTW
HHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ARGAQ
CCCCC
>Mature Secondary Structure 
STADTLAPPSVREPRSLAFAGWLDSRPAEVRRGLRRVLVLIGLMPLIVLLAVQAPLLSH
CCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GALLLGYGMLVLTATVSMMYLGFARYEDPSVHRSTDAGARDQCDFPALPPLPRVSLLVAV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEH
RDEVDGIEECVRTMVGSAYPDLEVIVIDDASTDGTPDVLRRLAAELDVTVIFKEINQGKK
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHH
HALTDGVRVASGEVLAFTDSDCVLAPDALSRCVRALVENPRLGAVSGHARALNAADTVLT
HHHHCCCEEECCCEEEEECCCCEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
RAQDTWYDGQFRVAKAAEATFGNVTCVSGPLAVFRRDAIVNYLPAWANDTFLGREFRFAT
HCCCCCCCCCEEEEHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCEEECCC
DRQLTGYVLGQVWKGQALKRRYADDPLVADHDHPERRWLVGYVRSAHVWTTVPARFRPFL
CCCHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCHHHHHHH
KQQVRWKKSFIRNLCFTGSFMWRRGFGAAALFYGHVLFVAVAPLMAVRHLVWAPANGLYF
HHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LTLLYLCGVVTKGFAWALAFKISNPGNPLWRYRLLMAVLGSMLLSWLLPYSLATIRKGTW
HHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ARGAQ
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]